International Journal of Advances in Medical Biotechnology (IJAMB)
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Managing Knowledge for Pharma and Biotech Innovation
Get PDFKnowledge Management (KM) involves a deliberate and systematic organization of people, processes, structure, and technology with the main objective of creating value for innovation from the reuse of data and information. Although there are several models for KM in various types of organizations, there is nothing concrete to integrate the knowledge generated in collaborative University-Industry projects. This work aimed to gather elements for the creation of a sustainable model of effective articulation in this scenario. It is a strategic action that can bring benefits of intellectual, economic, and social impact. This research used different instruments: systematic mapping, questionnaires, and experience reports. The mapping highlighted the need to consider the following aspects for the development of KM models: collaborative/competitive arrangements, tacit/explicit knowledge managers and change screening. The questionnaire and report demonstrated that the challenges go beyond aspects such as data organization. They must prioritize the social aspect of knowledge sharing, using safe coordination to prevent misconduct
Photoluminescent gels based on han purple: new frontiers in biotechnology
Get PDFAs a result of the increasing need for new biocompatible materials, polymer-based gels have become promising options. Lately, photoluminescent gels have shown potential for applications in biotechnology and non-invasive tracking due to their ability to emit light when temperature changes occur. This research investigates the incorporation of Han Purple (HP) pigment into a polyethylene glycol/Laponite matrix [92,5/7,5%] (P7LHP0%) to produce a 3D-printed gel. The gels were examined for possible use as smart sensors, focusing on their optical and thermal characteristics. Formulations with HP concentrations of 0.0%, 0.5%, and 2.0% were prepared, followed by extrusion-based 3D printing. Characterization techniques included FTIR, SEM, and optical analyses (emission and excitation spectra). The findings showed 3D structures with good shape fidelity while FTIR indicated suitable compatibility between HP and the matrix. Optical analysis revealed fluorescence with an excitation band between 400 and 700 nm, with a maximum at 620 nm, and an emission band at 830 - 1000 nm with a peak at 925 nm. This study highlights the potential of HP as a promising material for fluorescent gels in 3D printing, creating new opportunities for biotechnology application
Baccharis dracunculifolia extract as a promising active for healing chronic wounds
Get PDFChronic wounds are all wounds that have a difficult healing process and a delay in physiological healing repair. Such wounds are considered a public health problem, which generate high costs for health services. The Baccharis dracunculifolia (BD) plant, popularly known as “alecrim do campo” or “vassourinha” and widely used in folk medicine, has several biological activities, such as antibacterial and immunomodulatory activities, which may favor the wound repair process. In this context, the objective of this study is to analyze the biological activity of Baccharis dracunculifolia extracts regarding cytotoxicity for subsequent production of a dressing with future applications in tissue repair of chronic wounds. FTIR and TG analyzes were performed to identify functional groups and biological cytotoxicity assays revealed that the ethanolic extract of Baccharis dracunculifolia (EEBD) showed lower cytotoxicity for most of the tested concentrations
Intelligent embedded system for physiological control of ventricular assist devices in health 4.0 Background
Get PDFThe use of Left Ventricular Assist Devices (LVADs) has proven to be an effective treatment option for Congestive Heart Failure (CHF) patients who are not eligible for heart transplantation. These devices can serve as a bridge to heart transplantation (BTT) or as destination therapy (DT). While LVADs operate at a constant flow, this can affect the patient's quality of life and survival rate. To address this issue, Health 4.0 (H4) has developed new technological resources to personalize control systems and integrate medical devices into treatment. In this effort, a Physiological Control of LVAD (PC-LVAD) system was implemented within the H4 platform, using an Intelligent Embedded System (IES). The IES was developed using the MyRIO® development platform and tools such as LabVIEW® FPGA and RT, Quartus II® EDA, and MATLAB®. To evaluate its performance, preliminary criteria were assessed in experimental tests, analyzing the Internet of Things (IoT) characterization and applying best practices for information security. The results of the experimental tests showed that the IES could store and transmitting data in real-time to a graphical interface, and the data were found to be consistent with external measuring instruments
O Entrepreneurship in biotechnology in Brazil: the path to innovation development
No full textStudies and debates on entrepreneurship, innovation, and biotechnology have been highlighted on the world stage. Considering this context, it is necessary to evaluate innovation and its consequences for the entrepreneur because innovation is a fundamental requirement for the success of the entrepreneur, especially when it involves the biotechnology area. Innovation has the power to create a new product, a market success, and generate economic benefits for the company. In this context, this work aims to understand through literature research how the insertion of innovation in entrepreneurship can contribute to the biotechnology area. To gain the necessary understanding of the theme, the methodology used was bibliographic research with the purpose of collecting and synthesizing existing knowledge. The results found showed that there are gaps between entrepreneurship and the process of searching for innovation, the selection of ideas, and the challenges facing the changes needed for the entrepreneur's initiatives to be successful. In the biotechnology area, entrepreneurship can assist in innovation processes as well as strengthen the capacity for competitiveness. Therefore, this research puts into debate the relevant aspects of entrepreneurship, the innovation process in the biotechnology area, and its impact on the economy and society
Vesting in biostartups: analysis of new legal framework & fundamental rights
No full textThe purpose of this article is to examine the vesting contract in biostartups, with emphasis on the new legal framework from the perspective of the principle of maximum effectiveness of fundamental rights. The vesting contract is analyzed in relation to the effectiveness of these rights, divided into two dimensions. In the subjective dimension, the vesting contract is seen as a way to protect the fundamental rights of startup partners and investors, including the right to contractual freedom. In the objective dimension, the vesting contract is seen as a way to promote the effectiveness of fundamental rights to growth and to innovative entrepreneurship, mitigating labor and tax risks, optimizing the company’s development, and bringing a strong economic and social impact on the development of a nation. The results showed that the vesting contract can generate risk reduction and legal certainty for the partners in a private environment of prior trust. Furthermore, the inclusion of the term “innovation” in Brazilian Federal Constitution reinforces the importance of scientific and technological research for the development of the country. However, the implementation of these fundamental rights is still incipient, especially in the field of biotechnology, where companies are subject to extremely high risks and a very high mortality rate due to innovative projects and the lack of administrative knowledge on the part of managers. Finally, as to the methodology employed, the study has an exploratory and descriptive character, with the conclusions derived from the qualitative analysis of information delimited with a bibliographical and documental review of books, articles, websites, jurisprudence and legislation
Influence of carbon sources on the physicochemical properties and yield of bacterial cellulose production
Get PDFBacterial cellulose (BC) is a biopolymer of great interest for application in various industrial and medical areas, due to its peculiar characteristics of biocompatibility, tensile strength, high water retention capacity and crystallinity. CB can be produced using culture media with different nutrient sources, under static or agitated cultivation conditions. The objectives of this work were to produce CB membranes, using the bacterial strain Komagateibacter hansenii ATCC 23769, in static cultivation, using media containing different sources of carbon (glucose, fructose, glycerol and ethanol) and nitrogen (yeast extract and peptone), aiming to study the influence on the physicochemical properties of the BC produced and its possible biomedical application. The obtained BC were comparatively evaluated for dry mass yield, swelling capacity, and characterized by Field emission gun-scanning electron microscopy (FEG-SEM), and Fourier transform spectroscopy (FTIR). Membranes with significant swelling capacity were obtained, demonstrating that the composition of the culture medium influences the physicochemical properties of BC. The results of this work also demonstrate that the BC has great possibilities in several areas, including biomedical applications
Use of high energy milling and porosity insertion in the development of the Mg-Zn system aiming biomedical applications
Get PDFThe development of metal alloys with porosity controlled by powder metallurgy has shown to be suitable for obtaining biomaterials with the control of mechanical strength and modulus of elasticity, in addition to the possibility of controlling open porosity, which is essential for osseointegration. Magnesium alloys have shown encouraging results when used as tissue engineering scaffolds. Although a considerable number of studies encourage the use of magnesium alloys in bioactive implants for load-bearing in orthopedic applications, a great deal of research effort is still essential to assess in vivo, the long-term capability of such supports. Due to the excellent physical and mechanical properties of magnesium compared to other permanent (non-degradable) elements, porous magnesium alloys have become good candidates to develop biodegradable supports for bone treatments. Porous magnesium alloys could be used in applications where it would be interesting to use a biodegradable metallic material, while maintaining the requirements of mechanical strength, elastic modulus, corrosion resistance and adequate osseointegration. In this work, a new route of processing porous alloys of the MgZn system using high energy milling, via powder metallurgy, will be evaluated
Robotic arm inertial control for recreational child physiotherapy application
Get PDFAccording to reports from physical therapists, physiotherapy presents a painful and uninteresting process because it distances itself from the ludic, which is a natural essence of the human being, and easily attracts children when applied. In 2021, the “Robotic System for Children's Physiotherapy with Recreational Activities” project was developed, which consisted of a robotic arm to assist in the physiotherapy process of children with Cerebral Palsy. According to the conclusions of the initial project, the developed control was effective in what was proposed but not sufficient for project application in rehabilitation environments In this way, this work present a new control that is safer and that allows its application helping in the rehabilitation of these children. This new control allows the robotic arm to reproduce the movements of the human arm, so that the movement of the forearm, arm and hand are reproduced independently, simultaneously and in real time. Therefore, the prototype control operates reliably and robustly, achieving what was aimed at, a safer and more efficient physiotherapeutic process for users
The construction of a performance measurement system for self-evaluation of a graduate biotechnology program
Get PDFThe Literature on Performance Measurement Systems (PMS) is vast, however, little is found on the design stage of these for Higher Education. The purpose of this article is to present an SMD built for a Biotechnology Graduate Program (GP) to evaluate its performance. The Value Focused Thinking (VFT) approach was used to identify performance criteria. Mathematical modeling technique was used to identify the weights of these criteria through the Decision Support Method with Multiple Criteria: Analytic Network Process (ANP). Stakeholder decision compatibility was tested. Thirty-five performance indicators were built and grouped into eight fundamental objectives. The evaluation of the program identified that its strengths were Percentage of deadline fulfillment (by students) and Percentage of joint orientations between teachers and that managers should prioritize Percentage of patents or products students / teachers and Percentage teachers / students who participated as advisor / consultant.