898 research outputs found
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DESIGN AND SYNTHESIS OF NOVEL THERAPEUTIC AGENTS FOR VARIOUS FORMS OF BREAST CANCER
No full textThe most frequently diagnosed cancer for women is breast cancer Around 5 10 of diagnosed breast cancer cases are metastatic and close to 30 of patients with early stage disease will go on to relapse with metastatic disease 1 Hormone receptor positive breast cancer makes up 70 of breast cancer cases The first line treatment for breast cancer is endocrine therapy Endocrine therapy, also known as hormone therapy, adds, blocks, or removes hormones to treat the disease There are two types of endocrine therapy for breast cancer One type is drugs that prevent estrogen and progesterone from being available for breast cancer cells to grow The other type of endocrine therapy is drugs or surgery to keep the ovaries from making hormones There are several different types of treatment options (see Figure 1 While we have made many advances in this area, a significant number of patients develop endocrine resistance, prompting the need for newer therapeutic agents 2https://digitalcommons.xula.edu/build_xula/1006/thumbnail.jp
Volume 13 - Issue 1: La Créole - A Journal of Creole History & Genealogy
No full textThe Louisiana Creole Research Association, Inc., known as LA Creole, was founded on August 21, 2004 as a New Orleans-based, non-profit family research and educational organization. Its purpose is to assist Creoles of Color in researching their ancestry, to educate the general public about Creole history and culture, and to celebrate the contributions and legacy of a unique, sometimes forgotten people. La Créole, the Association’s journal is published annually.https://digitalcommons.xula.edu/lacreole/1011/thumbnail.jp
Intro - Visualizing Wealth and Personal Finance
Full text linkA short introduction to our 5-part workshop using Google Sheets to Visualize contemporary economic trends like investing, loans and budgeting!
See written instructions to follow attached to this video, or start with the worksheet and initial spreadsheet here: bit.ly/viz-wpfhttps://digitalcommons.xula.edu/data_instruct/1005/thumbnail.jp
New Zampanolide Mimics: Design, Synthesis, and Antiproliferative Evaluation.
No full textZampanolide is a promising microtubule-stabilizing agent (MSA) with a unique chemical structure. It is superior to the current clinically used MSAs due to the covalent nature of its binding to β-tubulin and high cytotoxic potency toward multidrug-resistant cancer cells. However, its further development as a viable drug candidate is hindered by its limited availability. More importantly, conversion of its chemically fragile side chain into a stabilized bioisostere is envisioned to enable zampanolide to possess more drug-like properties. As part of our ongoing project aiming to develop its mimics with a stable side chain using straightforward synthetic approaches, 2-fluorobenzyl alcohol was designed as a bioisosteric surrogate for the side chain based on its binding conformation as confirmed by the X-ray structure of tubulin complexed with zampanolide. Two new zampanolide mimics with the newly designed side chain have been successfully synthesized through a 25-step chemical transformation for each. Yamaguchi esterification and intramolecular Horner–Wadsworth–Emmons condensation were used as key reactions to construct the lactone core. The chiral centers at C17 and C18 were introduced by the Sharpless asymmetric dihydroxylation. Our WST-1 cell proliferation assay data in both docetaxel-resistant and docetaxel-naive prostate cancer cell lines revealed that compound 6 is the optimal mimic and the newly designed side chain can serve as a bioisostere for the chemically fragile N-acetyl hemiaminal side chain in zampanolide
Centering the Black Woman as a Subject of Portraiture in Nineteenth-Century French Art
Full text linkUntil the 19th century, artistic depictions of black women by European artists were rare. Often they were relegated to the background as domestic attendants to European noblewomen, serving as symbols of the latter’s colonial wealth and further provide contrast with the darkness of their skin against the aristocratic fairness of their white mistresses. The transition into the 19th century was a turbulent period in European history, especially for France, as the country saw multiple revolts and governmental changes at home. Simultaneously colonization overseas continued to expand, creating previously unheard-of access to foreign cultures and ideas.
Black women became an interesting subject of analysis within French art during this century, as their place at the bottom of the racial and gender hierarchy created a unique opportunity for artists to create a forum through which they could explore the conflict between French perceptions of the inherent inferiority of the colonized Other against their ideas of what it meant to be a modern nation with an increasingly diversifying population. This paper seeks to examine how the socio-cultural changes brought by French colonization efforts in the 19th century influenced key works by three continental artists - Marie-Guillemine Benoist, Charles Cordier, and Frédéric Bazille- that reimagined new ways of portraying the black female body over the course of the century
The Impact of Trust and Organizational Commitment on Professional Development Intention among Community College Faculty: a Grounded Theory Approach
Full text linkFaculty are integral in designing an environment that allows students to succeed. The landscape of community colleges has changed with an increase in technology and evolving student populations. Professional development is necessary to allow faculty to adapt to the current and future landscape of community college education. The purpose of this research study is to explore the reasons why community college faculty do not participate in professional development through grounded theory inquiry. This research focuses on the trust relationship between faculty members and administrators and the faculty’s organizational commitment to professional growth. The researcher investigated the following research questions using qualitative inquiry, specifically a grounded theory approach: (RQ1) How does trust manifest between community college faculty and administrators? (SubQ1) How does this relationship affect intent to participate in professional development? and (RQ2) How does the organizational commitment of community college faculty affect intent to participate in professional development activities? The findings from this research study suggest that the faculty-administrator relationship and the faculty’s organizational commitment influence faculty intent to participate in Trust Between Community College Faculty and Administrators professional development activities. Results from this study can be useful to college administrators in developing strategies that improve the trust relationship between faculty and administrators as a method to increase participation in professional development. Findings in this study will also be significant to academic officers in developing professional development programs that faculty members attend. Increased participation in professional development activities will strengthen faculty classroom skills to more effectively deliver content to students
Concordance of Vancomycin Population-Predicted Pharmacokinetics with Patient-Specific Pharmacokinetics in Adult Hospitalized Patients: A Case Series.
No full textBackground: Vancomycin empiric therapy is commonly dosed using clinical algorithms adapted from population-predicted pharmacokinetic parameters. However, precise dosing of vancomycin can be designed using patient-specific pharmacokinetic calculations. Objective: The objective of this study is to assess the correlational fit between vancomycin population-predicted and patient-specific pharmacokinetic parameters [elimination rate constant (Ke) and half-life (t1/2)] in a case series of adult hospitalized patients. Methods: This is a single-center case series of hospitalized adult patients who received vancomycin, had creatinine clearance calculation for derivation of population-predicted pharmacokinetic parameters, and had two vancomycin concentrations for calculation of patient-specific pharmacokinetic parameters. The primary objective of this case series is to evaluate the correlation between population-predicted and patient-specific pharmacokinetic parameters. The secondary objectives of this study are to evaluate the mean bias and precision between the population-predicted and patient-specific pharmacokinetic parameters and to assess the correlation between population-predicted and patient-specific pharmacokinetic parameters in special population subgroups (obese patients with body mass index ≥ 30 kg/m2 and patients with renal dysfunction). All correlation analyses were performed on the population-predicted pharmacokinetics using diverse methods of estimating renal function (Salazar–Corcoran and Cockcroft–Gault methods using either ideal, actual, or adjusted body weights). All significance testing was set at an α of \u3c 0.05. IBM SPSS Statistics version 25 and SAS version 9.4 were used to conduct all statistical analyses. Results: A total of 30 patients were included in the study; 33.3% (10/30) of the patients were obese and 56.7% (17/30) had renal dysfunction. In all patients in the study, the calculated population-predicted Ke and t1/2 using all four creatinine clearance estimation methods were each significantly correlated with patient-specific Ke and t1/2 (all Pearson correlation coefficients [r]: \u3e + 0.7, p \u3c 0.001). The population-predicted Ke and t1/2 calculated using Cockcroft–Gault creatinine clearance using adjusted body weight showed the strongest association with patient-specific Ke and t1/2. In the subgroup analyses, all the population-predicted Ke and t1/2 using four creatinine clearance estimation methods were each significantly correlated with patient-specific Ke and t1/2. The exception was the population-predicted t1/2 derived from Cockcroft–Gault creatinine clearance using actual body weight that did not show a significant correlation with patient-specific t1/2 in obese patients. Conclusions: In this case series, population-predicted pharmacokinetic parameters were strongly correlated with patient-specific pharmacokinetic parameters. The vancomycin population-predicted pharmacokinetic formula can be used safely to predict a patient’s vancomycin pharmacokinetic disposition and can be maintained as an empiric dosing strategy in various hospitalized adult patients
Fluorescence-Based Molecular Switches for piR 1245 Detection
No full textPiwi-interacting RNA (piRNA) is a type of non-coding small nucleotide sequence that was recently discovered. PiRNA serves as modulators of transcription and plays a key role in tumorigenesis. Our lab has been working with piR 1245, which serves as a clinical biomarker for colon cancer since it is upregulated in the disease state. Previous experiments have shown the design of a sensing mechanism for these short nucleotide sequences using aptamers which are single stranded sequences of DNA or RNA which can fold into complex threedimensional shapes and form binding pockets and cavities. In our previous experiment, our lab used fluorescence to demonstrate proof of concept that the introduction and hybridization of the piR1245 target sequence led to the displacement of the fluorophore-linked signaling sequences from the aptamer and that the signals were amplified using dual probes. Our goal is to use fluorophore based aptamer sensors for piRNA and conjugate the signaling sequences with flavin adenine dinucleotide (a redox trigger of the enzyme Glucose oxidase), rather than FAM (which is a fluorophore similar to FITC). The results will be detected using an apo-Glucose oxidase reactivation assay and provide enzymatic amplification in signaling.https://digitalcommons.xula.edu/build_xula/1011/thumbnail.jp
Second Line Memorials for Eva Perry
No full texthttps://digitalcommons.xula.edu/masked/1002/thumbnail.jp
