Advanced Emergency Medicine (E-Journal)
Not a member yet
458 research outputs found
Sort by
Review of Tumor Suppressor Gene P53
Get PDFBackground: During tumorigenesis, cells proliferate unchecked, altering tissue homeostasis and leading to subsequent hyperplasia. This process parallels the recovery of cell cycle, abnormal DNA repair, and the passivation of apoptotic programs in response to DNA damage. In most human cancers, these processes are associated with dysfunctions of the tumor suppressor p53. As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP53) plays a central role in response to various cellular stresses. A variety of biological processes are regulated by p53 such as cell cycle arrest, apoptosis, senescence and metabolism. Besides these well-known roles of p53, accumulating evidence show that p53 also regulates innate immune and adaptive immune responses. p53 influences the innate immune system by secreted factors that modulate macrophage function to suppress tumourigenesis. Dysfunction of p53 in cancer affects the activity and recruitment of T and myeloid cells, resulting in immune evasion. p53 can also activate key regulators in immune signaling pathways which support or impede tumor development[1]. Hence, it seems that the tumor suppressor p53 exerts its tumor suppressive effect to a considerable extent by modulating the immune response. In this review, we concisely discuss the emerging connections between p53 and immune responses, and their impact on tumor progression. Understanding the role of p53 in regulation of immunity will help to developing more effective anti-tumor immunotherapies for patients with TP53 mutation or depletion
Analysis of Metabolic Factors Associated with Hyperuricemia in Diabetes Mellitus
Get PDFAfter the occurrence of diabetes in patients, with the increase of the course of disease and the increase of the age of patients, the incidence of other combined diseases in patients is also increasing. Diabetes combined with hyperuricemia is a common clinical disease, and 40% of patients with diabetes will develop hyperuricemia and other complications, which not only makes the treatment of the disease more difficult, but also increases the burden of the hospital. Therefore, to analyze the metabolic factors related to hyperfatemia, and to provide a reference for the clinical exploration of active and effective treatment
Application of Nanotechnology in Oral Implantation Based on Exercise-Induced Tooth Injury
Get PDFWith the development of sports in various countries, more and more people participate in sports, and the rate of sports injuries to the oral and maxillofacial system also increases, especially the dental injuries caused by boxing are more common. At the same time, with the improvement of modern production, people's basic needs have been continuously met, and more and more people have begun to pay attention to their physical health and appearance characteristics. Among them, dental plastic correction and restoration have received great attention. In addition, with the application of nanotechnology in various fields in recent years, scholars at home and abroad have also tried or have continued to introduce nanomaterials into oral clinics, in order to improve and develop the application of oral materials, so that the oral clinic can be continuously improved and developed. Therefore, this paper reviews the current situation of sports injury of the oral and maxillofacial system, the mechanical analysis of tooth injury, the current situation of tooth restoration and the application of nanotechnology in the field of oral implantation
Music Analgesia Used in Delivery of Pregnant Women
Get PDFMusic therapy is one of the non-drug labor analgesia methods advocated during labor, which can relieve labor pain and anxiety and promote natural childbirth. The author here from the definition of music therapy, physiological principles, for labor analgesia on maternal and neonatal effects, as well as music therapy and doula accompany childbirth combined application effect were reviewed
The Value of Breast-Conserving Surgery Combined with Neoadjuvant Therapy for Breast Cancer
Get PDFObjective: To observe the efficacy of different methods in the treatment of breast cancer disease. Methods: A sample of 78 patients attending the clinic from 2020.8 to 2023.1 was randomly selected and divided into groups A and B. Thirty-nine patients each underwent conventional breast-conserving surgery and group B combined with neoadjuvant therapy to compare the effectiveness of treatment between the groups. Results: The overall efficiency of group B vs group A was 94.87% vs 71.79%, a significant difference (P < 0.05). Surgery-related indicators were better in Group B than in Group A (P < 0.05). Conclusion: Early intervention with breast-conserving surgery combined with neoadjuvant therapy is recommended for patients with breast cancer and has demonstrated high clinical value
Photothermally Induced Alkyl Radicals and Pyroptosis Synergistically Inhibit Breast Tumor Growth
Get PDFPhotothermal therapy (PTT) is an emerging local tumor ablation technique with clinical translation potential. After the NIR-II laser irradiates the tumor, the photothermal agent Hu-Kaiwen ink (Ink) converts light energy into hyperthermia and maintains the temperature at 42-45°C, thus achieving a low-temperature photothermal therapy. Alkyl radicals can kill tumor cells by overcoming the hypoxic microenvironment of the tumor. The photothermal reaction can induce the conversion of alkyl radicals from 2,2′-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) and thus have a synergistic tumor inhibition effect. the DNA methyltransferase inhibitor decitabine (DCT) can induce pyroptosis and cause inflammation and immune response to achieve systemic immunity. In this way, a synergistic combination of photothermal, alkyl radicals and pyroptosis could be used to kill breast tumor cells. Sodium alginate (ALG) was used as a carrier to form a hydrogel structure, which can improve the stability and duration of action of the mixed drugs. The significant tumor growth inhibitory effect of composite hydrogels has been demonstrated in both in vitro and ex vivo studies
Revolutionizing Health Management: An Insight into the Impact of AI and Big Data
Get PDFThis article explores the opportunities and challenges of artifcial intelligence (AI) and big data for health management. It argues that AI and big data can revolutionize health management by enabling personalized, preventive, and predictive medicine; enhancing health research and innovation; and transforming health systems and policies. However, it also acknowledges that AI and big data pose ethical, legal, social, and technical challenges and risks that need to be addressed and mitigated. It proposes that ethical and governance frameworks forAI and big data for health should be based on human values and principles. The article provides an overview of the main aspects of health management that can be revolutionized byAI and big data, as well as some recommendations or suggestions for future research or practice in this feld
The Development of Big Data & Artificial Intelligence in the Field of Healthcare——The Case of Ping An Health (Ping An Good Doctor)
Get PDFThis report explores the utilization of big data and artifcial intelligence (AI) in the healthcare sector, focusing on the case of Ping An Health (formerly Ping An Good Doctor) in China. The rapid advancement of Internet technology has propelled the widespread adoption of these technologies across various industries. PingAn Health leverages its platform’s advantages to continuously innovate and enhance user experience, positioning itself at the forefront of the industry. The report delves into Ping An Health’s AI and big data technologies, ofering critical analyses of the ethical, political, and social implications surrounding the company
Effects of Ginsenosides on Cardiomyocytes and NF in Type 2 Diabetes Rats B Expression
Get PDFObjective: To explore the clinical medicinal value of ginsenosides. Methods: 24 male type 2 diabetes rats aged 7 weeks were taken as the research object, and the myocardial cell morphology, infammatory factor content and NF in each group were observed by grouping them with diferent doses- κ B expression. Result: The swelling degree of cells in the CP Rg50 group was alleviated most signifcantly, with a signifcant reduction in deep staining of the nucleus, a signifcant reduction in cell shrinkage, and a basic trend towards normal cell morphology. Meanwhile, compared to the control group, the CP Rg50 and CP Rg25 groups showed signifcant diferences in IL-1 levels β/ IL-6, TNF- α It also signifcantly decreased horizontally (P0.05). Conclusion: Ginsenoside Rg1 has signifcant efects in the treatment of cardiomyopathy and is worth promoting in clinical practice
Meteorological factors and asthma in Hangzhou, China, a time-series study
Get PDFMany studies have linked meteorological factors to asthma attacks. However, few studies have been conducted in the subtropical monsoon climate zone. The relationship between age, temperature, humidity (other meteorological factors) and asthma attacks has not been analyzed.Disease data were collected from medical records of Xinhua hospital in Gongsu district. Meteorological data were collected from Chinese terrestrial climate data daily value data sets.Poisson generalized additive models was used and combined with distributed lag nonlinear models and piecewise linear models to model associations between daily asthma hospitalizations from 2010 to 2013 and meteorological factors. Subgroup analyses by age and season were performed.Risk of asthma hospitalizations peaked at a mean daily temperature of 10℃ and declined approximately linearly until 35℃.High humidity and low humidity were both associated with more asthma admissions. Wind speed had no significant association with asthma hospitalization. No seasonal difference in associations were observed.Asthmatic patients should limit outdoor activities in low temperature, unsuitable humidity to avoid exposure to adverse conditions