Open Journal Systems of Universitas Muhammadiyah Palangkaraya
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Natural Self-Foaming Clay Soap with Etlingera elatior Fruit Extract for Skincare
No full textEtlingera elatior (Wualae), a plant recognized for its flavonoid-derived antioxidant properties, presents a potential source for cosmeceutical applications. This study investigated the formulation and evaluation of a Self-Foaming Clay Soap (SFCS) incorporating an ethanol extract of E. elatior fruit. The SFCS base, comprising surfactant as a cleansing and foaming agent combined with bentonite clay for enhanced serviceability and oil adsorption, was formulated with varying concentrations of bentonite (0%, 5%, 10%, 15%, and 20% w/w), designated as FI to FV, respectively, alongside other necessary excipients. The resulting SFCS preparations underwent rigorous physical and chemical stability assessments following accelerated storage conditions (freeze-thaw cycles). Evaluated parameters included organoleptic properties, foam stability and height, viscosity, dispersibility, homogeneity, and pH. The evaluation revealed that Formulation II (FII), containing 5% w/w bentonite, exhibited the most favorable stability profile and met the established criteria for SFCS semisolid preparations. Specifically, FII demonstrated a foam stabilization rate of 84.61% and a foam height of 2.6 cm after freeze-thaw cycling, a viscosity of 10,000 cPs, a spreadability diameter of 4.1 cm, a homogeneous texture devoid of coarse particles, and a skin-compatible pH of 5. These findings suggest that an SFCS formulation incorporating a 5% w/w concentration of bentonite and E. elatior fruit extract holds promising potential as a stable and efficacious skincare preparation
Formulation and Evaluation of Antioxidant Activity of Instant Granules from 70% Ethanol Extract of Single Black Garlic (Allium sativum L.)
No full textFree radicals contribute to various diseases by inducing oxidative stress. Single black garlic (Allium sativum L.) is recognized for its phenolic compounds, which possess radical-scavenging properties. This study aimed to develop and evaluate instant granules containing black A. sativum extract for their antioxidant activity and physicochemical characteristics. An instant granule formulation was developed using a 70% ethanol extract of a single black A. sativum, with three distinct formulas containing 5%, 7.5%, and 10% extract (Formulas 1, 2, and 3, respectively). The granules were subjected to comprehensive physical quality assessments, including organoleptic properties, moisture content, angle of repose, flow rate, dissolution time, and tapped density. Antioxidant activity was quantified using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, reporting IC50 values. All instant granule formulations successfully met the established physical quality requirements across all evaluated parameters. Furthermore, the antioxidant activity demonstrated a concentration-dependent effect, with IC50 values of 119.576 ppm for Formula 1, 82.000 ppm for Formula 2, and 59.962 ppm for Formula 3. This study confirms that instant granules formulated with a single black A. sativum extract exhibit significant antioxidant potential and possess desirable physical characteristics, indicating their promise as a natural antioxidant supplement
Molecular Docking Study of Illicium verum Hook f. as Elastase and Collagenase Inhibitor in Anti-aging Mechanism
No full textSkin aging, a natural physiological process intensified by external factors that augment the activity of aging-related enzymes such as elastase and collagenase, leads to the degradation of collagen solubility and the disruption of elastin fiber cross-linking. This study aimed to investigate the potential of secondary metabolites from Illicium verum fruit as inhibitors of both elastase and collagenase through an in silico molecular docking approach. The methodology involved ligand and protein preparation, validation of the docking protocol, the molecular docking simulation itself, and subsequent visualization of amino acid residue interactions. The protein targets utilized were elastase (PDB ID: 1Y93) and collagenase (PDB ID: 2D1N). The docking results identified gingerol as exhibiting the highest binding affinity for elastase (-7.99 kcal/mol), followed by carvacrol (-6.79 kcal/mol) and ferulic acid (-6.24 kcal/mol). Similarly, for collagenase, gingerol displayed the strongest interaction (-8.47 kcal/mol), followed by carvacrol (-6.30 kcal/mol) and α-pinene (-6.24 kcal/mol). Notably, gingerol and carvacrol also demonstrated favorable amino acid similarity scores and promising interactions within the active sites of both elastase and collagenase. In conclusion, this molecular docking study suggests that the secondary metabolites of I. verum fruit possess potential anti-aging activity by inhibiting elastase and collagenase enzymes
Tourism Potential and Waste Management in Coastal Areas of Bengkulu City: Potensi Wisata Dan Pengelolaan Sampah di Wilayah Pesisir Kota Bengkulu
No full textThis study uses strategic management to uncover emerging issues intensively and comprehensively. This study aims to determine what efforts have been made to improve and maximize existing resources so that they can be used in the development of coastal tourism and what obstacles arise in coastal tourism objects in Bengkulu City. The focus of this study is on the strategy for improving the tourism sector, especially coastal tourism, as the main instrument for measuring the environment and obtaining strategies for strengths, weaknesses, opportunities and threats needed in the planning process for developing and developing coastal tourism. The conclusion of this study is based on the strategy for developing coastal tourism in Bengkulu City carried out by the Bengkulu City Tourism Office, there are still indicators that have not been successful, as seen from the uneven distribution of development in several leading destinations and the lack of foreign tourists visiting. One of the problems in the coastal area is waste management. Waste can cause environmental problems if its existence is not handled properly. Based on the results of this data collection, several strategies for waste management in the coastal area of Panjang Beach in Bengkulu City are presented, namely storage, collection, transportation, processing, final processing, financing institutions, regulations
Analisis Elemen Hingga Lapisan Tanah Menggunakan Geotekstil Sebagai Metode Perbaikan Tanah Lunak Dengan Software Plaxsis: Finite Element Analysis Of Soil Layers Using Geotextiles As A Soft Soil Improvement Method With Plaxsis Software
No full textThe case of embankment on soft clay soil that must be completed quickly can be assisted by additional reinforcement on the soft soil. One example is by using geosynthetics that have high tensile strength at the base of the embankment, thereby increasing the stability of the embankment. The use of geosynthetics is widely used in the improvement of soft clay subgrade in embankment construction in an effort to increase its bearing capacity. The purpose of this study was to determine the effect of the use of geotextiles under embankment soil to increase the stability of the soil below it and to determine the safety value, deformation and stress changes that occur in soil reinforced with geotextiles using Plaxis 2D software. The methods used in this final project consist of data collection methods, data analysis techniques, presentation methods and flow diagrams of planning studies.
From the results of the analysis, the safety factor is F = 0.742 <1.2 for embankment conditions without geotextiles while the safety factor is F = 1.380> 1.2 for embankment conditions with geotextiles. This shows that there is an effect of using geotextiles under the embankment in increasing the safety factor. The total deformation value for embankments without geotextiles is 25.10 mm, the total stress value for embankments without geotextiles is 180.35 kN/m2, the total deformation value for embankments with geotextiles is 36.27 mm, while the total stress value for embankments with geotextiles is 190.26 kN/m2
Empowering 21st Century Educators: Harnessing Learning Management Skills for Personalised Learning
No full textThe rapid advancement of technology has transformed educational environments, making Learning Management Systems (LMS) a pivotal tool for facilitating personalised learning experiences. This research explores LMS’s effectiveness in enhancing student engagement and academic performance while identifying essential skills educators need to harness these technologies effectively. A systematic literature review was conducted, analysing existing studies on LMS, personalised learning, and educator competencies. The findings reveal that LMS significantly improve customised learning through adaptive learning pathways, gamification and increased accessibility. Educators with digital literacy, data-driven decision-making and collaborative learning strategies are better positioned to create engaging learning environments and improve student outcomes. However, technological barriers and the need for ongoing professional development persist. The study concludes that while LMS hold great promise, addressing these challenges is crucial for maximising their potential. This research contributes to the field by providing a comprehensive understanding of how LMS can be effectively utilised in educational settings, highlighting the importance of equipping educators with the necessary skills. The insights gained from this study can inform academic institutions and policymakers in designing and implementing training programs, ensuring that educators and learners can thrive in increasingly digital learning environments. Ultimately, this research emphasises the vital role of LMS in shaping the future of education and the need for continuous adaptation and improvement in teaching practices
Perbedaan Penggunaan Alas Kaki Terhadap Prevalensi Jamur Penyebab Onikomikosis Pada Petani Di Kelurahan Handil Bakti Palaran
No full textOnikomikosis atau dikenal sebagai infeksi jamur kuku ditemukan di seluruh dunia dengan angka kejadian cukup tinggi di Indonesia. Infeksi jamur pada kuku dapat disebabkan oleh jamur dermatofita, non dermatofita dan yeast. Petani merupakan pekerjaan yang berisiko terjadinya onikomikosis karena lingkungan kerja yang berair mendukung terjadinya infeksi jamur pada kuku. Penggunaan alas kaki yang tertutup dalam waktu lama juga akan merangsang tumbuhnya jamur. Tujuan penelitian ini untuk mengetahui perbedaan penggunaan alas kaki terhadap prevalensi tumbuhnya jamur penyebab onikomikosis pada petani. Penelitian ini menggunakan studi observasional analitik dengan pendekatan cross sectional. Sampel berjumlah 60 kuku kaki petani dengan teknik purposive sampling. Pengambilan data menggunakan lembar observasi dan pengambilan kuku kaki pada petani di Kelurahan Handil Bakti Palaran. Metode pemeriksaan dilakukan pengamatan makroskopis dengan kultur jamur pada media SDA (Sabouraud Dextrose Agar) dan pengamatan mikroskopis dengan pembuatan slide kultur. Analisa data menggunakan uji chi square. Hasil penelitian didapatkan jamur yang paling banyak menyebabkan onikomikosis dari golongan non dermatofita yaitu Aspergillus sp (60,0%) dan golongan dermatofita yaitu Trichophyton sp (10,0%). Jamur penyebab onikomikosis pada petani yang menggunakan alas kaki sebesar 36,7% dan yang tidak menggunakan alas kaki sebesar 48,3% dengan analisis statistik p-value sebesar 0,026 (<0,05), maka disimpulkan terdapat perbedaan signifikan terhadap alas kaki dengan kejadian onikomikosis. Petani diharapkan dapat meningkatkan kesadaran akan pentingnya penggunaan alas kaki dan selalu menjaga pola hidup bersih dan sehat saat bekerja
Perbedaan Penggunaan Antikoagulan K3EDTA Konvensional dan Vacutainer Terhadap Kadar Indeks Eritrosit Menggunakan Hematology Analyzer
No full textAntikoagulan adalah zat yang digunakan untuk mencegah terjadinya pembekuan pada sampel darah. Pada pemeriksaan hematologi yang sering digunakan adalah antikoagulan K3EDTA. Keunggulan K3EDTA adalah tidak mempengaruhi morfologi dari komponen darah. Ketersediaan EDTA ada 2 bentuk yaitu konvensional (dengan melarutkan EDTA dari bentuk serbuknya) dan vacutainer (EDTA yang sudah siap pakai di tabung vacutainer ungu). Penggunaan 2 bentuk EDTA tersebut memiliki kelebihan dan kekurangn masing – masing. Penelitian ini bertujuan untuk mengetahui perbedaan penggunaan antikoagulan K3EDTA konvensional dan vacutainer terhadap kadar indeks eritrosit menggunakan hematology analyzer. Analisis data menggunakan uji T Independen. Setelah dilakukan pengujian, diperoleh p>0.05 yang artinya tidak terdapat perbedaan. Berdasarkan hasil tersebut dapat disimpulkan bahwa tidak terdapat perbedaan penggunaan antikoagulan K3EDTA konvensional dan vacutainer terhadap kadar indeks eritrosit menggunakan hematology analyzer
Analisa Status Gizi Anak yang Mendapatkan Obat Cacing pada Puskesmas Pattingalloang Makassar
No full textIndonesia masih menghadapi masalah kecacingan yang tinggi akibat iklim tropis, kelembapan udara, serta rendahnya tingkat kebersihan dan kesadaran masyarakat. Infeksi kecacingan yang ditularkan melalui tanah (Soil-Transmitted Helminth/STH) terutama menyerang anak usia sekolah, menyebabkan gangguan penyerapan gizi dan anemia yang berdampak pada pertumbuhan serta produktivitas. Pemberian obat cacing seperti albendazol atau mebendazol secara rutin setiap enam bulan menjadi strategi utama dalam pengendalian kecacingan. Penelitian ini bertujuan untuk mengetahui status gizi anak sebelum pemberian obat cacing, mengetahui status gizi anak setelah pemberian obat cacing, serta untuk menganalisis perbandingan status gizi anak sebelum dan setelah pemberian obat cacing. Penelitian ini adalah deskriptif analitik yang dilakukan dengan pendekatan cross-sectional. Hasil penelitian menunjukkan bahwa mayoritas anak memiliki status gizi normal (82%) sebelum pemberian obat, dengan distribusi lainnya meliputi risk of overweight (10%), overweight (4%), dan gizi kurang (4%). Setelah pemberian obat, terjadi penurunan anak dengan status gizi normal menjadi 78%, sementara kasus overweight meningkat menjadi 12% dan risk of overweight 10%. Pemberian obat cacing memberikan dampak signifikan terhadap status gizi anak dengan peningkatan rata-rata dari 3,14 menjadi 3,34 (didapatkan nilai P-value 0,04). Maka dapat disimpulkan bahwa Pemberian obat cacing secara rutin menunjukkan perubahan pada distribusi status gizi anak. Mayoritas tetap dalam kategori gizi normal, dengan beberapa pergeseran pada kategori overweight dan risk of overweight
Analisis Aktivitas Antibakteri Ekstrak Daun Kelor (Moringa oleifera Lam.) Terhadap Pertumbuhan Pseudomonas aeruginosa
No full textMoringa leaves (Moringa oleifera Lam.) are known to have various health benefits, one of which is their potential as an antibacterial agent. This study aims to activate the antibacterial activity of moringa leaf extract against the growth of Pseudomonas aeruginosa. The test was carried out with five treatments, namely moringa leaf extract with concentrations of 15%, 30%, 50%, positive control, and negative control. The well diffusion method was used in the test, with incubation at 37°C for 24 hours. The diameter of the inhibition zone was measured as an indicator of effectiveness. The results showed that a concentration of 15% did not produce an inhibition zone, while concentrations of 30% and 50% showed an average inhibition zone of 0.87 mm and 2.85 mm, respectively. Based on the CLSI criteria, all results were divided into resistant because the size of the inhibition zone was ≤ 15 mm. Thus, it can be concluded that moringa leaf extract has not shown optimal effectiveness in inhibiting the growth of Pseudomonas aeruginosa.