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LENFOMA VE SOLİD TÜMÖR TANILI PEDİATRİK ONKOLOJİ HASTALARINDA ANTRASİKLİNE BAĞLI AKUT VE KRONİK KARDİYOTOKSİSİTENİN RETROSPEKTİF DEĞERLENDİRİLMESİ
No full text Lenfoma ve solid tümör tanılı pediatrik onkoloji hastalarında antrasikline bağlı akut ve kronik kardiyotoksisitenin retrospektif değerlendirilmesiEsra Karataş1, Deniz Kızmazoğlu2, Dilek İnce2, Emre Çeçen2, Mustafa Kır3, Nur Olgun41 Dokuz Eylül Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, İzmir 2 Dokuz Eylül Üniversitesi, Onkoloji Enstitüsü, Çocuk Onkoloji Bilim Dalı, İzmir 3 Dokuz Eylül Üniversitesi Tıp Fakültesi, Çocuk Kardiyoloji Bilim Dalı, İzmir 4 Dokuz Eylül Üniversitesi, Onkoloji Enstitüsü, Çocuk Onkoloji Bilim Dalı/ Acıbadem Kent Hastanesi, İzmir Amaç: Antrasiklinler, modern kanser tedavisinde önemli bir yere sahip olmakla birlikte kardiyotoksik etkileri tedavi etkinliğini sınırlayabilmektedir. Bu çalışmada 2013-2024 yılları arasında merkezimizde antrasiklin tedavisi gören hastalarda kardiyotoksisitenin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Merkezimizde 2013-2024 yılları arasında lenfoma ve malign solid tümör tanısı ile antrasiklin tedavisi alan 287 hasta retrospektif olarak değerlendirildi.Bulgular: Hastaların K/E oranı 1,16 idi. Ortanca tanı yaşı 80 aydı. Dokuz hastada (%3) tanıda kalp hastalığı, 35 hastada (%12) aile öyküsünde kalp hastalığı vardı. Hastaların %31,7’si (n:91) lenfoma, %68,2’si (n:196) solid tümör tanısı almıştı. Hastaların %29,3’ünde mediasten tutulumu ve %9,4’ünde mediastene radyoterapi öyküsü vardı. Hastaların %98,2’si sadece doksorubisin almıştı. Kardiyotoksisite gelişme oranı %14,6 (n:42) iken, %69,0’unda akut; %11,9’unda erken başlangıçlı kronik ve %19,1’inde geç başlangıçlı kronik toksisite olarak geliştiği belirlendi. Akut kardiyotoksisite bulguları arasında en yaygın olanı taşikardi idi; EKG’de en sık sinüs taşikardisi saptandı. On hastada kardiyak marker pozitifliği vardı. Erken başlangıçlı kronik toksisite gelişen 5 hasta mevcuttu ve bir hastada kümülatif doz 450 mg/m2’ye ulaşmıştı. Geç başlangıçlı kardiyotoksisite gelişen 9 hasta mevcuttu ve bir hastanın kümülatif dozu 480 mg/ m2’ye ulaşmıştı. Kardiyotoksisite gelişiminde yaş, cinsiyet, lenfoma veya solid tümör tanıları arasında anlamlı bir fark bulunmadı. Antrasiklin öncesi ve sonrası ekokardiyografileri karşılaştırıldığında kardiyotoksisite grubunda ejeksiyon fraksiyonunda azalma olduğu tespit edildi. Mitral yetmezlik kardiyotoksisite grubunda daha yüksek bulundu. Metotreksat, VEGF inhibitörleri, mifamurtid kullanımının kardiyotoksisite ile ilişkili olduğu saptandı. İnfüzyon süresiyle ilişkili anlamlı fark bulunmazken kür sayısı ve kümülatif doz arttıkça riskin arttığı belirlendi. Sağkalımlar incelendiğinde bir hastanın kalp yetmezliği nedeniyle kaybedildiği görüldü. Sonuç: Antrasiklinler, kardiyotoksisitesini erken dönemde belirleme ve önleme çabalarına rağmen, bu yan etki hâlâ doz kısıtlayıcı bir sorun olarak karşımıza çıkmaktadır. Merkezimizde kardiyotoksisite oranı literatür ile benzer bulundu. </p
Tailoring the structure of graphene oxide: investigation the effect of acid intercalation
No full textThis study investigated the effect of intercalant ratios on graphene oxide (GO) structure, a topic of significant interest in the field of materials science. The study reveals that specific ratios of intercalant acids (H2SO4 and H3PO4) in the improved Hummers method have a profound impact on the structure of GO. To explore this, GO samples were produced with different H2SO4:H3PO4 ratios, and their structural, morphological, thermal, and optical properties were investigated. The study employed a rigorous methodology, including the use of a range of analytical techniques such as X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscope, thermogravimetric/ differential thermal analysis, ultraviolet–visible spectroscopy analysis, X-ray photoelectron spectroscopy, Raman analysis, contact angle measurement, and dye adsorption tests. The results showed that the use of high amounts of H2SO4 damaged the basal plane of GO, and the oxidation degree of GO increased with increasing utilization of the H3PO4 ratio during production. Also, with increasing H3PO4 amounts in production, GO samples’ hydrophilic and thermal properties improve due to higher hydrogen bonding. In the dye adsorption results, 98% of methylene blue dye was adsorbed by GO produced with a 25% H3PO4 ratio within 30 min
Utilization of hydrazide-based silica sorbent for ultrasound-assisted dispersive micro solid phase extraction of some heavy metals in water, milk, and fruit juice
No full textIn this study, (E)-N’((2-butyl-4-chloro-1H-imidazol-5-yl)methylene)isonicotinohydrazide was first synthesized, and this ligand was supported on the silica surface. The obtained hydrazide-based sorbent was used for ultrasonic-assisted dispersive micro solid phase extraction of Co(II), Cd(II), Ni(II), Pb(II), and Zn(II). The metal ions after extraction were analyzed by flame atomic absorption spectrometry. For the optimization of the method, parameters such as ligand concentration, type and volume of elution solvent, pH of sample solution, amount of sorbent, and extraction time were optimized in this study. Under the determined optimum conditions for all metal ions, the extraction recovery was ˃95 %. In the optimum conditions, the linear range was 5–500 µg L for Co(II), Pb(II), Zn(II), 10–500 µg L−1 for Cd(II) and Ni(II). The limit of detections obtained for Co(II), Cd(II), Ni(II), Pb(II), and Zn(II) were 1.48, 2.97, 3.17, 1.62, and 1.55 µg L−1, respectively. The preconcentration coefficient for all metal ions was obtained as 40. Intra-day and inter-day relative standard deviation values (between 1.22 % and 3.53 %) determined with 10 and 50 µg L−1 metal concentrations showed that the results were repeatable. The suggested method was successfully performed on two different water, milk, and fruit juice samples
Bi-allelic UGGT1 variants cause a congenital disorder of glycosylation
No full textCongenital disorders of glycosylation (CDGs) comprise a large heterogeneous group of metabolic conditions caused by defects in glycoprotein and glycolipid glycan assembly and remodeling, a fundamental molecular process with wide-ranging biological roles. Herein, we describe bi-allelic UGGT1 variants in fifteen individuals from ten unrelated families of various ethnic backgrounds as a cause of a distinctive CDG of variable severity. The cardinal clinical features of UGGT1-CDG involve developmental delay, intellectual disability, seizures, characteristic facial features, and microcephaly in the majority (9/11 affected individuals for whom measurements were available). The more severely affected individuals display congenital heart malformations, variable skeletal abnormalities including scoliosis, and hepatic and renal involvement, including polycystic kidneys mimicking autosomal recessive polycystic kidney disease. Clinical studies defined genotype-phenotype correlations, showing bi-allelic UGGT1 loss-of-function variants associated with increased disease severity, including death in infancy. UGGT1 encodes UDP-glucose:glycoprotein glucosyltransferase 1, an enzyme critical for maintaining quality control of N-linked glycosylation. Molecular studies showed that pathogenic UGGT1 variants impair UGGT1 glucosylation and catalytic activity, disrupt mRNA splicing, or inhibit endoplasmic reticulum (ER) retention. Collectively, our data provide a comprehensive genetic, clinical, and molecular characterization of UGGT1-CDG, broadening the spectrum of N-linked glycosylation disorders
Exploring the impact of light wavelength on indoor mould growth
No full textMould growth adversely impacts the structural integrity of buildings, human health and indoor air quality. Traditional mould prevention in buildings primarily focuses on humidity control and ventilation, while the potential of lighting as a non-chemical strategy remains underexplored. This research examines how various lighting configurations affect the growth dynamics of two common indoor mould species found in UK dwellings. In this study, cultures were incubated under continuous illumination with either long-wavelength (650–700 nm) or short-wavelength (435–465 nm) LED light alongside dark conditions at two water activity levels (aw 0.95 and aw 0.91). Mycelial growth was quantified by measuring colony diameter and dry cell weight, and spore concentration was measured using a hemacytometer. Results showed that for Aspergillus Niger, long-wavelength light significantly increased both mycelial growth and conidia production in both high and low-water activities. Short-wavelength light irradiation resulted in the lowest conidia production, suggesting that short wavelengths could inhibit spore formation. For Cladosporium sphaerospermum, long wavelength light also increased conidia production; however, it only resulted in higher mycelial growth in higher water activity media. This study shows that incorporating spectrally optimised lighting systems into building designs could generate mould-resistant conditions and minimise the need for chemical treatments while enhancing indoor air quality. Further research is recommended to investigate broad-spectrum lighting with a wide range of wavelengths on mould growth to determine the most effective spectral conditions for mould prevention in the built environment
Dislodgement of the stent from its balloon due to entanglement in the previously implanted stent and retriaval of both stent with snaring: An interesting complication case
No full textAlthough stent dislodgement is a rare complication in interventional cardiology, its incidence has increased with the number of percutaneous coronary interventions. Stent dislodgement is a risk-laden complication concerning morbidity and mortality, and the management of embolized material can involve various techniques, including the snare technique, balloon retrieval with a small balloon, twirling/wire entrapment technique, and surgical methods. This case report highlighted a 65-year-old male patient who underwent coronary angiography for a diagnosis of non-ST elevation myocardial infarction. During the procedure, stent dislodgement occurred at the ostial left anterior descending artery/left main coronary artery distal region. The dislodged stents were successfully retrieved using the snare technique. The report emphasized techniques that can be utilized for the retrieval of embolized material in cases of stent dislodgement.</p