1401 research outputs found
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Dataset associated with "Directed assembly of homo-pentameric globular proteins into high-order structures using coiled-coil appendages"
No full textCharacterisation data and microscopy images of tubular supra-molecular complexes of cholera toxin B subunit appended with a coiled coil domain
Supplemental material of manuscript entitled: Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England
Get PDFWe conducted a population-based, record-linkage, open-cohort study to quantify dose-related risks of adrenal insufficiency, Cushing’s syndrome and death in adults with six chronic inflammatory diseases commonly treated with oral glucocorticoids. We found high glucocorticoid dose-dependent increased risks of adrenal dysfunction and death but low absolute risks, indicating potential under-diagnosis in primary care and the need to increase physician and patient awareness and education about the risks of adrenal dysfunction induced by glucocorticoids
Dataset associated with 'Metastable room-temperature twist-bend nematic phases via photopolymerization'
Get PDFThe data provided in Figure 1b shows phase transition temperatures of binary CB7CB/RM257 mixtures before and after photopolymerisation. The data in Table S1 shows the enthalpy of phase transitions for second heating cycles of pure liquid crystals and polymerised Ntb and SmA samples. [Iso – isotropic, N – nematic, Ntb – twist-bend nematic, SmA – smectic A.
Zimbabwe Field Data Master File
No full textThe dataset contains the birds recorded during transects winter 2012 and summer 2013. The sites in the Debshan ranched area are labelled D1-D23, and the farmed sites in the resettled area are labelled R1-R22. The raw count data that form the basis of the project are listed in the ‘Birds’ worksheet
Dataset associated with "Tunable broadband terahertz polarizer using graphene-metal hybrid metasurface"
No full textAn electrically tunable polarizer for terahertz frequency electromagnetic waves formed from a hybrid graphene-metal metasurface is demonstrated
Data associated with Exploring the Reliability of DFT Calculations of the Infrared and Terahertz Spectra of Sodium Peroxodisulfate.
No full textThe data included in this dataset has been generated by A number of DFT programs with various combinations of pseudo-potentials and van der Waals' dispersive corrections have been used to optimize the structure of sodium peroxodisulfate and to calculate the infra-red, attenuated total reflectance and terahertz absorption spectra of the powdered crystal.
Comparison of the results from the different methods highlights the problems of calculating the absorption spectrum reliably. In particular the low frequency phonon modes are especially sensitive to the choice of grids to represent the wavefunction or the charge distribution, k-point integration grid and the energy cutoff.
A comparison is made between the Maxwell-Garnett (MG) and Bruggeman effective medium methods used to account for the effect of crystal shape on the predicted spectrum. Possible scattering of light by air inclusions in the sample and by larger particles sodium peroxodisulfate of is also considered using the Mie method.
The results of the calculations are compared with experimental measurements of the transmission and attenuated total reflection spectra
Writing Back dataset
Get PDFThis dataset contains letters exchanged between University of Leeds students and older, Yorkshire residents in 2017-18, written as part of the University's Writing Back Project. This includes letters written by School of English students and University-wide international postgraduate students. The international and undergraduate strands of the scheme relate to different participants and different data
Data associated with ‘Analysis of 2-D DNA Origami with Nanopipettes’
No full textIon current recordings of DNA origami translocation experiments. Nanopipettes are a useful tool for the detection and analysis of biological molecules at the single-molecule level. Here, we employ nanopipettes fabricated from glass capillaries to identify differently structured 2D DNA origami through the distinctive amplitude and dwell time of the ion current peak resulting from the translocation of the origami through the nanopipette pore. We demonstrate that the ion current peak originating from frame-like DNA origami comprises two individual peaks in contrast to solid tiles of similar size that only lead to a single peak in the ion current. Interestingly, the fine details of the shape of the double peak characteristic of the translocation of DNA origami frames are correlated with the structural features of the DNA origami. In particular, the size of the central cavity governs the lag time between the two constituent peaks of the double-peak. This work demonstrates the ability of glass nano- pipettes to identify and characterize differently structured DNA origami of similar size, advancing the potential of nanopipettes for high-sensitivity single-molecule studies
Cells under stress: An inertial-shear microfluidic determination of cell behaviour - dataset
No full textThe deformability of a cell is the direct result of a complex interplay between the different constituent elements at the subcellular level, coupling a wide range of mechanical responses at different length-scales. Changes to the structure of these components can also alter cell phenotype, thus the critical importance of cell mechano-response for diagnostic applications. The response to mechanical stress depends strongly on the forces experienced by the cell. Here we use cell deformability in both shear-dominant and inertia-dominant microfluidic flow regimes to probe different aspects of the cell structure. In the inertial regime we follow cellular response from (visco-)elastic through plastic deformation to cell structural failure and show a significant drop in cell viability for shear stresses above > 11.8 kN/m2. Comparatively, a shear-dominant regime requires lower applied stresses to achieve higher cell strains. From this regime, deformation traces as a function of time contain a rich source of information including; maximum strain, elastic modulus and cell relaxation times and thus provide a number of markers for distinguishing cell types and potentially disease progression. These results emphasise the benefit of multiple parameter determination for improving detection and will ultimately lead to improved accuracy for diagnosis. We present results for leukemia cells (HL60) as a model circulatory cell as well as for a colorectal cancer cell line SW480 derived from primary adenocarcinoma (Dukes stage B). SW480 were also treated with the actin disrupting drug Latrunculin A (LatA), to test the sensitivity of flow regimes to the cytoskeleton. We show that the shear regime is more sensitive to cytoskeletal changes, and that large strains in the inertial-regime cannot resolve changes to the actin cytoskeleton
Hip kinematics and kinetics in total hip replacement patients stratified by age and functional capacity
Get PDFThis dataset contains supplementary data linked with the following publication (D.E. Lunn, G.J. Chapman, A.C. Redmond, Hip kinematics and kinetics in total hip replacement patients stratified by age and functional capacity, Journal of Biomechanics (2019), doi:https://doi.org/10.1016/j.jbiomech.2019.02.002). The supplementary data contains the waveforms for all of the strata detailed in the paper. More information regarding the project underpinning this work can be found at doi.org/10.5518/319. Data associated with this work can be found at doi.org/10.5518/345. With planned future releases of the associated data being relased in the forthing coming months/years.
Abstract: To examine functional differences in total hip replacement patients (THR) when stratified either by age or by functional ability as defined by self-selected walking speed. THR patients and a control group underwent three-dimensional motion analysis under self-selected normal and fast walking conditions. Patients were stratified into five age groups for comparison with existing literature. The THR cohort was also stratified into three functional groups determined by their self-selected gait speed (low function 1S.D; normal function within 1S.D). Hip kinematics, ground reaction forces, joint moments and joint powers in all three planes (x-y-z) were analysed. 137 THR and 27 healthy control patients participated. When stratified by age, during normal walking the youngest two age groups walked quicker than the oldest two groups (p<0.0001) but between-group differences were not consistent across age strata. The differences were diminished under the fast walking condition. When stratified by function, under normal walking conditions, the low function and normal function THR groups had a reduced extension angle (mean=1.75°, SD=±7.75, 1.26°±7.42, respectively) compared to the control group (-6.07°±6.43; p<0.0001). The low function group had a reduced sagittal plane hip power (0.75watts/kg±0.24), reduced flexor (0.60Nm/kg±0.85) and extensor moment (0.51Nm/kg±0.17) compared to controls (p<0.0001). These differences persisted under the fast walking condition. There were systematic differences between patients when stratified by function, in both walking conditions. Age related differences were less systematic. Stratifying by biomechanical factors such as gait speed, rather than age, might be more robust for investigating functional differences