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Carbapenem resistant gram negative bacteremia in intensive care unit patients: Development and validation of a nomogram-based 30-day mortality risk prediction model
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A novel trinuclear copper(II) complex bearing mono- and dianionic 5-fluorouracil ligands: Synthesis, crystal structure, Hirshfeld surface analysis, and in silico assessment of thymidylate synthase inhibition
No full textA novel Cu(II) complex, namely [Cu3(H2O)(bpy)3Cl(5FU)2(mu 3-5FU)(mu 2-OH)]& sdot;H2O & sdot;2EtOH, was synthesized and characterized using FTIR, TG/DTA and single crystal X-ray crystallography. The trinuclear Cu(II) complex is the first example containing both mono-and dianionic 5-fluorourasilate (5-FU) ligands. It consisted of neutral discrete molecules, in which three Cu(II) centres were bridged by a dianionic 5-FU ligand in a mu 3 fashion. Additionally, each Cu(II) centre was coordinated by a bidentate 2,2 '-bipyridine (bpy) ligand, and two of the Cu (II) ions were coordinated by a monodentate 5-FU ligands. Furthermore, the hydroxo ligand also acted as a bridging ligand between two copper centres. The three Cu(II) ions were five-coordinated with a distorted square-pyramidal geometry. Hirshfeld surface analysis was used to investigate non-covalent interactions. In silico studies of the Cu(II) complex against human thymidylate synthase (TS) as a cancer target protein were performed using molecular docking and molecular dynamics (MD) simulation methods. The free binding affinity of the complex toward TS was significantly higher than those of 5-fluorodeoxyuridine monophosphate (FdUMP), indicating the anticancer potential of the complex. Additionally, MD studies confirmed that the TS-Cu(II) complex was stable for a period of 100 ns
Coğrafya Öğretmenliği Programlarındaki Öğretim Elemanlarının Akademik Profillerinin Sürdürülebilir Kalkınma Hedefleri Açısından Analizi*
No full textTurkish adaptation and psychometric properties of caring ability of mother with preterm infant scale (CAMPIS)
No full textBackground This study aimed to adapt the Caring Ability of Mother with Preterm Infant Scale (CAMPIS) into Turkish and evaluate its psychometric properties. Methods This methodological and cross-sectional study was conducted with 210 mothers of premature infants in a NICU in Southeastern Türkiye between June and July 2025. Data were collected using a demographic form and the original CAMPIS. Translation procedures followed standard forward–backward techniques, with content validity evaluated by seven experts. Construct validity was examined via exploratory and confirmatory factor analyses (EFA and CFA). Reliability was assessed using Cronbach's alpha, McDonald's omega, item–total correlations, and split-half reliability. Results The content validity index was 0.98. EFA revealed a three-factor structure—cognitive ability, knowledge and skills abilities, and psychological ability—explaining 45.9 % of the variance. CFA confirmed the structure (χ2/df = 2.466, RMSEA = 0.084, GFI = 0.83, CFI = 0.81, IFI = 0.82, NFI = 0.73, TLI = 0.79), indicating acceptable model fit. CFA showed factor loadings ranging from 0.39 to 0.68 for cognitive ability, 0.39–0.75 for knowledge and skills abilities, and 0.25–0.94 for psychological ability. Cronbach's alpha was 0.792; McDonald's omega was 0.723. Split-half coefficients confirmed internal consistency. Item–total correlations ranged from 0.249 to 0.465. Significant differences between upper and lower 27 % groups supported discriminatory power ( p < 0.001). Conclusion The Turkish version of CAMPIS is a valid and reliable instrument for assessing caregiving ability in mothers of preterm infants. Implications to practice The Turkish version of CAMPIS can be used by nurses and healthcare professionals to assess caregiving ability in mothers of preterm infants
Valorization of Strained Yogurt Wastewater as Production Medium Nutrient for Arthrospira platensis and Haematococcus pluvialis
No full textMiddle Pleistocene tectonic events around the SE Aegean Sea: Insights from magnetostratigraphy, (U–Th)/He zircon dating, and fault kinematics in the Datça Graben (SW Türkiye)
No full textNew morpholine or triphenylphosphine-liganded palladium(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, and anticancer activity
No full textA series of morpholine(Morp.)-liganded palladium(II) complexes (1a–c) and triphenylphosphine(PPh3)-liganded palladium(II) complexes (2a–c) bearing 4-fluorobenzyl substituted N-heterocyclic carbene (NHC) were synthesized from NHC-Pd(II)-pyridine and Morp./PPh3 by ligand exchange method. The new complexes were fully characterized using 1H NMR, 13C NMR, 19F NMR, 31P NMR, FTIR spectroscopy and elemental analysis techniques. Furthermore, single crystal X-ray diffraction was used to elucidate the structures of complexes 1a and 2b. The anticancer activities of the new complexes against MCF-7 (Human Breast Cancer) cell line were investigated. With an IC50 value of 37.54 for complex 1a, it can be said that it is more cytotoxic to MCF-7 cells compared to other complexes, while the least cytotoxicity was observed in complex 1b