Advanced Emergency Medicine (E-Journal)
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Effect of Endocrine Therapy Combined with Trastuzumab Targeted Therapy on Response Rate and Quality of Life in HER2-Positive Metastatic Breast Cancer
Get PDFObjective: To analyze the effect of endocrine therapy combined with trastuzumab targeted therapy on HER2 (human epidermal growth factor receptor-2) positive metastatic breast cancer on the treatment efficiency and quality of life. Methods: Selected 100 patients with HER2-positive metastatic breast cancer who were treated in our hospital from January 2019 to December 2021, and divided them into a control group and an observation group according to the random number table method, with 50 cases in each group, and were given the clinical effects of single trastuzumab targeted therapy and endocrine therapy combined with trastuzumab targeted therapy were compared. Results: There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05); the remission rate in the observation group was significantly higher than that in the control group (P<0.05); the overall health scale and function scale scores in the observation group were higher than those in the control group, and the individual items Measurement and symptom scale scores were lower than those in the control group (P < 0.05). Conclusion: Endocrine therapy combined with trastuzumab targeted therapy for HER2-positive metastatic breast cancer can effectively relieve the patient's condition and improve the patient's quality of life. The clinical effect is significant, and it is worthy of widespread application
Endoscopic Injection of Recombinant Human Adenovirus Type 5 Combined with Chemotherapy in the Treatment of Gastric Cancer: A Case Report
Get PDFPurpose: To investigate the endoscopic injection of recombinant human adenovirus type 5 (H101) in the treatment of gastric cancer. Method: The diagnosis and treatment data of one patient with advanced gastric cancer were collected and discussed. Result: The patient ,a 51-year-old middle-aged male, was diagnosed with gastric malignant tumor (adenocarcinoma stage IV) with liver metastasis and lymph node metastasis combined with the results of gastroscopy, imaging and pathological examination. The patient underwent endoscopic injection of recombinant human adenovirus type 5 (H101) and chemotherapy.After 4 times of endoscopic treatment, the patient had no serious adverse reactions,pyloric obstruction was relieved, carcinoembryonic antigen was significantly reduced, intragastric ulcerated-like tumor was healed,the range of liver metastases was reduced.In outpatient follow-up, no tumor recurrence or metastasis was found, and the general condition was good. Conclusion: Endoscopic injection of recombinant human adenovirus type 5 showed good efficacy and safety and tolerability in patients with advanced gastric cancer.It is worthy of further promotion in clinical practice
Clinical Retrospective Study of Pterygomaxillary Implant Combined with Anterior Implant in the Repair of Atrophic Edentulous Maxilla
Get PDFObjective: To retrospectively analyze the therapeutic effect of pterygomaxillary implant combined with anterior implant in the repair of atrophic maxillary edentulous jaw. Methods: The clinical data of 26 patients with atrophic edentulous maxilla who received pterygomaxillary implants combined with anterior implants from January 2019 to December 2020 were analyzed retrospectively. All patients were followed up for ≥ 1 year. The retention of anterior implants (105) and pterygomaxillary implants (45) were compared Patients' satisfaction with deep and middle periodontal examination (MBPD) and plaque (PLI). Results: The anterior implant retention rate was 97.14%, which was close to 93.33% in pterygomaxillary area (P > 0.05);The levels of PD, PLI, mesial MBL and distal MBL of anterior implants were similar to those of pterygomaxillary implants (P > 0.05); Patients' satisfaction with treatment was 92.31%. Conclusion: In the treatment of patients with posterior atrophic edentulous maxilla, the pterygomaxillary implant and the anterior implant supported complete arch fixed denture can bear the weight immediately, the short-term clinical effect is acceptable, and the patient satisfaction is high. It is a predictable and feasible repair method
Analysis of HER2 Gene Amplification and Certain Prognostic Factors in Breast Cancer
Get PDFObjective: The HER2 gene amplification and certain prognostic factors in breast cancer were analyzed. Method: The gene amplification and protein expression of human epidermal growth factor receptor in 100 breast cancer tissues detected by FISH and IHC detection method in the hospital from January 2020 to December 2021 were analyzed. To analyze some breast cancer prognostic factors. Result: 0 is 8 cases of HER-2 protein breast cancer, (1+) is 11 cases, (2+) is 49 cases, (3+) is 32 cases. The HER2 gene was amplified in 49 cases, of which 23 cases showed red signals in clusters, and 26 cases showed red signals in dots. 51 cases of HER-2 gene were not amplified. There are differences in the detection results of FISH and IHC detection methods (P＞0.05). ER, PR and polysomy of chromosome 17 are prognostic factors associated with HER2 gene amplification in certain breast cancers. (P＜0.05) Conclusion: To analyze the HER2 gene amplification in breast cancer and targeted select FISH and IHC detection methods can improve the therapeutic effect and prognostic factor, which deserves clinical attention
Correlation Between Blood System Impairment and Immune Index in Patients with Primary Sjögren's Syndrome
Get PDFObjective: To analyze the relationship between blood system impairment and immune indexes, including autoantibody, immunoglobulin and lip gland biopsy in patients with primary Sjogren's syndrome (pSS). Methods: The serological data of patients with Sjogren's syndrome in hospital were collected and divided into hematological system impairment group and normal group. The incidence of hematological system damage in patients with pSS and its correlation with immune indexes were analyzed. Results: 123 patients with pSS were included in this study. There were 57 patients in the blood system involvement group (46%), in which the proportions of leucopenia, anemia and thrombocytopenia were in turn; 17. 89%; 33. 3%; 4. 88%. The antibodies in the blood system affected group were abundant, and the positive rates of anti SSA and Ro-52 antibodies were significantly higher than those in the normal group. The increase of serum IgG in pSS patients accounted for nearly 50%; The levels of serum IgG and complement C3 were significantly different from those in the control group. The positive rate of lip gland biopsy in pSS patients was more than 90%, and there was no significant difference between the two groups. Conclusion: Hematological system involvement was common in PSS patients. The positive rates of anti SSA and Ro-52 antibodies increased significantly, the level of IgG increased and the level of complement C3 decreased; However, there was no significant difference in blood system involvement between high IgG and low IgG groups; The positive rate of lip gland biopsy in PSS patients was more than 90%
Effect of YKL-40 RNA Interference on VEGF Gene Polymorphism Expression in Atherosclerotic Mice
Get PDFAims: To investigate the effect of YKL-40 RNA interference on VEGF gene polymorphism expression in atherosclerotic mice. Methods: After the atherosclerosis models in mice were built, the mice were divided into three groups including control group, negative control group and observation group, which were separately given to normal saline, negative virus (5 × 107 TU) and YKL-40 RNA interference lentivirus. Then the whole blood DNA was extracted and genotyped in each group of mice and the expression of VEGF in each group of mice was detected by PCR, while the expression level of inflammatory factors in each group of mice was detected by ELISA. Meanwhile, the aortas of mice in each group were pathologically analyzed and the atherosclerosis of mice was detected. Results: Compared with the control group, the VEGF content in both the virus negative control group and the observation group was significantly increased（P<0.05）. The detection rates of CC genotype and C allele at rs699947 of VEGF gene in the observation group were significantly higher than those in the control group and the virus negative control group, and the difference was statistically significant. There were no significant changes for the expression of HDL-C, LDL-C, TC and TG in mice of each group（P>0.05）. Moreover, the levels of Lp-PLA2 and MCP-1 in the negative control group were significantly increased (P < 0.05), while those in the observation group were significantly decreased (P < 0.05) compared to that in control group. What’s more, the histomorphology of the observation group was significantly different from that of the control group and the virus negative control group. The thickness of the fibrous cap of the as plaque was significantly higher than that of the control group and the virus negative control group, but the plaque area and fat content were significantly lower than that of the control group and the virus negative control group and the NC group. Besides, there was no significant difference in lipid content, fiber cap thickness and plaque area between the control group and the virus negative control group. Conclusion: YKL-40 RNAi could improve the VEGF polymorphism, reduce the expression of LPâƒPLA2 and MCPâƒ1, and significantly inhibit the occurrence and development of atherosclerosis, which was expected to provide a new target for the prevention and treatment of atherosclerosis
The Impact of Parental Young Onset Dementia on Children and Young People’s Educational Careers
Get PDFThe aim of Sikes and Hall’s(2018) study was to discover the impact of having a parent with young onset dementia (YOD) on children or young people’s educational careers by interview 24 subjects among the ages from 6 to 31 years old (Sikes & Hall, 2018). In this paper, the theoretical perspectives will be identified from the perspective of ontology and epistemology. Methodology and methods will also be discussed. Furthermore, evaluating consistency of the relationship between theoretical perspective and the chosen methodology with the methods conducted is also focused on. Finally, the discussion of ethical issues in the study is also an important part of this paper, not only the ones claimed by the author but also the implicit ones should be considerate
Update and Application Analysis of Resident Health Records in Basic Public Health Services
Get PDFUnder the new era background, people's material living standards gradually improve, attention to self health also continue to improve, and through the establishment of residents' health records, can ensure the timely update of health information, can also provide effective reference for basic public health services, help people develop good health awareness, and improve the efficiency of basic public health services, maintain residents' health, promote social harmonious development. Based on this, this paper discusses the value of residents' health records in basic public health services, and proposes specific strategies for update and application for reference
Effect of Two Kinds of Bone Replacement Materials on Bone Formation in Repairing Bone Defects around Mandibular Posterior Area: A Case Study of Bone Defects around Mandibular Posterior Area Caused by Boxing
Get PDFObjective: To investigate the effect of two kinds of bone replacement materials on bone formation in repairing bone defect around mandibular posterior area. Methods: A total of 60 patients with Bone defects around mandibular posterior area caused by boxing were selected from a hospital from January 2020 to June 2020. They were divided into Perio Glas (group P) and Bone Plant (group B) by random number table method, with 30 patients in each group. Perio Glas Bone graft was used in group P and Bone Plant graft was used in group B. The vertical height and buccal lingual bone plate width of the two groups were observed at baseline and after treatment, and the success rate of implants was compared between the two groups. Results: The success rate of implant in group P was significantly lower than that in group B (P < 0.05). The vertical height and buccal lingual bone plate width in group P were significantly lower than those in group B (P < 0.05). Conclusion: Compared with Perio Glas, Bone Plant can better maintain the vertical height and buccal lingual Bone plate width of patients with Bone defects around mandibular posterior area caused by boxing, and has better effect of inducing Bone regeneration and osteogenesis
Estimation of the Incubation Period and the Serial Interval of COVID-19 in Chongqing, China
Get PDFIn December 2019, the initial case of COVID-19's disease appeared in Wuhan, Hubei Province, China. But it soon caused an outbreak in Chongqing as well. Reasonable estimates for the incubation period distribution and the serial interval distribution would provide timely information to guide intervention policy for the government of Chongqing. We collect individual information from Chongqing Center for Disease Control and Prevention(CQCDC). We use doubly interval-censored data to estimate the incubation period and the serial interval for confirmed cases exposed to COVID-19 during incubation period,the mean incubation period is estimated to be 7.5(6.6-8.6,95% CI) days and the mean serial interval is estimated to be 6.1 (5.0-7.5,95% CI) days. The analysis result show that COVID-19 could spread in the incubation period,which may complicate quarantine work. The implementation of control measures is indispensable in reducing the spread of asymptomatic incubation period in high-risk population