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さまざまな固形がんに高頻度に発現している 10種類の 共通がん抗原由来の 68種類の HLA-A24 および -A2拘束性 cytotoxic T lymphocyte (CTL)誘導ペプチドの同定
東京理科大学博士(理学)2024doctoral thesi
学校教育で活用容易な津波観察装置の開発 - 押し出し式造波器を用いた小型簡便な実験器 -
津波災害のように大規模な自然現象の学習では、現実そのものを再現することは困難なので、自
然現象の中の重要な要素に注目して、それについて訴求力のある再現装置を用いて学習することが効果的かつ効率的である。本研究では、津波の基本的な性質を観察できる小型で軽量、操作が容易な水路型実験装置の製作方法を開発した。水路はビニールシート製のバッグと透明樹脂板のパネルの二重構造としたので、漏水しにくく緒元(長さや幅等)の自由度も大きい。造波装置は自転車の廃棄チューブと水道用塩化ビニール管を用いた押し出し機構としたので、構造が単純で堅牢であり吐出量の調整も容易である。装置の製作は容易で材料費も安価なので、小学校~高等学校まで広く生徒実験への活用が期待できる。departmental bulletin pape
The rice asura mutant exhibits abnormal stigma morphology caused by a T-DNA insertion in the gene for serine carboxypeptidase SCP5, a putative regulator of homeotic proteins
The rice asura mutant, which showed an increased number of stigmas, was found to contain a T-DNA insertion in one of the two alleles of the Os01g0833500 gene,
encoding a serine carboxy peptidase II-like protein, SCP5. In the mutant allele, T-DNA was inserted into the region between the chain A and B domains, resulting in the generation of an aberrant transcript with a stop codon downstream of the chain A domain region. In the asura mutant, the transcripts corresponding to the chain A domain were more abundant than those corresponding to the chain B domain. From the mutant gene,
an additional protein consisting only of the chain A domain was expected to be produced.
This was predicted to recognize the substrates but did not exhibit catalytic activity. The phenotype of increased stigma numbers was detected in both the transformants overexpressing the chain A domain region in SCP5 and in genome-edited mutants in which the downstream region of the chain A domain was disrupted. SCP5 interacted with several regulatory proteins involved in flower morphogenesis. Furthermore, a protein consisting only of the chain A domain interacted with these proteins. These findings imply that excess production of the chain A domain protein in the asura mutant would impair the function of these regulatory proteins, resulting in insufficient control of stigma number and an increase in stigmas within spikelets.journal articl
Scaling Hypothesis of Quantum Spatial Search in Complex Networks
東京理科大学博士(理学)2024doctoral thesi