1401 research outputs found
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Central Tottori Earthquake geodetic slip inversion tools and data
Get PDFThis dataset contains all the data required to run perform a geodetic slip inversion using the software slipBERI (https://doi.org/10.5518/444) for the 2016, Mw 6.2 Central Tottori, Japan earthquake. Additionally this dataset contains the models runs of the solutions found in the associated thesis and paper
Strain rate dependant and dynamic mechanical properties of porcine superflexor tendons - dataset
No full textData on the strain rate dependant and dynamic mechanical properties of native and decellularised porcine superflexor tendons
Hydrogen production from bio-oil: a thermodynamic analysis of sorption-enhanced chemical looping steam reforming - dataset
No full textThis dataset contains the results of a thermodynamic study on the advanced reforming of bio-oil via sorption enhancement and chemical looping. A full description of the study is given in the associated paper
Data associated with 'Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins'
Get PDFAs newly synthesized polypeptides emerge from the ribosome, it is crucial that they fold correctly. To prevent premature aggregation, nascent chains interact with chaperones that facilitate folding or prevent misfolding until protein synthesis is complete. Nascent polypeptide– associated complex (NAC) is a ribosome- associated chaperone important for protein homeostasis. However, how NAC binds its substrates remains unclear. Using native electrospray ionization MS (ESI MS), limited proteolysis, NMR and cross-linking, we analysed the conformational properties of NAC from Caenorhabditis elegans and studied its ability to bind proteins in different conformational states. Our results revealed that NAC adopts an array of compact and expanded conformations and binds weakly to client proteins that are unfolded, folded, or intrinsically disordered, suggestive of broad substrate compatibility. Of note, we found that this weak binding retards aggregation of the intrinsically disordered protein α-synuclein both in vitro and in vivo. These findings provide critical insights into the structure and function of NAC. Specifically, they reveal the ability of NAC to exploit its conformational plasticity to bind a repertoire of substrates having unrelated sequences and structures independently of actively translating ribosome
Analysis and comparison of FFEA with all-atom molecular dynamics
No full textInput scripts, structural information and output trajectories, measurement and analysis data of Arfaptin and xylanase, using FFEA and all-atom molecular dynamics, in order to support the results presented in the article "Fluctuating Finite Element Analysis (FFEA): A Continuum Mechanics Software Tool for Mesoscale Simulation of Biomolecules" in PLoS Computational Biolog
Dataset associated with 'Biochemical fingerprint of colorectal cancer cell lines using label-free live single-cell Raman spectroscopy'
No full textRaw Raman spectra of the average of each single cell in different colorectal cencer cell lines, and preprocessed data used for multivariate analysis
The Garden of Earthly Delights
No full textThe Garden of Earthly Delights was the third and final event conducted as part of my practice-led PhD: Painting as emergent knowledge. It was held on 18th May 2017 in Alec Clegg Studio, stage@leeds. This is a brief tour of the event. It is referred to in Chapter Five
Data associated with 'pH-responsive polymer microcapsules for targeted delivery of biomaterials to the midgut of Drosophila suzukii'
No full textDrosophila suzukii (or spotted wing Drosophila) is an economically important pest which can have a devastating impact on soft and stone fruit industries. Biological pesticides are being sought as alternatives to synthetic chemicals to control this invasive pest, but many are subject to degradation either in the environment or in the insect gut and as a result require protection. In this study we identified a sharp change in pH of the adult midgut from neutral to acidic (pH 6, but underwent rapid dissolution at pH < 4.2. In vivo studies showed that the natural acidity of the midgut of D. suzukii also induced the breakdown of the responsive P2VP microcapsules to release FITC-dextran which was taken up into the body of the insect and accumulated in the renal tubules
Data to support study "Structure-switching M3L2 Ir(III) coordination cages with photo-isomerising azo-aromatic groups"
Get PDFSpectroscopic raw data, crystal strcutures and other characterisation for study of 'Structure-switching M3L2 Ir(III) coordination cages with photo-isomerising azo-aromatic groups'
Dataset associated with publication: ‘Coincident Molecular Auxeticity and Negative Order Parameter in a Liquid Crystal Elastomer’
Get PDFContains opto-mechanical testing data for an all acrylate Liquid Crystal Elastomer observed to display a negative Poisson’s ratio coincident with a state of negative liquid crystal ordering. Also contains images from AFM and SEM studies of the material confirming the LCE has zero detectable porosity in strained and unstrained states. Dataset includes plotting files used to generate figures