Advanced Emergency Medicine (E-Journal)
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Tumor Vaccine Based on Targeted Neoantigen: A Powerful Immunotherapy Weapon in Acute Meyroid Leukemia
Get PDFAcute myeloid leukemia (AML) is a common type of leukemia. The existing chemotherapy regimens and hematopoietic stem cell transplantation can not achieve the ideal treatment effect, and more efficient treatment methods are needed in the clinical treatment of AML patients. As a star method of immunotherapy, tumor vaccines have attracted much attention. Choosing neoantigen as the target antigen in vaccine is a new and exploreable design plan for AML. In this review, we will carefully summarize the current neoantigen-related vaccine research progress, reasonably speculate its application prospects in AML, and put forward the key challenges and risks in the research
Research Progress of Improving MDD by Fecal Microbiota Transplantation Affecting Intestinal Microbiota-Gut- Brain Axis
Get PDFIt has been improved that fecal microbiota transplantation (FMT) can alleviate gastrointestinal disorders such as Clostridium difficile infection (CDI). Moreover, some studies have also concluded that FMT is available in alleviating Major Depressive Disorder (MDD), also known as depression widely, by regulating microbiota-gut-brain axis (MGBA), hence, this paper summarized the relationship between MGBA and MDD and mechanisms of MDD which is related with MGBA. And this review retrospected the animal experiments and clinical studies on the treatment of depression with FMT in recent years and discussed the future development of FMT, in order to assess whether FMT is potential and credible in the treatment of depression
Application and Safety Evaluation of Integrated TCM-WM in the Treatment of COVID-19
Get PDFIntroduction: With the emergence of more infectious mutant strains and the appearance of new crown sequelae, early precise treatment is particularly important. The traditional Chinese medicine and Western medicine (TCM-WM) treatment plan exhibits unique superiority in the COVID-19 treatment, but the efficacy and safety have not been fully elucidated. Methods: A analysis of the clinical characteristics of 7 COVID-19 patients diagnosed in our hospital, as well as the results of precise individual intervention treatment with TCM-WM, including laboratory examination, and CT changes of imaging. Results: On admission, laboratory results showed that 7 patients' overall Lymphocyte count (LYM#), Percent Lymphocytes (LYM %), and Alanine aminotransferase (ALT) were reduced, but Neutrophil percentage (NEU%) were increased. CT imaging showed that most patients had multiple patchy shadows and ground-glass shadows in both lungs. After TCM-WM treatment, the above pathological states were significantly improved. All patients were followed up and had a good prognosis. Conclusions: Accurate therapy with TCM-WM can quickly and effectively alleviate and treat patients with COVID-19, without severe Long Covid
Clinical analysis of tenofovir combined with sorafenib in patients with hepatitis B-related intermediate to advanced primary liver cancer
Get PDFAim：To investigate the clinical efficacy of tenofovir combined with sorafenib in the treatment of patients with hepatitis B-related intermediate to advanced primary liver cancer. Methods：Sixty patients with hepatitis B-related intermediate to advanced primary liver cancer admitted to our hospital between January 2021 and December 2021 were selected and divided into 30 cases each in the study group and the control group according to the random number table method, in which the control group was treated with sorafenib and the study group was treated with tenofovir on top of the control group. Finally, the liver function indexes and clinical efficacy of the two groups of patients were observed and compared. Results：The total effective rate of treatment in the study group was 83.33%, while the total effective rate of treatment in the control group was 46.67%, There was a significant difference (P < 0.05) between the two groups comparing, Liver function indexes such as TBIL, ALB, PT and AFP before treatment in the study group were not significantly different from those in the control group (P > 0.05)，there were significant differences in liver function indexes such as TBIL, ALB, PT and AFP after treatment compared with the control group (P < 0.05). Conclusion：The short-term clinical efficacy and safety of tenofovir in combination with sorafenib in the treatment of patients with hepatitis B-related intermediate to advanced primary liver cancer is remarkable and worthy of clinical application
Clinical Research Progress on the Effect of Different Anesthesia Methods on the Prognosis of Elderly Hip Fractures
Get PDFHip fracture will have a great impact on the life of the patient. The treatment and recovery of hip fracture is an extremely long process. In the early treatment stage, the patient will feel a strong sense of pain. Hip fractures are the most common in the elderly, and the elderly are often accompanied by osteoporosis, and there is a risk of fracture when exposed to mild external forces in daily life [1]. Surgical treatment is most common in elderly patients with hip fractures. In order to reduce the pain of the patient, anesthesia is usually given to the patient. Anesthesia is divided into general anesthesia and local anesthesia, both of which can reduce the pain of the patient and improve the cooperation degree of the operation. Under general anesthesia, the patient is basically in a state of unconsciousness without any consciousness. General anesthesia is generally achieved by intravenous injection of anesthetic drugs or inhalation of gas, and local anesthesia is achieved by intrathecal or epidural injection of anesthetic drugs [2]. Studies have shown that these two anesthesia methods have been widely used in orthopedic surgery, and have achieved good results. However, the choice of anesthesia methods for elderly patients with hip fractures is still controversial. This article reviews the research progress on the effects of different anesthesia methods on the prognosis of elderly hip fractures by reviewing relevant literature
Regulating Intestinal Microbes to Decrease the Incidence of Heart Disease
Get PDFThis paper studies the correlation between intestinal microbes and heart disease. In the paper, the process of human body producing Trimethylamine-N-oxide (TMAO) under the role of intestinal microbes has been analyzed, and the ways to reduce the level of TMAO which can increase the incidence of heart disease has been designed. The expected result is that the level of TMAO in plasma is successfully reduced by regulating intestinal microbes. This paper can provide useful information for further studies in self-healing therapy by regulating intestinal microbes
Research Review on Effects of Exercise on Neuroglial Cells after Central Nervous System Diseases
Get PDFAstrocyte and microglia are two types of neuroglia that are relatively widely distributed and functionally important in the mammalian central nervous system. These two cells play an important role in CNS diseases. The mechanism of the effect of exercise on various CNS diseases is still unclear. In this paper, the effect of exercise on neuroglial cells after CNS diseases is investigated in depth from the function and structure of glial cells
Blood Oxygen Saturation Analysis Model Based on Multiple Normalized Regression
Get PDFSeveral factors that may have an impact on the saturation of the oxygen saturation, respectively, are age, BMI, gender, and current smoking conditions. For the blood oxygen saturation of 36 patients collected, the data preprocessing, the abnormal data were removed, and the blood oxygen saturation was the dependent variable, with the BMI, age, gender, the current smoking condition is the independent variable, and the stata is normalized. In the case of significant sexual testing of variables, the discovery of the current smoking condition was significant for the oxygen saturation of the blood oxygen, while the bmi and gender in the t test were not different from zero, indicating that the blood oxygen saturation was affected by the BMI, and the influence of gender could be ignored, and the effect of age and current smoking condition on the oxygen saturation was mainly considered
Conflict and Balance Between Intellectual Property Protection of Pharmaceuticals and Public Health
Get PDFIn December 2019, the emergence of unexplained pneumonia (later named COVID-19) caught people all over the world off guard. Until now, the epidemic situation is still not optimistic, and global health is seriously threatened. Prevention and control measures for COVID-19, accurately all infectious diseases, people are no longer strange. There are three ways, that is, to control the source of infection (isolation), cut off the transmission path (wearing masks), and protect the susceptible population (vaccines and specific drugs).[]Â Among them, the last link - screening and developing new drugs and vaccines is the focus of the current efforts of medical institutions, pharmaceutical companies, and scientific research institutions. In January 2020, the news that Chinese researchers at the Wuhan Institute of Virology filed for a patent on the use of Remdesivir, an investigational drug from the US company Gilead, caused widespread controversy, because patent protection would limit people's access to vaccines and drugs.[]Â This also raises the question of how to balance the conflict between intellectual property protection for new pharmaceutical products and public health in the face of a global pandemic. This article mainly discusses three aspects, the fact of high cost, increasing complexities, and high rewarding of new pharmaceuticals, the status of strong protection in the pharmaceutical industry, and the negative public health impact of this strong protection. Although WTO members and some countries have responded accordingly to the consequences, the effect has been limited. This article will use this three-aspect analysis to in turn provide some information to increase the availability of vaccines and medicines for COVID-19 and other diseases
Research Progress on Influencing Factors of Refractive Error in Preschool Children
Get PDFPreschool is the key period of children's visual function development, which is called the "critical period of visual development plasticity". Any abnormal stimulus during this period can have an adverse impact on children's vision. Ametropia is the main cause of poor vision in preschool children. There are many reasons for ametropia. This paper reviews the influencing factors of ametropia in preschool children in recent years, which are classified into three aspects: demographic factors, physiological factors, and lifestyle factors