Advanced Emergency Medicine (E-Journal)
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ACE Inhibitor Combined with Spironolactone in the Treatment of Non Adenoma Primary Hyperaldosteronism
Get PDFObjective: To investigate the clinical effect of ACE inhibitor (ACEI) combined with Spironolactone in the treatment of non adenoma primary Hyperaldosteronism (PA). Methods: 80 patients who entered our hospital from August 2021 to August 2022 were randomly selected for this investigation. According to the random grouping method, the patients were randomly divided into the observation group and the control group. A total of 40 patients in the control group were treated with Spironolactone. A total of 40 patients in the observation group were treated with perindopril on the basis of the control group. After treatment in different ways, the treatment efficiency of the two groups was compared, The left ventricular end diastolic diameter (LVEDD), left ventricular Ejection fraction (LVEF) and left ventricular end systolic diameter (LVESD) before and after treatment were compared between the two groups, and the incidence of adverse reactions after treatment was compared between the two groups. Result: The effective rate of treatment in the observation group was 95%, significantly higher than 78% in the control group. The difference between the two groups was significant and statistically significant (p<0.05). Before treatment, there was no significant difference in LVEDD, LVEF, and LVESD between the two groups (p>0.05). After treatment, the LVEF of both groups of patients increased, but the observation group was significantly higher than the control group, and the LVEDD and LVESD of both groups of patients were significantly reduced, but the observation group was significantly lower than the control group, The difference between the two groups was significant and statistically significant (p<0.05). The incidence of adverse reactions in the observation group was 12.5%, while the incidence of adverse reactions in the control group was 15%. There was no significant difference between the two groups and there was no statistically significant difference (P>0.05). Conclusion: The combination of Spironolactone and ACEI in PA patients has a more significant effect, can significantly improve the treatment efficiency of patients, improve the cardiac function indicators of patients more significantly, and will not increase additional adverse reactions. It has clinical value
Application of Electrochemical Sensor Based on the Reaction of Potassium Ferricyanide and Uric Acid in Uric Acid Detection
Get PDFAt present, the number of patients with hyperuricemia and gout in China is increasing year by year, and the demand for uric acid detection is increasing. In the current situation, a uric acid detection chip was designed based on the redox reaction between potassium ferricyanide and uric acid and the principle of electrochemical sensor, and the uric acid content was measured by the electrochemical detection chip and the software PSTrace5.8, and the error of the result was within ±10%. The method is low cost and high accuracy, which can provide a new technical means for uric acid detection
Screening of Potential Hub Genes in Glioma Progression Based on Bioinformatics Analysis
Get PDFObjectives: Glioma is the most common primary tumor of the central nervous system, and its therapeutic effect is not optimistic. In recent years, related therapeutic technologies have developed rapidly, but unfortunately, the improvement of clinical therapeutic effect is not satisfactory. In addition to conventional therapies, there are some attractive therapies, such as biological therapy (immunotherapy), gene therapy, etc[1]. Therefore, searching for potential target genes of glioma is of great significance for developing new therapeutic directions and designing new biomarkers[2]. Methods: Download gene expression data set, GSE137902 gelatin and GSE13790 matrix through NCBI-G to screen overlapping differential expression genes (DEGs). In order to identify central genes from these genes, we conducted protein protein interaction (PPI) network. To further explore the potential mechanism of central genes in glioma, we performed gene ontology (GO) and Kyoto Gene and Genome Encyclopedia (KEGG) analysis. Then get the intersection of key genes according to five algorithms of Closeness Degree EPC MCC Stress. The intersection is obtained through GSE117423, GSE188256 and GSE90598 in geo database, and finally verified through Receiver Operating Characteristic (ROC) curve. Results: A total of 1274 differentially expressed genes are identified, and then 309 genes are obtained by intersection of the two. 16 Hub genes were obtained, and then the intersection of the two genes with GSE117423, GES188256 and GSE90598 genes was verified to obtain the key gene TIMP1 of glioma. Made the ROC curve of key gene.The intersection with hub gene was determined to identify TIMP1 as the key gene. Conclusion: The DEGs and Hub genes and signal pathways found in this study can confirm that the key gene TIMP1 is closely related to the occurrence and evolution of glioma, and provide candidate targets for the diagnosis and treatment of glioma
Summary of Professor Wang Xiaoyan's Experience in Treating Insomnia
Get PDFProfessor Wang Xiaoyan applied the theory of "monism of qi" in traditional Chinese medicine to study insomnia, and believed that insomnia was caused by a variety of pathogenic factors, which affected the normal rise and fall of qi in various organs of the human body, and eventually led to the rise of yang, which could not be submerged. Yang did not enter into yin, but became sleepless. By "supporting yang", the yang returned to its place, and this group of vitality moved slowly and orderly in the human body, and yin and yang combined to sleep peacefully
A Case Report of Ovarian Carcinoid Complicated with Mucinous Cystadenoma and Review of Relevant Literature
Get PDFOvarian mucinous cystadenoma is a common tumor of the female reproductive organs, but ovarian carcinoid is very rare, accounting for about 0.1% of all ovarian tumors [1]. A case of ovarian carcinoid complicated with mucinous cystadenoma was reported. The clinical manifestations, histological features, diagnosis, treatment and prognosis were discussed
Clinical Effect of Intranasal Corticosteroids Combined with Nasal Irrigation in the Treatment of Allergic Rhinitis
Get PDFObjective: To explore the clinical effect of intranasal corticosteroids combined with nasal irrigation in the treatment of allergic rhinitis. Method: 100 patients with allergic rhinitis who received treatment in Shaanxi Provincial People’s Hospital from January 2020 to January 2021 were selected as the research subjects. The grouping method adopts a random approach, dividing 100 patients into two groups with 50 patients in each group. They are the control group and the experimental group, respectively. The control group patients were treated with conventional intranasal corticosteroids therapy. The experimental group patients were treated with intranasal corticosteroids combined with nasal irrigation. Two groups of patients are required to undergo treatment and follow-up for 3 and 6 months to compare their quality of life and nasal symptoms after receiving treatment. Result: The quality of life of the experimental group patients was significantly higher than that of the control group. The difference was significant (P<0.05); The nasal symptoms of the experimental group patients were significantly reduced compared to the control group patients, with a significant difference (P<0.05). Conclusion: The combination of intranasal corticosteroids and nasal irrigation can effectively improve the quality of life and nasal symptoms of patients with allergic rhinitis
Research Advance about Poor Response to Anti-VEGF in Neovascular Age-Related Macular Degeneration
Get PDFNeovascular age-related macular degeneration (nAMD) has become one of the main causes of vision damage in middle-aged and elderly people, Now, anti-vascular endothelial growth factors (anti-VEGF) therapy has achieved a milestone in the treatment of nAMD, However, in clinical practice, the phenomenon of poor or even non-response of anti-VEGF drugs is still found, even maximal anti-VEGF treatment to some patients. The research on poor response to anti-VEGF therapy is also a hot topic in recent years. This article gives a brief review on diagnostic factors, This article gives a brief review on diagnostic factors, pathogenesis, characteristics of lesions and drug factors for the poor response of anti-VEGF drugs to nAMD
Study on the Status and Influencing Factors of First Aid Knowledge and Skills of Community Residents
Get PDFTo analyze the current situation of first aid knowledge and skills of community residents in Yibin City and related influencing factors, and to explore effective ways to improve the knowledge and skills of community residents in Yibin City. A questionnaire survey was conducted with a convenience sample of 589 community residents in Yibin city. The first aid questionnaire designed by Li Li was used to investigate the knowledge of seven aspects, including first aid telephone, cardiac and respiratory arrest, trauma, accidental injury, common emergencies and other first aid. The score of first aid knowledge was (35.2±6.9), and the pass rate was 72.84%. It was found that there were statistical differences in the total pass rate of first aid knowledge and skills among community residents with different genders, ages, occupations, training experiences, and text studies, but there was no statistical difference in the total pass rate of first aid knowledge and skills among community residents with different health conditions and different first aid experiences. Community residents who were female, 18-25 years old, medical personnel/medical students, had training experience, and had obtained a first aid certificate had the highest pass rates and the best first aid knowledge and skills
Clinical Characteristics and Survival Analysis of Two Groups of Patients with Colon Cancer with Different Social Support
Get PDFColon cancer is the third largest cancer in the world at present[1], which is very common in developed countries, and the incidence rate in developing countries is also increasing year by year. The latest epidemiological report shows that 376000 new colon cancer patients and 191000 deaths have occurred in China. In the past ten years, our understanding of cancer has made new progress [2]. However, in the current research, there has been no progress in the research on the occurrence, development and prevention of colon cancer related to physical and mental diseases. In the latest research, there are studies on the influence of psychological factors in the molecular field from the perspective of psychology, which is of great help to the research on the occurrence, development and prognosis of colon cancer. In order to explore the influence of social psychological factors on the occurrence, development and prognosis of colon cancer, the experiment collected clinical data, social support scores, and followed up disease-free survival period and total survival period of colon cancer patients
Comparison and Analysis of Various Representative Schools of Head Needling
Get PDFIn this paper, by studying and reading the literature related to head acupuncture, its aim is to summarize and compare the similarities and differences in the principle of action, positioning and operation methods of different schools of head acupuncture. At present, the more widely used schools of head acupuncture include Jiao Shunfa head acupuncture, Fang Yunpeng head acupuncture, and Tang Songyan head acupuncture. The principles of stimulation site selection vary among schools, and their principles of action range from basic meridian doctrine principles to biological holographic principles. In terms of acupuncture method, Fang Yunpeng emphasizes that the depth of acupuncture needs to reach the periosteum, and the acupuncture site is inconsistent among different schools, which should be clinically and experimentally confirmed to confirm the scientific nature of the theory of scalp acupuncture, to protect the clinical experience of each school of acupuncture, to gather the strengths of all schools, to determine the best scheme of head acupuncture, to reduce blind clinical operations, to improve the efficacy, and finally to promote the promotion of head acupuncture