Indonesian Journal of Medicine (IJM)
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Role of Copeptin in predicting of Major Adverse Cardiovascular Events (MACE) during Hospitalization on Acute Myocardial Infarction Patients
Get PDFBackground: Copeptin has been considered as a potential biomarker for AMI which also give information regarding the prognostic of the Acute myocardial infarction (AMI). The aim of this study is to understand the role of copeptin as a predictor of major adverse cardiovascular events (MACE) during hospitalization in AMI patients.Subjects and Method: This was a cohort analytical study conducted at Dr. Moewardi Hospital, Surakarta, from March to May 2021. The dependent variable was MACE. The independent variable was the copeptin level. We observe the MACE during hospitalization and analyze the cut-off point value for optimal copeptin levels to predict the occurrence of MACE using the receiver operating characteristic (ROC) curve. Linear multiple regression was conducted to predict determinants of MACE in hospitalization patients.Results: 52 patients recruited in this research (44 males, 8 females). During hospitalization, MACE occurred in 52% of these subjects, with the respective proportions for acute heart failure, cardiogenic shock, arrhythmias, cardiopulmonary resuscitation, and mortality of 28%, 10%, 8%, 4%, and 2%. The ROC curve showed that the cut-off point of copeptin was 2,141.50 pg/mL and area under curve (AUC) value of 0.710 with sensitivity of 75.0%, specificity of 68.80% and accuracy of 71.15%. Hence, the AUC values and accuracy present fair results for predicting MACE during hospitalization in AMI patients.Conclusion: Copeptin has a role as a predicttor of MACE during hospitalization in AMI patients.Keywords: copeptin, mayor adverse cardiovascular events, acute myocardial infarctionCorrespondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital. Jl. Kol. Sutarto 132, Surakarta 57126, Central Java. Email: trisulo.wasyanto@gmail.com.Indonesian Journal of Medicine (2021), 06(02): 230-238https://doi.org/10.26911/theijmed.2021.06.02.12.
The Effect of Sleep Duration on Overweight or Obesity in Female Adolescents: A Meta-Analysis Study
Get PDFBackground: Overweight or obesity is a condition of excessive accumulation of fat in the body which is indicated by a Body Mass Index value exceeding 25 kg/m2. WHO estimated that in 2022 adolescents will experience more obesity cases than underweight cases. One of the behaviors that can reduce the risk of overweight and obesity is having adequate sleep duration. This study aimed to analyze the magnitude of the effect of sleep duration on overweight or obesity in female adolescents with a meta-analysis study.Subjects and Method: This was a systematic review and meta-analysis study. The study was carried out by following the PRISMA diagram. The process of the search for articles through a database that included: PubMed, Google Scholar, and Springer Link. The articles were selected in the period 2009-2020. The keywords used include: "sleep duration" AND adolescents, overweight AND "female adolescents", obesity AND adolescent, "sleep duration" OR "overweight obesity" OR adolescents OR "cross-sectional", "sleep duration" AND "overweight obesity "AND adolescent," sleep timing "AND obesity AND girls. The inclusion criteria were full-text articles with cross-sectional study design, English and Indonesian articles, and articles that used multivariate analysis with adjusted Odds Ratio. The articles that qualify were analyzed using the Review Manager 5.3 application.Results: A total of 9 primary articles from Korea, China, and the USA had conducted a meta-analysis with a sample of 104,726 female adolescents. The results of the meta-analysis showed that female adolescentswith short sleep duration had a risk of overweight or obesity 1.44 times compared with female adolescents with long sleep duration (aOR= 1.44, 95% CI= 1.24 to 1.69, p<0.001).Conclusion: Short sleep duration significantly increases overweight/obesity in female adolescents.Keywords: duration of sleep, overweight or obesity, female adolescentsCorrespondence: Putri Isriyatil Jannah. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: putriisriyatil@gmail.com. Mobile: 089634956745.Indonesian Journal of Medicine (2021), 06(01): 52-61https://doi.org/10.26911/theijmed.2021.06.01.06.
The Relationship between Tumor Size and Carcinoembryonic Antigen (CEA) Levels in Stage IV Colorectal Adenocarcinoma Patients at Dr. Moewardi Hospital, Indonesia
Get PDFBackground: Colorectal adenocarcinoma is one of the most common types of colorectal cancer based on histopathology, accounting for about 10% of cancer cases diagnosed worldwide each year. Tumor size and levels of carcinoembryonic antigen (CEA) are used to determine the presence and evaluation of colorectal cancer. However, studies on the correlation between the size of colorectal cancer based on CT scan abdominal with contrast and the CEA levels are still very minimal in the Indonesian population. This study aimed to analyze the relationship between tumor size examined by abdominal CT scan with contrast and carcinoembryonic antigen (CEA) levels in stage IV colorectal adenocarcinoma patients.Subjects and Method: A cross-sectional study was conducted at the radiology department, Dr. Moewardi hospital, Surakarta, from February 2021 to July 2021. A total of 40 patients with stage IV colorectal adenocarcinoma were selected in this study. The patient already had the examination results of blood CEA levels and performed an abdominal CT scan with contrast. The dependent variable was blood CEA levels. The independent variable was tumor size. Data were collected from medical records and analyzed by the Spearman test.Results: There was a positive and significant relationship between tumor size and CEA levels (r= 0.47; p= 0.003).Conclusion: Tumor size is positively correlated to blood CEA levels in patients with stage IV colorectal adenocarcinoma.Keywords: colorectal adenocarcinoma, contrast abdominal CT scan, carcinoembryonic antigen (CEA).Correspondence: Sulistyani Kusumaningrum. Department of Radiology Dr. Moewardi Hospital/ Faculty of Medicine of Universitas Sebelas Maret, Surakarta. Email: [email protected] Journal of Medicine (2021), 06(03): 285-290https://doi.org/10.26911/theijmed.2021.06.03.0
The Use of Modified Cervical Colar in Reducing Neck Pain
Get PDFBackground: One of the conditions of pain in the neck area where there is a stiff neck, so sometimes there is pain radiating from the shoulder to the hand, the symptom is often called cervical syndrome. This condition occurs because the vertebral root is compressed for a long time in the use of activities. In the long term, the pain can even radiate to both shoulders and even to the arms of the arch, this situation will result in abnormal and rapid fatigue. According to studies conducted by researchers, this situation may be prevented by giving a special cervical collar design to Tafidz Ouran students. In this study, it will be investigated how effective the special collar model is to overcome the problems/prevention of cervical syndrome for Tafidz Ouran students in Karanganyar. The purpose of this study was to determine how effective a special cervical collar design is to reduce pain in cervical syndrome.Subjects and Method: This research is a Randomized Controll Trial (RCT) where in this study before being randomized in determining the control and treatment groups, matching was done first. In the control group in this study were students who used regular collars (collars sold in the market) and in the intervention group were given special collars. The sample in this study was the students of the Tahfidz boarding school in the Karanganyar area as many as 160 students who experienced cervical syndrome. Each group in this study amounted to 80 students. The sampling technique was simple random sampling. The variables in this study, the dependent variable is the cervical syndrome condition of the Tafidz Quran students and the use of a special cervical collar model as the independent variable. Analysis of the data using the Independent samples t test if the data is normal, and using the Mann Whitney test if the data is not normal.Results: After the intervention, it was shown that pain in the special cervical collar group (mean = 2.51; SD = 0.50) was lower than that in the regular collar group (mean = 5.50; SD = 0.59) and was statistically significant (p value = 0.000).Conclusion: The use of a special cervical collar is better than a regular cervical collar to reduce neck pain.Keywords: cervical syndrome, cervical collar, special cervical collarCorrespondence: Alfan Zubaidi. Department of Orthotic Prosthetic, Ministry of Health Surakarta. Jl. Letjen Sutoyo, Mojosongo, Surakarta, Central Java, Indonesia. Email: [email protected] Journal of Medicine (2021), 06(04): 460-464https://doi.org/10.26911/theijmed.2021.06.04.12
Skin Coverage for Acute Fingertip Injuries – A case series of Traumatic Injury at Prof. Dr. R. Soeharso Hospital, Surakarta
Get PDFBackground: Traumatic fingertip injuries are the most common injuries of the hand. Several million estimated visits to primary care providers and the emergency department occur each year. But the handling is often not done properly and comprehensively. Reconstruction of the fingertip must be done as soon as possible in the acute stage, resulting in better outcomes in the future. Aim of the surgery was to restore as much finger length, preserve sensation fingertip properties and achieve normal nail growth, and cosmetics appearance as well.Case presentation: Three cases of emergency patients with fingertip injury treated at the hospital in the acute setting. All of these patients experienced work injuries and were immediately taken to the emergency department.Results: The debridement and skin coverage reconstruction were carried out. Functional and aesthetic outcome were a postoperative assessment.Conclusion: The right choice of treatment and good wound care will produce a better outcome.Keywords: traumatic injury, fingertip injury, skin coverageCorrespondence: Tito Sumarwoto. Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java.Indonesian Journal of Medicine (2020), 05(04): 331-336https://doi.org/10.26911/theijmed.2020.05.04.08.
Meta Analysis the Effect of Acupuncture Therapy on Pain Reduction in Osteoarthritis Patients
Get PDFBackground: Osteoarthritis (OA) is the most common joint condition and is characterized by progressive erosion of the articular cartilage. Based on data from Basic Health Research (2018) the prevalence of joint disease in Indonesia is recorded at around 7.3% and osteoarthritis (OA) or arthritis is a common joint disease. As the two main non-surgical methods, physiotherapy and acupuncture have been shown to be safe and effective in the therapy of osteoarthritis.Subjects and Method: This was a systematic review and meta-analysis study. The articles used in this study were obtained from several databases including PubMed, Google Scholar, and Springer Link. The articles used in this study were those published from 2000-2020. The article search was carried out by considering the eligibility criteria defined using the PICO model. The population in the study were patients with osteoarthritis complaints with intervention in the form of acupuncture therapy, the comparison was the sham acupuncture outcome in the form of pain reduction. The keywords for finding articles are as follows: "Acupuncture" OR "Osteoarthritis" AND "Randomized Controlled Trials". The articles included in this study are full text articles with an observational study design. Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: A total of 9 articles were reviewed in this study. A meta-analysis of 9 randomized control trials showed that acupuncture therapy reduced pain in osteoarthritis patients (SMD= -0. 49; 95% CI= -0.88 to -0.10; p= 0.01).Conclusion: Acupuncture therapy reduces pain in osteoarthritis patients.Keywords: acupuncture, osteoarthritis, acupuncture osteoarthritis, randomized control trialCorrespondence: Fahmi Eko Susilo. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: fahmiekss@gmail.com. Mobile: 081393644991.Indonesian Journal of Medicine (2021), 06(01): 95-103https://doi.org/10.26911/theijmed.2021.06.01.10.
Meta-Analysis of the Effect of Pelvic Floor Muscle Training in Reducing Urinary Incontinence and Elevating Quality of Life in Women
Get PDFBackground: Urinary incontinence is a complaint of involuntary loss of urine and often occurs in women due to bladder dysfunction or weakened pelvic floor muscles. Pelvic floor muscle training (PMFT) is an exercise to treat urinary incontinence. This study aimed to analyze the effectiveness of pelvic floor muscle training to reduce urinary incontinence and improve quality of life in women.Subjects and Method: This was a systematic review and meta-analysis. The data was obtained through journal databases including PubMed, Science Direct, and Google Scholar by selecting articles published in 2010-2020. The keywords used were ("pelvic floor muscle training" OR "pelvic floor exercise" OR "kegel") AND ("urinary incontinence" OR "leaking urine" OR "urinary leakage") AND ("women" OR "female") AND "quality of life" AND "randomized controlled trial". The inclusion criteria were full paper articles with the Randomized Controlled Trial (RCT) research method. The size relationship used's of Mean SD, the intervention given was pelvic floor muscle training; female research subjects were 20-75 years old and experienced urinary incontinence. Search articles were done by using the PICO model. Population= Women with urinary incontinence, Intervention= pelvic floor muscle training, Comparison= not given PMFT, and Outcome= decreased urinary incontinence and improved quality of life. Articles were collected by using PRISMA flow diagrams and analyzed using the Revman 5.3 application.Results: Meta-analysis of 7 articles showed that pelvic floor muscle training could reduce urinary incontinence by 0.56 times higher compared to other interventions or no intervention (SMD= -0.56; 95% CI= -1.03 to -0.09; p= 0.020). Meta-analysis of 9 articles showed that pelvic floor muscle training improved quality of life by 0.32 times higher compared to other interventions or no intervention (SMD= -0.32; 95% CI= -0.66 to 0.02; p=0.070).Conclusion: Pelvic Floor Muscle Training (PMFT) reduces urinary incontinence and improves the quality of life in women.Keywords: pelvic floor muscle training, urinary incontinence, quality of lifeCorrespondence: Ragil Aidil Fitriasari Addini. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 089609133808.Indonesian Journal of Medicine (2021), 06(03): 258-270https://doi.org/10.269¬11/theijmed.2021.06.03.03
Comparison of the Effectiveness of the Chemosurgery and Cryosurgery for the Treatment of Patients with Condyloma Acuminatum at Dr. Moewardi Hospital, Surakarta
No full textBackground: Condyloma acuminatum (CA) is one of the most common sexually transmitted infections. Several therapeutic modalities that can be used are chemosurgery with trichloroacetic acid and cryosurgery with liquid nitrogen. Recurrence in CA often occurs, so selecting the right therapeutic modality and eliminating the lesion also prevents recurrence. This study aimed to compare the effectiveness of chemosurgery and cryosurgery therapy in patients with CA who are treated at Dr. Moewardi Hospital, Surakarta.Subjects and Method: A retrospective cross-sectional study was conducted at the Dermatology and Venereology Polyclinic, Dr. Moewardi Hospital, Surakarta, from January 1, 2018, to December 31, 2020. The study subjects were 78 patients diagnosed with CA based on ICD-10 criteria, while chemosurgery and cryosurgery procedures were based on ICD-9. The dependent variable was healing time in weeks. The independent variables were chemosurgery and cryosurgery therapy. The data came from the patient's medical record. Data were analyzed using an independent t-test.Results: Based on univariate analysis, most patients were male (67.9%), and the age group was 20-29 years (51.28%). Most of the CA patients work as private employees (46.15%). The most sexual orientation was heterosexual (53.8%), the most common site of lesions was genital (47.4%), and 52.6% were coinfected with HIV. Most CA patients received chemosurgery (70.5%). Bivariate analysis showed that chemosurgery therapy provided faster clinical improvement (Mean= 23.34; SD= 26.45) than cryosurgery therapy (Mean= 28.69; SD= 19.84), and the difference was statistically significant (p= 0.037).Conclusion: Treatment of CA using chemosurgery provides clinical improvement faster than cryosurgery, so that faster treatment time can reduce treatment costs and improve the patient's quality of life.Keywords: chemosurgery, cryosurgery, HPV, condyloma acuminatumCorrespondence: Prasetyadi Mawardi. Department of Dermatology and Venereology, Faculty of Medicine of Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Central Java, Indonesia. Email: [email protected]/ [email protected]. Mobile: +6281229750211.Indonesian Journal of Medicine (2021), 06(03): 290-297https://doi.org/10.26911/theijmed.2021.06.03.0
Effectivity Biopsychosocial intervention with Cognitive Behavioral Therapy and Exercise Therapy Program in Chronic Low Back Pain: Meta-analysis
Get PDFBackground: Pain is a common complaint that causes decreased work productivity and a cause of disability. Biomedical interventions failed to inhibit the increase in chronic low back pain (CLBP) treatment costs. The pain perception of CLBP patients is influenced by emotional psychological and cognitive factors that require biopsychosocial intervention. This study aimed to summarize the existing literature data regarding the effectiveness of biopsychosocial interventions with Cognitive Behavioral Therapy (CBT) and Exercise Therapy Program (ETP) in CLBP.Subjects and Method: This research was systematic review and meta-analysis of the Randomized Control Trial study on the electronic database Pubmed, Google scholar, Willey Online Library, Research Gate, Science Direct. Data analysis was performed using the Revman 5.3 program with Cohen's effect size d.Results: There are 7 articles included in this research. The results of the analysis of studies on the effectiveness of biopsychosocial interventions for CBT and ETP in reducing the intensity of CLBP pain were very large with the effect size (d= -1.31; 95% CI= -2.39 to -0.23; p <0.001), while the effect size of the disability index was very large (d= -1.62; 95% CI= -2.70 to -0.54; p<0.001).Conclusion: Biopsychosocial interventions for CBT and ETP are effective in reducing the pain and disability index of CLBP. The effectiveness of biopsychosocial interventions with CBT and ETP methods is due to the patient's efficacy in completing the rehabilitation program.Keywords: biopysichosocial, CBT, ETP, CLBPCorrespondence: Arif Fadli. Masters Program in Public Health Sciences, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +6281355377050.Indonesian Journal of Medicine (2021), 06(02): 177-193https://doi.org/10.26911/theijmed.2021.06.02.0
Comparison Neutrophil to Lymphocyte Count Ratio with C-Reactive Protein as a Predictor for Neonatal Sepsis
Get PDFBackground: Accurate early detection of bacteriemia plays an important role in the treatment and prognosis of infected neonates, but is constrained by the limitations of specific sepsis markers for detecting bacteriemia. NLCR or neutrophil to lymphocyte count ratio in adult population shows a more sensitive parameter in predicting infection and has the advantage of being economical and widely available. The role of NLCR in the neonatal population has not been widely studied. The purpose of this study was to analyze NLCR versus CRP as a predictor of neonatal sepsis.Subjects and Method: This study take analytic observatinal with diagnostic test approach to subject with sepsis risk factor and neonatal sepsis at dr. Moewardi hospital from April until May 2017. Characteristics data as gestational age, gender, birth weight, IT ratio, leucocyte count, neutrophil and lymphocyte count, NLCR, CRP and blood culture. Data presented descriptively and statistical analysis was performed.Results: No significant correlation between subject’s characteristics and neonatal sepsis. NLCR with cutoff point for 2.22 has sensitivity, specificity, positive and negative predictive value for 87.5%, 75%, 70% and 90%, respectively. CRP with cutoff point for 0.25 has sensitivity, specificity, positive and negative predictive value for 83.3%, 55.6%, 55.6% and 83.3% respectively. While IT-rasio has sensitivity, specificity, positive and negative predictive value for 29.2%, 91.7%, 70% and 66%, respectively.Conclusion: NLCR has a satisfactory predictive value for neonatal sepsis that widely available and economic predictor alternative with cutoff point for 2.22.Keywords: NLCR, CRP, predictor, neonatal sepsisCorrespondence: Irfan Dzakir Nugroho. Masters Program in Family Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java.Indonesian Journal of Medicine (2021), 06(01): 112-118https://doi.org/10.26911/theijmed.2021.06.02.02