Journal of Ayurveda and Integrated Medical Sciences (JAIMS)
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An Ayurvedic perspective on Hyperprolactinemia: A Review of Pathophysiology and Management
No full textHyperprolactinemia is one of the most common neuroendocrine disorders affecting women of reproductive age. It is characterized by elevated serum prolactin levels, leading to a spectrum of clinical manifestations such as menstrual irregularities, galactorrhoea, and infertility. While modern medicine attributes the condition to physiological, pathological, or pharmacological causes, Ayurveda interprets it because of Vata Doṣha vitiation, particularly involving the Manovaha and Artavavaha Srotas. The condition is closely linked with Viṣama Agni and Artava Agni Duṣhṭi, which impair hormonal regulation. This paper explores the Ayurvedic pathogenesis of hyperprolactinemia, emphasizing the role of disturbed Vata in neurohormonal imbalance and presents a holistic line of management through Trividha Chikitsa- Daivavyapasraya, Yuktivyapasraya, and Sattvavajaya. Specific therapies such as Basti, Nasya, Shirodhara, and Medhya Rasayanas are discussed for their potential to regulate the Gut-Brain Axis, pacify Vata Doṣha, and restore hormonal balance
Therapeutic Potential of Ikshuraka (Asteracantha longifolia Nees.): A Review
No full textAyurveda delves it roots through “Swasthasya Swasthya Rakshanam Aturasya Vikara Prashamanam cha” which means to keep the health of the healthy person and to cure the diseased condition. The goal of Ayurveda is to extend a person’s healthy life in terms of their mental, physical, social, and spiritual well-being. In the classical literature (Asteracantha longifolia Nees.) synonymously known as Kokilaksha has Vrishya (aphrodisiac), Mutravirechaka (diuretics), Rasayana (rejuvenating) and Ashmaribhedaka (lithotryptic) properties. Its multidimensional therapeutic applications across Samhitas, Nighantus and Chikitsa Granthas reflect its significant role in the management of disorders related to different Srotas. It is one of the most important herbs commonly used in the traditional system of medicine. Ikshuraka is specifically described in the Samhitas, Nighantus and Chikitsa Granth along with synonyms and therapeutic indications. It is most used in Vatarakta, Shoola, Gulma, Agnimandhya, Raktapitta, Pleeha Roga. The present review of Asteracantha Longifolia Nees. can be useful to know about the different formulation and their indication in various disorders along with different pharmacological activities. In this article all the formulations mentioned in Ayurveda classical texts have been described, along with the formulations mentioned in Chikitsa Grantha have also been described, and it has also been told which formulation is used for which disease
Integrating Charaka\u27s Wisdom of Pandu Formulations in Healthcare- A Narrative Review
No full textCharaka Samhita is a key text for Ayurveda practitioners, offering a comprehensive foundation of medical knowledge, principles, and treatment methods. Panduroga, classified by dosha types, includes some rarely seen variants. In contrast, anemia is diagnosed by general practitioners through patient history and clinical symptoms, supported by laboratory tests. Both Panduroga and anemia are common health issues that have been extensively studied in the medical field. Understanding the connection between these two conditions is crucial for developing effective treatment strategies. Previous research suggests that Panduroga can resemble anemia, and some formulations from Charaka\u27s classical Pandu may help in managing anemia. However, there is still a gap in research on how specifically Charaka\u27s traditional Pandu formulations work for different types of anemia. This review aims to compile recent evidence-based studies on herbo-mineral formulations described in the Charaka Samhita for Panduroga, including certain Lauha Kalpas often used to treat various forms of anemia. Studies show that most research focuses on Iron deficiency anemia and Garbhini Pandu, while other types of anemia are often examined alongside different diseases. Additionally, most remedies have been well-studied, whereas some have received less attention. The results indicate that certain remedies can reduce specific signs and symptoms in over 80% of cases and significantly improve blood parameters. As a result, these formulations are considered effective for alleviating particular symptoms associated with different forms of anemia
A Critical Review of Pakwashaya as the Sthana of Vata Dosha
No full textAyurveda literature claims that there are two types of Dosha. They are Shareerika (Physical) Dosha and Manasika (Mental) Doshas. Each of these Dosha has a place in the Shareera to carry out their function. Ayurvedia describe Pakwashaya (large intestine/colon) as the Sthana (seat) of Vata, attributing to its principal functions related to movement, excretion, and final stages of digestion. This article aims to compile textual, physiological, and clinical lines of evidence that support the designation of Pakwashaya as the Sthana of Vata. Using a structured textual review of classical Shastras, correlation with modern anatomical and neurophysiological knowledge (enteric nervous system and motility), and clinical observations commonly seen in Vatavyadhi involving the colon, we argue that the properties and functions attributed to Vata align closely with the structure and function of the large intestine. The synthesis supports the traditional classification while suggesting areas for future empirical research
Ayurvedic Management of Sthoulya (Obesity) through Virechana Karma: A Case Series with Clinical Insights
No full textBackground: Obesity is a growing global health issue characterized by excessive fat accumulation in the body that impairs overall health and increases the risk of chronic diseases. Modern lifestyles, including sedentary habits, unhealthy diets, and psychological stress, have significantly contributed to its rise. While modern medicine often manages obesity symptomatically, long-term, and root-cause treatment remains limited. In Ayurveda, obesity is classified as Sthoulya, a Santarpanajanya Vyadhi (disorder due to over-nutrition), caused by an imbalance in Ahara (diet), Vihara(lifestyle), and Manasika Bhavas (mental state). Ayurvedic therapies such as Virechana Karma aim to correct these imbalances holistically.
Aim: To evaluate the efficacy of Virechana Karma in the management of Sthoulya.
Methods: A consecutive case series was conducted on six patients diagnosed with obesity. The treatment protocol included Deepana, Pachana, Snehapana, and Virechana. Followed by Shamana Aushadhi for 60 days. The assessment was based on changes in anthropometry, body weight, Body Mass Index (BMI), Lipid profile, and digital body fat monitor. Parameters were recorded at baseline and end of the follow-up period.
Results: All six patients showed significant reductions in weight, BMI, waist circumference, and body fat percentage. No adverse effects or complications were reported during treatment. Patients additionally reported increased energy levels, improved digestion, and better mental clarity.
Conclusion: Virechana Karma proved to be a safe and effective Ayurvedic approach for managing obesity. Its holistic action not only supports weight reduction but may also help prevent the long-term complications associated with obesity by improving metabolism and promoting systemic balance
Pharmacovigilance Insights from Nigandu Adharsh
No full textThe traditional systems of medicine in India—Ayurveda, Siddha, and Unani (ASU)—have been practiced for centuries and remain integral to healthcare. With globalization and rising interest in complementary medicine, concerns about the safety and regulation of these systems have grown. Although severe toxicity from Indian medicinal plants is rare, risks exist. Classical Ayurvedic texts identify certain plants as toxic, permitting their use only after detoxification (Shodhana). Yet misconceptions persist that all “natural” products are inherently safe and that long-term traditional use guarantees efficacy, assumptions that may not hold in modern contexts. Serious concerns arise when ASU medicines are consumed alongside allopathic drugs, leading to potential adverse interactions. Reports of adulteration with synthetic pharmaceuticals such as corticosteroids and NSAIDs further undermine credibility and pose health risks. As ASU products enter international markets and are often sold over-the-counter without professional supervision, adverse events are frequently linked to poor quality, misuse, or improper administration. Despite established pharmacopoeial standards, the lack of formal oversight highlights the need to integrate ASU systems into pharmacovigilance (PV). Pharmacovigilance—defined as the detection, assessment, understanding, and prevention of adverse effects—has traditionally focused on synthetic drugs. However, its inclusion of traditional medicines is increasingly necessary to ensure consumer safety in globalized markets. Spontaneous reporting systems, central to PV, enable early detection of safety signals and guide risk management, and their relevance is now recognized for traditional medicine. Ayurvedic pharmacovigilance draws on classical textual knowledge, centuries of clinical practice, and individualized therapy. Treatment considers patient-specific factors such as Prakriti (constitution), Desha (region), Kala (season), Ahara (diet), and Anupana (vehicle), underscoring Ayurveda’s cautious, context-sensitive approach. This paper explores insights from Nighantu Adarsha, a lexicon by Vaidya Bapalal G. Shah, which documents adverse reactions and safety concerns, demonstrating that drug safety monitoring was acknowledged in classical Ayurvedic literature
To Evaluate the Efficacy of Total Ayurvedic Regimen in Ekakushta w.s.r. to Psoriasis - A Case Series
No full textIn present generation beauty is a combination quality of such as colour, appearance, are the main core of individual personality. But due to Pradnyparadha (sinful act), psychological, dietary and other causes skin diseases seems to be very common in this era. In Ayurveda all skin diseases are classified under heading Kushtaroga. Ekkushta is one among them can be corelated with Psoriasis. Ekkustha is one of the irritating disease cosmetically. So, to show that this burden can be successfully lowered down via Ayurvedic treatment protocol case series is presented on Ekkushta. Here through classical ayurvedic formulation Shidharthaksnana and Shodhana (Bio purification) i.e. Virechana (purgation) significant positive results are found. As there is always stigma associated with the Kushta Rogas in society which lowers self-esteem and confidence via this treatment protocol one can relieved from symptoms of Ekkushta, helps to regain confidence and skin rejuvenation
The Tale of 21 leaves : Devotion meets Science
No full textVinayaka Puja, celebrated across India and other parts of the world during Sukla Paksha Chaviti of Bhadrapada Masa, involves offering 21 sacred leaves to Vinayaka for ten days. This ritual, preserved for centuries, has underlying pharmacological relevance: certain leaves emit volatile compounds with airborne effects such as insect repellency and positive influence on human physiology and psychology, while others, when immersed in water during Nimarjana, impart purifying and mild therapeutic effects. This review explores the airborne and waterborne properties of these 21 leaves, highlighting the intersection of traditional practice and scientific insight, and demonstrating that ancient rituals were thoughtfully aligned with environmental and health considerations
Amlapitta as a Nidana of Hypertension: With Therapeutic Trial of Paniyabhakta Gutika
No full textThe terms "Amla" (sour) and "Pitta" (gastric juice) combine to produce the phrase "Amlapitta". Pachaka Pitta, or gastric juice, is produced in greater amounts when there is Amlapitta. Pitta, or gastric juice, loses its typical bitter taste (alkaline) and gains more sourness (acidic) as a result of fermentation. This heightened sour quality is referred to as Amlapitta. It is a digestive illness brought on by abnormal pancreatic and stomach enzyme synthesis. It is referred to as Acid Peptic Disorder (APD) in medical study. It is referred to as Amlapitta in Ayurveda. It is a worldwide illness that is quite common. In 2021, an Indian study found that over 32% of people between the ages of 30 and 44 said they had. Acidity and indigestion were seen to be higher among older adults and seniors. Aasharya Aasharayi Bhava is associated with the Rakta Dhatu and Pitta Dosha. When Pitta Dosha becomes vitiated, Rasa and Rakta Dhatu\u27s natural makeup is upset. Alterations in the typical components of both Dhatu and Vyana Vayu impact the latter\u27s function; a decrease in Vyana Vayu influences blood circulation, and an increase in blood circulation can lead to Hypertension
Molecular regulation of Ritucharya
No full textIntroduction: Ayurveda promotes health through daily and seasonal routines that may trigger beneficial epigenetic changes.DNA defines an individual’s genotype, which is stable, while the phenotype, physical traits and behaviour is shaped by external factors. Epigenetics studies how environment, stress, and lifestyle can alter gene expression without changing DNA. These changes can be inherited, with factors like pollution and trauma affecting future generations. Materials and Methods: Current studies and literature are thoroughly analysed to investigate the molecular mechanisms underlying ritucharya. Results: Circadian rhythms regulate sleep, metabolism, hormones, and immunity. Disruptions can lead to inflammation, metabolic disorders, and weakened immunity. Ayurvedic practices like Ritucharya support natural rhythms by aligning lifestyle with seasonal changes, helping regulate hormones (e.g., Melatonin, Cortisol, Vitamin D) and immune function. Seasonal routines enhance metabolism, reduce inflammation, and support gut health. The gut microbiome and circadian clock interact closely, influencing each other and overall health. Ritucharya routines and therapies like Nasya, Abhyanga, and fasting - reduce oxidative stress and improve immune response at the molecular level. Discussion: Ritucharya, Ayurveda’s seasonal regimen, aligns diet and lifestyle with environmental changes to balance doshas, digestion, and immunity. These practices closely mirror modern circadian and seasonal biology, where light, hormones, and feeding rhythms regulate metabolism and immune function. Seasonal shifts affect hormones like melatonin and cortisol, gut microbiota, and inflammation levels. Ayurvedic practices such as massage, nasal therapy, and seasonal detox help reduce stress, support circadian balance, and enhance overall health