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Rabies post-exposure prophylaxis in children: adherence to national guidelines in a country at ongoing risk.
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Tuberculosis-related periprosthetic joint infections: Report of eleven cases from a single center
No full textBackground: Tuberculosis-related periprosthetic joint infection (TB-PJI) is an uncommon but challenging complication after arthroplasty, particularly in endemic regions. Its diagnosis is often delayed due to nonspecific symptoms, prior antibiotic exposure, and culture negativity. Methods: We retrospectively analyzed all patients with culture-confirmed Mycobacterium tuberculosis PJI diagnosed between January 2000 and January 2025 at a tertiary care center. Demographic, clinical, microbiological, histopathological, and surgical data were collected. Outcomes and follow-up status were assessed through patient interviews and review of hospital records. Results: Eleven patients (8 females; median age 66.8 years) were included. The knee (6/11) and hip (5/11) were the affected joints. The median interval between arthroplasty and symptom onset was 30 months. All cases were culture-positive for M. tuberculosis; GeneXpert MTB/RIF testing was performed in four patients and was positive in all. Histopathology demonstrated granulomatous inflammation in all cases, necrotizing in six. Two patients (18.1 %) had bacterial co-infections, and none had prior active tuberculosis. All patients received 10-14 months of anti-tuberculosis therapy, and nine underwent two-stage revision, while two had resection arthroplasty. Prosthesis reimplantation was achieved in nine patients. No recurrence occurred during a median follow-up of 77 months. Conclusion: TB-PJI should be considered in culture-negative or refractory prosthetic infections, especially in endemic areas. Diagnostic workup should include mycobacterial culture, molecular assays, and histopathology. Prolonged anti-tuberculosis therapy combined with two-stage revision yielded excellent outcomes in our series. A diagnostic and management algorithm is proposed to facilitate early recognition and improve treatment outcomes for this rare but serious condition
Wearable sensors for health monitoring: Current applications, trends, and future directions
No full textWearable sensors are redefining health, wellness, and performance monitoring by enabling continuous, non-invasive measurement of biochemical and biophysical signals directly on the body. In this review, we focus on two major classes of wearable technologies: wearable biochemical biosensors, including sweat, tear, saliva, and epidermal-based biochemical sensing, and wearable physical sensors, which monitor pressure, strain, temperature, motion, and other non-biological signals. We summarize recent advances in materials, microfluidics, and electronics that are enabling more practical and versatile wearable sensing platforms. Particular attention is given to multimodal systems that combine chemical and physical measurements on a single device, on-body fluid handling and sampling strategies, and data processing with embedded algorithms. Commercial examples such as continuous glucose monitors, smart patches, and consumer wearables are also highlighted. Key challenges include getting enough biofluid in a reliable way, reducing signal drift and biofouling, dealing with user-to-user variability, keeping data secure, making sensors comfortable to wear, and setting clear on-body or clinical validation protocols. We also highlight recent efforts that aim to address these issues through better surface coatings, more stable sensor designs, new power and energy-harvesting options, and improvements in data management and manufacturing. This review mainly covers studies published between 2018 and 2025, with a particular focus on work from the last 4–5 years
No Regression With Imatinib Treatment for Craniofacial Fibrous Dysplasia Associated With McCune-Albright Syndrome.
No full textManipulation of magnetic nanofluids by a Lagrange point-based permanent magnetic actuator for micropumping applications
No full textIn this study, a Lagrange point-based manipulation strategy is proposed to generate a micropumping effect using a permanent magnetic actuator. First, the effects of different actuator parameters, such as the angular position, the diameter of the permanent magnets, and the distance between the permanent magnets, on the Lagrange points generated in the microchannel and the magnetic force are numerically investigated. Moreover, the interaction between magnetic force and magnetic nanofluid is examined through flow analyses. Then, a real actuator setup working with magnetic nanofluid is designed and manufactured in accordance with the results of numerical analyses. Following, proof-of-concept experiments are conducted for the parameters utilized in the numerical analyses, varying actuator speeds, and the volumetric concentration of the magnetic nanofluid. According to the observations from the proof-of-concept experiments, the proposed actuator design can successfully pump the magnetic nanofluid by trapping it at the stable Lagrange point. Moreover, a flow rate range of 8.6-34.3 mu l/min is reached for actuator speeds of 3-12 rpm
Real-world effectiveness and safety of eculizumab in AQP4-IgG-positive neuromyelitis optica spectrum disorder.
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