University of Las Palmas de Gran Canaria
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103636 research outputs found
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Parental profiles and online supervision in the digital age
No full textAmidst the escalating digital engagement observed among adolescents, it becomes imperative for parents to hone specific skills related to digital parenting. This study endeavors to delineate parental profiles by scrutinizing their interaction with technology, establishing a correlation between these profiles and their proficiency in overseeing and guiding their adolescent children's utilization of Information and Communication Technology (ICT). Employing LatentGold V.6.0 software, we conducted a latent class analysis involving 1200 parents with adolescent children aged 11-17 in Spain (x = 46.61 years, range 28-69 years). The analysis unveiled three distinct profiles: 'Instrumentals' (39.61%), characterized by a utilitarian and necessity-driven use of ICT; 'Digital Passives' (31.88%), who scarcely engage with ICT; and 'Digital Actives' (28.51%), who are characterized by habitual engagement with ICT. Notably, they not only use technology for utility but also adeptly leverage its benefits, enjoying recreational digital pursuits. The latter profile, primarily composed of young parents, demonstrated that their tools and knowledge not only enrich their digital experience but also enhance their effectiveness in digital-age parenting. This underscores the importance of targeted interventions designed to help parents integrate into the 'Digital Actives' class. Such initiatives should promote engagement with ICT, fostering essential digital competencies and cultivating a positive appreciation for the benefits of technology, including the expansion of digital leisure activities for the entire family.1
Preliminary safety and efficacy of DB-OTO gene therapy in pediatric patients with profound deafness due to otoferlin variants: The CHORD phase 1/2 open-label trial
No full textOtoferlin is critical for inner hair cell (IHC) signal transmission
to auditory nerve fibers. Biallelic otoferlin gene
(OTOF) variants typically cause severe-to-profound deafness.
As per preclinical data, DB-OTO gene therapy promotes
IHC-selective otoferlin expression from the human
OTOF gene, which may instate high-quality hearing. In this
first-in-human multicenter, phase 1/2 open-label clinical trial
with DB-OTO (CHORD, NCT05788536), safety, tolerability
and preliminary efficacy of DB-OTO is evaluated in pediatric
patients with profound OTOF-related deafness.E136E13611,0914,1Q2Q1SCIE11,
Linking science and industry: influence of scientific research on technological innovation through patent citations
No full textThis study explores the connection between patent citations and scientific publications across six fields: Biochemistry, Genetics, Pharmacology, Engineering, Mathematics, and Physics. Analysing 117,590 papers from 2014 to 2023, the research emphasizes how publication year, open access (OA) status, and discipline influence patent citations. Openly accessible papers, particularly those in hybrid OA journals or green OA repositories, are significantly more likely to be cited in patents, seven times more than those mentioned in blogs, and over twice as likely compared to older publications. However, papers with policy-related references are less frequently cited, indicating that patents may prioritize commercially viable innovations over those addressing societal challenges. Disciplinary differences reveal distinct innovation patterns across sectors. While academic visibility via blogs or platforms like Mendeley increases within scholarly circles, these have a limited impact on patent citations. The study also finds that increased funding, possibly tied to applied research trends and fully open access journals, negatively affects patent citations. Social media presence and the number of authors have minimal impact. These findings highlight the complex factors shaping the integration of scientific research into technological innovations.121,0082,9Q1Q1SSCI11,0ERIH PLU
A multi-metabolite signature robustly predicts long-term mortality in the PREDIMED trial and several US cohorts
No full textMetabolome-based biomarkers contribute to identify mechanisms of disease and to a better understanding of overall mortality. In a long-term follow-up subsample (n = 1878) of the PREDIMED trial, among 337 candidate baseline plasma metabolites repeatedly assessed at baseline and after 1 year, 38 plasma metabolites were identified as predictors of all-cause mortality. Gamma-amino-butyric acid (GABA), homoarginine, serine, creatine, 1-methylnicotinamide and a set of sphingomyelins, plasmalogens, phosphatidylethanolamines and cholesterol esters were inversely associated with all-cause mortality, whereas plasma dimethylguanidino valeric acid (DMGV), choline, short and long-chain acylcarnitines, 4-acetamidobutanoate, pseudouridine, 7-methylguanine, N6-acetyllysine, phenylacetylglutamine and creatinine were associated with higher mortality. The multi-metabolite signature created as a linear combination of these selected metabolites, also showed a strong association with all-cause mortality using plasma samples collected at 1-year follow-up in PREDIMED. This association was subsequently confirmed in 4 independent American cohorts, validating the signature as a consistent predictor of all-cause mortality across diverse populations.152,79210,9Q1Q
Governance Strategies for the Management of Museums and Heritage Institutions
No full textThe management of museums and cultural heritage institutions requires a collaborative approach that involves diverse actors in decision-making. This study analyses four models of cultural management (dependent, autonomous, non-profit, and private) through case studies on the island of Gran Canaria, highlighting their advantages and limitations. As a result, a hybrid model of governance is proposed that integrates elements of the public, private, and social sectors, promoting the active participation of all stakeholders. However, the implementation of this model faces challenges such as resistance to change on the part of some institutions, the difficulty of coordinating divergent interests between public and private actors, and the need to establish regulatory frameworks that facilitate collaboration without compromising heritage conservation. Despite these obstacles, this approach seeks to improve the sustainability, efficiency, and adaptability of heritage institutions to contemporary tourism and conservation challenges.236,
Improved Design of Electroforming Equipment for the Manufacture of Sinker Electrical Discharge Machining Electrodes with Microtextured Surfaces
No full textThe development of microtextures has had a transformative impact on surface design in engineering, leading to substantial advancements in the performance, efficiency, and functionality of components and tools. This study presents an innovative methodology for fabricating SEDM electrodes. The methodology combines additive manufacturing by mask stereolithography with an optimized electroforming process to obtain high-precision copper shells. A key aspect of the study involved redesigning the electroforming equipment, enabling the independent examination of critical variables such as anode–cathode distance and electrolyte recirculation. This approach allowed precise analysis of their impact on metal deposition. This redesign enabled the assessment of the impact of electrolyte recirculation on the quality of the shells obtained. The findings indicate that continuous recirculation at 60% power effectively reduced thickness deviation by up to 32.5% compared to the worst-case scenario, achieving average thicknesses within the functional zone of approximately 110 µm. In contrast, the absence of flow or excessive turbulence did not generate defects such as unfilled zones or non-uniform thicknesses. The shells obtained were validated as functional tools in SEDM, demonstrating their viability for the generation of textures with high geometric fidelity. This approach optimizes the manufacturing of textured electrodes and opens new opportunities for their application in advanced industrial processes, providing a more efficient and sustainable alternative to conventional methods.150,5653,1Q2Q1SCIE10,
Trends and Scientific Production on Isometric Training: A Bibliometric Analysis
No full textIsometric training is a method focused on muscle strengthening without joint movement and has gained attention in recent years due to its applicability in rehabilitation and sports medicine. However, no comprehensive bibliometric analysis focused exclusively on adult populations has been performed. This study aimed to analyze the scientific production related to isometric training in adults; identify prominent authors, journals, and thematic trends; and evaluate the evolution of interest in this field over time. A bibliometric review was performed using the Web of Science Core Collection (SCI-E, SSCI, and ESCI). A specific search strategy was applied to identify articles and reviews focused on isometric training in adult populations. A total of 238 records met the inclusion criteria. Data were analyzed using Excel 2016 and VOSviewer software1.6.20. Bibliometric indicators such as Price’s Law, Bradford’s Law, Lotka’s Law, h-index, and co-occurrence and co-authorship network analysis were applied. The results showed a steady increase in publications in the last decade, highlighting the categories of Sports Science, Physiology, and Cardiovascular. The Journal of Applied Physiology was the most frequent source, and Springer Nature was the most prolific publisher. The h-index identified 21 highly cited papers, and Lotka’s Law confirmed the existence of a small group of prolific authors. VOSviewer analysis revealed clear thematic clusters, mainly around blood pressure regulation, rehabilitation, and aging. International collaboration was evident, with the United States, Canada, and the United Kingdom leading the co-authorship networks. Scientific interest in isometric training for adult populations is growing, particularly in relation to cardiovascular health and rehabilitation. Despite this, gaps remain in terms of methodological consistency and standardized protocols. Addressing these issues could improve the applicability and scientific impact of this training modality.200,787Q1ESCI7,
Power optimization modelling as a computational tool for power take off design in wave energy converters
No full textThis study presents a computational tool called Power Take-Off Optimisation Modelling (POM), a methodology for optimizing the design parameters of the Power Take-Off (PTO) in wave energy converters (WECs). POM uses a control optimization algorithm based on a differential evolution multi-objective approach to maximize the electrical power extracted by WECs while minimizing design costs. The methodology integrates a wave-to-wire (W2W) model in the time domain, including a PTO loss model. It also considers the sea states where WECs operate, and constraints related to the PTO rated force. These features allow a comprehensive evaluation of the electrical energy generated and the optimization of PTO design parameters. POM has been applied to a real case study involving a linear generator-based PTO operating under different sea states. The analysis includes four WEC technologies and two sea states to assess the tool's effectiveness. Results show that PTO length influences not only CAPEX minimization but also optimal modular system design. Additionally, a sensitivity analysis indicates that the number of modules required to meet force requirements is not significantly affected by PTO efficiency. In conclusion, POM is a versatile support tool for technology developers and researchers, helping optimize PTO design to balance WEC manufacturing costs and generated power.481481,1844,3Q1Q1SCIE11,
