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Duygusal Özgürleşme Tekniğinin Hemşirelik Öğrencilerinin Yaşadığı Premenstrüel Sendrom, Menstrüel Semptom ve Yaşam Kalitesi Üzerine Etkisi: Randomize Kontrollü Çalışma
No full textYoneyama's 3/2 test for the asymptotic stability of delay dynamic equations
No full textWe consider the linear delay dynamic equation (*) x Delta(t)+p(t)x(tau(t))=0fort is an element of[t0,infinity)T. We enhanced the results in Wu and Zhou [2007. Stability for first order delay dynamic equations on time scales. Computers and Mathematics with Applications, 53(12), 1820-1831] by removing the boundedness criterion from the delay and graininess functions to cover the result in Zhang et al. [1999. Global attractivity of difference equations with variable delay. Dynamics of Continuous, Discrete and Impulsive Systems, 6(3), 307-317]. Furthermore, we have defined new functions that will assist us in proving our main results. We have presented some examples that illustrate the essence of our results in this work
Assessment of the effect of sodium tetraborate on oxidative stress, inflammation, and apoptosis in lead-induced nephrotoxicity
No full textExposure to Pb, a toxic heavy metal, is a risk factor for renal damage. Borax, an essential trace element in cellular metabolism, is a naturally occurring compound found in many foods. This study investigated the effects of sodium tetraborate (ST), a source of borax, on renal oxidative stress and inflammation in rats exposed to Pb. Wistar Albino rats (n = 24) were divided into four groups: Control (0.5 mL, i.p. isotonic), Pb (50 mg/kg/day/i.p.), ST (4.0 mg/kg/day/oral), and Pb + ST groups. At the end of the five-day experimental period, kidney tissue samples were obtained and analyzed. Histopathologically, the Pb-induced damage observed in the Pb group improved in the Pb + ST group. Immunohistochemically, Pb administration increased the expression of inducible nitric oxide synthase, cyclooxygenase-2, and caspase-3. When evaluated biochemically, Pb application inhibited catalase and glutathione peroxidase (GSH-Px) enzyme activities and activated superoxide dismutase enzyme activity. An increase in malondialdehyde levels was considered an indicator of damage. ST application increases glutathione peroxidase enzyme activity and decreased malondialdehyde levels. These results indicate that ST might play a protective role against Pb-induced renal damage via the upregulation of renal tissue antioxidants and cyclooxygenase-2, inducible nitric oxide synthase, and caspase-3 immunoexpression
Investigation of the relationship between attitudes toward migration and life satisfaction of nurses working in Turkey
No full textBackground: Nurse migration contributes to the nursing shortage in developing countries. Understanding nurses' attitudes toward migration and related factors is crucial for policy-making and healthcare workforce planning in Turkey. Aim: This study aimed to investigate the relationship between nurses' attitudes toward migration and their life satisfaction in Turkey. Methods: The study included working nurses with social media accounts on a social media platform in Turkey who followed nursing-related content. A sample of 423 nurses completed an online survey. Independent variables included nurses' sociodemographic characteristics and inclination toward migration, while dependent variables were life satisfaction and migration attitude levels. Data were collected via an online questionnaire, incorporating the Brain Drain Attitude Scale (BDAS) and Life Satisfaction Scale (LSS), between April and May 2023. Results: The study found a negative correlation between nurses' life satisfaction levels and their attitudes toward migration (r = −.349, p <.001). Nurses dissatisfied with their profession (F = 6.575, p <.05), lacking professional support (F = 8.641, p <.05), and lacking social support (F = 6.307, p <.05) scored higher on the BDAS. Conversely, those satisfied with their profession (F = 31.455, p <.05), receiving professional support (F = 26.307, p <.05), and social support (F = 33.990, p <.05) scored higher on the LSS. Conclusion and implications for nursing: The study revealed that decreased life satisfaction among nurses in Turkey correlates with increased migration attitudes. These results underscore the need for strategies to enhance nurses' job satisfaction and support systems to mitigate migration tendencies. This study contributes valuable insights into the high inclination of Turkish nurses toward emigration
Microwave digestion method for sulfide analysis of Çanakkale region coal
No full textQuantitative analysis of sulfide content in coal is a necessary step for complete analysis. Conventional analysis methods take several days, whereas it takes a few hours in microwave digestion method. In the present study, a new wet chemical analysis technique was developed and applied to quantify the sulfide content in Turkish coal samples. In the initial step, 5 M HCl solution is employed to dissolve the sulfate phases present in the coal. Subsequently, pyrite is separated from the residue obtained in stage 1 through the utilization of 2 M HNO3 solution. The final stage involves the determination of organic sulfur, wherein concentrated HNO3, HCl, HF, and boric acid are utilized to completely decompose the remaining residue from stage 2. The extracted solutions from each stage are promptly analyzed for sulfur content using ICP-OES. The cumulative values of the three sulfur forms consistently correspond with certified total sulfur data for the majority of the examined coals. Among several advantages, the analysis duration is the most distinctive feature. Chemical analysis of sulfide in coal with microwave analysis method completed three times rapid than with conventional analysis
Associating Age of Symptom Onset with Cognitive Impairment Severity in Multiple Sclerosis: A Comparative Study
No full textIs fat quantification based on proton density fat fraction useful for differentiating renal tumor types?
No full textPurpose This study retrospectively assessed the diagnostic accuracy of fat quantification based on proton density fat fraction (PDFF) for differentiating renal tumors. Methods In this retrospective study, 98 histologically confirmed clear cell renal cell carcinomas (ccRCCs), 35 papillary renal cell carcinomas (pRCCs), 14 renal oncocytomas, 16 chromophobe renal cell carcinomas (chRCCs), 10 lymphomas, 19 uroepithelial tumors, 10 lipid-poor angiomyolipomas (AMLs), and 25 lipid-rich AMLs were identified in 226 patients (127 males and 99 females) over 5 years. All patients underwent multiparametric kidney MRI. The MRI protocol included an axial plane and a volumetric 3D fat fraction sequence known as mDIXON-Quant for PDFF measurement. Demographic data were recorded, and PDFF values were independently reviewed by two radiologists blinded to pathologic results. MRI examinations were performed using a 1.5 T system. MRI-PDFF measurements were obtained from the solid parts of all renal tumors. Fat quantification was performed using a standard region of interest for each tumor, compared to histopathological diagnoses. Sensitivity and specificity analyses were performed to calculate the diagnostic accuracy for each histopathological tumor type. Nonparametric variables were compared among the subgroups using the Kruskal-Wallis H test and Mann Whitney U test. P-values < 0.05 were considered statistically significant. Results In all, 102 patients underwent partial nephrectomy, 70 patients underwent radical nephrectomy, and the remaining 54 had biopsies. Patient age (mean: 58.11 years; range: 18-87 years) and tumor size (mean: 29.5 mm; range: 14-147 mm) did not significantly differ across groups. All measurements exhibited good interobserver agreement. The mean ccRCC MRI-PDFF was 12.6 +/- 5.06% (range: 11.58-13.61%), the mean pRCC MRI-PDFF was 2.72 +/- 2.42% (range: 2.12-3.32%), and the mean chRCC MRI-PDFF was 1.8 +/- 1.4% (range: 1.09-2.5%). Clear cell RCCs presented a significantly higher fat ratio than other RCC types, uroepithelial tumors, lymphomas, and lipid-poor AMLs (p < 0.05). Lipid-rich AMLs demonstrated a very high fat ratio. Conclusion MRI-PDFF facilitated accurate differentiation of ccRCCs from other renal tumors with high sensitivity and specificity
High PEEP with recruitment maneuvers versus Low PEEP During General Anesthesia for Surgery -a Bayesian individual patient data meta-analysis of three randomized clinical trials
No full textBackground: The influence of high positive end-expiratory pressure (PEEP) with recruitment maneuvers on the occurrence of postoperative pulmonary complications after surgery is still not definitively established. Bayesian analysis can help to gain further insights from the available data and provide a probabilistic framework that is easier to interpret. Our objective was to estimate the posterior probability that the use of high PEEP with recruitment maneuvers is associated with reduced postoperative pulmonary complications in patients with intermediate-to-high risk under neutral, pessimistic, and optimistic expectations regarding the treatment effect. Methods: Multilevel Bayesian logistic regression analysis on individual patient data from three randomized clinical trials carried out on surgical patients at Intermediate-to-High Risk for postoperative pulmonary complications. The main outcome was the occurrence of postoperative pulmonary complications in the early postoperative period. We studied the effect of high PEEP with recruitment maneuvers versus Low PEEP Ventilation. Priors were chosen to reflect neutral, pessimistic, and optimistic expectations of the treatment effect. Results: Using a neutral, pessimistic, or optimistic prior, the posterior mean odds ratio (OR) for High PEEP with recruitment maneuvers compared to Low PEEP was 0.85 (95% Credible Interval [CrI] 0.71 to 1.02), 0.87 (0.72 to 1.04), and 0.86 (0.71 to 1.02), respectively. Regardless of prior beliefs, the posterior probability of experiencing a beneficial effect exceeded 90%. Subgroup analysis indicated a more pronounced effect in patients who underwent laparoscopy (OR: 0.67 [0.50 to 0.87]) and those at high risk for PPCs (OR: 0.80 [0.53 to 1.13]). Sensitivity analysis, considering severe postoperative pulmonary complications only or applying a different heterogeneity prior, yielded consistent results. Conclusion: High PEEP with recruitment maneuvers demonstrated a moderate reduction in the probability of PPC occurrence, with a high posterior probability of benefit observed consistently across various prior beliefs, particularly among patients who underwent laparoscopy
Why are Turkish nurses migrating? A mixed-methods study
No full textAim: This study aimed to identify the factors influencing nurses’ migration patterns in Turkey. Background: The flow of nurse migration from developing countries to developed countries is steadily increasing. As a result, countries that are sources of migration tend to develop domestic inequities with respect to the population's ability to access health services. In particular, fragile economic conditions and the pandemic triggered the migration of nurses from Turkey, a developing country. Methods: This study employed a mixed-method explanatory sequential design and was conducted in Turkey between April and November 2022. The decision to migrate was the focus of both the quantitative aspect, involving 237 participants, and the qualitative aspect, with 20 participants. Quantitative data were gathered through a questionnaire, and qualitative data were obtained using open-ended questions during in-depth individual interviews. We followed the Strengthening the Reporting of Observational Studies in Epidemiology checklist in the quantitative phase and the Consolidated Criteria for Reporting Qualitative Research checklist in the qualitative phase. Descriptive statistics and thematic analyses were used to analyze the data. Results: In the quantitative stage of the study, nurses’ reasons for deciding to migrate were identified as economic conditions, working conditions, society's outlook on the profession, political factors, and professional growth opportunities. In the qualitative stage, four major themes influencing nurse migration patterns emerged: devaluation and poor collegiality in nursing; inadequate management support; negative work environment; and health, social, and economic policies. Conclusion: The results of the study showed that the three factors most influential in the decision to migrate were economic issues, a negative work environment, and political climate. Implications for nursing and health policy: In developing countries, there is an urgent need for nurse administrators and health workforce decision-makers to create healthy working conditions and manage resources efficiently, focusing on improving nurses’ economic situations while developing appropriate nationwide and international strategies
