Asian Journal of Pharmaceutical Research and Health Care (AJPRHC)
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Evaluating Endometrial Thickness and Vascular Ultrasound Pattern and Pregnancy Outcomes in Intrauterine Insemination Cycle
Full text linkThe current study aims to investigate whether endometrial thickness and pattern, and blood flow in color Doppler of sonography on the day of administration is a predictor of intrauterine insemination (IUI) success. The study was designed as a cross-sectional prospective clinical study with one-hundred women undergoing an IUI cycle. Interventions of the study include endometrial thickness and pattern and color Doppler flow on the day of administration and cycle parameters were compared between pregnant and non-pregnant patients. Main outcome measures are endometrial thickness and patterns and blood flow in color Doppler. The results showed that the overall pregnancy rate was 38%, which mean that endometrial blood flow on the day of administration was significantly greater in cycles, pregnancy achieved, but endometrial thickness and pattern of sonography were found to have no predictive value on endometrial receptivity. In multi-variant analysis, the following variable affected the pregnancy rate: the women’s age, duration of infertility, type, number of IUI cycle, the number of ampules to stimulate dominant follicle, sperm count. In our study, this variability was found to have no predictive value on the outcome of IUI but endometrial flow in color Doppler was positively associated pregnancy outcome
Prevalence of Substance Abuse/Alcohol Consumption and their Predictors among Patients Admitted in Operating Rooms of a General Educational Hospital, Tehran, Iran
Full text linkSubstance/alcohol abuse is an important public health threat in most countries. Social stigmatization and legal restrictions prevent accurate and direct estimate of prevalence of substance/alcohol abuse in Iran. This study aimed to estimate of the prevalence of alcohol and substance use among Iranian patients who were admitted to operating rooms of a general hospital in Tehran and identified risk factors that may predict alcohol and substance use. This cross-sectional study was conducted among all consecutive patients who were admitted to 16 operating rooms in Vali-e-Asr General Educational Hospital (Tehran, Iran) during March 2014 to September 2015. Data were derived from a medical history form prior to operation by trained nurses who were working in the operating rooms. Among 1136 patients admitted to operating rooms, 105 (28.7%) men and 21 (2.7%) women were substance/alcohol users. The main substance of abuse was opium (57.3%) followed by alcohol consumption (25.6%) and water pipe smoking (14.8%). Cigarette smoking was reported by 110 (30.1%) men and 21 (2.7%) women. Sex, cigarette smoking and family history of alcohol and substance abuse predicted 42.3% of the variance in substance abuse/alcohol consumption. Substance use, especially opium, alcohol, water pipe tobacco and cigarette smoking were found to be significantly high particularly among male patients. Being a man, current cigarette smoking and having a first-degree family member who had abused substances should be considered when planning preventive or therapeutic programs
The Comparison of Job Stress among Dental Professionals of Dentistry Faculty Members of Tabriz University
Full text linkSeveral studies have so far focused on occupational stress among dentists and the results have shown that many factorscan cause stress. However, the level of stress among experts in the fields of dentistry has not yet been studied in Iran.The aim of this study is to examine the causes and levels of job stress among dental professionals in Tabriz University ofMedical Sciences. This cross-sectional study included all dental professionals of Dentistry Faculty; an overall of 55 subjectsin Tabriz were studied in this research and their level of stress was evaluated using “The Health and Safety ExecutiveManagement Standards Indicator Tool” (HSE stress questionnaire) from September up to October 2014. The level of stressin each dental specialty was examined descriptively (mean, standard deviation). Statistical analysis was performed usingSPSS 20. The findings of the study showed that the highest stress among dental professionals from different fields wasobserved in the field of oral and maxillofacial radiology; fields of oral medicine, endodontics, oral and maxillofacial surgeryand pediatric dentistry ranked later. The lowest stress was seen among orthodontics specialists. Based on the results of thepresent study, the rate of job stress varied significantly among dental professionals
Appendectomized Patient and Infections after Surgery
Full text linkAppendicitis is one of the common surgeries all over the world, and its diagnosis is difficult and based on clinicalexaminations or its symptoms. Moreover, after the surgery is accomplished, it is probable that the patient is faced withcertain problems and complications. In this regard, the present study was carried out in order to review the infectionscaused after appendicitis surgery. The databases like PubMed, Google Scholar, and Science Direct and relevant articleswere collected, in which keywords like appendicitis surgery, perforation, laparoscopy, and infection had been used. A totalnumber of 6,000 articles were retrieved, out of which, 74 relevant articles were examined. The results of the presentstudy indicated that perforated appendix can be the biggest cause of infection and abscess after intra-abdominal surgery.An increase in the level of C-reactive protein and leukocytes is accompanied with the risk of postoperative complicationsincluding infection and abscess. Numerous studies have reported that formation of infection and abscess after laparoscopicappendectomy is a little more than open appendectomy. It is not necessary to consume antibiotics after a non-perforatedappendectomy. It is sufficient to consume antibiotics for 3 to 5 days after a perforated appendectomy to prevent infectionand abscess. With the above results now it is evident that the appendicitis and its complications are still a common problemamong people all over the world. There is still much to discuss among the surgeons with regards to appendicitis and itscomplications
Pharmacodynamics Drug Interactions of Metformin with Aspirin and Nifedipine
Full text linkMetformin is now being recognized as the standard therapy in T2D patients who are overweight. Metformin has many drug-disease interactions that can increase the risk of metformin-associated lactic acidosis. Therefore this study was conducted to evaluate any possible pharmacodynamic interactions between metformin and drugs used to treat chronic diseases e.g. Hypertension. The rats were fasted overnight before inducing diabetes with streptozotocin. The rats were given an intraperitoneal injection of streptozotocin (50 mg kg−1) freshly prepared in 0.1M sodium citrate buffer. The diabetic state was confirmed 72 h after streptozotocin injection. Diabetic rats were grouped into seven groups each group of five rats and distributed among the normal control group diabetic control group and the treatment groups. The treatment continued for 10 days. Blood samples were taken before treatment and after 10 days and analyzed for serum glucose, cholesterol, HDL, LDL, and triglycerides. In the diabetic control group which was given STZ alone the blood glucose level decreased significantly (p < 0.05) after 10 days but still above the hyperglycemic level (200mg/dl). The same was observed in the group treated with metformin. The group treated with nifedipine and aspirin showed significant reduction (p < 0.01) in the glucose level below the hyperglycemic level (200mg/dl). While the groups treated with (Metformin + Nifedipine) and (Metformin +Aspirin) showed highly significant reduction (P<0.001) in blood glucose level. These results conclude that the combination of (metformin +Nifedipine) and the combination of (Metformin + Aspirin) have highly significant hypoglycemic effect. It also showed that Nifedipine has promising role in reducing blood glucose level, lipid profile especially LDL-cholesterol, and body weight
Simultaneous Quantification of Ciprofloxacin, Quinine and 3-hyrdoxyquinine in Human Plasma using a HPLC Method
Full text linkMalaria has been shown to strongly predispose patients in areas of malaria endemicity to bacteremia with severe outcomes, thus justifying the use of antibiotics in combination with antimalarial therapy in patients with severe malaria. This study describes a High-Performance Liquid Chromatographic (HPLC) method for simultaneous determinations of Ciprofloxacin (CPN), Quinine (QN), and its major metabolite, 3-Hydroxyquinine (3-HQN), in human plasma. Following a simple precipitation with acetonitrile, chromatographic separation was achieved on a reversed-phase Agilent Zorbax (CN) column (5 µm, 150 X 4.6 mm i.d) using a mobile phase consisting of acetonitrile: potassium dihydrogen phosphate (pH = 2.8; 0.02 M) (42:58, v/v). Retention times for CPN, 3-HQN, IS and QN were 2.7, 3.3, 3.6 and 4.9 minutes respectively. The limits of detection and validated lower limits of quantitation were 30 and 70 ng/ml for both QN and 3-HQN while the corresponding values were 50 and 100 ng/ml for CPN, respectively. The new HPLC method here developed, when compared with previous methods for the analysis of either or both drugs is simple, rapid, selective, reproducible and costeffective. It is also suitable for conducting a simultaneous therapeutic monitoring of quinine and ciprofloxacin in patients when concomittantly administered as demonstrated in five healthy volunteers
The Relationship between High Sensitive C-reaction Protein (hs-CRP) and Diastolic Heart Function in Diabetes Mellitus Type II
Full text linkAmong several inflammatory markers, high sensitive C-reaction protein (hs-CRP) is outstandingly observed in diabetic individuals. Serum hs-CRP is the main marker of inflammation whose levels independently predict the risk of cardiovascular events, and it has a prognostic value in heart patients. On the other hand, diabetes can lead to diastolic dysfunction of the heart. Diastolic dysfunction can cause symptoms of exertional dyspnea, which restricts the patient’s activity. It is likely to predict diastolic dysfunction by screening through hs-CRP. The present investigation was a case-control study that was carried out on 52 patient diagnosed with diabetes mellitus type II. After the demographic data were recorded, and following the collection of data on the patients’ history, physical examination, and para-clinical measures, individuals who had factors interfering with level of serum hs-CRP (kidney and liver diseases, inflammatory and infectious diseases, peripheral vascular disease, cerebrovascular disease, connective tissue disease, malignant tumor, trauma, consumptionof statins, aspirin, ACEI, and fibrates) and diastolic dysfunction (ischemic heart disease, cardiomyopathies, pericardial disease, arrhythmias and valvular disease) were crossed out of the study. Serum hs-CRP was measured by nephelometry method. According to the results of tissue Doppler echocardiography, these patients are divided into two groups: onewith diastolic dysfunction and the other without diastolic dysfunction. The serum hs-CRP levels of these patients were compared with each other. Among the participants, 30.8% were men and 69.2% were women, 36 individuals (69.2%) had diastolic dysfunction while 16 (30.8%) did not. There was a high level of correlation between the level of serumhs-CRP and diastolic dysfunction (p=0.02, t=2.36). The results of the present study indicated that there is a correlation between level of serum hs-CRP and diastolic dysfunction, such that the more the level of hs-CRP, the higher probability of diastolic dysfunction existence will be
Screening of some Naturally Isolated Microalgal Strains for Polyunsaturated Fatty Acids Production
Full text linkBackground and Purpose: Nowadays, polyunsaturated fatty acids (PUFAs) are playing a great role in human wellbeing and health improvement. A wide spectrum of biological, medical and health benefit effects ranging from cardiovascular, neuronal, anticancer and antioxidant have been reported from different PUFAs in human. Methodology: In this study, six different species of microalgae belonging to the chlorophyta and cyanobacteria phylum were isolated from soil and water samples collected from Persian Gulf. Their growth rate, biomass and lipid production and productivity and more importantly their ability to produce PUFAs was investigated. Results: The isolated species represented a great fatty acid profile including many different polyunsaturated fatty acids (PUFAs) ranging from 6-20 carbon atoms. S. obliquus and N. muscorum proven to have a better profile for PUFAs production, whilst C. vulgaris could be considered as a more robust strain to produce other fatty acid classes. Besides, C. vulgaris with its higher growth rates (0.39 d-1)and S. obliquus owing to its higher total lipid content (43.92%) seems more interesting strains for scale up studies. Conclusion: The obtained results demonstrated the great potential of naturally isolated strains of microalgae for PUFA production and provided some insights in next studies to explore more producing strains
The Effects of the Roy’s Adaptation Model on Primigravida Women’s Self-Concept: A Randomized Controlled Trial
Full text linkMost women do not have a positive self-concept and impression about themselves during pregnancy because they become less active and gain more weight. Self-concept significantly contributes to individuals’ mental health. This controlled trial was performed to assess the effect of an intervention based on the Roy’s adaptation model on self-concept among primigravida women. This study was conducted on a random sample of 83 Iranian primigravida women. Women in the experimental group received educational and counseling services in five sessions held in five consecutive weeks. Thereafter, they received a four-week follow-up care. Before the intervention, there were no significant differences between the two groups regarding adaptation knowledge and self-concept adaptation. However, after the intervention, these differences were statistically significant. The Roy’s adaptation model has positive effects on primigravida women’s physical and interpersonal self-concept adaptation. Given its simplicity and easy applicability, this model can be used for improving pregnancy-related outcomes
Aflatoxin M1 Contamination in Traditional Yoghurts Produced in Guilan Province, Iran
Full text linkAflatoxin M1 is a major carcinogenic compound that may be existed in dairy products. The aim of this study was to determine the occurrence of AFM1 in traditional yoghurt samples in Guilan Province (Northern Iran). Ninety samples of traditional yoghurts were collected during summer and autumn 2014. Enzyme linked Immunosorbentassay (ELISA) which is a rapid and sensitive method was used to determine the presence and levels of AFM1. 100% of the yoghurt samples were contaminated with 5 and 83 ng/kg of AFM1. In general, AFM1 in 20 samples (22.22%) were higher than the maximum tolerance limit (50 ng/kg) accepted by the European Union. It was therefore concluded that, high occurrence of AFM1 in yoghurt is a serious risk for public health