Asian Journal of Pharmaceutical Research and Health Care (AJPRHC)
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DESIGN AND ANTIINFLAMATORY ACTIVITY OF SOME NOVEL OXADIAZOLE DERIVATIVES – AN OVERVIEW
Full text linkOxadiazole derivates play vital role in biological field suchas anti-microbial, anti-viral, anti-tubercular, antiinflammatoryand anti-convulsant activity. Therapeuticsignificance of these clinically useful drugs in treatment ofinflammation encouraged the development of some morepotent and significant compounds. oxadiazole derivativesare remarkably effective compounds for inflammation andanalgesic activity. Extensive biochemical andpharmacological studies have confirmed that thesemolecules are effective in inflammation. Thiscomprehensive overview summarizes the chemistry ofdifferent derivatives of substitute
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND TAPENTADOL HYDROCHLORIDE IN TABLET DOSAGE FORM
Full text linkA simple, precise, accurate and reproducible spectrophotometric method has been developed forSimultaneous estimation of Paracetamol and Tapentadol Hydrochloride by employing first order derivativezero crossing method in 0.1 N Sodium Hydroxide. The first order derivative absorption at 257.1 nm (zerocross point of Paracetamol) was used for quantification of Tapentadol HCl and 289.0 nm (zero cross point ofTapentadol HCl) for quantification of Paracetamol. The linearity was established over the concentrationrange of 15-3
EVALUATION OF THE POWDER AND COMPACTION PROPERTIES OF MICROCRYSTALLINE STARCH (MCS) DERIVED FROM CASSAVA (MANIHOT ESCULENTA CRANTZ) STARCH BY ENZYMATIC HYDROLYSIS
Full text linkThe aim of this study was to investigate and determine the powder and compaction properties of microcrystalline starch (MCS) and compare with the properties of a well known direct compression filler-binder, microcrystalline cellulose (MCC). Cassava starch was extracted from the freshly harvested tubers of Manihot esculenta Crantz and subjected to 5hours of enzymatic hydrolysis to yield microcrystalline starch. The powder and compaction properties were evaluated and compared with MCC 101, a commercial brand of microcrystalline cellulose. Results of the powder properties of MCS revealed differences in the particle size, angle of repose, flow rate, bulk density, tapped density, true density, Hausner’s ratio, Carr’s index and powder porosity when compared to MCC. The compaction studies of both materials revealed that MCS had a faster onset of deformation and a greater extent of deformation in comparison to MCC. These results suggest that MCS has the potential of being used as a filler-binder in direct compression tableting
A PILOT STUDY HIGHLIGHTING DIFFERENCES IN PHARMACISTS’ PERCEPTIONS REGARDING USE OF PHARMACOGENETIC INFORMATION IN THEIR PROFESSION (IN LOUISVILLE METRO AREA) BASED ON PRACTICE SETTINGS
Full text linkThe aim of this study was to highlight differences in pharmacist’s perceptions regarding use of pharmacogenetic information in their professional activities based on their practice settings. A survey was electronically administered using the Survey Monkey to 48 practicing pharmacists in the hospitals and non-hospital study groups which include community pharmacy and managed care around the metro Louisville, Kentucky areaBarring minor deviations, there was overall homogeneity in our pilot study group’s general knowledge, overall confidence in pharmacogenetics and perceptions about possible impact of this emerging field in their profession, regardless of their professional practice environment. Overall low to moderate levels of pharmacists’ confidence in pharmacogenetics and related areas even a decade after completion of Human Genome Project (HGP) seems to be a matter of concern
SYNTHESIS AND CHARACTERIZATION OF SOME BENZIMIDAZOLE DERIVATIVES USING AS ANTI-HYPERTENSIVE AGENTS
Full text linkA new series of non peptide angiotensin(A-II) receptor antagonist has been prepared. This N-(biphenyl methyl) imidazoles e.g. 5-substituted (amino) -2-phenyl-1-(2’carboxy biphenyl-4-yl) benzimidazoles differ from the previously reported and related compounds in that they produce a potent hypertensive effect upon oral administration. The earlier series were generally active only when administered intravenously. It has been found that 2’-position of biphenyl is essential. Only ortho substituted acid possess both high affinity for the AII receptor and oral anti-hypertensive potency. Following the discovery of benzimidazole derivatives, numerous structural modifications have been made to the benzimidazole nucleus to increase the anti-hypertensive potency
PROSOPIS CINERARIA (L) DRUCE: A DESERT TREE TO BRACE LIVELIHOOD IN RAJASTHAN
Full text linkThe Prosopis cineraria (L) Druce is an important tree (Khejri- a local name in Rajasthan)for the Thar Desert withhard climatic adaptation and one of the lifeline in desert habitat as mentioned in ancient literature. This is a speciesrepresenting all five F viz., Forest, Fiber, Fuel, Fodder and Food. This tree is also mythological important in localcommunities. High value of this species recognized as a State symbol (state tree of Rajasthan). Prosopis cineraria(L.) Druce is a tree endemic to hot deserts of India, belonging to the family Leguminosae. Pods locally called“Sangri” are considered as dry fruit of desert and are one of the main ingredients of quintessential Rajasthani dish -The Panchkuta. In the present article, we have attempted to review different characteristics of the pods, tounderstand its health benefits. Various phytoconstituents like tannins (gallic acid), steroids (stigmasterol,campesterol, sitosterol, etc.), Flavone derivatives (prosogerin A, B, C, D, and E), alkaloids (spicigerine,prosophylline), etc. have been isolated from the sangri pods .As this plant is found in water stress (or deficient area)so antioxidant potential of pods has also been discussed. Prosopis cineraria (L) Druce is one of the highly valuedplant in the Indigenous System of Medicine. P. cineraria pods provide protein, iron, vitamins A and C and othermicro minerals Unripe pods are also nutritious and are used to prepare curries and pickles. Its bark is said to be apotent drug for several ailments such as leprosy, dysentery, bronchitis, asthma, leucoderma, piles, muscular tremors,asthma, rheumatism and inflammations. Pharmacological activities like analgesic, antipyretic, antihyperglycemic,antioxidant, antihypercholesterolemic, antitumor, nootropic anthelmintic, antibacterial, antifungal, antiviral andanticancer activities have been reported from different plant extracts. In view of its medicinal importance, thepresent review is focused to delineate its chemical constitution and therapeutic potentiality, precisely
VALIDATED SPECTROFLUOROMETRIC METHOD FOR DETERMINATION OF ATENOLOL IN PHARMACEUTICAL PREPARATIONS
Full text linkIn this study, a new and rapid spectrofluorometry method was developed for determination of atenolol in pure and pharmaceutical preparation. The solvent system and wavelength of detection were optimized in order to maximize the sensitivity of the proposed method. Parameters such as linearity, precision, accuracy, specificity, stability, limit of detection and limit of quantification were studied according to the International Conference on Harmonization (ICH) Guidelines. The linearity was established between the concentration range of 50-4000 ng/mL. The intra- and inter-day relative standard deviation (RSD) was less than 2.97%. Limits of detection and quantification were determined as 15.2 and 46.1 ng/mL, respectively. The mean recovery value of atenolol was 99.3% for pharmaceutical preparation. The method was applied for the quality control of commercial atenolol dosage form to quantify the drug and to check the formulation content uniformity
MICROBUBBLES: A NOVEL DELIVERY SYSTEM
Full text linkMicrobubbles designate air or gas filled microspheres suspended in a liquid carrier phase which generally results from the introduction of air or gas. The liquid phase contains surfactants to control the surface properties as well as stability of the bubble. Microbubbles have an average size less than that of RBC’s i.e. they are capable of penetrating even into the smallest blood capillaries & releasing drugs or genes, incorporated on their surface, under the action of ultrasound. Microbubbles in general have a wide variety of applications. However in the biomedical field these are primarily used as diagnostic agents in combination with ultrasound for molecular imaging of various organs and even tumors. These are also proposed for drug and gene delivery to targeted regions in combination with various ligands. Most of the physicians today prefer imaging with ultrasound in combination with microbubbles compared to other diagnostic techniques for low cost and rapidity
A VALIDATED REVERSED PHASE HPLC-METHOD FOR THE DETERMINATION OF ACECLOFENAC AND TIZANIDINE IN TABLETS
Full text linkA new simple, accurate, precise and reproducible Reverse Phase-High Performance Liquid Chromatographic method has been developed for the simultaneous estimation of Aceclofenac and Tizanidine in tablet dosage forms using C18 column (Ineretsil, 250 x 4.6 mm, 5 μm) in isocratic mode. The mobile phase consisted of acetonitrile, methanol and 20 mM phosphate buffer adjusted to pH 3.5 in ratio of (40:30:30 v/v) with Ultraviolet-Visible detection at 230 nm. The method was linear over the concentration range for aceclofenac120-280 μg/ml and for tizanidine 2-40 μg/ml. The recoveries of Tizanidine and Aceclofenac were found to be in the range of 99.45-100.61% and 99.56-101.32% respectively. The validation of method was carried out using International Conference on Harmonization-guidelines. The described High Performance Liquid Chromatographic method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form
FORMULATION AND IN VITRO EVALUATION OF ARAUCARIA BIDWILLI GUM-BASED SUSTAIN RELEASE MATRIX TABLETS OF DICLOFENAE SODIUM
Full text linkA gel forming Polysaccharide gum obtained form the bark of Araucaria bidwilli was employed as a matrix sustained release tablet formulation of Diclofenac sodium (a non steroidal anti inflammatory agent). The effect of Araucaria bidwilli gum (Natural) and Synthetic polymer Hydroxypropyl methyl cellulose (HPMC K4 M) on the release of Diclofenac sodium was studied. The FT-IR spectroscopic studies of drug, gum and mixture indicated no chemical interaction. Six formulations were prepared by wet granulation method containing Araucaria bidwilli gum powder concentration 10% 20% & 30% w\w and 10% 20% &30% w\w of HPMC K4 M with sufficient volume of granulating agent Polyvinyl pyrrolene (PVP K 30), Avicel pH101 as diluents, Magnesium stearate and Aerosil is used lubricant and glidant respectively.This study was carried out to find out the difference between synthetic and natural gum and whether synthetic gum can be replaced by natural gums. Physical and technological studies of granules and tablets were compliance with Pharmacopoial standards.The drug release increased with Araucaria bidwilli gum when compared to synthetics polymer concentration .The value of release exponent were found to be almost straight line and regression coefficient value between 0.938 and 0.998.This implies that the release mechanism is diffusion. Formulation F3 ( contained 30% w\w Araucaria bidwilli gum) met the desired requirements for a sustained release dosage form