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Επαγγελματικό Προφίλ Εκπαιδευτικού Πολιτικού Έργων Υποδομής / Μηχανικού Έργων Υποδομής ΤΕ
Get PDFΗ σύνταξη του παρόντος οδηγού επαγγέλματος για τους πτυχιούχους του Τμήματος Εκπαιδευτών Ηλεκτρολογίας της Α.Σ.ΠΑΙ.Τ.Ε. υλοποιήθηκε σε συνεργασία με το Γραφείο Διασύνδεσης της Α.Σ.ΠΑΙ.Τ.Ε. Ο κύριος στόχος της εργασίας ήταν η δημιουργία ενός εύχρηστου οδηγού για την ενημέρωση των πτυχιούχων του τμήματος Εκπαιδευτικών Εκπαιδευτικών Μηχανικών Πολιτικών Έργων Υποδομής γύρω από τις συνθήκες εργασίας που επικρατούν στον αντίστοιχο επαγγελματικό τους χώρο
Assessment of the Impacts of Climate Change on European Ozone Levels
Get PDFThe objective of this study is to investigate the potential impact of future climate change on ozone air quality in Europe. To provide a full assessment, simulations with the global chemical transport model GEOS-CHEM driven by the NASA Goddard Institute for Space Studies general circulation model (NASA/GISS GCM) are conducted. To isolate the effects from changes in climate and anthropogenic emissions four types of simulations are performed: (1) present-day climate and emissions (2) future climate following the IPCC Special Report on Emission Scenarios (SRES) A1B scenario and present-day anthropogenic emissions of ozone precursors (3) present-day climate and future emissions and
(4) future climate and future emissions. Results indicate that climate change impact on its own leads to an increase of less than 3 ppb in western and central Europe whereas decreases are evident for the rest of the areas with the highest (about 2.5 ppb) in southeastern Europe (Italy, Greece). Increases are attributed to the increases of isoprene biogenic emissions due to increasing temperatures whereas decreases are associated with the increase of water vapor over sea which tends to decrease the lifetime of ozone as well as the increased wind speeds in the 2050 climate. When future emissions are implemented in the future climate simulations, the greatest increases are seen in the southwest and southeast Mediterranean (about 16 ppb) due to the increased isoprene biogenic emissions under higher levels of NOx in the model. Decreases up to 2 ppb of ozone are shown for France, Switzerland, Northern Italy and northern Europe
Investments in next generation access infrastructures under regulatory uncertainty
Get PDFThis article studies the impact of regulatory uncertainty on an incumbent’s incentives to undertake the socially optimal investments in NGA networks. Thus, aregulatory non - commitment setting in which the regulator sets the access price after the deployment of the NGA network is used. In particular, it is assumed that the regulator sets the access price at the marginal cost of providing the access with some probability and gives an access markup, which equals the average cost of the investments, with the complementary probability. It is found that when the slope of the marginal investment cost function is not particularly steep in relation to the impact of investments on demand, the incumbent underinvests compared to the socially optimal investment level. On the contrary, in a more realistic case when the impact of investments on demand is low in relation to the slope of the marginal investment costfunction, the incumbent may overinvest or underinvest depending on the probability of incorporating an access markup into the access price
Morphology of articular surfaces can solve a phylogenetic issue: one instead of two ancestors for Candiacervus (Mammalia: Cervoidea)
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Advanced glycation end-products induce endoplasmic reticulum stress in human aortic endothelial cells
Get PDFBackground: Advanced glycation end products (AGEs), the final products of the Maillard reaction, have been shown to impair endothelial proliferation and function, thus contributing to endothelial cell injury present in diabetes, inflammatory and cardiovascular diseases. Endoplasmic reticulum (ER) stress triggered under hyperglycemic, hypoxic and oxidative conditions has been implicated in endothelial dysfunction through activation of the unfolded protein response (UPR). The present study investigates the role of AGEs in ER stress induction in human aortic endothelial cells exposed to variable AGE treatments.
Methods: Human aortic endothelial cells (HAEC) were treated with increasing concentrations (100, 200 μg/mL) of AGE-bovine serum albumin (AGE-BSA) at different time-points (24, 48, 72 h). The induction of ER stress and the involved UPR components were investigated on mRNA and protein levels. Apoptosis was quantitatively determined by flow cytometry detecting propidium iodide expression and annexin V binding simultaneously.
Results: AGEs administration significantly reduced HAEC proliferation in a time- and dose-dependent manner. An immediate induction of the ER chaperones GRP78, GRP94 and the transcriptional activator, XBP-1 was observed at 24 h and 48 h. A later induction of the phospho-lF2α and proapoptotic transcription factor CHOP was observed at 48 h and 72 h, being correlated with elevated early apoptotic cell numbers at the same time-points.
Conclusions: The present study demonstrates that AGEs directly induce ER stress in human aortic endothelial cells, playing an important role in endothelial cell
apoptosis. Targeting AGEs signaling pathways in order to alleviate ER stress may prove of therapeutic potential to endothelial dysfunction-related disorders
