Advanced Emergency Medicine (E-Journal)
Not a member yet
458 research outputs found
Sort by
Impact of Rhabdomyosarcoma (RMS) Characteristics on Prognosis of Pediatric RMS: a SEER Database Large Population Study
Get PDFTo provide a better insight into the epidemiology, characteristics, therapeutics, and outcomes of pediatric RMS. Data of 1,623 pediatric RMS were acquired from the Surveillance, Epidemiology and End Results (SEER) database. Detailed information on demographics, primary site, size, subtype, stage, surgery, and survival had been recorded during 1975-2016. The most common subtype was embryonal RMS (64.9%) followed by alveolar RMS (29.9%). Additionally, the majority of RMS size was larger than 5 cm. Multivariable analysis exhibited that the age over 10, unfavorable primary site, distant metastasis was respectively correlated with the poor OS, whereas surgery could improve the outcomes of pediatric RMS. In conclusion, our large population-based analysis described that age, subtype, primary tumor sites, stage and surgery are all independent prognosis factors for RMS
Simultaneous Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae, Ureaplasma Urealyticum by Multiplex PCR-Running
Get PDFChlamydia trachomatis (CT), Ureaplasma urealyticum (UU) and Neisseria gonorrhoeae (NG) are the most common pathogens of sexually transmitted infections (STIs), frequently founded in urogenital infections, and showed a criminal role in increasing the risk of potential adverse outcomes. In this study a multiplex PCR assay for the simultaneous detection and accurate identification of 3 clinically relevant pathogens of STIs, i.e., CT, NG and UU in a single tube was developed and evaluated. The limits of detection for the multiplex PCR assay were ~10 copies of DNAs per reaction. This assay has comparable clinical sensitivity to the conventional monoplex real-time PCR assay and considerable potential to be routine molecular diagnostic tool for simultaneous identification of STIs at relatively low cost due to multiplexing
"Hang" and "Crash" in Fault Analysis of Philips HD Series Color Doppler Ultrasound in Summary of Medical Equipment Maintenance Experience
Get PDFColor doppler ultrasound is an important imaging equipment to examine systemic diseases in hospital.Over the past years, the Philips HD series ultrasound system have attracted great attention for their outstanding imaging ability. This paper introduce the structure principle of HD series ultrasound system,and introduces the difference and different troubleshooting methods when HD color doppler ultrasound system displays' Hang 'and' Crash 'faults
The Mediating Role of Personality Strengths in the Relationship Between Gender Roles and Occupational Well-Being of Nurses
Get PDFBackground: The purpose of the study is to explore the relationships amongst gender roles, personality strengths and occupational well-being of nurses in Mainland China. Design: A crossâ€sectional study was used. Method: A total of 318 nurses from a tertiary hospital in Wenzhou City, Zhejiang Province, were measured with general information questionnaire, gender role scale (simplified version), three-dimensional character advantage questionnaire, and medical worker occupational well-being scale. Results: The character strengths and occupational well-being scores of the nurses in this study were (57.29±7.16) and (79.59±12.67), respectively. Bisexuality in gender roles was positively correlated with personality dominance and occupational well-being (r=0.535, r=0.204,P<0.01); undifferentiated was negatively correlated with both (r=-0.529, r=-0.230,P<0.01); and personality dominance was positively correlated with occupational well-being (r=0.350,P<0.01). In the effect of nurses' gender roles on occupational well-being, personality strengths played a fully mediating role. Conclusion: Gender roles and character strengths are important factors affecting nurses' professional well-being, and gender roles can indirectly affect nurses' professional well-being through character strengths. Clinical nursing managers should take relevant measures to cultivate character strengths appropriate to different gender roles to improve nurses' occupational well-being
Development and Influencing Factors of Patients with Depression
Get PDFDepression is the most common psychological disease, which is characterized by long-term depression. It is the main type of emotional disorder. This paper mainly summarizes the influencing factors in the occurrence and development of the disease, draws the disease types of patients with depression and their own personality characteristics, analyzes the existing problems, and affects the influencing factors in the occurrence and development of the disease, which is conducive to a more comprehensive and correct understanding of the disease, It has clinical significance for the prevention and treatment of depression
Auto-Encoder and Representation Learning Based MiRNA-Disease Association Prediction
Get PDFAs expressions of miRNAs are often associated with diseases, understanding the pathophysiology of illness at the miRNA level is beneficial for the treatment and prevention of associated diseases, as well as the creation of related medicines. Recent computational methods for predicting miRNA-disease associations integrate their pertinent heterogeneous data. The difficulty in this study is how to extract the implied associations from sparse data. In the present study, by drawing on natural language processing, a learning-based method is used to extract dense and high-dimensional representations of illnesses and miRNAs from integrated disease semantic similarity, miRNA functional similarity, and heterogeneous related interaction data. To predict disease-miRNA associations, we use a deep autoencoder and its reconstruction error as a measurement. Our experimental results suggest that our strategy is comparable to cutting-edge methods for predicting disease-related miRNAs
Effect of Pain on Quality of Life in Patients with Parkinson's Disease
Get PDFObjective: To analyze the impact of pain on the quality of life of patients with Parkinson's disease. Methods: 200 patients with primary Parkinson's disease admitted in the Shaanxi Provincial People's Hospital from August 2019 to November 2020 were selected for the experiment, and these patients were divided into pain group and non-pain group in turn. Among them, there were 98 patients in the pain group and 102 patients in the non-pain group. King's Parkinson's disease pain scale was used to evaluate the severity and type of pain, and then ess and HAMD-17 were used to evaluate patients' depression and daytime sleepiness. Results: the incidence of pain in patients with Parkinson's disease was about 49%, including 38% of wave related pain and 74% of musculoskeletal pain. The score of quality-of-life Scale-39 in the pain group was higher than that in the non-pain group, and the difference was statistically significant (P < 0.01). Conclusion: musculoskeletal pain is a common type of pain in patients with Parkinson's disease, followed by nocturnal pain and fluctuation related pain. Its pain will have a direct impact on the quality of life of patients with Parkinson's disease
Influencing Factors and Etiological Analysis of Incision Infection after Abdominal Surgery in Patients with Multiple Traumas
Get PDFObjective: To analyze the influencing factors and etiological characteristics of postoperative incision infection in patients with multiple traumas. Methods: A retrospective analysis was carried out on the clinical case data of 195 patients with multiple trauma who underwent abdominal surgery in our hospital. All patients were admitted to the hospital from January 2016 to December 2021. According to the information obtained, the postoperative incision infection and pathogen distribution of the patients were counted, and the risk factors affecting postoperative incision infection were analyzed. Results: According to the analysis, after abdominal surgery, 38 patients had incision infection, and the infection rate was 19.49%. Through the cultivation of pathogenic bacteria, there were 54 strains of pathogenic bacteria, and the highest proportion was gram-negative bacteria, which was 59.26%, and the lowest was fungus at 9.26%; through univariate analysis, it was found that age, hospital stay, white blood cells, albumin, diabetes, C-reactive protein, blood loss and ISS score between the infected and uninfected groups. There was a significant difference (P<0.05); multivariate logistic regression analysis found that incision infection in patients with multiple traumas after abdominal surgery was associated with increased age, increased albumin level, combined diabetes, increased blood loss and ISS score factors (P <0.05). Conclusion: For patients with multiple traumas who underwent abdominal surgery, the probability of postoperative incision infection was higher, and gram-negative bacteria were the main pathogenic bacteria, and postoperative infection was not only related to one factor, but it is related to a variety of factors, and appropriate amount of antibiotics should be given according to the actual situation of the patient
Research Progress of Neural Stem Cell Transplantation Combined with Biological Scaffold in the Treatment of Spinal Cord Injury
Get PDFSCI is a kind of nerve injury disease caused by direct or indirect factors. The result is the damage of motor mechanism and the partial or total loss of sensory function below the injury site. The researchers found that planting neural stem cells in a biological scaffold and then colonizing the site of SCI greatly improved the survival rate of stem cells and promoted the repair of injury. However, different biomaterials have different differences. In order to better promote the recovery of function after SCI, it is important to select an appropriate scaffold combination
Efficient Screening of nNOS-PSD95 Uncoupling Agents Based on Radiometric Fluorescent Molecularly Imprinted Sensors
Get PDFNovel and efficient ratiometric fluorescent molecularly imprinted sensors (RFMIS) based on epitopes were developed, which can be used for the sensitive detection of neuronal nitric oxide synthase in the screening of neuronal nitric oxide synthase-postsynaptic density95 (nNOS-PSD95) coupling inhibitors. Under appropriate conditions, the fluorescence of the carbon dots quenched with the increasing concentration of nNOS1-133, while the fluorescence of the quantum dots remained unchanged. The fluorescence ratio had a good linearity in the concentration range of 0-500 ng mL-1 for nNOS1-133 and the determination limit was 0.14 ng mL-1. Using the classical nNOS-PSD95 coupling inhibitor (ZL006) as a control, the RFMIS were used as the detector to detect the free nNOS released by Gnetol and 2,3,5,4ʹ-tetrahydroxystilbene-2-O-β-Dglucoside from natural medicine after inhibition of nNOS-PSD95. The results have shown that the uncoupling efficiencies was consistent with co-immunoprecipitation experiments. The study provides a new idea and a new way for efficient screening of nature nNOS-PSD95 coupling inhibitors from natural medicine with the advantages of high efficiency, sensitivity and traceability