E-Journal UMSIDA (Universitas Muhammadiyah Sidoarjo)
Not a member yet
1909 research outputs found
Sort by
Collagen Biomarkers Indicate Increased Tissue Damage in Connective Tissue Disorders: Biomarker Kolagen Mengindikasikan Peningkatan Kerusakan Jaringan pada Gangguan Jaringan Ikat
No full textBackground: Connective tissue disorders such as rheumatoid arthritis, osteoarthritis, and systemic lupus erythematosus are characterized by chronic inflammation and collagen degradation, which contribute to tissue damage and disease progression. Specific Background: Collagen degradation biomarkers, including matrix metalloproteinases (MMP-1, MMP-9), tissue inhibitors of metalloproteinases (TIMP-1), and inflammatory markers (CRP, TNF-α), reflect the extent of tissue remodeling and inflammation. However, limited studies comprehensively evaluate their diagnostic and prognostic value in these disorders. Knowledge Gap: There is insufficient evidence comparing the levels of these biomarkers between patients with connective tissue disorders and healthy individuals, particularly regarding their role in disease monitoring and progression. Aims: This study aims to assess and compare collagen degradation biomarkers (MMP-1, MMP-9, TIMP-1, CTX, CRP, TNF-α) between patients with connective tissue disorders and healthy controls to explore their diagnostic and prognostic significance. Results: Patients exhibited significantly elevated levels of MMP-1, MMP-9, TIMP-1, CTX, CRP, and TNF-α compared to healthy controls (p < 0.05), suggesting increased collagen turnover and chronic inflammation. BMI was also significantly higher in patients (p = 0.003). Novelty: This study provides comprehensive comparative data on multiple biomarkers, highlighting the simultaneous elevation of collagen degradation and inflammatory markers as potential indicators for disease severity. Implications: These findings suggest that assessing collagen degradation biomarkers can enhance early diagnosis, monitor disease progression, and guide therapeutic strategies for connective tissue disorders.
Highlights:
Collagen biomarkers indicate tissue damage in connective tissue disorders.
Compare collagen biomarkers in patients and healthy controls for diagnostic value.
Biomarkers are significantly elevated in patients, indicating increased collagen turnover and inflammation.
Keyword: Collagen degradation, MMPs (Matrix metalloproteinases), TIMP-1 (Tissue inhibitor of metalloproteinases), CTX (C-terminal telopeptide of collagen), Chronic inflammation, Connective tissue disorder
Structural Racism and Institutional Inequality: A Historical and Discourse Analysis: Rasisme Struktural dan Ketidaksetaraan Institusional: Sebuah Analisis Sejarah dan Wacana
No full textGeneral Background: Racism is a deeply entrenched social phenomenon shaped by historical, cultural, economic, and political structures. Its manifestations are complex, extending from colonial expansion and the transatlantic slave trade to contemporary institutional discrimination. Specific Background: Existing literature predominantly focuses on racism as a historical consequence or a socio-political issue, yet there remains a need for comprehensive analyses that integrate its structural, ideological, and systemic dimensions. Knowledge Gap: Limited research has explored how economic systems, political structures, and cultural institutions perpetuate racial inequalities, particularly within healthcare, education, and professional environments during crises like COVID-19. Aims: This study employs qualitative and analytical methodologies, including content analysis and critical discourse analysis, to examine the historical foundations and modern implications of racism. Results: Findings reveal persistent ideological structures that reinforce racism, with economic and institutional frameworks sustaining social inequalities. Critical discourse analysis highlights how racist ideologies are embedded within policies and institutional narratives. Novelty: Unlike previous studies, this research integrates historical texts, contemporary sociological data, and intersectional analyses to provide a multi-dimensional perspective on racism’s structural perpetuation. Implications: The study contributes to academic discourse and anti-racism initiatives by offering a deeper understanding of racism’s systemic nature, fostering policy recommendations, and supporting equitable institutional reforms.
Highlights:
Racism is historically entrenched, influencing institutions and societal structures.
Analyzing systemic racism through history, institutions, and discourse.
Supports anti-racism policies and equitable institutional reforms.
Keywords: Racism, discrimination, race, Origins of Racism, Impact of Racism, Paths to Resolution
Biofilm Formation and Antibiotic Resistance of Staphylococcus aureus Isolates: Pembentukan Biofilm dan Resistensi Antibiotik pada Isolat Staphylococcus aureus
No full textGeneral Background: Biofilm-associated infections represent a major clinical challenge due to their persistence and resistance to antibiotics. Specific Background: Staphylococcus aureus is a common pathogen implicated in chronic and hospital-acquired infections, particularly due to its biofilm-forming capability. Knowledge Gap: Despite global reports on S. aureus resistance, limited data exist regarding its biofilm formation and antibiotic susceptibility in clinical isolates from Mashhad Hospital. Aims: This study aimed to investigate the prevalence, biofilm formation, and antibiotic resistance profile of S. aureus isolated from hospitalized patients. Results: A total of 150 clinical samples (blood, urine, wounds, and secretions) were collected from 95 male and 55 female patients, yielding 70 S. aureus isolates. All isolates were biofilm-positive. Antibiotic susceptibility testing revealed 100% resistance to ampicillin, 80.3% to azithromycin, and 70.7% to cefoxitin, while all isolates remained sensitive to vancomycin and clarithromycin. Statistical analysis showed significant associations (p < 0.05) between patient sex and both biofilm formation and antibiotic resistance patterns. Novelty: This study provides updated, localized resistance data and highlights the universal biofilm-forming potential of S. aureus in this region. Implications: The findings underscore the need for enhanced infection control strategies and the prudent use of antibiotics to mitigate biofilm-related resistance in hospital settings.
Highlights:
S. aureus causes resistant, biofilm-related hospital infections.
70 isolates: all biofilm-positive, high resistance to common antibiotics.
Requires improved antibiotic stewardship and infection control measures.
Keywords: S. aureus, Antibiotic Resistance, Biofilm, Clinical sample
Genotyping Staphylococcus aureus in Endocarditis Using Multilocus Sequence Typing: Genotipe Staphylococcus aureus pada Endokarditis Menggunakan Pengetikan Sekuens Multilokus
No full textBackground: Infective endocarditis (IE) is a rare but life-threatening infection that can occur post-cardiac valve surgery, with Staphylococcus aureus (SAB) being the leading causative pathogen due to its virulence and resistance traits. Specific Background: Molecular typing methods like multilocus sequence typing (MLST) offer improved resolution in understanding SAB epidemiology compared to conventional culture-based techniques. Knowledge Gap: However, the clonal diversity and genetic lineages of SAB isolates associated with IE in regional healthcare settings remain underexplored, particularly in populations with low culture positivity. Aims: This study aimed to genotype SAB isolates from IE patients using MLST to investigate their strain-level diversity, clonal relationships, and antibiotic resistance profiles. Results: Among 281 blood samples, only 43 (15.3%) yielded bacterial growth, with 11 (25.6%) confirmed as SAB. MLST revealed genetic heterogeneity, identifying ST-1 (biofilm-associated), ST-21 (community-acquired), ST-215 (healthcare-related), and emerging regional clones ST-59 and ST-531. Novelty: This study presents the first molecular characterization of SAB in IE patients in this region, linking sequence types to clinical contexts. Implications: Findings underscore the utility of MLST in identifying transmission patterns, informing infection control strategies, and highlighting the need for ongoing molecular surveillance of multidrug-resistant SAB strains.
Highlights:
Staphylococcus aureus causes infective endocarditis post-heart valve replacement surgery.
Used MLST to genotype SAB; found ST-1, ST-21, ST-215.
MLST reveals SAB diversity; aids targeted control of resistant regional strains.
Keywords: Infective endocarditis (IE), S.aureus, genotyping, multilocus sequence typing, biomarker
Prevalence and Risk Factors of Head Lice Among Schoolchildren in Kirkuk: Prevalensi dan Faktor Risiko Kutu Rambut di Kalangan Anak Sekolah di Kirkuk
No full textBackground: Head lice (Pediculus humanus capitis) are common, blood-sucking ectoparasites that infest the human scalp, with significant public health relevance, particularly among school-aged children. Specific Background: These wingless insects, belonging to the order Phthiraptera, are highly transmissible in dense environments such as schools. Knowledge Gap: Despite global awareness, there is limited region-specific data on infestation prevalence and contributing factors in northern Iraq, particularly in Kirkuk City. Aim: This study aimed to determine the prevalence of pediculosis and identify associated sociodemographic and behavioral risk factors among schoolchildren in Kirkuk. Results: Visual inspections of 300 pupils from five schools revealed an overall infestation rate of 10.3%, with higher prevalence among females (13%) compared to males (4.44%). Children aged 6–12 and those in lower educational levels exhibited significantly higher infestation rates. Behaviors such as sharing combs and clothing were also associated. Novelty: This is the first extended surveillance-based study in Kirkuk that combined clinical inspection with behavioral questionnaires over a full year. Implications: Findings underscore the need for enhanced school-based health education, early detection, and hygiene practices to mitigate the spread of pediculosis. Regional strategies should incorporate community involvement and consistent provision of preventive treatments.
Highlights:
High-risk group: Females and children aged 6–12 most affected.
Transmission factors: Sharing combs, clothes, and beds increases risk.
Prevention focus: Health education and treatment programs are essential.
Keywords: Pediculosis, Head lice, Schoolchildren, Prevalence, Public healt
Continuing Difficulties in English Teachers' Preparation for Cambridge Exams
No full textStandardized teacher assessments such as the Cambridge Teaching Knowledge Test (TKT) are increasingly used to evaluate pedagogical knowledge, yet their integration into local educational settings remains challenging. Specifically in Indonesia, elementary English as a Foreign Language (EFL) teachers face unique barriers during TKT preparation due to contextual misalignment. Despite existing studies on teacher training and assessment, limited research addresses the lived experiences of teachers navigating TKT preparation in resource-constrained environments. This study aims to explore the perceptions, challenges, and outcomes encountered by eight Indonesian EFL teachers during a six-session TKT preparation program using a narrative inquiry approach. Findings reveal minimal improvement in test readiness, largely influenced by limited preparation time, insufficient training resources, and incongruity between TKT content and local teaching realities. The novelty lies in its focus on narrative insights from in-service primary school teachers, often underrepresented in assessment literature. Implications suggest that for standardized assessments like the TKT to be effective and equitable, localized training support, contextual adaptation, and sustained mentoring are essential. This study contributes to the discourse on EFL teacher development by exposing the practical dissonance between global certification frameworks and local instructional ecosystems.
Highlights:
Highlights contextual barriers faced by Indonesian EFL teachers during TKT prep.
Reveals misalignment between global tests and local teaching practices.
Emphasizes need for localized support in standardized teacher training.
Keywords: Narrative Study, Cambridge TKT Preparation, Teacher Training Challenges, EFL Test Readiness, Standardized Teacher Assessment
 
Social Media Branding Strategies that Strengthen School Image Among Stakeholders: Strategi Branding Media Sosial yang Membangun Citra Positif Sekolah
No full textGeneral Background: In the digital era, social media has become a key medium for communication and institutional promotion. Specific Background: Educational institutions increasingly utilize these platforms to build and manage their public image. Knowledge Gap: However, there is limited comprehensive synthesis of effective branding strategies specifically tailored to the educational context through social media. Aims: This study aims to explore and analyze branding strategies via social media to construct institutional image, with a focus on educational settings. Results: Using a qualitative approach and literature study method, the research reviews 19 national and international peer-reviewed articles on educational branding through social media. The analysis identifies key strategies including consistent visual identity, interactive content, storytelling, and community engagement. These elements contribute to improved public perception, stronger institutional identity, and increased stakeholder trust. Novelty: The study offers a synthesized, literature-based framework of digital branding practices applicable to schools, bridging theoretical insights with practical application. Implications: The findings provide actionable guidance for educational institutions, particularly in optimizing social media as a branding tool to enhance image, attract students, and remain competitive in an increasingly digital educational landscape.
Highlights:
Social media shapes school identity and public perception.
Key strategies include visual consistency, storytelling, and interaction.
Literature synthesis offers practical guidance for digital branding.
Keywords: Social Media Branding, Educational Institutions, School Image, Digital Identity, Community Engagement
 
Development of Educational Game Based on Canva Application on Reading Comprehension Skills of Fifth Grade Elementary School Students: Pengembangan Media Game Edukatif Berbasis Aplikasi Canva pada Aspek Keterampilan Membaca Pemahaman Siswa Kelas V Sekolah Dasar
No full textGeneral Background: Reading comprehension is a fundamental skill in primary education, influencing students' academic performance across subjects. Specific Background: However, traditional teaching methods often fail to engage students effectively, particularly in Indonesian language classes. Knowledge Gap: Limited use of interactive and technology-based learning media contributes to low reading comprehension outcomes among elementary students. Aims: This study aims to develop and evaluate an educational game based on Canva to enhance reading comprehension skills of grade V students at SDN Sungguminasa V. Results: Utilizing the Borg & Gall development model, the research involved stages from needs analysis to product refinement. The resulting Canva-based educational game was validated by experts with a feasibility score of 97%, showed high practicality with an implementation score of 95.83% and positive teacher feedback (91.66%), and demonstrated strong effectiveness through student responses (99.16%) and significant score improvement from 35.83% (pretest) to 90% (posttest). Novelty: This study presents a novel integration of Canva as a platform for developing subject-specific educational games tailored to primary students’ cognitive levels.Implications: The findings highlight the potential of Canva-based educational games as effective, feasible, and engaging media to support reading comprehension in Indonesian language instruction.
Highlights:
Enhances student engagement through interactive learning.
Significantly improves reading comprehension scores.
Validated as highly feasible, practical, and effective.
Keywords: Educational Game, Canva, Reading Comprehension, Elementary Schoo
Cost Optimization in Spare Parts Inventory with Lagrange Method
No full textGeneral Background: Managing spare parts inventory is crucial for maintaining operational efficiency in manufacturing industries. Specific Background: PT ABC experienced overstocking of steel plate materials, causing increased storage costs and exceeding warehouse capacity. Knowledge Gap: Current company methods lack optimization under space constraints, leading to inefficiencies. Aims: This study aims to determine the optimal order quantity that minimizes total inventory costs while considering warehouse space limitations. Method: The Lagrange Multiplier approach was applied to optimize inventory levels under capacity constraints, using data on demand, ordering and holding costs, and storage volume. Results: The proposed method reduced total inventory costs to Rp46,259,547, compared to Rp185,458,780 using the company’s approach, achieving a 75.05% reduction. Novelty: Unlike standard EOQ-based systems, this study integrates Lagrange Multipliers to handle physical constraints, producing feasible and cost-effective solutions. Implications: Implementing this approach in similar manufacturing contexts can significantly reduce storage costs and prevent inefficiencies caused by overstocking.Highlights:
Lagrange Multiplier reduced inventory costs by over 75%.
Optimal inventory levels aligned with warehouse limits.
Forecasting enhanced ordering precision for future cycles.
Keywords: Inventory Management, Lagrange Multiplier, Spare Parts, Warehouse Capacity, Cost Reduction
 
Serological Detection of Toxoplasmosis in Relation to marital status, Cats Contact and Abortion in Wasit province, Iraq
No full textGeneral Background: Toxoplasma gondii represents a globally distributed protozoan parasite capable of infecting warm-blooded animals, including humans, with particular concern for pregnant women due to risks of miscarriage and congenital malformations. Specific Background: While toxoplasmosis has been extensively investigated worldwide, limited epidemiological data exist regarding its prevalence and associated risk factors among women in Wasit Province, Iraq. Knowledge Gap: The relationship between T. gondii seropositivity and socio-demographic factors such as marital status, cat contact, and abortion history remains inadequately characterized in this region. Aims: This study aimed to determine the seroprevalence of T. gondii antibodies (IgG and IgM) among women of reproductive age and examine associations with marital status, cat contact, and abortion history. Results: Among 300 women tested, 51% demonstrated seropositivity for T. gondii antibodies, with significantly higher rates observed in married women (54% vs. 30%, p=0.05) and those with abortion history (69% vs. 42%, p=0.05). Novelty: This study provides the first comprehensive assessment of toxoplasmosis seroprevalence and risk factors specifically among women in Wasit Province. Implications: These findings underscore the necessity for targeted public health interventions, including periodic screening of reproductive-age women, health education on food hygiene and cat interactions, and environmental preventive strategies to reduce T. gondii transmission.Highlight :
The study found 51% seroprevalence of T. gondii antibodies among women in Wasit Province, Iraq, indicating a significant public health concern.
Married women showed higher seropositivity (54%) than unmarried women (30%), linked to household exposure and contaminated food handling.
Women with abortion history had elevated seroprevalence (69%), highlighting the need for routine toxoplasmosis screening in prenatal care.
Keywords : Toxoplasma gondii, Seroprevalence, Reproductive Health, ELISA Diagnostic, Zoonotic Infectio