Asian Journal of Pharmaceutical Research and Health Care (AJPRHC)
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ISOLATED PERIORBITAL EDEMA ASSOCIATED WITH NAPROXEN: A CASE REPORT
Full text linkHypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs), resulting in urticaria and angioedema, is being observedwith increasing frequency partly due to the large size of the exposed (at risk) population. Prevalence rates range from 0.1–0.3%. Facial angioedema constitutes the most common form of clinical presentation, and one-third of the patients show amixed clinical pattern of cutaneous (urticaria and/or angioedema) and respiratory symptoms which include upper respiratorytract edema, rhinorrhea, cough, breathlessness and tearing. But to the best of our knowledge there is no isolated periorbitaledema reported to date due to naproxen in the literature. In this report, a 62-year-old woman who developed reversiblebilateral periorbital edema after naproxen ingestion was presented. The periorbital edema due to NSAIDs was discussed
FRUGAL INNOVATIONS: THE FUTURE OF AFFORDABLE HEALTH CARE
Full text linkFrugal innovations are cost-conscious innovations developed to meet the needs in resource-poor settings, withoutcompromising quality. While there have been various innovations in the field of health care in the past decades, there is avast difference in the distribution and utilization of these innovations between developed and developing countries. Frugalinnovations can play a potential role in bridging the gap between countries and ensure affordable health care for all
CURCUMIN- PHARMACOLOGICAL ACTIONS AND ITS ROLE IN DENTISTRY
Full text linkTurmeric (Curcuma longa) is an ancient dye, flavouring and medical herb, widely used in Asian countries. It is a herb that has been widely used in Indian medicine, cookery, and cosmetics. The main component of turmeric is curcumin. Curcumin has a surprisingly wide range of beneficial properties includes anti inflammatory, antioxidant, chemopreventive, chemotherapeutic activity etc. The activity of curcumin derived from its complex chemistry as well as its ability to influence the multiple signalling pathways. This review article is to highlight the pharmacological action and its therapeutic role in dentistry.
DIURETIC POTENTIAL OF AERVA LANATA AND ECBOLIUM LIGUSTRINUM ROOT EXTRACTS
Full text linkBased on the ethnobotanical importance as diuretics Aerva lanata and Ecbolium ligustrinum were selected for presentscreening. Experiment was carried out on male wister strain albino rats using furosemide as standard drug. 20mg/kg and200mg/kg oral doses are selected for standard and test respectively. For quantifying the diuretic activity the urine output,urine pH, sodium, potassium and chloride levels in the urine are measured. The diuretic index value of Ecbolium ligustrinumis 1.70 and nearer to the standard furosemide value 1.80. Aerva lanata group shows less diuretic index of 1.49 compared tostandard. The ratio of the concentration of sodium ions to the potassium ions in control group was found to be 1.39 and theratio for standard, Aerva lanata and Ecbolium ligustrinum are 1.78, 1.49 and 1.68 respectively. Ecbolium ligustrinumaffected the amount of urine excreted and also the electrolyte concentration in urine. The present study concluded that rootsof Aerva lanata and Ecbolium ligustrinum are having diuretic nature
SUSTAINED RELEASE ITOPRIDE HYDROCHLORIDE MATRIX TABLET
Full text linkOral route gets the highest priority for thedelivery of the drug as well as better patient compliance incase of self delivery dosage formulation. The aim ofpresent investigation was undertaken with the objective offormulating sustain release formulation of Itopridehydrochloride for oral drug delivery. Itopride hydrochlorideis highly water soluble prokinetic drug.Hydroxypropylmethylcellulose K4M (lower viscositygrade) and K100M (higher viscosity grade) were used as amatrix forming agents to control the release of drug. HPMCK4M and HPMC K100M were used individually as well asin combination with different proportion in the preparationof the Sustained release formulation. 32 factorial designswere applied to the polymer concentration that affects thedrug release profile. Reduced equation for drug release at2hr,6hr,and10hrwere22 1 2 1 Q 37.644 5.41X 3.25X 2.017X ,26 1 2 1 Q 72.367 8.05X 4.4X 3.75X ,and10 1 1 2 90.844 5.8 2.633 2.8 2 Q X X X Xrespectively. Optimized batch F019 shows good tabletproperties like hardness(7-9kg/cm2), thickness(4.48mm),friability(0.024%),assay(99.3%) and nearly similar drugrelease profile to the targeted reference drug release profileand it was indicated by similarity factor (f2=86.04)
APPROACHES AND DEVICES USED IN PULMONARY DRUG DELIVERY SYSTEM: A REVIEW
Full text linkTargeting drug delivery into the lungs has become one of the most important aspects of systemic or local drug delivery.Consequently, in the last few years, techniques and new drug delivery devices intended to deliver drugs into the lungs havebeen widely developed. Currently, the main drug targeting regimens include direct application of a drug into the lungs,mostly by inhalation therapy using either pressurized metered dose inhalers (pMDI) or dry powder inhalers (DPI).Intratracheal administration is commonly used as a first approach in lung drug delivery in vivo. To convey a sufficient doseof drug to the lungs, suitable drug carriers are required. These can be solid, liquid, or gaseous excipients. Liposomes, nanoand microparticles, cyclodextrins, microemulsions, micelles, suspensions, or solutions are all examples of this type ofpharmaceutical carrier that have been successfully used to target drugs into lungs. The use of micro reservoir type systemsoffers clear advantages, such as high loading capacity and possibility of controlling size and permeability, and thus ofcontrolling the release kinetics of the drugs from the carrier systems. These systems make it possible to use relatively smallnumbers of vector molecules to deliver substantial amounts of a drug to the target. This review discusses the approaches anddevices required to be administer drug into the lungs
REVIEW ON PHYTOCHEMISTRY AND PHARMACOLOGICAL ASPECTS OF EUPHORBIA HIRTA LINN.
Full text linkABSTRACT:Medicinal herbs are the local heritage with global importance. Medicinal herbshave curative properties due to presence of various complex chemical substance ofdifferent composition, which are found as secondary plant metabolites in one or moreparts of these plants. These plant metabolites according to their composition are groupedas alkaloids, glycosides, corticosteroids, essential oils etc. Euphorbia hirta, (family-Euphorbiaceae) is an herb found in many parts of the world. In Sanskrit it means“Dugadhika” According to the Doctrine of Signatures, the plant has a reputation forincreasing milk flow in women, because of its milky latex, and is used for other femalecomplaints as well as diseases of the respiratory tract. The plant has been reported asincrease in urine output, antidiarrheal, antispasmodic, anti-inflammatory etc
HEPATOPROTECTIVE EFFECT OF THE METHANOLIC EXTRACT OF WHOLE PLANT OF BORRERIA ARTICULARIS ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RATS
Full text linkThe hepatoprotective activity of methanolic extract of Borreria articularis (L.F) F.N. Willams: (Rubiaceae) at doses of 250 mg/kg and 500 mg/kg were evaluated by carbon tetrachloride (CCl4) intoxication in rats. The toxic group which received 25%CCl4inolive oil (1 ml/kg) per oral (p.o), alone exhibited significant increase in serum ALT, AST, ALP, TBlevels. It also exhibited significant (P<0.001) decrease in TP and ALB levels. The groups received pretreatment of Borreria articularis at a dose of 250 and 500 mg/kg b.w.p.o. had reduced the AST, ALT, ALP and TB levels and the effects were compared withstandarddrug(Silymarin100mg/kgb.w.p.o).Thetotal protein (TP) and albumin (ALB) levels were significantly increased in the animalsreceived pretreatment of the extract at the moderate and higher dose levels and the histopathological studies also supported the protective effect of the extract
SIMULTANEOUS ESTIMATION OF SAXAGLIPTIN HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE IN ACTIVE PHARMACEUTICAL INGRIDENT BY RP-HPLC
Full text linkA new simple, accurate, precise and reproducible RP-HPLC method has been developed for the simultaneousestimation of Saxagliptin and Metformin in bulk drug form using C18 column (Phenomenex, 250 x 4.6 mm, 5 μm) inisocratic mode. The mobile phase consisted of 0.02M Potassium dihydrogen phosphate (KH2PO4), Acetonitrile,Methanol in the ratio of 50:25:25 (v/v/v) at pH 4.3. The detection wavelength was carried out at 240 nm. Themethod was linear over the concentration range for Saxagliptin 10-50μg/ml and for Metformin 5-25 μg/ml. Therecoveries of Saxagliptin and Metformin were found to be 100.48and 101.1% respectively. The validation of methodwas carried out utilizing ICH-guidelines. The described HPLC method was successfully employed for the analysisof pharmaceutical formulations containing combined dosage form
MOLECULAR ANALYSIS OF STREPTOCOCCUS THERMOPHILUS SUPPORTING PROBIOTIC ACTION TOWARDS DRUG TARGETS
Full text linkStreptococcus thermophilus is a Gram-positive facultative anaerobe with probiotic action. Nearly 2070 genes arepredicted in complete genome out of which 566 genes are related to hypothetical and uncharacterized genes. Thepredicted gene percent obtained by characterization of complete genome of S.thermophilus is 72.67% with 25functional categories. There is high number of transport, protein synthesis, binding and cell envelop proteins thatdon’t have pathogen responses. The genes ptsK, glgP, malQ, lacZ, amyL, scrB, etc are related to energy metabolism(with biodegradation and synthesis of polysaccharides) are found in chromosome CNRZ 1066. The genes such asglgP, malQ, lacZ and amyl had shown direct interactions that has not found direct link with scrB gene. All theproteins are observed with more the 50 percent identities that are present in homology models