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Integrated Adaptive Water Allocation Scenarios for Wetland Restoration: A Case Study of Lake Marmara Under Climate Change
No full textWetlands, as critical ecological systems, face increasing threats from anthropogenic pressures and climate change. This study investigates dynamic water allocation strategies forthe restoration of Lake Marmara, a nationally important wetland within the Gediz RiverBasin of Türkiye, which has experienced complete desiccation in recent years. Within thescope of the PRIMA-funded “Mara-Mediterra” project, an integrated modeling approachwas employed to evaluate multiple restoration scenarios using the WEAP (Water Evaluation and Planning) platform. Scenarios varied based on the initial storage capacity ofGördes Dam, irrigation demands, environmental flow priorities, and a potential waterdiversion investment from the Tabaklı reach. Results indicate that under current conditions,Lake Marmara’s ecological water needs can be sustained without the Tabaklı investment.However, under 2050 climate projections, scenarios lacking the Tabaklı investment or deprioritizing ecological needs consistently failed to meet the lake’s minimum water thresholds.Conversely, scenarios combining moderate dam storage levels, environmental prioritization, and Tabaklı inflow succeeded in restoring lake volumes by over 90%. These findingshighlight the need for adaptive water planning that aligns with projected hydro-climaticshifts to ensure long-term wetland sustainability</p
Sosyal Bilimlerde Stratejik Karar Verme: Çok Kriterli Karar Verme Yöntemleri ile Uygulamalar
No full textThe transmission of Levantine sensory heritage: An examination of the Bayetav Art and Arkas Carpet Museum
No full textProgress and challenges of multi-habitat marine restoration in the eastern Aegean Sea, Türkiye
No full textEcological restoration is an increasing global priority and is critical to reverse ecosystem decline caused by anthropogenic impacts. We outline the approach to marine restoration in Gökova Bay, Türkiye and present observations from lesser to more highly assisted restoration interventions and trials, including enforcing multi-habitat No Fishing Zones (including Posidonia oceanica, macroalgae and rocky reef) within a wider Marine Protected Area network. We consolidate evidence from ecological monitoring, small-scale fisheries catch data, marine patrol threat monitoring and a macroalgae trial intervention. It remains difficult to decipher interactions in this system where anthropogenic threats persist and change is not linear but we observe that areas of restoration (No Fishing Zones) demonstrated a lower proportion of Non Indigenous Species compared to fished areas. This work provides a new case study of the progression of multi-habitat interventions and the potential for marine ecosystem recovery in the eastern Mediterranean Sea, informing restoration at scale
Searching the Role of AKT Expression on Adiponectin Induced Cardiac Cells
No full textDiabetic Cardiomyopathy (DCM) refers to abnormalities inthe structure and function of the myocardium resulting from diabetes. In thehealthy heart, glucose and long-chain fatty acids are used equally as energysources. There is a dynamic balance in their uptake and transport. Adiponectin(APN) is an adipokine synthesized and secreted by adipose tissue. APNconcentration is reduced in insulin resistance and type 2 diabetes. APNprevents insulin resistance by increasing fatty acid excretion and glucose byskeletal muscle. Insulin-activated phosphatidylinositol 3′-kinase-dependentserine/threonine kinase AKT functions as a regulator of glucose transport,glycolysis, glycogen synthesis, suppression of gluconeogenesis, proteinsynthesis, lipogenesis, cell survival, cell size determination, and cell cycleprogression. Accumulationof AKT in the plasma membrane of insulin-stimulated adipocytes results indifferent substrate specificity and involvement in the regulation of GLUT4transport. Activated AKTconverts to p-AKT which translocates to the nucleus to activate its substrates.p-AKT can phosphorylate a wide range of proteins. The aim of this study is tosearch the role of AKT Expression on adiponectin induced cardiac cells invitro. The cardiac characteristics of H9c2 cells were confirmed throughimmunofluorescence staining followed by fluorescence microscopy imaging ofmuscle-specific desmin intermediate filaments, cardiac-specific myosin and perinuclear Atrial Natriuretic Factor(ANF). DCM model was created using the H9c2 cell line and time courseexperiment were made with different concentration level of adiponectin andexamine the expression change of Akt by Western Blot method.Immunofluorescencestudy was showed H9c2 cell line’s cardiac behavior. Time-dependent treatment ofAPN in different concentrations to H9c2 cells resulted in changes in AKTexpressions.This study aims to define new mechanisms that play a role in thepathogenesis of Diabetic cardiomyopathy.</p
GESTASYONEL DİABETES MELLİTUS ÖYKÜSÜ OLAN HASTALARDA UZUN DÖNEMDE TİP 2 DİYABET GELİŞİMİNİ PREDİKTE EDEN ANTENATAL VE PERİNATAL FAKTÖRLERİN DEĞERLENDİRİLMESİ
No full textGestasyonel diyabetes mellitus (GDM) öyküsü olan hastaların, gebeliğinde normoglisemik seyretmiş kişilere göre sonraki dönemde tip 2 diyabet gelişme riski daha yüksektir. Çalışmamızda GDM öyküsü olan hastalarda tip 2 DM gelişmesi-ne etkili olan faktörleri inceledik. Dokuz Eylül Üniversitesi Endokrinoloji bölümünde 2001- 2008 yılları arasında GDM nedeniyle takip edilmiş 229’un hastanın, verilerine ulaşılabilen 155 hasta çalışmaya dahil edildi. Bu hastalar 2024 yılına kadar olan takip verilerine hastane ka-yıtlarından ulaşıldı. Kaplan-Meier eğrisi ile diyabetsiz sağ kalım zamanı incelendi. Diyabet gelişen ve gelişmeyen hastalar birbiri ile karşılaştırıldı. Cox regresyon analizi ile diyabet gelişimindeki risk faktörleri araştırıldı. Çalışmaya dahil edilen 155 hastanın gestasyonel diyabet tanısı aldığındaki yaşı 30 (34 – 37 ) ve BMI 29.0 (26.1- 32.3) olup hastaların takip süresi 18 yıl (16 – 19) idi. Hastalardan 78’inde (%50,3) T2DM gelişmişti ve diyabet gelişme yaşı 42 (36 – 48) saptandı. GDM tanısı sonrası diyabet gelişmeden sağkalım 18.5 yıl (%95 CI, 15.1 – 17.8 yıl) olarak bulundu. Diyabet gelişen hastalarda gelişmeyenlere göre GDM tanısındaki vücut kitle in-deksi (VKI), ağırlığı ve doğumdaki ağırlığı daha yüksek bulundu (p <0.001). GDM tanısında yapılan 100 gr. OGTT’de 0, 1,2 ve 3. Saat glukoz değerleri diyabet gelişenlerde daha yüksekti (p <0.05). Diyabet gelişen hastalarda gebelik sırasında maksimum insulin ünitesi ihtiyacı daha yüksekti (30 (12 – 45) vs 13 (8 – 32); p = 0.032). Gebelik ve doğum sayısı diyabet gelişenlerde daha fazla iken, bebeğin doğum ağırlığında ya da haftasında farklılık yoktu. Diyabet gelişen hastaların güncel glukoz, Hba1c ve trig-liserit değerleri diyabet gelişmeyen hastalara göre daha yüksek iken, HDL değeri daha düşük olarak saptandı. Tek değişkenli analizde hastaların insulin tedavisi alması veya tanı sırasında VKI 30 üzeri olması diyabet gelişimi riskini artırdığı gösterildi. Çok değişkenli analizde (HR, %95 CI) ise GDM tanısı konulduğunda VKI>30 ise diyabet gelişiminin riskini 2.75 (1.69-4.46, p<0.001) oranında artırdığı saptandı. GMD öyküsü olanların uzun dönemde yaklaşık yarı-sında diyabet gelişmektedir. Diyabet gelişen hastalarda gebelikte VKI, glukoz değerleri ve insulin ihtiyacı daha yüksek bulundu. Gebelikte VKI yüksek olması diyabet gelişim riskini artırmaktadır. </p
A comparative study on the effectiveness of fly ash and blast furnace slag as partial cement substitution in 3D printable concrete
No full textThe environmental friendliness of 3D printable mixes is most likely achievable through recycling industrial waste. The effect of partially replacing ordinary Portland cement (OPC) with different ratios (0 %, 20 %, 40 %, and 60 % by weight of OPC) of fly ash (FA) and ground granulated blast furnace slag (BFS) on various properties of 3D printable concretes has been studied. The water-tobinder ratio and aggregate volume percentage were 0.3 and 41 %, respectively. A standard flowtable test was conducted to adjust superplasticizer dosages for the target flow diameter in the presence of a constant viscosity modifying agent content in all mixtures. A manual injection gun was used to simulate the printing process and monitor the buildability of the mixes. A rotational rheometer was employed to measure the rheological properties. Furthermore, ram extrusion and green strength tests were conducted to quantify the time-dependent properties at early ages. Flexural and compressive strengths were assessed at 7 and 28 days of standard curing. Finally, the embodied carbon (EC) and energy (EE) were evaluated. The findings of this study highlight that at an equal flow diameter, BFS and FA inclusion significantly influence extrusion forces, open time, and green strength of printable mixtures in contrasting ways. BFS improved the green strength, buildability, and static yield stress, increasing the green strength by up to 163.41 %; however, it may reduce the open time proportionally with its content. In contrast, FA replacement can extend the open time by lowering the development of extrusion force. However, FA reduced the green strength, with a decline of up to 35.4 %. Both pozzolans increased the 28-day flexural and compressive strength, but this effect was not observed in the 60 % fly ash-bearing mixture. Overall, BFS outperforms FA in enhancing buildability and structural performance, particularly at an early age. Incorporating BFS and FA significantly reduced carbon emissions and embodied energy, with reductions of up to 40 % and 41 % for BFS and 62 % and 57 % for FA, respectively
