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EVALUATION OF SMOKY QUARTZ CRYSTALS IN THE AYDIN-KOÇARLI REGION WITHIN THE SCOPE OF GEO-TOURISM FROM THE PERSPECTIVE OF VOCATIONAL EDUCATION AND LOCAL DEVELOPMENT
No full textDecision Making in Older Adults
No full textAs the population ages, we increasingly encounter older and more complex patients with multiple comorbidities in clinical practice. Medical, ethical, and patient-centered approaches should be considered when making treatment decisions for these patients. Factors such as multimorbidity, polypharmacy, and reduced physiological reserve often complicate treatment options. Treatment decisions should consider the patient's overall health status, life expectancy, functional capacity, and individual preferences. For some older patients, cognitive impairments can complicate the decision-making process. In these cases, decisions may need to be made with the support of family members and ethics committees. Moreover, ageism should be prevented to ensure that older individuals are not disadvantaged in accessing treatment. The balance between aggressive treatment methods and conservative management should be carefully evaluated, especially in older adults. Unnecessary invasive procedures should be avoided, and approaches aimed at enhancing the patient's quality of life should be prioritized while maintaining a clinical benefit-risk balance. In this challenging decision-making process, evidence-based medicine guidelines, ethical principles, and respect for the preferences of the patient and their family should guide the effort to ensure a dignified and high-quality life for older individuals.</p
Erken Okuryazarlık Mobil Uygulaması Geliştirme: Tasarım Süreci ve ÖzelGereksinimli Çocuklarla Uygulamanın Test Edilmesi
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Radiation Therapy Outcomes of the National Protocol in Childhood Neuroblastomas: Turkish Society for Radiation Oncology Hematological Oncology, Pediatric Oncology, and TBI Working Group Study (TROD 03-004).
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Endoskopik Ultrasonografinin Çocuklarda Tanı ve Tedavideki Yeri ve Önemi: Tek Merkez Deneyimi
No full textEffect of repeated xylazine-ketamine or medetomidineketamine administration on selected reproductive parameters in male rats
No full textBackground: Sperm retrieval methods and surgical interventions are typically performed with the aid of anesthetic agents. In cases where the depth of anesthesia is insufficient, the procedure is often repeated. Aims: This study aimed to investigate the effects of repeated administration of xylazine-ketamine (XK) and medetomidine-ketamine (MK), as commonly used agents in laboratory animals, on sperm parameters, reproductive hormones, and testicular oxidative stress status. Methods: A total of 60 rats were used in the study. The animals were divided to two groups of thirty animals each as XK or MK groups, then each group was further divided into five subgroups (control, single dose, 1 repeat, 2 repeats, 3 repeats). Results: In the MK application group, the 2 repeats group exhibited a significant decrease in motility (P<0.001), an increase in the percent of abnormal sperms (P<0.05), and an elevated dead-to-live sperm ratio (P<0.001). In the MK 3 repeats group, a decrease in testosterone levels was observed (P<0.001). In all application groups (XK and MK), mRNA levels of testicular catalase (CAT), superoxide dismutase 1 (SOD]), androgen receptor (AR), and caspases 3/8/9 were significantly reduced (P<0.001). Conclusion: Despite the adverse effects of repeated anesthesia on certain testicular parameters, this study revealed that XK application is safer than MK in terms of spermatological characteristics
Validation of the Turkish version of the Lewy body composite risk score
No full textThe Lewy Body Composite Risk Score (LBCRS) has been developed to increase the sensitivity and specificity of the diagnosis attributable to Lewy body pathology outside of specialty centers. We aimed to assess the validity and reliability of the Turkish version of the LBCRS in patients with dementia with Lewy Bodies (DLB) and investigate the discriminative power of the test in Turkish patients with Alzheimer’s disease (AD) and DLB, and control group. The sample population (n = 512) comprised DLB (n = 113), DLB-Mild Cognitive Impairment (MCI)(n = 12), AD (n = 42), AD-MCI (n = 21), and control group (n = 324). A significant group difference was observed in the Turkish version of the LBCRS scores of the five groups (p 1. In patients with DLB, the cutoff score of ≥3 showed sensitivity (92%) and specificity (81%) (area under the curve [AUC] = 0.883, 95% CI: 0.815–0.951), p <.001) compared with the AD. Compared to the control group, the cutoff score of ≥3 showed a sensitivity of 98% and specificity of 97% (AUC = 0.994, 95% CI: 0.989–0.999, p <.001). The Turkish version of LBCRS permits accurate diagnosis of DLB with high sensitivity and specificity. Also, it can be useful to inform the caregivers regarding the course of the disease during the follow-up