Advanced Emergency Medicine (E-Journal)
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Changes of Acylating Stimulating Protein (ASP) and Blood Lipid in Patients with Acute Myocardial Infarction
Get PDFObjective:Â To study the changes of acylating stimulating protein (ASP) and blood lipid in patients with acute myocardial infarction. Method: There were three groups,25 cases of acute myocardial infarction patients (acute myocardial infarction group), 32 cases of coronary heart disease patients without myocardial infarction (CHD group) and 30 cases of healthy people (control group). They respectively detected the ASP, low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C), and analyzed the correlation between them. Results:Â (1) ASP, TG, TC and LDL-C of acute myocardial infarction group and coronary heart disease group were significantly higher than those of control group, while HDL-C was lower than control group, the difference was statistically significant (P < 0.05). (2) TG in coronary heart disease group was higher than that in acute myocardial infarction group, while ASP, TC, LDL-C and HDL-C had no significant difference. Conclusion:Â ASP and blood lipid are risk factors of CHD, ASP can be used as risk index of CHD. There was no significant difference in plasma ASP between patients with acute myocardial infarction and patients with coronary heart disease without myocardial infarction. ASP cannot be used as a surrogate marker of acute myocardial infarction
High Flow Nasal Catheter (HFNC) for Sepsis Induced Respiratory Failure After Extubation Meta Analysis of Clinical Control Studies on Reintubation Rate and Mortality
Get PDFObjective: To analyze the reintubation rate and mortality of patients with sepsis complicated (or induced) respiratory failure after extubation, and to seek evidence-based basis for the efficacy of HFNC in the re intubation rate and mortality of sepsis induced respiratory failure after extubation. Methods: The databases of PubMed, EMBASE, Ovid, CNKI, CBM, VIP and Wanfang were searched to find the clinical studies of patients with sepsis and respiratory failure, and meta-analysis was carried out by Stata software. Results: Meta analysis showed that there was no significant difference between HFNC and noninvasive positive pressure ventilation (NPPV) in 72 hour reintubation rate, mortality during ICU and 28-day in hospital. Conclusion: The reintubation rate and mortality of HFNC after extubation in sepsis induced respiratory failure are equivalent to that of NPPV
Treating Cartilage Injuries in Young Patients
Get PDFYoung people tend to suffer from cartilage injuries caused by extraneous trauma. There are many treatments for cartilage injuries. This article recommends treatments for different cartilage injuries targeted towards young patients. For young patients with mild or asymptomatic symptoms without cartilage displacement, this article recommends mandatory conservative treatment for young patients. Depending on the recovery condition of conservative treatment, the surgeon can subsequently plan for surgical treatment. Depending on lesion size, this article recommends the following operations. For lesions less than 1 cm2, arthroscopic debridement is recommended. For lesions between 1 and 4 cm2, MACI is recommended. For lesions larger than 4 cm2, OCA is recommended as a priority. If OCA is not feasible, OAT can be considered
Progress in the Application of Gait Analysis in Orthopedics and Physical Rehabilitation
Get PDFHuman walking function is the biggest characteristic that distinguishes other animals, and it needs the coordination of multiple parts of the body to complete the movement.Gait analysis is a new method to study walking function and state, and it is also a hot topic of medical researchers and medical workers in orthopedics, physical rehabilitation and other fields in recent years.After hundreds of years of development, the medical field has realized the accurate and objective measurement of gait, and developed a variety of gait analysis systems suitable for different needs, such as plantar pressure measurement system, unmarked gait analysis system, wearable sensor system, etc.In the context of the continuous progress of related hardware and software technology, the scope of application of gait analysis is also gradually expanding. This paper mainly combined with the research situation of gait analysis in orthopedics and physical rehabilitation in recent years, to review the new progress of related research
Analysis of Clinical Efficacy of Single-Port Endoscopic Breast-Conserving Surgery and Modified Radical Mastectomy in the Treatment of Early Breast Cancer
Get PDFObjective:Â To analyze the effect of single-port endoscopic breast-conserving surgery and modified radical mastectomy in the treatment of early breast cancer. Methods:Â The research subjects included in this study were 52 patients with early breast cancer who were admitted to our hospital from February 2020 to February 2021. They were divided into control group and experimental group by random number table method. The control group received modified radical mastectomy(26 cases), and the experimental group received single-port endoscopic breast-conserving surgery (26 cases). The treatment effects of the two groups were compared. Results:Â The blood loss, incision length and hospital stay in the experimental group were lower than those in the control group (P<0.05), but the operation time was significantly longer than that in the control group (P<0.05). There were significant differences in breast beauty between the two groups, and the experimental group was better (P<0.05). Conclusion:Â Single-port endoscopic breast-conserving surgery and modified radical mastectomy are used in the treatment of early breast cancer, and the treatment effect of the former is significantly better than that of the latter. This treatment method can be promoted
Preparation and Characterization of Epitope-Based Ratiometric Fluorescent Molecularly Imprinted Polymers
Get PDFIn order to solve the problem of difficult detection of neuronal nitric oxide synthase in the screening of neuronal nitric oxide synthase-postsynaptic density95 (nNOS-PSD95) uncoupling agent, this study used 133 amino acids (nNOS1-133) at the nitrogen terminal of nNOS as template molecules, carbon dots and quantum dots as ratio fluorescence recognition elements, SiO2 as matrix for the first time, combined with surface molecular imprinting technology and antigen-determining principle, to prepare ratiometric flurescent molecularly imprinted polymers (RFMIPs). The resulting RFMIPs were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy and thermogravimetric analysis，exhibiting uniform spherical morphology, which unambiguously confirmed the successful formation of the nanosensor. The result indicates that the synthesized sensors have promising potential for the assay of trace peptides in complex matrices
The Mechanism and Some Controversies of SGLT2 Inhibitor Protects the Cardiovascular System
Get PDFSGLT2 inhibitor, a kind of hypoglycemic drug, whose mechanism is to suppress glucose reabsorption in proximal renal tubules in the kidney to promote the excretion of glucose, has been demonstrated to have a positive effect on our cardiovascular system and reduce the risk of suffering from cardiovascular events. In this review, we will focus on four aspects to elaborate on its mechanism. First: diuresis and electrolytes, second: blood pressure, hormone, and nerve, third: regulating lipid metabolism, and the last: the direct effect on cardiomyocytes. This paper presents some puzzles of different mechanisms, aiming for waiting to be answered in later research
Research Progress on the Role of Atorvastatin in the Treatment of Coronary Heart Disease
Get PDFThe basic pathological change of coronary heart disease is atherosclerosis, and the main risk factor is abnormal lipid metabolism. Atorvastatin is the most commonly used lipid-lowering drug. This paper mainly describes the research progress of atorvastatin in terms of pharmacological effects, dosing and deficiencies
An Investigation of the Efficacy of Glycine Theophylline Sodium Extended-Release Tablets in the Treatment of Bronchial Asthma
Get PDFObjective: To observe the effect of treatment with theophylline extended-release tablets in patients with bronchial asthma. Methods: The medical records of 76 asthma patients admitted from 2020.8 to 2022.9 were extracted. 38 cases in the reference group received conventional basic treatment and 38 cases in the observation group received conventional + sodium theophylline glycinate treatment, and the condition control of the patients in the two groups was compared. Results: The patients in the observation group all disappeared from the disease symptoms earlier than the reference group (P < 0.05). In terms of total effective rate, the difference between the reference group and the observation group was 65.79% vs 92.11% (P < 0.05). Conclusion: Oral treatment with sodium theophylline glycinate is recommended for asthma patients to better control their condition
The Value of Cefoperazone Sulbactam and Amiloride Hydrochloride in the Treatment of Chronic Obstructive Pulmonary Disease
Get PDFObjective: To observe the effect of different drug regimens in the treatment of chronic obstructive pulmonary disease (COPD). Methods: Sixty-two patients with COPD admitted from 2020.9 to 2022.12 were divided into two equal groups, group A and group B. Thirty-two patients each were treated with cefoperazone sulbactam, while group B was treated with ambroxol hydrochloride. Results: The total effective rate in Group B reached 93.55%, higher than 67.74% in Group A (X²=5.063, P=0.024<0.05). The time to disappearance of disease symptoms and hospital stay were shorter in Group B than in Group A. The difference reached a significant level (P < 0.05). Conclusion: Clinical treatment of COPD patients with amiloride hydrochloride combined with cefoperazone sulbactam as early as possible is effective and worth promoting