University of Las Palmas de Gran Canaria
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Dosis De Dialisis Y Marcadores Emergentes De Inflamación Y Mortalidad En Pacientes En Hemodialisis Crónica: Cloro Sérico E Índice Proteina C Reactiva/ Cloro Sérico.
No full textPrograma de Doctorado en Investigación en Biomedicina por la Universidad de Las Palmas de Gran CanariaLa inflamación en los pacientes en hemodiálisis crónica es un problema vigente a pesar de la
mejoría en la tecnología empleada: nuevos tipos de membranas, modalidades y accesos
vasculares.
Asimismo, existen marcadores de pronóstico emergentes, tales como el cloro sérico, que han
demostrado su utilidad en diversas cohortes de pacientes con patología cardiovascular y renal.
Un aspecto coherente con el enfoque cardio-reno-metabólico que se está adoptando con más
énfasis en los últimos años.
En este sentido,se ha diseñado este trabajo para optar al grado de doctor en base a tres estudios
principales y uno extra con los siguientes objetivos y conclusiones:
1 er estudio:
“Inflamación y adecuación de la hemodiálisis: ¿están los niveles de proteína C reactiva
influidos por la dosis de diálisis recibida?”
Objetivos: El objetivo principal fue determinar si existe relación entre el grado de inflamación,
medido por proteína C reactiva (PCR) y la «dosis de diálisis» recibida (medida por Kt o Kt/V por
dialisancia iónica) en pacientes prevalentes en hemodiálisis crónica. Como objetivos secundarios
se planteó determinar si existe relación entre el grado de inflamación medido por PCR y otros
parámetros tales como el hierro sérico, la ferritina, el índice de saturación de transferrina, la
transferrina, el índice neutrófilo-linfocito (INL) y el índice plaquetas-linfocito (IPL).
Conclusiones: la peor adecuación, en términos de dosis de diálisis: valores bajos de Kt/V y ΔKt,
puede contribuir a que el grado de inflamación sea más alto en los pacientes en hemodiálisis
crónica.
2º estudio:
“Cloro sérico como marcador de mortalidad cardiovascular y general en pacientes en
hemodiálisis crónica: estudio de seguimiento a 5 años.”
Objetivos: Determinar si el cloro sérico puede estar asociado con la mortalidad cardiovascular y
general y con la inflamación.
Conclusiones: los niveles más bajos de cloro sérico, en nuestra cohorte de pacientes incidentes
en hemodiálisis crónica, estuvieron asociados a una mayor mortalidad tanto cardiovascular
como general. Estudios adicionales, preferiblemente prospectivos, son necesarios para
determinar las implicaciones clínicas de este hallazgo.
3 er estudio:
“Índice proteína C-reactiva/cloro sérico: un nuevo marcador de mortalidad general en
pacientes prevalentes en hemodiálisis crónica.
Objetivos: Evaluar la relación entre el índice proteína C-reactiva/cloro sérico y la mortalidad
general en pacientes en hemodiálisis. Como objetivo secundario: analizar la relación de este
índice y diferentes variables de composición corporal obtenidas por bioimpedancia.
Conclusiones: Los valores más altos del índice proteína C-reactiva/cloro sérico estuvieron
asociados a una mayor mortalidad general en nuestros pacientes prevalentes en hemodiálisis
crónica. Se requieren estudios prospectivos de este parámetro para validar su relevancia frente
a otros marcadores pronósticos ya establecidos.
Estudio extra:
“Hipocloremia asociada a una mayor incidencia de neumonía en pacientes en hemodiálisis
crónica con COVID-19: experiencia en un centro”
Objetivos: Analizar la relación del cloro sérico y la incidencia de neumonía en pacientes en
hemodiálisis crónica con COVID-19. Otros objetivos: Analizar la relación del cloro sérico con la
necesidad de ser admitido en la unidad de cuidados intensivos y la mortalidad.
Conclusiones: Los pacientes con hemodiálisis crónica con infección por SARS-CoV-2 y niveles más
bajos de cloro, en el momento del ingreso hospitalario, podrían tener una mayor tendencia a
desarrollar neumonía y precisar ingreso en la unidad de cuidados intensivos
Justicia social y perspectiva de género en el acceso a la jubilación anticipada
No full texthttps://cpage.mpr.gob.e
Abordando desafíos de salud mental en la educación universitaria: experiencias innovadoras en dos facultades
No full textEn el contexto del Proyecto de Innovación Docente 392: «Impacto de laatención emocional en el rendimiento académico de estudiantes de grado»,se presentan experiencias en las Facultades de Derecho y de Comercio yTurismo utilizadas para comprobar en el aula que una integración continuada de la atención emocional redunda en una mejora notable en el rendimiento académico y la satisfacción subjetiva de los estudiantes. Se expondrán estrategias de intervención para mitigar problemas de salud mental,confianza, estrés, pesimismo y desmotivación entre los estudiantes. Incluyeevaluaciones y charlas individuales, recopilación de sugerencias del alumnado, reflexiones grupales específicamente sobre salud mental y visitas asitios de interés, como medios para promover el bienestar emocional y lamotivación. Por otro lado, se expondrá un estudio de caso centrado endinamizar turísticamente un camino de peregrinaje en la Comunidad deMadrid. Esta iniciativa busca motivar a los/las alumnos/as mediante la participación en un proyecto con potencial impacto real, con el objetivo demejorar su confianza y motivación. Ambos enfoques representan contribuciones aún en fase inicial para abordar las necesidades emocionales de los/las estudiantes universitarios y mejorar su experiencia educativa, partiendode nuestras propias observaciones y las estrategias que sugieren los estudios en neurociencia afectiva.32151
Endothelial and circulating progenitor cells as prognostic biomarkers of stroke: A systematic review and meta-analysis
No full textPurpose: Endothelial progenitor cells (EPCs) are biomarkers of neurovascular repair in cerebral vascular disease (CVD). Low quantification of EPCs and/or their dysfunction has been associated with stroke severity and post-stroke functionality. This systematic review (SR) and meta-analysis aimed to analyze whether EPC quantification contributes to stroke severity and functional prognosis. Methods: Articles were selected from the PubMed, ScienceDirect, and Ovid MEDLINE databases, according to the guidelines of the PRISMA 2020 [1] statement. Detailed observational studies of samples from subjects with a clinical diagnosis of CVD (ischemic stroke-IS, hemorrhagic stroke-HS, or transient ischemic attack-TIA) aged >45 years during 2003-2023 were included. Evaluation of study quality was based on the Critical Appraisal Skills Programme checklist(Santamaria, 2017 [2]). Results: We included 22 articles in our SR. Patients with IS and good functional outcomes had higher EPC levels during the first week of admission than those with worse functional outcomes. Higher EPC levels were associated with reduced infarct growth, improved NIHSS scores at 48 h (OR 0.8; 95 % CI: 0.72-0.90; p < 0.0002) 7 (r =-0.607; p < 0.0001), and 90 days (r =-0.570; p < 0.0001), with a negative correlation between EPC levels and NIHSS score (overall pooled r =-0,32, 95 % CI:-0.39-0.24), and good functional outcomes with better mRS scores at 24 h, 3, 6, and 12 months (overall pooled SMD 4.51, CI 95 %: 0.70-0.83). Lower EPC quantification and worse functional outcomes during admission were predictors of IS recurrence. Higher EPC levels were associated with better functional outcomes and lower bleeding volumes in patients with HS and were protective markers for the progression high-risk TIA. Conclusion: EPCs seems to be predictive biomarkers of better clinical outcomes in patients with CVD, exhibiting lower severity (NIHSS) and better functional prognosis (mRS).91,0987,5Q1Q1SCIE11,
Value contribution of leniolisib in the Treatment of Activated PI3Kδ syndrome (APDS) in Spain using Multi-Criteria Decision Analysis (MCDA)
No full textBackground: Activated phosphoinositide 3-kinase (PI3K) delta Syndrome (APDS) is an ultra-rare, potentially life- threatening disease that lacks approved treatments in Spain. This study aimed to apply Multi-Criteria Decision Analysis (MCDA) to assess the value of the first pharmacological treatment for APDS in Spain. Methods: A multidisciplinary group of 8 experts evaluated the selective PI3K delta inhibitor leniolisib against Standard of Care (SoC). An MCDA framework tailored for Orphan Drugs (ODs), consisting of 5 comparative and 2 quantitative non-comparative criteria, was used. Re-scoring followed a group discussion. Results: Leniolisib scored higher than SoC in all criteria, including efficacy and safety. It was deemed highly valuable as the first disease-modifying treatment, with a positive therapeutic impact and potential to improve patients' quality of life. Additionally, leniolisib may lead to cost savings. The supporting data was considered of high quality. Conclusion: Based on MCDA methodology and stakeholder experience in APDS management, leniolisib is seen as a value-added treatment option compared to SoC in Spain.1597ESC
Modelado de un acumulador de energía dinámico mediante volante de inercia enSimulink
No full textEl volante de inercia es un sistema mecánico robusto que almacena energía cinética, con aplicaciones potenciales en ingeniería
como transporte, energías renovables y vehículos espaciales. Destacan su alta densidad de potencia, eficiencia y larga vida útil.
Se considera una opción viable para aplicaciones que requieren almacenamiento energético con ciclos de trabajo elevados. En
este estudio, se busca crear un modelo lineal de pérdidas de un volante de inercia, proponiendo una estrategia inteligente para
gestionar su velocidad angular. Se investiga si el método propuesto modela adecuadamente el comportamiento de la velocidad
angular. El volante, ubicado en el Laboratorio de Diseño y Mantenimiento de Máquinas de la Universidad de Las Palmas de
Gran Canaria, está diseñado para estabilizar una microrred eléctrica basada en energía eólica.The flywheel is a robust mechanical system that stores kinetic energy, with potential applications in fields such as
transportation, renewable energy, and space vehicles. Its high-power density, efficiency, and long service life are outstanding. It
is considered a viable option for applications requiring energy storage with high duty cycles. In this study, we aim to create a
linear loss model of a flywheel and propose an intelligent strategy to manage its angular velocity. We investigate whether the
proposed method adequately models the behaviour of the angular velocity. The flywheel, located in the Machine Design and
Maintenance Laboratory of the University of Las Palmas de Gran Canaria, is designed to stabilize an electrical microgrid based
on wind energy.6863
Variability of plankton communities in relation to the lunar cycle in oceanic waters
No full textThe short-term variability of plankton communities in the oceanic realm is still poorly known due to the paucity of high-resolution time-series in the open ocean. Among these few studies, there is compelling evidence of a lunar cycle of epipelagic zooplankton biomass in subtropical waters during the late winter bloom. However, there is few information about lower trophic levels and zooplankton physiological changes related to this lunar cycle. Here, we studied the short-term variability of pico-, nano-, micro-, and mesoplankton in relation to the lunar cycle in subtropical waters. Weekly sampling was carried out at four stations located north of the Canary Islands from November 2010 to June 2011. Zooplankton abundance and biomass, gut fluorescence (GF), electron transfer system (ETS), and aminoacyl-tRNA synthetase (AARS) activities were measured before, during, and after the winter vertical mixing in these waters in a wide range of size classes. Chlorophyll a, primary production, and zooplankton biomass were low, showing a rather weak late winter bloom event due to the high temperature and stratification observed. Chlorophyll, nanoplankton, diatoms, and mesozooplankton proxies for grazing (GF), respiration (ETS), and growth (AARS) varied monthly denoting a lunar pattern. Chlorophyll a, nanoplankton, diatoms, and mesozooplankton proxies for grazing and respiration peaked between 4 and 6 days after the new moon, followed by an enhancement of the mesozooplankton index of growth between 8 to 9 days after the new moon. However, mesozooplankton biomass only increased during the productive period when supposedly growth exceeded mortality. Coupled with previous results in pico-, nano-, and microplankton, we suggest that the lunar cycle governs the development of planktonic communities in the high turnover warm subtropical ocean. This study provides further evidence of the match of plankton communities with the predatory cycle exerted by diel vertical migrants, adding essential information to understand the short-term functioning of the open ocean.170,9072,8Q1Q1SCIE10,
Tracing metals in Mediterranean and Atlantic Sardina pilchardus: Unveiling impacts on food safety
No full textThis study evaluates the concentration of metals and trace elements (Al, Cd, Cu, Fe, Li, Pb, Zn) in the muscle tissue of Sardina pilchardus from three northeast Atlantic localities (Lisbon, Canary Islands, Rabat) and two western Mediterranean sites (Málaga, Cartagena) to assess food safety and environmental impact. A total of 100 sardines were sampled between January and June 2019, with specimens collected, homogenized by size and weight, and analyzed for metal content using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). Results show significant geographical variation in metal concentrations, with Cartagena exhibiting the highest levels due to industrial and urban activities, while the Canary Islands had the lowest, likely influenced by geographical isolation and stringent environmental regulations. Intermediate levels were observed in Lisbon, Rabat, and Málaga, with Rabat ranking second highest. Importantly, none of the samples exceeded EU safety limits for lead (0.3 mg/kg) or cadmium (0.25 mg/kg), confirming their suitability for human consumption regarding metal content. These findings emphasize the role of local environmental and industrial factors in influencing metal bioaccumulation in marine ecosystems. Genetic and ecological dynamics, such as the Almería-Oran Front and the Canary Islands' isolation, likely contribute to these patterns. The study underscores the importance of continuous monitoring to safeguard food safety and marine ecosystem health. Despite Cartagena's elevated contamination levels, which pose a higher potential risk if sardine consumption is frequent, sardines from all locations remain within safety limits. Moving forward, research should prioritize long-term monitoring and explore genetic and ecological factors influencing bioaccumulation trends, contributing to sustainable management and effective pollution control measures. This highlights the interconnectedness of environmental health and human dietary safety, emphasizing the need for a proactive approach to monitoring marine contamination.131,9989,8Q1Q1SCIE11,
Neural network modelling of kinematic and dynamic features for signature verification
No full textOnline signature parameters, which are based on human characteristics, broaden the applicability of an automatic signature verifier. Although kinematic and dynamic features have previously been suggested, accurately measuring features such as arm and forearm torques remains challenging. We present two approaches for estimating angular velocities, angular positions, and force torques. The first approach involves using a physical UR5e robotic arm to reproduce a signature while capturing those parameters over time. The second method, a cost-effective approach, uses a neural network to estimate the same parameters. Our findings demonstrate that a simple neural network model can extract effective parameters for signature verification. Training the neural network with the MCYT300 dataset and cross-validating with other databases, namely, BiosecurID, Visual, Blind, OnOffSigDevanagari-75 and OnOffSigBengali-75 confirm the model's generalization capability. The trained model is available at: https://github.com/gvessio/SignatureKinematics.13613071,43,9Q1Q2SCIE11,