North Carolina Agricultural and Technical State University
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Differential Expression of Human microRNAs in Triple Negative Breast Cancer Tumors in Women of African and European Ancestry
No full textPoster presented at the National Council of Honors Conference in Kansas City, Missouri
Triple negative breast cancer (TNBC) is comprised of heterogenous tumors that are estrogen receptor, progesterone receptor, and HER2 negative. These tumors are aggressive and present a 40% higher mortality rate amongst African American patients. The causation and pathogenesis of this phenotype and the basis of health disparities are not well understood. MicroRNAs are small, noncoding RNAs that regulate gene expression through the process of mRNA degradation or interference of mRNA translation. The objective of this project was to determine the differential expression of known and novel microRNAs in TNBC in women of European Ancestry (EA) and African Ancestry (AA). We found the differential upregulation and downregulation of in AA and EA. It is possible that the differentially expressed miRNAs found may be involved in regulating TNBC pathogenesis and health disparities. Further studies are in progress address this question.https://digital.library.ncat.edu/undergraduate-research-posters/1011/thumbnail.jp
Investigating Microglia Phagolysosomal Activity Following Encephalitis Induced Seizures
No full textPoster presented at the Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS) in Pittsburgh, Pennsylvania
This poster investigates the role of microglia in phagocytosis during Theiler’s murine encephalomyelitis virus (TMEV)-induced epilepsy, a viral model for temporal lobe epilepsy (TLE). TMEV preferentially infects hippocampal CA1 neurons, leading to acute and recurrent seizures. Microglia, the central nervous system’s primary immune cells, become reactive during TMEV infection. This study examines microglial activation and phagocytic activity using immunohistochemistry and 3D imaging to assess the microglial response in the hippocampus. Results show increased microglial density and phagolysomal activity in TMEV-infected mice compared to controls, suggesting microglia contribute to tissue repair during the inflammatory response. Future research will explore the role of reactive microglia in epileptogenesis, with plans for RNA sequencing and further investigations using TREM2 knockout models.https://digital.library.ncat.edu/undergraduate-research-posters/1005/thumbnail.jp
New Farmers of America Association
No full textMan plowing in a field with a horse.https://digital.library.ncat.edu/photos/1897/thumbnail.jp
New Farmers of America Association
No full textJessie Strand\u27s cow project.https://digital.library.ncat.edu/photos/1907/thumbnail.jp
New Farmers of America Association
No full textGroup of men observing a penned herd of cattle.https://digital.library.ncat.edu/photos/1915/thumbnail.jp
New Farmers of America Association
No full textTwo men and two women sitting and talking on a porch.https://digital.library.ncat.edu/photos/1923/thumbnail.jp
New Farmers of America Association
No full textRoom with a variety of produce and canned goods on tables.https://digital.library.ncat.edu/photos/1944/thumbnail.jp
New Farmers of America Association
No full textYoung men sitting and standing next to wooden frames while writing.https://digital.library.ncat.edu/photos/1948/thumbnail.jp
New Farmers of America Association
No full textCars and people in front of brick building. Labeled \u27Blaine.\u27https://digital.library.ncat.edu/photos/1952/thumbnail.jp
New Farmers of America Association
No full textMan standing in a field of crops.https://digital.library.ncat.edu/photos/1971/thumbnail.jp