1401 research outputs found
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Structural and mechanical scaling law behaviour in folded protein hydrogel networks. [Dataset].
No full textSmall angle neutron scattering and rheology dat
Data for "OmpA specifically modulates the activity of OMP enzymes in the crowded bacterial outer membrane"
No full textSource data files containing fluorescence folding traces, raw activity data for all assays, gel images, DLS and Alphafold prediction file
Dataset Associated with 'Free-space and polarisation maintaining delivery of terahertz radiation from a quantum cascade laser in a dry dilution refrigerator'
No full textDataset for the associated review of scientific instruments paper. Contains thermometry, photovoltage and terahertz spectra data
Dataset for 'The thermodynamic potential of ferroelectric nematic liquid crystals and consequences for polarisation switching'
No full textThe dataset contains spontaneous polarisation data for the ferroelectric nematic liquid crystal, FNLC-919. The tests are done using the current reversal technique (as described by Miyasato et al. in 1983) which gives values of polarisation when a voltage is applied to a sample, so the data mainly consists of polarisation values for the samples taken at a range of voltages. Tests were done to check the polarisation response in four different thicknesses (4, 10, 23, and 46 microns) as well as to check the longevity of a sample when preparation conditions were varied (i.e. if it was prepared in the polar (ferroelectric nematic) phase or one of the nonpolar phases (nematic or isotropic))
Influence of wettability on diffusion limited nanoparticle adsorption at gas-liquid interfaces - Dataset
No full textData related to study into the influence of hydrophobicity on particle adsorption by examining the behavior of hydrophobized silica particles at air-water interfaces. Langmuir-Blodgett (LB) trough studies of butanol (‘SiO-butane’) and hexanol (‘SiO-hexane’) esterified particles provided contrasting behavior. The SiO-butane particles formed weaker particle layers that underwent partial collapse with compression, leading to formations significantly below hexagonal close-packed estimates. In contrast, the SiO-hexane particles exhibited improved monolayer behavior and longer-range stability. Droplet surface tensions demonstrated that the hydrophobic particles significantly altered the dynamic tension during adsorption, when methyl isobutyl carbinol (MIBC) was added as a co-surfactant. Short-term modeling elucidated the role of diffusion and energy barriers on adsorption dynamics, with SiO-hexane having reduced diffusion coefficients with respect to SiO-butane and unmodified particles. Long-term modelling allowed calculation of specific adsorption rates
Dataset for the study of The Impact of Carotenoid Energy Levels on the Exciton Dynamics and Singlet-Triplet Annihilation in Isolated Bacterial Light-Harvesting 2 Complexes
No full textThis dataset shows the raw data, analysed data and documentation related to figures and tables from the study "The Impact of Carotenoid Energy Levels on the Exciton Dynamics and Singlet-Triplet Annihilation in Isolated Bacterial Light-Harvesting 2 Complexes". This includes: absorbance spectra, fluorescence decay curves and spectra, analysis of fitting of fluorescence spectroscopy data, femtosecond and nanosecond transient absorption data
Molecular dynamics simulation data of the S345F mutant PLCg1 protein from the publication - Bunney et al., Biochem J (2025) 482 (20), "Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors"
No full textRepository of molecular dynamics simulation data described in the publication "Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors", Bunney et al., Biochemical Journal (2025),
https://doi.org/10.1042/BCJ20253358. Phospholipase C gamma (PLCγ) enzymes are key components of intracellular signal transduction processes and are involved in disease development, including immune dysregulation, specific cancer types and neurodegeneration. Although recognised as important targets for intervention, validated pharmacological tools are lacking. Here, we demonstrate that inhibitory nucleotides bind directly to an allosteric site at the interface between the PLC-core and regulatory-array unique for PLCγ, underlying their specificity for the PLCγ family. This binding site overlaps with the PLCγ autoinhibitory interface, suggesting that the inhibitory impact of nucleotides involves stabilisation of autoinhibition. We have also analysed disease-linked variants of PLCγ1 and PLCγ2 to show that multiple mechanisms could underpin their gain-of-function phenotype. While the sensitivity of these variants to physiological nucleotide inhibition is reduced, we identified artificial nucleotide compounds that can inhibit such variants not only in vitro but also in cell-based assays. Therefore, our findings suggest a route for development of isozyme specific PLCγ inhibitors allowing further studies of their roles in health and disease
Data for - A Novel Analytical Approach for Evaluating Thermally Active Underground Retaining Walls
No full textThis dataset contains all numerical and analytical results developed for the paper "A Novel Analytical Approach for Evaluating Thermally Active Underground Retaining Walls". The numerical results correspond to simplified two dimensional models for energy walls that were created in the COMSOL Multiphysics 5.5. All numerical models have a time step of 1 hour and a simulation period of 1 year. Parallelly, temperature changes were also calculated through the analytical method, which here is the FIS method or Flux and IPS Splitting method, which used IPS or Infinite Plane Source as the base model to compare energy wall to a planer source. The data sheets presented in this data set contains all these information along with the variables used in the calculations. Through this, any information presented in the article can either be calculated, cross-checked or derived
Data repository for heat stress and the cooling system in Pune, India
No full textThis repository contains data collected for the project "Co-creating visions and pathways for integrated urban heat systems" undertaken by researchers at the University of Leeds in collaboration with Dr. Bhanuben Nanavati College of Architecture. Data in this repository contain both processed quantitative data online from other sources and primary qualitative data collected during fieldwork conducted in informal settlements - Kishkindha Nagar and Shinde Vasti - during the project
Motion capture dataset of 137 post-operative total hip replacement patients performing activities of daily living
No full textThis dataset comprises comprehensive motion capture and ground reaction force data from 137 post-operative total hip replacement (THR) patients. Data were collected between 2013 and 2015 using a 10-camera Vicon system and dual force plates during a range of activities of daily living (ADLs), including level walking, stair negotiation, sit-to-stand, lunge, and squat tasks. Marker trajectories and ground reaction forces were processed using standard biomechanical techniques and segmented into key movement events. The dataset has previously been used to identify biomechanical differences in THR patients by age, gender, BMI, and function, and to explore joint contact forces and their impact on bone loading. It is now released for wider use in musculoskeletal modelling, with potential application in AI and machine learning model development. This study was supported by the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. GA-310477 LifeLongJoints. A small subset of this dataset (comprising a limited number of participants and trials) was previously made available under DOI 10.5518/319 as part of our previous publication. The current dataset represents the complete release, encompassing all participants and all recorded activities of daily living collected under the same methodological framework. The overlap is therefore limited to a few shared example files used for demonstration in the earlier publication