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Synthesis and Biological Evaluation of New Ceramide Analogs
No full textBreast cancer is the most diagnosed form of cancer in women in the United States. It is estimated that on average, every two minutes a woman is diagnosed with breast cancer; and one woman will die of the disease every thirteen minutes. Many anti-cancer drugs used to clinically treat breast cancer mediate tumor cell death through the initiation of apoptosis. Multidrug-resistance is a major cause of cancer chemotherapy failure in clinical treatment. As a result, molecular pathways involved in tumor cell proliferation, including the ceramide signaling pathway, have become potential targets for pharmacological intervention. Ceramides have been shown to potentiate signaling events that drive apoptosis, autophagic responses, and cell cycle arrest. Ceramide analogs can be designed to inhibit ceramide-metabolizing enzymes in order to increase intra-cellular ceramide levels in cancer cells, leading to increased cell death. Our approach is to design and synthesize such ceramide analogs. Some of our synthesized analogs have been shown to have greater efficacy and specificity than endogenous ceramides. Evidence shows that multidrug-resistant cancer cells are as sensitive as corresponding regular cancer cells under the exposure to some of our anti-cancer ceramide analogs. Previously, a number of ceramide analogs with a flavone moiety on the backbone were synthesized. Initial docking studies showed that flavone moieties are too big for the binding pocket of human ceramidase. Coumarin-containing ceramide analogs, however, are smaller in size, and are expected to have increased efficiency along with self-fluorescence. For this project, new ceramide analogs containing a coumarin moiety on the sidechain were synthesized in order to study their biological activities.https://digitalcommons.xula.edu/build_xula/1007/thumbnail.jp
Saving the black Catholic experience of Xavier University of Louisiana
Full text linkThe digital conversion and creation of accessible records from the Sisters of the Blessed Sacrament (SBS) Oral History Collection includes recorded and transcribed interviews with the Sisters of the Blessed Sacrament who, in 1915, founded Xavier University of Louisiana (XULA) and continue to serve today. This article reflects on the beginnings of XULA and its unique place in Southern black history as the only Roman Catholic historically black college or university (HBCU) in the United States. It examines the necessity of archival oral history preservation at an African-American institution of higher education and the work archivists at Xavier University of Louisiana are doing now to help conserve rare primary research materials for the long-term preservation of black Catholic history
Interview with Tyrone Casby, Big Chief of the Mohawk Hunters and Principal of L. B. Landr-O.P. Walker College and Career Preparatory High School.
No full textA video interview of Tyrone Casby, by Kim Vaz-Deville. Tyrone Casby is an educator from Algiers, near New Orleans and the Big Chief of Mohaw Hunters. He talked about his history with the group, significance of masking tradition, the connection to slavery and native americans, how he likes to incorporate civil rights movement and current political conditions to masking and designing mardi gras indian suits.https://digitalcommons.xula.edu/masked/1014/thumbnail.jp
Novel Synthesis of Divergent Aryl Imidazoles from Ketones Involving Copper-Catalyzed α-amination and Oxidative C-C Bond Cleavage
No full textA one-pot synthesis, initiated by a copper salt with inorganic (NH4)2CO3 as the nitrogen source, forms divergent aryl imidazole derivatives from ketones via a-amination and oxidative C–C bond cleavage reactions. The approach provides a simple and rapid synthesis of imidazole derivatives and has certain versatility
Action Strategy Worksheets
Full text linkInformed by prioritization and feedback on solutions by Implementation Tables and the Youth Planning Board, the Youth Master Plan partners (CYPB, NOYA, and the City\u27s Office of Youth & Families) have identified the solutions that will be launched in the first two years of the 10-year Youth Master Plan
Key Components And Milestones
Full text linkThe children and youth of New Orleans deserve lives filled with positive experiences and healthy relationships simply because they are our children and youth, worthy of our collective best. The Youth Master Plan will apply the positive youth development framework and an equity lens, ensuring its design and implementation sets a path for every youth to have access to what they need to be successful. In return, our children and youth can become change agents who continuously improve New Orleans
Tracking Functional Connectivity using Dynamic Independent Component Analysis During the Meditative State
No full texthttps://digitalcommons.xula.edu/build_xula/1000/thumbnail.jp
Characterizing electronic cannabis cigarette usage and motivations in Black, college age students.
No full texthttps://digitalcommons.xula.edu/build_xula/1014/thumbnail.jp