1401 research outputs found
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Dataset associated with the paper "Exploring the effects of mineral depletion on renewable energy technologies net energy returns"
No full textThis dataset provides the input data and R code needed to fully reproduce the analysis conducted in the paper "Exploring the effects of mineral depletion on renewable energy technologies net energy returns." To do so, the code reads the material intensities of each renewable energy technology and the energy intensities of mining each material, and estimates the variation in net energy returns for each renewable energy technology. The methodology is described in-depth in the associated paper
Simulation data from the publication "Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilisation to the plasma membrane"
No full textA repository of simulation data from the publication "Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilisation to the plasma membrane". Here we provide new molecular insight into the first step of AKT activation where AKT binds to the plasma membrane and its orientation is stabilised in a bilayer with lateral heterogeneity (Lo-Ld phase coexistence). We have applied coarse-grained and atomistic molecular simulations and molecular and cell biology approaches and demonstrate that AKT recruitment to the membrane occurs via a secondary binding site in the AKT Pleckstrin Homology domain that acts cooperatively with the known canonical binding site. We showed that disrupting either the canonical or secondary binding sites the membrane localisation and AKT activity is attenuated. Given the precision with which we have identified the protein-lipid interactions, the study offers new directions for AKT-targeted therapy and for testing small molecules to target these specific amino acid-PIP molecular bonds.
This dataset contains:
- DATASET 1: coarse-grained MD simulation data for the binding of the WT AKT-PH to a model membrane
- DATASET 2: coarse-grained MD simulation data for the binding of the mut1 AKT-PH to a model membrane
- DATASET 3: coarse-grained MD simulation data for the binding of the mut2 AKT-PH to a model membrane
- DATASET 4: coarse-grained MD simulation data for the binding of the mut3 AKT-PH to a model membrane
- DATASET 5: coarse-grained MD simulation data for the binding of the WT AKT-PH to a model membrane without PIP lipids
- DATASET 6: atomistic MD simulation data for the binding of the WT AKT-PH to a model membrane
Data associated with 'Asynchronous optical sampling of on-chip terahertz devices for real-time sensing and imaging applications'
No full textThis dataset provides the data presented in figures 2, 3, and 4 of the related publication "Asynchronous optical sampling of on-chip terahertz devices for real-time sensing and imaging applications". A detailed description of the data collection and analysis procedures is provided in the related publication (see README)
The Hollies dataset
Get PDFThis dataset consists of primary sources from 'The Hollies' Weetwood, Leeds, which from 1925-1960 (excluding September 1939- 1948) was a residential establishment for children at risk of tuberculosis. The dataset consists of:
a. two anonymised transcribed interviews with people with direct connections to The Hollies in the 1950s, one was a child resident and the other a visiting doctor.
b. anonymised data about children resident at The Hollies from The Register 1934-1938 and 1948-1960 (Excel data files), the SPSS files used to analyse this data and the SPSS output file
Twenty cam-type hip shapes described using a new 'contour' shape map and assessed for impingement occurrence and depth
Get PDFThis dataset includes the input, raw output and processed data from a study investigating the predicted cam-type hip impingement of a set of human subjects using a newly developed contour method. The associated project aimed to investigate the severity of a subject’s predicted impingement by assessing: the height of the cam entering the acetabulum during impingement; the frequency of impingement occurrence; and the impingement depth over a range of activities. The study looked to further investigate whether key shape features (maximum cam alpha angle, cam extent, cam location, average acetabular coverage) affected the severity of predicted impingement. The model input data is in the form of sets of points used to describe the femoral head-neck junction and acetabular rim of each subject. High level shape measures of cam apex, extent and location are included. Additional parametric data, such as femoral head size is provided for context along with the patient sex for comparison with previous work. The raw impingement occurrence output data of the shape-motion model providing information on which motion cases generate predicted impingement. Detailed data is included for the maximum impingement depth at every location around the acetabula, along with the post processed maximum impingement depth for each motion case for each subject. Methods documents are included explaining how measures were taken
Datasets associated with the paper: 'Assessing the energy and socio-macroeconomic impacts of the EV transition: A UK case study 2020-2050'
No full textThis file contains the following MARCO-UK model input and results data used in the following paper: Nieto, J., Brockway, Sakai, M., and Barrett J. “Assessing the energy and socio-macroeconomic impacts of the EV transition: A UK case study 2020-2050.” Applied Energy, 2024 available at https://doi.org/10.1016/j.apenergy.2024.12336
Dataset for 'Synergistic effect of Fe and Ni on carbon aerogel for enhanced oxygen reduction and H2O2 activation in electro-Fenton process'
Get PDFThis is the abstract dataset for the manuscript that is published, including data of degradation performance and material characterization
Dataset associated with "Structure-Property Relationships in Auxetic Liquid Crystal Elastomers – The Effect of Spacer Length"
Get PDFThis dataset contains the data associated with the article titled "Structure-Property Relationships in Auxetic Liquid Crystal Elastomers – The Effect of Spacer Length", published in Polymers. This data is provided in the form of the files used to plot the figures in the published article
Dataset for the Study of Evidence for a Transfer-To-Trap Mechanism of Fluorophore Concentration Quenching in Lipid Bilayers
No full textThis dataset shows the raw data, analysed data and documentation related to figures and tables from the study “Evidence for a transfer-to-trap mechanism of fluorophore concentration quenching in lipid bilayers”. This includes: fluorescence microscopy images; fluorescence decay histograms; other graphical analyses; tabulated numerical data
Data from Evaluating the Recommended Summary Plan for Emergency Care and Treatment (ReSPECT) in Primary Care
Get PDFMaterials used in workshops with people with a learning disability, accessible participant information sheet and consent form and topic guide for carers of people with a learning disability in focus group or interview for Evaluating the Recommended Summary Plan for Emergency Care and Treatment (ReSPECT) in Primary Care (NIHR HS&DR 13/13/16)