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Molecular Docking Study of Substituted Benzamide Derivatives as Analgesic Candidates
No full textThiourea derivatives represent a diverse class of compounds exhibiting a range of pharmacological activities, including antitubercular, analgesic, antiviral, and anticancer effects. Of particular interest is N-allyl-N'-(benzoylcarbamothioyl)benzamide, which is hypothesized to possess analgesic properties. A comprehensive in silico molecular docking study was undertaken to evaluate this potential. In silico assays, leveraging computer simulations, are invaluable tools for predicting outcomes, generating hypotheses, and accelerating drug discovery. Molecular docking, a prominent in silico application, facilitates structure-based screening by computationally assessing the binding affinity of compounds to target proteins. This research specifically aimed to predict the analgesic activity of N-allyl-N'-(benzoylcarbamothioyl)benzamide derivatives. To achieve this, various substituents, including methyl, methoxy, tert-butyl, dimethylamino, and halogens, were strategically incorporated at the ortho, meta, and para positions of the benzoylcarbamothioyl ring, generating a library of novel analgesic drug candidates. Compound activity was primarily evaluated using the rerank score. Additionally, ProTox-3.0 and pkCSM were utilized to predict these synthesized compounds' toxicity and physicochemical properties. Initial findings were encouraging, with 18 derivatives of N-allyl-N'-(benzoylcarbamothioyl)benzamide demonstrating enhanced predicted analgesic activity. Among these, six compounds exhibited promising analgesic properties without predicted toxicity. In conclusion, these in silico results suggest that certain N-allyl-N'-(benzoylcarbamothioyl)benzamide derivatives hold significant promise as potential analgesic agents, warranting further validation through subsequent laboratory and in vivo investigations
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 8 No. 3 August 2025: From Borneo's Bounty to Global Insights: Embracing Natural Products and Computational Innovation in Pharmacy
No full textAssalamu’alaikum Wr. Wb.
Alhamdulillahirabbil ‘alamin. The newest edition of Borneo Journal of Pharmacy (Borneo J Pharm) was published in August 2025. This edition contains ten articles: Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Analytical Pharmacy-Medicinal Chemistry, Microbiology Pharmacy, Natural Product Development, Clinical-Community Pharmacy, and Management Pharmacy. This edition includes writings from three countries: India, Indonesia, and Russia. The authors come from several institutions, including Universitas Pakuan, Universitas Surabaya, Universitas Airlangga, Universitas Sam Ratulangi, Universitas Muslim Indonesia, Uttaranchal University, Virtual Research Center for Bioinformatics and Biotechnology, Universitas Brawijaya, Ural State Agrarian University, Gorbatov Research Center for Food Systems, South Ural State Agrarian University, Yaroslav-the-Wise Novgorod State University, Universitas Islam Negeri Mataram, Universitas Ma Chung, National Research and Innovation Agency of the Republic of Indonesia, Universitas Mulia, Universitas Muhammadiyah Klaten, Rumah Sakit Umum Pusat Dr. Sardjito, Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Universitas Sari Mulia, and Universitas Muhammadiyah Yogyakarta.
This collection of articles powerfully showcases the journal's commitment to advancing pharmaceutical science across three vital frontiers: natural products research, cutting-edge computational analysis, and health system optimization. The research presented here not only taps into the rich biodiversity of Indonesia, particularly the Borneo region and its cultural connections, but also leverages modern technology to accelerate drug discovery and enhance patient care.
Harnessing Nature's Pharmacopoeia
A significant portion of this issue is dedicated to the scientific validation of traditional remedies, highlighting the pharmacological promise of flora from the region and beyond.
In a compelling in vivo study, the effect of javanese chili (Piper retrofractum) and lemon (Citrus limon) formula on total cholesterol levels in male white rats demonstrates the potential of optimizing herbal combinations. The research found that the two extracts' specific ratios (1:1 and 1:2) yielded substantial hypocholesterolemic effects, even superior to the positive control simvastatin. This reinforces the necessity of dosage and ratio optimization in herbal formulation.
Further contributing to the natural products sphere, comparison of characteristics and antibacterial activity of mandai cempedak vinegar with variations in fermentation methods explores a traditional fermented food product from East Kalimantan. This work characterizes the potential probiotic lactic acid bacteria (LAB) from Mandai vinegar, providing a valuable foundation for its future development as a functional food ingredient.
Rounding out this theme, two studies focus on the ubiquitous red ginger (Zingiber officinale var. rubrum). Comparison of chromatogram profiles of red ginger (Zingiber officinale var. rubrum Theilade) rhizome essential oil based on differences in growing places provides critical industrial insight, showing that geographic location significantly alters the vital oil composition—a finding crucial for standardization and quality control. Complementing this, the physicochemical profile and stability of red ginger (Zingiber officinale var. rubrum) SNEDDS as a potential aphrodisiac demonstrates that advanced delivery systems, specifically SNEDDS, can effectively enhance the stability of this valuable extract, paving the way for superior pharmaceutical products.
Accelerating Drug Discovery with In Silico Power
This issue strongly features the application of computational pharmacy, demonstrating how molecular docking and predictive modeling are revolutionizing the identification of new drug candidates: In silico analysis of the antigastritis activity of gedi (Abelmoschus manihot) flower flavonoids on H2 receptor identified quercetin as a key flavonoid in gedi flower with promising potential as an H2 antagonist for gastritis treatment; molecular docking analysis of flavonoids from Syzygium cumini (L.) Skeels: proapoptotic potential as an anticancer mechanism points to epigallocatechin 3-O-gallate and ellagic acid as potent anti-Non-Small Cell Lung Cancer (NSCLC) agents, targeting key apoptotic proteins; and molecular docking study of substituted benzamide derivatives as analgesic candidates employed computational screening to identify promising derivatives of N-allyl-N'-(benzoylcarbamothioyl)benzamide, generating a library of novel compounds that warrant further in vivo validation. These studies underscore the efficiency of in silico methods in prioritizing targets, saving resources, and guiding future laboratory investigations. They are further supported by discovery of novel alkaloids from Magnolia Genus: a literature review from 2002-2024. This comprehensive review consolidates the recent identification of novel bioactive alkaloids, providing a roadmap for natural product drug development.
Advancing Clinical Pharmacy and Health Economics
Beyond product development, the journal remains committed to applied research that improves healthcare delivery: balancing need and feasibility: stakeholder insights on frequent blood glucose monitoring in Indonesia provide a qualitative analysis of the barriers (e.g., irregular patient visits, negative emotions) and facilitators (e.g., active role of pharmacists, free NHI testing) to essential blood glucose and HbA1c monitoring. This research is crucial for developing targeted strategies to ensure medication effectiveness and patient safety in primary care settings, and finally, the cost analysis of inpatient stroke treatment at PKU Muhammadiyah Yogyakarta Hospital based on INA-CBG's tariff in 2023 delves into health economics, analyzing the financial feasibility of stroke management under the updated INA-CBG's reimbursement system. Such studies are vital for ensuring hospital sustainability and effective resource allocation within the national health insurance framework.
Collectively, this issue presents a vibrant mosaic of pharmaceutical research—from traditional phytochemistry and modern nanodelivery to computational screening and health policy analysis. We hope this diverse findings will inspire further collaboration between academic research, industry, and clinical practice, ultimately translating knowledge into better health outcomes.
Editorial boards are fully aware that there is still room for improvement in this edition; hence, with all humility, we are willing to accept constructive suggestions and feedback for improvements to the publication for the subsequent editions. The editorial board would like to thank all editors, reviewers, and contributors to the scientific articles who have provided the repertoire for this issue. We hope that all parties, especially the contributors, could re-participate in the publication in the next edition in November 2025.
Wassalamu’alaikum Wr. Wb
Analisis Penentuan Jenis Pondasi Konstruksi Gedung Menggunakan Data CPT: Analysis Of Foundation Type Determination For Building Constructions Using CPT Data
No full textThe increase in building infrastructure development in an area is certainly unavoidable. Soil, which is an important part of infrastructure development, certainly has provisions as a requirement to be used as a loan or good bearing capacity to receive the load above it so that it can maintain the stability of the construction above it. Not all soils have a stable bearing capacity for the construction above it. Soil investigations need to be used to determine the bearing capacity of the soil, so that the type of building construction foundation can be determined appropriately according to the CPT test data. The research location is in the Kupang Regency area and consists of 7 data collection locations. Soil physical test data is classified by AASTHO method and CPT test data is classified by soil type using qr and Fr relationship graph according to Robertson and Campanella and soil consistency according to Terzaghi and Peck. Based on the CPT data, the appropriate depth and type of foundation are determined. The CPT test results were then analysed to obtain the Permitted Bearing Capacityand Foundation Bearing Capacity values for each point. The analysis results show that all 7 locations have a foundation depth of ≥ 6 m and the appropriate foundation type is a mini pile foundation with a cylindrical size of Ø 0.50 m and a triangular size of 0.20 x 0.20 m
Fostering Ecological Awareness from an Early Age: Integrating Environmental Education Based on the Qur’an and Hadith into Primary School Learning
No full textThis study explores the integration of ecological messages from the Qur’an and Hadith into primary school education as a means to foster ecological awareness and character in young learners. Amidst the global environmental crisis, early education plays a pivotal role in shaping values and behaviors that support sustainability. While environmental themes are present in Indonesia’s primary curriculum, they often lack spiritual grounding. Islam offers rich theological and ethical foundations for environmental care, such as the prohibition of corruption (fasād), the role of humans as stewards (khalifah), the importance of balance (mīzān), and commands for cleanliness. This qualitative research utilizes document analysis and content analysis to examine how these values can be contextualized in classroom practices. The findings reveal that the Qur’an and Hadith provide not only cognitive knowledge but also spiritual and moral imperatives that can be internalized through thematic learning, project-based activities, and character education. The Merdeka Curriculum and the Pancasila Student Profile Strengthening Project (P5) enable cross-subject integration of Islamic ecological values in subjects like Islamic Education, Science, Social Studies, and Bahasa Indonesia. Teachers play a crucial role as value facilitators by modeling environmentally conscious behavior rooted in Islamic teachings. Furthermore, the involvement of families and communities enhances the educational impact, reinforcing that caring for the environment is an act of worship. This research contributes to the development of spiritually grounded environmental education strategies and highlights the potential of Islamic values to promote sustainable living from an early age
Evaluation of Career Counseling Management on Career Maturity: A Cipp Model-Based Correlational Study
No full textThis study evaluates career counseling management in three senior high schools in Palangka Raya City, Indonesia, using the CIPP model. Through a mixed methods approach, the study involved 186 grade XII students as well as in-depth interviews with counseling guidance teachers and school principals. The results showed that all CIPP dimensions were positively but weakly correlated with students' career maturity, with the Product dimension having the strongest relationship (r = 0.254). Multiple regression analysis showed a significant but limited influence of the CIPP dimensions on career maturity (R² = 0.109), with Product being the dominant predictor. Thematic analysis identified challenges with structural support, limited resources, and variable student engagement, indicating a gap between policy and practice. Overall, career counseling management is structured but not yet optimal in enhancing students' career maturity, requiring policy strengthening, resource development, and more personalized counseling strategies
Penerapan Model Pembelajaran Berbasis Proyek (PjBL) Menggunakan Scratch Untuk Meningkatkan Kreativitas dan Kemampuan Pemecahan Masalah Pada Siswa
No full textKeterampilan berpikir kreatif dan pemecahan masalah merupakan kompetensi utama abad ke-21 yang perlu dikembangkan dalam pembelajaran. Namun, pembelajaran informatika di SMP Negeri 1 Wonosari masih didominasi metode konvensional, sehingga siswa cenderung pasif dan mengalami kesulitan memahami materi seperti algoritma dan pemrograman. Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar siswa yang menggunakan model pembelajaran berbasis proyek (PjBL) berbantuan aplikasi Scratch dengan siswa yang menggunakan pembelajaran konvensional pada mata pelajaran Informatika. Penelitian ini menggunakan metode quasi eksperimen dengan desain nonequivalent control group design. Sampel terdiri dari dua kelas VIII, masing-masing 20 siswa. Instrumen penelitian berupa soal pre-test dan post-test. Analisis data meliputi statistik deskriptif, uji normalitas, uji homogenitas, serta uji hipotesis menggunakan Paired Sample t-Test dan Independent Sample t-Test. Hasil penelitian menunjukkan nilai signifikansi < 0,001 pada kedua uji, yang berarti terdapat peningkatan signifikan pada kelas eksperimen serta perbedaan signifikan antara kelas eksperimen dan kelas kontrol. Dengan demikian, model PjBL berbantuan Scratch terbukti lebih efektif dibandingkan pembelajaran konvensional dalam meningkatkan hasil belajar siswa pada mata pelajaran Informatika.
Kata kunci: Project-Based Learning, Scratch, Kreativitas, Pemecahan Masalah, Informatik
The Impact of Chromebook Integration on Student Engagement and Learning Outcomes in a Rural Junior High School: A Case Study at Junior High School Satap 4 Sematu Jaya
No full textIn the digital era, educational technology integration is becoming increasingly important, particularly in rural schools that lag in technology access and utilization. This study aims to analyze the impact of Chromebook use on student engagement and learning outcomes at SMP Satap 4 Sematu Jaya, a rural school that has recently adopted these devices. The research used a case study with data collection techniques through observation, interviews, document analysis, and questionnaires. Analysis was conducted qualitatively (thematic) and quantitatively (descriptive statistics). The results showed a significant increase in student engagement, both cognitively, emotionally, and behaviorally, after implementing Chromebooks. As many as 85% of students felt more motivated and were able to access digital learning resources that were previously unavailable. Average grades in Mathematics and Science increased by approximately 10% compared to before the use of Chromebooks.
Furthermore, there was an increase in students' digital literacy, including the ability to search for information and collaborate online. However, the study also identified obstacles, such as limited internet access, a lack of teacher training, and inequality of access at home for students from low-income families. These findings confirm that Chromebook integration can improve engagement and learning outcomes in rural schools if supported by adequate infrastructure, teacher training, and equitable access. In conclusion, technologies like Chromebooks have the potential to narrow the education gap in remote areas, but their success requires implementation strategies that adapt to local conditions
Persepsi Konsumen terhadap Kualitas Layanan: Analisis Psikologis pada Mixue dan Momoyo di Palangka Raya
No full textPenelitian ini bertujuan untuk menganalisis perbedaan kualitas layanan antara Mixue dan Momoyo di Kota Palangka Raya, serta mengidentifikasi aspek-aspek layanan yang paling berpengaruh terhadap kepuasan konsumen. Penelitian menggunakan pendekatan kuantitatif komparatif dengan teknik simple random sampling. Populasi penelitian mencakup konsumen kedua merek di Kota Palangka Raya, dengan sampel sebanyak 338 responden yang dihitung menggunakan rumus Slovin (margin of error 5%).Responden terdiri dari 169 konsumen Mixue dan 169 konsumen Momoyo yang dipilih secara acak dari 8 outlet Mixue dan 3 outlet Momoyo di Kota Palangka Raya. Data dikumpulkan melalui kuesioner dengan skala Likert (1–4) yang mengukur lima dimensi kualitas layanan (reliability, responsiveness, tangibles, assurance, dan empathy). Instrumen telah diuji validitas (r > 0,3) dan reliabilitas (Cronbach’s Alpha = 0,917). Hasil penelitian ini menunjukkan bahwa terdapat perbedaan signifikan kualitas layanan antara Mixue dan Momoyo, dengan Mixue lebih unggul dalam kecepatan respon dan keandalan. Rekomendasi untuk Momoyo mencakup pelatihan staf dan perbaikan fasilitas fisik, sementara Mixue perlu mempertahankan konsistensi layanan. Penelitian selanjutnya dapat mengeksplorasi pengaruh harga dan lokasi terhadap kepuasan konsumen
Model Pemilihan Kendaraan Umum Dan Kendaraan Pribadi Untuk Perjalanan Bekerja Di Kota Palangka Raya: Mode Choice Public Transportation And Private Vehicle For Work In Palangka Raya City
No full textLow utility of public transport has reduced a lot of public transport passenger numbers and increased use of private modes travel for work, so public transport should be solution has turned into a burden for transportation systems increase the traffic volume due to urban. This study aims to produce models to predict the behavior mode choice valid and reliable, for design the operating model of a competitive public transport and climate policies support the existence of public transportation. To find a way for public transport back to the main mode transportation that are reliable and have a major high utility as well as to suppress the use of motorcycles and private cars. The main model has used was polynomial discrete choice mode by developing a single answer choices at Palangka Raya. The Results has received 2 different logit models. Based on logit models of type I, to up the uses public transport, can be done by pressing the ownership of private vehicles by restricting ownership 1 motorcycle and 1 car. The calculation of logit model II, increasing the use of public transport, can be done by speeding up public transport travel time and adjust travel times using private modes
Peran Pembina Lapas Narkotika Dalam Penanaman Pendidikan Karakter Islami Bagi Warga Binaan
No full textThe problem behind this research is the lack of supervisors in the Class II A Kasongan prison, so that coaching cannot run optimally and this has an impact on prisoners who have been released from prison (returned to the community), still behave criminally, this is proven with the prisoners who are back to being drug suspects again. The purpose of this study is to describe 1) What is the role of narcotics prison supervisors in instilling Islamic character education for narcotics abuse convicts in Class II A Kasongan penitentiary. 2) Knowing the inhibiting factors for narcotics prison supervisors in instilling Islamic character education for narcotics abuse convicts in class II A Kasongan correctional institutions. 3) Knowing the efforts made by narcotics prison supervisors in planting Islamic character education for narcotics abuse convicts in Class II A Kasongan correctional institutions. This research is a qualitative research with a descriptive approach. The data collection techniques used are interviews, observation and documentation. The results of this study 1) The role of the Kasongan class II A narcotics prison supervisor is as a coach or mentor for prisoners so that they become aware and can play a role in social life after their detention period is over. 2) The inhibiting factor that occurs in the development of narcotics prisoners in the Class II A Kasongan prison is the lack of existing supervisors, making it quite difficult for prison residents to get guidance from someone who is competent in spiritual guidance. 3) The efforts that have been made by the prison itself are collaborating with the Ministry of Religion and the administrators of several mosques in the Kasongan area to add outside coaches to help carry out coaching in prisons