Advanced Emergency Medicine (E-Journal)
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Human Papillomavirus Infection in Relation to Vaginal Microflora and Immune Factors
Get PDFObjective: Clarify the vaginal microflora and immune factors in women with human papilloma virus (HPV) infection, and explore its association with HPV infection. Methods: This study collected vaginal secretions and blood from 160 women initially diagnosed as HPV positive in our hospital from June 2020 to December 2020 and 80 healthy women with HPV negative physical examination in the same period. The vaginal microflora of the patients were detected by 16S rDNA sequencing and the expression of immune factors was measured by a high-performance liquid phase chip. Results: The different types of HPV were HPV mix (64,40%), HPV52 (39,24.375%), HPV16 (30,18.750%), HPV58 (18,11.250%), HPV18 (6,3.750%), HPV53 (1,0.625%), HPV55 (1,0.625%), and HPV68 (1,0.625%).α diversity analysis showed that there was no significant difference in vaginal microflora between different HPV types (P=0.733). The genus level abundance of vaginal microflora in each group was mainly Lactobacillus, followed by Gardnerella and Prevotella. LEfSe Analysis showed that the mix group was Gardnerella and the type HPV16 group was Streptococcus. The immune comparison showed that MIP-1β was significantly upregulated in the HPV-positive group, but EGF in the HPV-negative group. Conclusion: This study revealed that HPV infection can change the proportion of vaginal microbial bacteria and the expression of immune factors, which provides a basis for local vaginal treatment and prevention of HPV infection after HPV infection
Risk Factors for Artificial Kidney Failure During Continuous Renal Replacement Therapy
Get PDFObjective To explore the influencing factors of artificial kidney failure (AKF) during continuous renal replacement therapy (CRRT). Methods We conducted a retrospective observational study on 70 patients undergoing 199740 minutes of CRRT comprising 143 circuits at the Department of Intensive Care Medicine of First Affiliated Hospital of Chongqing Medical University from August 2021 to August 2022. Results The occurrence rate and total time of access outflow dysfunction (AOD) in AKF group increased significantly than those in nAKF group. Receiver Operating Characteristic (ROC) Curve analysis showed the optimal cutoff value of AOD total time (AODTT) was 7 minutes. Logistic regression analysis further showed that AODTT≥7 min was an independent predictor of AKF. Conclusion The presence of AOD was related to AKF. AODTT≥7 min during CRRT was an independent risk factor for AKF
A Review of Studies on the Treatment of Severe Acute Pancreatitis
Get PDFAcute pancreatitis (AP) is one of the common acute abdominal diseases in clinic, and the main mechanism is due to a variety of triggers that activate pancreatic enzymes in the pancreas, and then cause the inflammatory reaction of pancreatic tissue self digestion, edema, hemorrhage and even necrosis, with many complications and a high case fatality rate. Among them, especially severe acute pancreatitis (SAP), often leads to severe complications and even death in patients due to various factors such as prompt medical treatment and misdiagnosis, which is a clinically intractable disease
Identification of Potential Therapeutic Targets Inducible Co-Stimulator (ICOS) in Cancer Immunotherapy Using Bioinformatics Analysis
Get PDFClinical trials testing Inducible Co-Stimulator (ICOS) agonists in cancers are under way. However, Co-expression and Interaction of ICOS at the Gene and Protein Levels, the correlations of ICOS to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear. ICOS expression was analyzed via the Oncomine database and Tumor Immune Estimation Resource (TIMER) site. Analysis of the expression difference of ICOS shows that the expression of ICOS is significantly increased in BRCA, ESCA, HNSC, KIRC, KIRP, LIHC, STAD and UCEC. We evaluated the influence of ICOS on clinical prognosis using Kaplan-Meier plotter and Gene Expression Profiling Interactive Analysis (GEPIA). This analysis confirmed that low ICOS expression was significantly correlated with poor overall survival (OS) and progression-free survival (PFS) in ovarian cancer. The correlations between ICOS and cancer immune infiltrates were investigated via TIMER. Metascape and Protein-protein interaction (PPI) analysis suggest that ICOS plays an important role in the process of immune activation. ICOS is a potential target for the development of antibody drugs
Observation on the Curative Effect of Yiyuan Pingchuan Decoction Combined with Ultra-Low Frequency Combined with Physiological Frequency Electrical Stimulation on Chronic Obstructive Pulmonary Disease in Stable Stage
Get PDFObjective: To observe the clinical efficacy of Yiyuan Pingchuan Decoction combined with ultra-low frequency combined with physiological frequency electrical stimulation on chronic obstructive pulmonary disease in stable phase. Method: 89 patients were randomly divided into control group (44 cases)and observation group (45 cases). The control group was treated with conventional western medicine, while the observation group was treated with ultra-low frequency combined with physiological frequency electrical stimulation and Yiyuan Pingchuan Decoction on the basis of the control group. The 6-minute walking score (6MWT), SGRQ score, Borg fatigue score, lung function, and clinical efficacy after 30 days were observed at day 15 and day 30, respectively. Results: The 6MWT, SGRQ score, Borg fatigue score and lung function were improved more significantly in observation group than those in control group (p<0.05). The total effective rate of observation group (91.1%) was significantly higher than that of control group (79.5%) (p<0.05). Conclusion: Yiyuan Pinghuan Decoction combined with ultra-low frequency combined physiological frequency electrical stimulation can significantly improve the 6MWT, SGRQ score, Borg fatigue score and lung function of patients with stable chronic obstructive pulmonary disease, improve clinical efficacy, and then improve the quality of life of patients, so as to improve the clinical prognosis of patients
Effectiveness of Plastic Breast-Conserving Surgery in the Treatment of Early Breast Cancer
Get PDFObjective: To observe and compare the effects of different surgical procedures in the treatment of early breast cancer. Methods: Seventy patients admitted from 2020.7 to 2022.4 were selected as the study sample and divided into control and trial groups, 35 patients each received conventional and reconstructive breast-conserving treatment, respectively, to compare the treatment of patients between groups. Results: The excellent rate of breast repair in the trial group was 91.42% compared with 71.43% in the control group, with a significant difference (P < 0.05); the indicators of intraoperative blood loss and hospital stay were better in the trial group than in the control group, with significant differences between the groups (P <Â 0.05). Conclusion: Early breast cancer patients treated with plastic breast-conserving surgery not only have better results in breast repair, but also achieve early discharge from hospital, which is worth promoting
A Literature Review Study: a Meta-Analysis and Investigation of the Frequency Pattern of Point Selection Based on Clinical Studies of Acupuncture for Postoperative Treatment of the Anterior Cruciate Ligament
Get PDFA Literature Review Study: a Meta-Analysis and Investigation of the Frequency Pattern of Point Selection Based on Clinical Studies of Acupuncture for Postoperative Treatment of the Anterior Cruciate Ligamen
Observation on the Clinical Treatment Effect of Gynecological Endocrine Disorders
Get PDFObjective: To explore the clinical treatment methods and specifc therapeutic efects of gynecological endocrine disorders. Method: An experiment was conducted on endocrine disorders patients admitted to the gynecology department of a certain hospital in China from No-vember 2021 to November 2022. Forty patients were randomly selected as the experimental study subjects and divided into a control group and a study group. Among them, the control group adopts conventional treatment methods, while the research group adopts clomiphene capsules and hormone therapy based on conventional treatment methods. The clinical efcacy of the two experimental groups of patients is compared to determine the appropriate conventional treatment method. The levels of sexual hormones before and after the two experimental groups of patients and the clinical treatment efect are compared. Result: The treatment efect of the control group patients will be lower than that of the study group, and the treatment efectiveness rate of the control group patient group is about 70%. The efective rate of treatment in the patient group of the research group is about 95%. Conclusion: Through experimental argumentation, it can be understood that adding hor-mone and clomiphene capsules to the clinical treatment efect based on conventional treatment methods will be better, and it can be promoted and popularized
Observation of Pelvic Floor Structure in Women Undergoing Second Natural Delivery Using Intelligent Pelvic Floor Ultrasound
Get PDFObjective: To observe and study the pelvic floor structure of women undergoing second natural childbirth using intelligent pelvic floor ultrasound. Methods: Fifty pregnant women who completed second natural delivery in our hospital from April 2019 to April 2020 were selected as the experimental group, while 50 pregnant women who underwent first natural delivery during the same postpartum review were selected as the control group. Analyzing the test data of the two groups of patients, use two-dimensional ultrasound to observe whether there is pelvic floor organ prolapse and related parameter abnormalities in the two groups of pregnant women, and measure the movement of the bladder neck, urethral rotation angle, and posterior bladder angle of the pregnant women under Valsalva status; Real-time three-dimensional ultrasound was used to measure the area of the levator ani muscle hiatus under resting and Valsalva conditions, and to measure the pelvic floor muscle strength of the two groups of pregnant women. Results: There was no significant difference between the two groups in bladder neck movement, urethral rotation angle, and posterior bladder angle under Valsalva status (P>0.05). There was no statistically significant difference in the area of levator ani muscle hiatus between the two groups of parturients at rest [(14.00 ± 3.76) cm2 vs (14.51 ± 3.60) cm2] and Valsalva [(24.98 ± 326) cm2 vs (25.53 ± 3.40) cm2] (P>0.05); There was no significant difference in the incidence of pelvic floor organ prolapse and related abnormalities between the two groups (P>0.05); There was no statistically significant difference between the two groups in the unqualified rate of Class I (64.07% vs 69.00%) and Class II pelvic floor muscle strength (74.58% vs 78.00%) (P>0.05). Conclusion: The incidence of abnormal pelvic floor structure in women after second natural delivery is not significantly higher than that after first natural delivery, which provides imaging evidence for clinical guidance in selecting delivery methods and postpartum pelvic floor rehabilitation training for women after second natural delivery
Some Thoughts on the Development of Biomedical Engineering Technology and industry in China
Get PDFThis paper briefly introduces the development status of domestic biomedical engineering, summarizes the current mainstream biomedical engineering technology, and analyzes the development of nanomedicine, genetic drugs and regenerative medicine. Combined with the current medical development in China, it puts forward strategies such as realizing the development of the whole industrial chain, perfecting the patent support and establishing the industrial development road combining "production, learning and research", with a view to helping the relevant units to better understand the development direction of China's biomedical engineering technology and industry, and providing references to further promote the development of this field