Advanced Emergency Medicine (E-Journal)
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Application Comparison of Different Tip Positions of Midline Catheters in Neurosurgical Patients
Get PDFObjective To compare the clinical effect of midline catheter tip in different locations. Methods The 205 patients admitted to the
neurosurgery department were divided into 105 patients in the catheter of the test group and 100 patients in the control group,the catheter tip
of the test group located in the subclavian vein and the catheter tip of the control group in the axillary vein of the chest. Results There was no
statistical difference in the catheter retention time and complications and the control group (P> 0.05). Conclusion The tip of the midline catheter is located in the subclavian vein and the axillary vein of the chest
Reperfusion Combined with Neuroprotective Agents Treatment in Acute Ischemic Stroke: a Literature Review of Current Progress
Get PDFAcute ischemic stroke remains to be a heavy burden causing serious mortality and disability. Clinical studies of neuroprotective
agents produced disappointing results in the treatment, and recanalization may be a precondition for it to be successful. By searching for relevant randomized controlled trials concerning combination therapy in the online databases and analyzing them, this literature review investigated the therapeutic effect of reperfusion combined with neuroprotective agents treatment in acute ischemic stroke. We found that reported
trials specifically designed to investigate the efficacy of combination treatment are scarce. Overall, use of uric acid and nerinetide in the
combination therapy exhibited positive results. These results indicate a high potential for clinical use with further confirmation. Future studies are still needed. They should focus on (1) designing clinical trials that investigate combination therapy specifically or include prespecified
subgroup analyses for different types of recanalization, (2) reaffirming previous positive clinical trials with more patients of different characteristics or geographical locations, (3) employing multitarget neuroprotectant combinative therapy (cocktail therapy) to target multiple targets
of ischemia-reperfusion injury instead of the currently prevalent single neuroprotectant with recanalization therapy
Mesenchymal stem cells secretions for treating neurological diseases and their mechanism of action
Get PDFNeurological diseases are a class of diseases that seriously affect human health, including stroke, Parkinson’s disease, Alzheimer’s
disease and spinal cord injury. Traditional treatments have some limitations in the treatment of these diseases, such as drug side effects, surgical risks, etc. In recent years, secretions from mesenchymal stem cells (MSCs) have attracted much attention as a new method to treat neuro_x005flogical diseases. The secretions are composed of a variety of bioactive components, which can exert their therapeutic effects by regulating the
inflammatory response, promoting the regeneration and repair of nerve cells, and resisting oxidative stress. This review aims to review the
application of MSC secretions in the treatment of neurological diseases and explore the mechanism of action
Anaphylactic shock causing cardiac arrhythmia: A case analysis of successful precordial thump intervention
Get PDFThis article presents a clinical case analysis of cardiac arrhythmia induced by anaphylactic shock, along with the diagnosis and
treatment methods employed in the case. The article provides a detailed explanation of the causes and mechanisms of allergic reactions
caused by neuromuscular blocking agents and the subsequent cardiac arrhythmias. It also discusses treatment methods such as precordial
thump. This article can serve as a reference for clinicians dealing with similar cases
Severe Myelosuppression Induced by Piperacillin/Tazobactam: A Case Report
Get PDFThis case report presents an elderly patient who developed severe bone marrow suppression following the administration of Piperacillin/Tazobactam. The patient exhibited a declining trend in platelet and white blood cell counts during Piperacillin/Tazobactam treatment.
Subsequently, upon discontinuation of Piperacillin/Tazobactam, platelet and white blood cell counts gradually increased. Negative drug allergy test results and the absence of evidence for bone marrow suppression caused by platelet antibodies or other drugs led to the consideration
of the possibility of immune-mediated bone marrow suppression induced by Piperacillin/Tazobactam. This report emphasizes the importance
of close monitoring of hematological parameters to mitigate the risk of bone marrow suppression during the clinical use of Piperacillin/Tazobactam
Application Analysis of Combining Scenario Simulation with the Problem-Based Learning (PBL) Model in Orthopedic Teaching
Get PDFThe development of medical expertise demands a meticulous and scientific approach, relying not solely on extensive theoretical
foundations but also on ample practical experience to reinforce theoretical applications. This is particularly evident in orthopedic teaching,
where an understanding of the skeletal system, analysis of pathogenesis, and treatment are essential. Practicality becomes crucial in this context. To augment teaching effectiveness, it is imperative to employ effective teaching methods and strategies. Integrating scenario simulation
with the Problem-Based Learning (PBL) model allows for a more intuitive presentation of pathological knowledge to students. This method
aids students in better absorbing theoretical content, fostering deeper communication and learning during scenario simulation, and ultimately
achieving superior learning outcomes
Contributions of Integration of Traditional Chinese and West_x005fern Medicine to the Prevention and Treatment of Respiratory Diseases
Get PDFRespiratory disease is a relatively common disease currently recognized in society, which brings a burden to individuals and society that beyond measure. The Integration of traditional Chinese medicine (TCM) and Western medicine(WM) to prevent and treat respiratory
diseases is a new method of comprehensive application of TCM and WM for prevention and treatment. Its advantage point in the treatment
of respiratory diseases have become increasingly prominent, becoming one of the important measures in the field of disease control Nowadays. Integration of TCM and WM(ITCWM) brings a more effective and sustainable approach to the prevention and treatment of respiratory
diseases and alleviates the pain and suffering of patients during treatment. The contribution of ITCWM to the prevention and treatment of
respiratory diseases is not only reflected in treatment, but also in prevention, health-care and health education. This article will explore the
particular contribution of ITCWM in the prevention and treatment of respiratory diseases in the disease control and human well-being
Study On The Mechanism Of Jiedu Sanjie Recipe In The Treatment Of Liver Cancer Based On Network Pharmacology
Get PDFObjective: to study the mechanism of action of Jiedu Sanjie Recipe in the treatment of Liver Cancer through network pharmacology. Method: Collect and screen the active ingredients of Jiedu Sanjie Recipe through the Traditional Chinese Medicine System Pharmacology
Database and Analysis Platform (TCMSP), and search for the human target protein corresponding to the active ingredients in the database;
screen out the target set of liver cancer-related diseases through GeneCards and OMIM database; construct a Venn diagram to obtain the key
target of Jiedu Sanjie Recipe for treating liver cancer; use Cytoscape 3.8.0 software to construct drug-component-target-pathway network;
use Cytoscape software and BisoGenet plug-in to construct protein interaction network, use CytoNCA plug-in and R language to perform
network topology analysis, gene ontology functional annotation (GO) and KEGG rich Collect pathway analysis to understand the possible
biological processes and pathways of Jiedu Sanjie Decoction in treating liver cancer. Results: A total of 89 active ingredients of Jiedu Sanjie
Prescription, 170 targets and 1885 liver cancer targets were obtained; After mapping, 114 potential targets of Jiedu Sanjie Recipe for liver
cancer are obtained, and the core active ingredients are quercetin, luteolin, kaempferol, wogonin, baicalein, etc. The core targets NTRK1,
TP53, CUL3, ESR1, MCM2, etc., involving lipids and atherosclerosis, chemical carcinogenesis-receptor activation signaling pathways, Ka_x005fposi’s sarcoma-associated herpes virus infection, fluid shear stress and atherosclerosis Cirrhosis, hepatitis C, AGE-RAGE signaling pathway,
hepatitis B, human cytomegalovirus infection, cancer proteoglycan, TNF signaling pathway, IL-17 signaling pathway, etc.Conclusion: This
study reveals the mechanism of the multi-component, multi-target, and multi-channel treatment of liver cancer by “Knowing Du Sanjie Decoction”, and provides a basis for the clinical application of Chinese medicine prescriptions for liver cancer
Visual Analysis of The Citespace-based COPD Research On The Stable Care Field
Get PDFObjective To explore the research hotspot and development frontier of stable care in COPD. Methods The CNKI database was
searched, and the search year was set from January 1,2013 to March 31,2023. citespace software was used to visually analyze the distribution
of publications, authors and institutions, keyword co-occurrence and clustering. Results A total of 511 articles were included, among which
the number of articles showed a significant upward trend from 2013 to 2019;Xiaolei Shang Shang , Guifang Yu and other 21 authors; the
school of Nursing of Nanjing Medical University has 3 articles; The research focus focus on quality of **life, extended nursing, compliance,
TCM nursing, etc. The research frontier is mainly in exercise endurance. Conclusion Clinical medical staff should establish scientific evi_x005fdence-based intervention program and establish evidence-based patient care in stable COPD to improve patients’ exercise endurance
Study on the effect of different doses of Ermiaosan on inflammatory response in CIA model rats
Get PDFObjective: To investigate the effect of different doses of Ermiaosan on improving the inflammatory response in collagen-induced
arthritis (CIA) model rats. Methods: The CIA rat model was established and randomly divided into the model group (CIA group), and low,
medium, and high dose Ermiaosan groups. Each group was treated with the corresponding drugs, while the healthy control group and the
model group were given an equal volume of saline by gavage. The expression of inflammatory factors IL-1β, IL-6, and TNF-α in each group
was detected using ELISA, and the pathological changes in rat joints were observed using Masson staining. Results: Rats in the CIA group
showed significant tissue damage, tissue proliferation, and inflammatory infiltration in the joints. The low, medium, and high dose Ermiaosan
groups exhibited reduced joint tissue destruction and proliferation. Different doses of Ermiaosan were able to alleviate joint lesions in CIA
rats. The expression levels of IL-1β, IL-6, and TNF-α in serum were significantly reduced in all dose groups (