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Data for 'Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive inhibitory discrimination learning task'
No full textDeposited as a condition of manuscript review (to be shared upon publication)Data for 3 experiments, as described in the manuscript 'Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive inhibitory discrimination learning task
United Kingdom QR value per 4* output or impact case study returned to REF in the 2023-2024 financial year
No full textData is a collation of Quality-Related (QR) funding allocations to UK institutions as published by UKRI. Additional information is included, such as number of outputs and impact case studies expected from a submission with the respective number of FTE; and calculation for QR value of a 4* output and a 4* impact case study.
Original data acquired from: https://www.ukri.org/publications/higher-education-provider-grant-data-tables-2023-to-2024
Discovery and Computational Modelling of Adsorbent Polymers that Effectively Immobilize SARS-CoV-2 with Potential Practical Applications
No full textViral translocation is considered a common way for respiratory viruses to spread and
contaminate the surrounding environment. Thus, the discovery of non-eluting polymers
that immobilize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon
contact provides an opportunity to develop new coating materials for better infection
control. Here, virion binding polymers are discovered from an existing monomer library
via experimental high-throughput screening. Among them, poly(2-diethylamino) ethyl
acrylate (pDEAEA) demonstrates dual-function: binding virions strongly and its speed
to inactivate adsorbed SARS-CoV-2. Computational models are built based on the
experimental screening data. Polymers which are predicted to be pro-adsorption by the
virtual screening are poly(1-4-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-piperidin-1-yl]-
prop-2-en-1-one) (pMPPPP), poly(1-(6-isobutyloctahydropyrrolo[3,4-d]azepin-2(1H)-
yl)-2-methylprop-2-en-1-one) (piBOHPAMP) and poly(N-(3-((1-benzylpiperidin-4-
yl)oxy)propyl)acrylamide) (pBPOPAm), and these are found to adsorb virions.
However, due to limitations in the diversity of structures in the training set, the
computational models are unable to predict adsorption of virions for all polymer
structures. Summarily, these findings indicate the utility of the methodology to identify
coating polymers that effectively immobilize SARS-CoV-2 with potential practical
applications (e.g. water and air filtration)
Meteorites paper
No full textThe data have been used in the meteorites paper and can be shared with public
Spatial Proximity Determines Overshadowing Between Landmarks in Human Spatial Navigation
No full textPrevious studies involving birds and humans have identified spatial proximity as a source of overshadowing between landmarks in navigation. In Herrera et al. (2024), subjects were trained in an open environment to find a hidden goal with reference to a cross-shaped array of four landmarks placed at various distances from it. Critically, two of the four landmarks (i.e., target landmarks) were placed at distances that were common among groups whereas the remaining two were either proximal or distal from them. Landmarks near to the goal overshadowed (i.e., competed with) learning about the further ones, and this effect disappeared in the groups trained with distal landmarks. However, neither of these studies included a control group providing a base line performance to assess the extent of competition; were the data indicative of overshadowing or facilitation of learning? Thus, we assessed whether spatial proximity determines overshadowing or facilitation between landmarks, including a control group trained with the target landmarks only. We conducted three experiments with varied training length: 6 training trials in Experiment 1 and 16 in Experiments 2 and 3. We also extended the distance of the landmarks to the goal in Experiment 3. In all experiments, we observed overshadowing in the groups trained with closer nontarget landmarks (relative to the target) but no overshadowing when the nontarget landmarks were distal from the target landmarks. Overall, these experiments reveal spatial distance is a critical determinant of overshadowing between landmarks, a finding that is consistent with domain-general theories of learning, such as a modification of Pearce’s configural model
Genome mining reveals a novel nephthenol-producing diterpene synthase from the sandfly Lutzomyia longipalpis
No full textSupporting data for publication of the same nam
"A web-based artificial intelligence-driven virtual patient simulator versus actor-based simulation for teaching consultation skills: a multi-centre randomised cross-over study"
No full textQualitative data gathered and analysed for the stud
FEMUR: Functioning of Elder Muscle; Understanding Recovery
No full textProtocol for muscle phenotyping in frail older patients having hip surgery following fracture
Spinning Q-ball Superradiance in 3+1D
No full textThe data stored here was generated in the paper https://arxiv.org/abs/2402.03193 and used for the figures in that paper
Investigation into the impact of egg white addition on the structural properties and flavour profile of gluten-free sourdough bread
No full textThe impact of egg white addition on structural and sensory qualities of gluten-free sourdough bread was investigated at three egg white-to-sourdough ratios: 25:75, 45:55, and 85:15, versus a sourdough-only control (0:100) In this study, mild acidity from sourdough promoted gluten-like network formation in egg white-added breads, evidenced by significantly thicker cell walls versus control (p<0.05), with the greatest improvement in samples with 45 % egg white and 55 % sourdough. Specific volume and textural parameters of breads with 45-85 % egg white were significantly improved versus control (p<0.05). Principal Component Analysis showed positive multivariate correlations between egg white content and improved chewiness, area of cells and density. Positive correlations were identified between sourdough content and favourable acetic acid, phenylethyl alcohol and 6-methyl-5-heptan-2-one, and samples with egg white-to-sourdough ratios 45:55 contained positive flavour attributes throughout storage, with the greatest concentrations of acetic acid and phenylethyl alcohol by day six. This research demonstrated that the combination of egg white and sourdough in similar proportions promotes the formation of gluten-like networks, producing gluten-free breads with similar structural and sensory attributes to conventional breads, which are retained over storage