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The effects of static and PNF hamstring stretching exercises in patients with knee osteoarthritis
No full textOtomobil Satışlarından Elde Edilen Özel Tüketim Vergisi Gelirlerinin Değerlendirilmesi (2020-2022)
No full textFunctional and microvascular sequelae of type 1 retinopathy of prematurity: insights from OCT-A and microperimetry.
No full textBackground: This study evaluated the long-term structural, functional, and microvascular outcomes in school-aged children with a history of laser photocoagulation (LP) therapy for the treatment of type 1 retinopathy of prematurity (ROP). The macular integrity, retinal sensitivity, fixation stability, and microvascular parameters were assessed using microperimetry and optical coherence tomography angiography (OCT-A). Methods: This retrospective cross-sectional study included children aged 10–15 who underwent detailed ophthalmologic examinations. Participants were divided into three groups: (1) children who had received LP for the treatment of ROP in infancy, (2) prematurely born infants without any ROP diagnosis, and (3) full-term controls. Statistical analysis was conducted to compare fixation stability, foveal avascular zone (FAZ) area, and vascular density (VD). Results: A significant difference was found in fixation stability among the groups, demonstrating more stable fixation in term-born children compared to preterm groups and significantly eccentric fixation in laser-treated infants (p = 0.019 and p < 0.001, respectively). Furthermore, FAZ areas were substantially smaller, and VD values were higher in laser-treated infants (p < 0.001 for both). A negative correlation was identified between fixation instability and FAZ size (p = 0.016 and p = 0.015), suggesting a relationship between fixation behaviour and foveal microvascular integrity. Conclusion: The diagnosis and treatment of ROP can significantly affect long-term visual functions, fixation behaviours, and macular vascular development. These findings emphasise the importance of long-term follow-up for preterm infants and the need for further studies to investigate the relationship between fixation stability and retinal microvasculature
Natural radioactivity levels and related risk assessment in soil and rock samples from the Çine submassif, defining Western Anatolia, Turkey
No full textIn this paper, the natural radioactivity levels and related radiological hazards in rock and soil samples from the Çine submassif, including all lithological units in Central-Western Anatolia, Turkey, were investigated. To achieve this, 15 rock samples and 15 surface soil samples were collected from 15 stations representing the geological structures of the Çine submassif. Rock samples are dominated by high-grade metamorphic rocks derived from granitic and litharenitic/subarkosic sandstones. The activity concentrations of natural radionuclides 226Ra, 232Th, and 40K, designated CRa, CTh, and CK, in the collected rock and soil samples were measured using a high-purity germanium detector system. The mean CRa, CT, and CK values for the rock samples were found to be 33.67 ± 3.47 Bq kg−1, 47.00 ± 3.47 Bq kg−1, and 871.20 ± 56.08 Bq kg−1, respectively. The respective mean values for the soil samples were found to be 40.00 ± 3.54 Bq kg−1, 51.40 ± 3.94 Bq kg−1, and 833.93 ± 50.94 Bq kg−1, respectively. The mean value of CRa for rock samples was within the worldwide permissible limits of 35 Bq kg−1. However, both the mean value of CRa in soil samples and the mean values of CTh and CK in both rock and soil samples were above the globally accepted values reported by UNSCEAR. Twelve radiological health hazard indices, namely indoor and outdoor absorbed dose rates (ADRin and ADRout), indoor and outdoor annual effective dose rates (AEDRin and AEDRout), indoor and outdoor excess lifetime cancer risks (ELCRin and ELCRout), annual gonadal dose equivalent (AGDE), radium equivalent activity (Raeq), external and internal hazard indices (Hex and Hin), and gamma and alpha indices (Iγand Iα), were calculated for both soil and rock samples and then compared with worldwide averages. The mean values of all ADRin, ADRout, AEDRin, AEDRout, ELCRin, ELCRout, and AGDE indices for both rock and soil samples are above the UNSCEAR acceptable limits. However, the mean Raeq values for rock and soil samples were 167.96 and 177.71 Bq kg−1, respectively, and thus below the UNSCEAR limit of 370 Bq kg−1. In addition, the average values of the Hex, Hin, Iγ and Iα indices were found to be less than one, indicating that they are below acceptable limits and therefore pose no risk to the people living in the investigated region. The radiological health hazard indices determined in this study can be contributed to the database of natural radioactivity levels in the Çine submassif, defining Western Anatolia, Turkey, providing information on the distribution of CRa, CTh, and CK as well as radiation doses to individuals in contact with the study area
İmplant Destekli Restorasyonlar ile Doğal Dişler Arasındaki İnterproksimal Mesafenin Değerlendirilmesi: Retrospektif Bir Araştırma
No full textAmaç:Bu retrospektif çalışmanın amacı, implant destekli restorasyonlar ile komşu doğal dişler arasındaki interproksimal mesafenin değerlendirilmesi, kontakt kaybı prevalansının belirlenmesi ve bu durumun gıda sıkışması şikâyeti ile peri-implant yumuşak doku sağlığı üzerindeki etkisinin incelenmesidir.Gereç ve Yöntem:Araştırma, Dokuz Eylül Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Anabilim Dalında 2023–2025 yılları arasında tedavisi tamamlanmış 22 hastanın (15 kadın, 7 erkek; yaş aralığı 37–69) klinik ve radyografik verilerinin retrospektif incelenmesiyle gerçekleştirilmiştir. İmplant üstü tek üye sabit restorasyonların mezial ve distal kontakları diş ipi ile değerlendirilmiş, gevşek ve açık kontaktlar kontakt kaybı olarak sınıflandırılmıştır. Gıda sıkışması şikâyeti hasta kayıtlarından elde edilmiştir. İmplant çevresindeki Plak İndeksi (PI), Sondalamada Cep Derinliği (SCD), Sondalamada Kanama (BOP) ve Klinik Ataşman Düzeyi (ÇD) parametreleri değerlendirilmiştir.Bulgular:Toplam 22 implant üstü restorasyonun %68,2’sinde en az bir yönde (mezial veya distal) kontakt kaybı saptanmıştır. Mezial yönde %36,4, distal yönde %40,9 oranında kontakt kaybı görülmüştür. Kontakt kaybı bulunan 15 olgunun 9’unda (%60,0) hastalar gıda sıkışması şikâyeti bildirmiştir. Kadın hastalarda kontakt kaybı oranı %86,7 iken erkeklerde %28,6’dır. İmplantların %81’inde peri-implant mukozitis varlığı (BOP pozitifliği) tespit edilmiştir.Sonuç:İmplant destekli tek üye restorasyonlarda interproksimal kontakt kaybı sık gözlenen bir komplikasyondur ve sıklıkla gıda sıkışması ile ilişkilidir. Kadın hastalarda kontakt kaybı oranının daha yüksek olması dikkat çekicidir. Bulgular, peri-implant dokuların korunması ve restorasyon başarısının sürdürülmesi açısından düzenli klinik kontrollerin önemini vurgulamaktadır.Purpose:This retrospective study aimed to evaluate clinical and radiographical changes in the interproximal area between implant-supported restorations and adjacent natural teeth.Materials and Methods:This study included a total of 22 implants placed in 18 patients (12 females, 6 males; mean age: 52.38 ± 8.78 years) who received implant therapy at the Department of Periodontology, Faculty of Dentistry, Dokuz Eylul University, between 2023 and 2025. All patients received implant-retained dental prosthesis and followed up to 24 months. Of the 22 implants, 18 were located in the molar region and 4 in the premolar region. During recall appointments, clinical periodontal and peri-implant parameters, radiographic findings, implant location, vitality of adjacent teeth, presence of parafunctional habits, restorations on neighboring teeth, condition of the opposing dentition, and patient-reported food impaction reports were recorded.Results:Loss of interproximal contact in at least one site (mesial or distal) was detected in 68.2% of the implant-supported restorations. The rate of contact loss was 36.4% on mesial surfaces and 40.9% on distal surfaces. In 9.1% of implants, contact loss was observed on both surfaces. Among the 15 implants with contact loss, 9 (60.0%) were associated with a reported food impaction complaint. Contact loss was present in 86.7% of female patients and 28.6% of male patients. Peri-implant mucositis was detected in 8 of the 15 implants (53.3%) exhibiting interproximal contact loss.Conclusion:Interproximal contact loss may occur over time between implant-supported restorations and adjacent natural teeth. Such contact loss can lead to food impaction complaints and contribute to periodontal and peri-implant tissue inflammation. Therefore, regular clinical and radiographic evaluation of interproximal contacts between implant restorations and adjacent teeth is essential for maintaining peri-implant tissue health.</p
Impact of fibrinogen-to-erythrocyte suspension ratio on mortality and functional outcomes in major perioperative bleeding (Approximate Dose-Equivalent of Fibrinogen-to-Erythrocyte Suspension (ADEFES) study): Protocol for a prospective observational study
No full textIntroduction Early and balanced replacement of blood products appears to be the key factor in improving outcomes of major bleeding patients including acute trauma, cardiac, obstetric and transplant surgery patients. Definitive clinical guidance regarding the optimal ratio of blood products, including those containing fibrinogen, is still lacking. Therefore, we tested the hypothesis that increasing the fibrinogen content to erythrocyte suspension ratio improves the mortality and functional outcomes of patients undergoing surgeries with expected major bleeding. Methods and analysis The Approximate Dose-Equivalent of Fibrinogen-to-Erythrocyte Suspension (ADEFES) ratio is a multicentre, prospective, observational, cohort study of patients undergoing major surgical procedures with expected major perioperative bleeding (ie, requiring packed red blood cells (PRBC)>4U/24 hours). For 5U of cryoprecipitate and 1.5 U of fresh frozen plasma (FFP), the approximate dose-equivalent for fibrinogen is considered as 1 gram of fibrinogen. Association of the ADEFES ratio at 24 hours will be assessed on the primary objective, which will consist of the composite of 30-day all-cause mortality, 30-day bleeding-specific mortality and the € highly-dependent scores' of Katz index of independence in activities of daily living. Ethics and dissemination The study protocol was approved by the Ethics Committee of Ankara Bilkent City Hospital (approval no. E2-23-4265, dated 07 June 2023; Chair: Prof. Dr. F.E. Canpolat) and by the institutional review boards of all participating centres. The study will be conducted in accordance with the principles of the Declaration of Helsinki and the Strengthening the Reporting of Observational Studies in Epidemiology guidelines, as well as in compliance with national regulations on data protection and Good Clinical Practice standards. Written informed consent will be obtained from all participants prior to inclusion in the study. The results of this study will be disseminated through peer-reviewed scientific journals, presentations at national and international conferences, and communication with relevant stakeholders including clinical practitioners and healthcare institutions. If applicable, study outcomes will also be shared via institutional newsletters and digital platforms to reach a broader audience in the medical community. Trial registration number NCT06021184
