OBGYNIA - Indonesian Journal of Obstetrics & Gynecology Science
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The Role of Zinc-Rich Food Consumption on Zinc Level and the Incident of Preeclampsia
Get PDFObjective: Investigate the correlation between dietary intake of zinc, preeclampsia and blood zinc levels. Methods: This study, which compared pregnant women in the third trimester at the Wahidin Sudirohusodo Hospital and the educational network hospital with and without preeclampsia, used a Cross Sectional methodology. Zinc level testing was carried out at Prodia using ICP-MS method. Mann Whitney, Kruskal Wallis, and chi square tests were used to examine the data.Results: Preeclampsia group (n=38) and control group (n=40) were two groups made up of a total of 78 pregnant women. Zn level of severe preeclampsia (47.73 ± 11.23 ng/mL) was lower than preeclampsia (50.50 ± 13.59 ng/mL) and non-preeclampsia (50.58 ± 10.12ng/mL), but not significantly. Lower zinc rich-food consumption was a significant effect on zinc deficiency (p 0.05).Conclusion: Low intake of zinc-rich foods and occasionally exposure to cigarette smoke are the causes of zinc insufficiency in third trimester pregnancy, but has little impact on the occurrence of preeclampsia.Peranan Konsumsi Makanan Kaya Zink terhadap Kadar Zink dan Insiden PreeklamsiaAbstrak Tujuan: Mengetahui korelasi antara asupan zink, preeklamsia dan tingkat zink serum.Metode: Penelitian ini membandingkan ibu hamil trimester III di RS Wahidin Sudirohusodo dan RS jejaring pendidikan dengan dan tanpa preeklampsia menggunakan metodologi Cross Sectional. Pengujian kadar zink dilakukan di Prodia dengan menggunakan metode ICP-MS. Uji Mann Whitney, Kruskal Wallis dan Chi Square digunakan untuk menganalisis data. Hasil: Kelompok preeklamsia (n=38) dan kelompok kontrol (n=40) adalah dua kelompok yang terdiri dari total 78 ibu hamil. Kadar Zn preeklamsia berat (47.73 ± 11.23 ng/mL) lebih rendah dibandingkan preeklamsia (50.50 ± 13.59 ng/mL) dan non preeklamsia (50.58 ± 10.12ng/mL), tetapi tidak bermakna. Rendahnya konsumsi makanan kaya zink berpengaruh signifikan terhadap defisiensi zink (p0.05). Kesimpulan: Diet rendah zink dan paparan asap rokok adalah penyebab defisiensi zink pada kehamilan trimester III, tetapi memiliki dampak kecil terhadap insiden preeklamsia.Kata kunci: preeklamsia, kehamilan, zin
Gambaran Disfungsi Seksual Wanita pada Tenaga Medis di RSUP Dr. Hasan Sadikin Bandung
Get PDFTujuan: mengetahui gambaran disfungsi seksual wanita pada tenaga medis usia reproduksi di RSUP Dr. Hasan Sadikin Bandung (RSHS)Metode: penelitian ini adalah studi deskriptif observasional dengan pendekatan potong silang menggunakan data primer kuisioner Female Sexual Function Index (FSFI) berbahasa Indonesia dengan responden tenaga medis (perawat dan bidan). Karakteristik subjek meliputi usia, pendidikan, tempat tinggal, usia pasangan, paritas, lama menikah, pasca melahirkan dalam 6 bulan, riwayat trauma perineum, dan diabetes melitus. Apabila hasil FSFI ≤26,5, disimpulkan adanya disfungsi seksual. Dilakukan analisis menggunakan uji chi-square, Exact Fisher, dan Uji Kolmogorov smirnov. Nilai P 0,05).Kesimpulan: prevalensi disfungsi seksual wanita pada tenaga medis usia reproduktif di RSHS cukup tinggi mencapai 41,8%. Tidak didapatkan perbedaan yang bermakna baik dari berbagai sisi demografik pasien terhadap angka kejadian disfungsi seksual.Female Sexual Dysfunction among Reproductive Health Practitioners at Dr. Hasan Sadikin General HospitalAbstractObjective: to investigate female sexual dysfunction among reproductive-aged health practitioners at Dr. Hasan Sadikin General Hospital. Method: This was a descriptive cross-sectional study using primary data gained from validated Indonesian version of Female Sexual Function Index (FSFI) questionnaire, and filled by nurses and midwives. Subject characteristics include age, educational background, address, partner’s age, parity, marriage duration, having given birth in last 6 months, perineal trauma history and diabetes mellitus. If the FSFI score was ≤26,5, sexual dysfunction was present. An analysis involving each characteristic was performed using chi-squared test, Fisher’s Exact test and Kolmogorov-Smirnov test. P0.05). Conclusion: There was a high prevalence of female sexual dysfunction among health practitioners at Dr. Hasan Sadikin Hospital amounting to 41.8%. There was no statistically significant difference between various demographic aspects and female sexual dysfunction. Key words: Sexual Dysfunction, Health Practitioners, FSF
Hubungan antara Resistensi Insulin dan Kadar Hepsidin (Regulator Zat Besi) Terhadap Fenotipe Sindrom Ovarium Polikistik (SOPK)
Get PDFTujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara Resistensi Insulin dan kadar hepsidin serum terhadap fenotipe Sindrom Ovarium Polikistik (SOPK). Resistensi insulin dan hiperinsulinisme yang terjadi pada SOPK dapat meningkatkan eritropoiesis, yang dapat menyebabkan penurunan regulasi ekspresi hepsidinMetode: Penelitian ini menggunakan metode cross sectional dan dilakukan di beberapa rumah sakit pendidikan di Makassar, Indonesia. Kami memasukkan pasien yang didiagnosis dengan sindrom ovarium polikistik (SOPK) berusia 18-40 tahun. Resistensi Insulin diperiksa mengunakan metode HOMA-IR dan kadar hepsidin diperiksa menggunakan metode enzyme-linked immunosorbent assay (ELISA) pada semua subjek yang memenuhi syarat. Hasil yang diperoleh selanjutnya dianalisis secara statistik.Hasil: Sebanyak 52 pasien SOPK dilibatkan dalam penelitian ini, 40 pasien dengan resistensi insulin dan 12 pasien tanpa resistensi insulin. Setelah memeriksa kadar hepsidin serum, kami tidak menemukan perbedaan resistensi insulin diantara keempat fenotipe SOPK (p>0,05), namun terdapat perbedaan kadar hepsidin SOPK fenotipe A dengan fenotipe C (p0.05), however there is PCOS level difference of phenotype A and phenotype C (p<0.05). We observed as well medium negative correlation between serum hepcidin level and the homeostatic model assessment for insulin resistance (HOMA-IR) (r=-0.419; p<0.05).Conclusions: Correlation is found where the higher the insulin resistance, the lower the hepcidin serum level. Also no difference is observed in insulin resistance of PCOS among the four phenotypes, however serum hepcidin level difference is indicated higher on PCOS phenotype A compared to that of PCOS phenotype C.Key words: polycystic ovarian syndrome, hepcidin, insulin resistanc
Perbandingan Respon Terapi dan Toksisitas Regimen Kemoterapi Kombinasi antara Paclitaxel, Carboplatin, dan Ifosfamide (TIP) dengan Paclitaxel dan Carboplatin (TP) pada Kanker Serviks Stadium IIb
Get PDFTujuan: Mengetahui perbandingan respon terapi dan toksisitas regimen kemoterapi kombinasi Paclitaxel Carboplatin Ifosfamide dengan Paclitaxel Carboplatin pada kanker serviks stadium IIB.Metode: Sebanyak 30 pasien yang baru terdiagnosis kanker serviks stadium IIB dibagi menjadi dua kelompok terapi kombinasi yaitu kelompok Paclitaxel-Carboplatin-Ifosfamide (TIP) dan Paclitaxel-Carboplatin (TP). Volume tumor dan respon terapi diukur sebelum dan sesudah tiga siklus kemoterapi.Hasil:Tingkat penurunan rata-rata volume tumor pada kelompok Paclitaxel-Carboplatin-Ifosfamide dan Paclitaxel-Carboplatin sebesar (23,66% vs 39,08%). Tidak ada perbedaan secara bermakna angka respon parsial, angka respon progresif dan tidak ada respon antara kelompok dengan Paclitaxel-Carboplatin-Ifosfamide dengan kelompok Paclitaxel-Carboplatin dengan p > 0,05. Hasil antara Paclitaxel-Carboplatin-Ifosfamide dan Paclitaxel-Carboplatin pada respon parsial (46,7 % vs 73,3%), respon progresif (13,3% vs 13.3%), dan tidak ada respon (40,0 % vs 1,3%) dan toksisitas kelas 2 lebih dominan pada kelompok Paclitaxel-Carboplatin-Ifosfamide yaitu mual, kerontokan (53,3%) dan fatique, muntah (46,7%).Kesimpulan: Regimen kemoterapi kombinasi Paclitaxel-Carboplatin lebih efektif dalam menurunkan ukuran tumor kanker serviks stadium IIB dengan efek samping yang lebih minimal dibandingkan kombinasi Paclitaxel-Carboplatin-Ifosfamide.Comparison of Therapy Response and Toxicity of Combination Chemotherapy Regimens Between Paclitaxel, Carboplatin And Ifosfamide (PCI) with Paclitaxel and Carboplatin (PC) in Stadium IIB Cervical CancerAbstractObjective: To compare the therapeutic response and toxicity of a combination chemotherapy regimen of Paclitaxel Carboplatin Ifosfamide with Paclitaxel Carboplatin in stage IIB cervical cancer. Methods: A total of 30 patients newly diagnosed with stage IIB cervical cancer were divided into two combination therapy groups, namely the Paclitaxel-Carboplatin-Ifosfamide (PCI) and Paclitaxel-Carboplatin (PC) groups. Tumor volume and clinical response were measured before and after three cycles. Result: The average reduction rate of tumor volume in the Paclitaxel-Carboplatin-Ifosfamide and Paclitaxel-Carboplatin groups was (23.66% vs 39.08%). There was no significant difference in the partial response rate, progressive response rate and no response between the Paclitaxel-Carboplatin-Ifosfamide group and the Paclitaxel-Carboplatin group with p > 0.05. Results between Paclitaxel-Carboplatin-Ifosfamide and Paclitaxel-Carboplatin on partial response (46.7% vs 73.3%), progressive response (13.3% vs 13.3%), and no response (40.0% vs 1, 3%) and class 2 toxicity was more dominant in the Paclitaxel-Carboplatin-Ifosfamide group namely nausea, hair loss (53.3%) and fatigue, vomiting (46.7%). Conclusion: The Paclitaxel-Carboplatin combination chemotherapy regimen is more effective in reducing the tumor size of stage IIB cervical cancer with lower side effects than the Paclitaxel-Carboplatin-Ifosfamide combination.Key words: cervical cancer, chemotherapy, side effect
Hubungan Antara Neutrophil Gelatinase Associated Lipocaline (NGAL) dan Kejadian Preeklamsia: Penelitian Potong-Lintang
Get PDFTujuan: Untuk mengetahui hubungan antara kadar Neutrophil Gelatinase Associated Lipocaline (NGAL) pada kehamilan normal, Preeklamsia Berat (PEB) tanpa Komplikasi, dan PEB dengan Komplikasi.Metode:Desain penelitian cross sectional dilakukan pada ibu hamil dengan usia kehamilan lebih dari 20 minggu di RSUP Dr. Wahidin Sudirohusodo dan rumah sakit jejaring pendidikan lainnya sejak bulan Januari hingga Juni tahun 2022. Data dikumpulkan menggunakan sampel darah dan diperiksa lebih lanjut dengan metode ELISA. Uji Chi-Square digunakan untuk menganalisis hubungan antara kadar NGAL dan derajat keparahan PEB.Hasil: Pada penelitian ini mencakup 156 sampel, yang terdiri atas wanita hamil normal (n=53), wanita hamil dengan PEB tanpa komplikasi (n=50), dan wanita hamil dengan PEB dan komplikasi (n=53). Penelitian ini menemukan bahwa semakin berat derajat preeklamsia, maka semakin rendah kadar NGAL-nya yaitu kadar NGAL diamati pada 58% wanita PEB dengan komplikasi dan 32,1% wanita PEB tanpa komplikasi dan 9,8% pada kehamilan normal (p <0,05). Hasil penelitian ini tidak sesuai dengan teori yang menemukan peningkatan kadar NGAL pada pasien PEB. Penurunan kadar NGAL ini mungkin dapat disebabkan oleh prevalensi obesitas yang banyak pada kelompok PEB dengan dan tanpa komplikasi. Obesitas merupakan kondisi inflamasi sistemik dan NGAL dapat bertindak sebagai regulator negatif terhadap aktivitas inflamasi yang dimediasi oleh disfungsi adiposit. Pada kelompok PEB juga didapatkan pemberian MgSO4, yang memiliki peran untuk menghambat kadar IL-6 sehingga dapat menurunkan kadar NGALKesimpulan: Penurunan kadar NGAL berpotensi untuk menjadi biomarker dalam menilai derajat keparahan preeklamsia.Correlation Between Neutrophil Gelatinase Associated Lipocaline (NGAL) and Preeclampsia: A Cross-sectional StudyAbstract Objective: to observe the correlation between level of Neutrophil Gelatinase Associated Lipocaline (NGAL) on normal pregnancy, severe preeclampsia (SPE) without complication, & SPE with complication. Method: Cross-sectional Study Design method is performed on pregnant women with gestational age of more than 20 weeks at Dr. Wahidin Sudirohusodo hospital & the other educational networking hospitals from January to June 2022. Data were collected using blood samples & further examined with ELISA method. Chi-Square test is used to analyze the correlation between NGAL level & degree of severity of the severe preeclampsia.Results: this study includes 156 samples consisting of normal pregnant women (n=53), pregnant women with SPE without complication (n= 50), & pregnant women with SPE with complication (n= 53), we found out that the more severe the degree of preeclampsia, the lower the level of NGAL where the level of NGAL is observed on 58% of pregnant women with complication & 32.1% pregnant women without complication, & 9.8% on women with normal pregnancy (p<0.05). This study result is irrelevant with the theory which found the rising level of NGAL on patients with SPE, this decreasing level of NGAL might be caused by obesity prevalence mostly found on pregnant with & without complication since obesity is a systemic inflammatory condition & NGAL can act as negative regulator against inflammatory activity mediated by adipocyte disfunction. On SPE group there is also MgSO4 administration functioning as a hindrance for IL6 level thus may lessen the NGAL level.Conclusion: the decreasing level of NGAL is potential to become a biomarker in evaluating the severity of preeclampsia.Key words: degree of severity, Neutrophil Gelatinase Associated Lipocaline, preeclampsi
Gambaran Faktor Risiko Kanker Endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022
Get PDFTujuan: Mengetahui faktor risiko pasien kanker endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022.Metode: Penelitian metode deskriptif dengan menggunakan data sekunder. Kriteria inklusi yaitu pasien dengan diagnosis utama kanker endometrium.Hasil: Mayoritas pasien kanker endometrium berusia 50 – 59 tahun (34,8%), multipara (40,9%), Indeks Masa Tubuh ≥25 kg/m2 (33,2%), usia menarche ≥12 tahun (68,8%), tidak memiliki riwayat infertilitas (49,0%), belum menopause (36,4%), tidak memiliki riwayat terapi hormon (74,1%), pasien tidak memiliki riwayat kanker/lynsch syndrome (71,7%), tidak memiliki riwayat keluarga dengan lynch syndrome (75,7%), tidak menggunakan kontrasepsi (42,5%), dan tidak memiliki riwayat hipertensi (72,9%).Kesimpulan: Pasien kanker endometrium di RSUP Dr. Hasan Sadikin Bandung periode tahun 2020 – 2022 ditemukan paling banyak pada rentang usia 50 – 59 tahun, status paritas yaitu multi para (≥2 kelahiran hidup), indeks massa tubuh ≥25 (obesitas), belum menopause, usia menarche ≥12 tahun, tidak memiliki riwayat terapi hormon, tidak terdapat riwayat infertilitas, pasien tanpa riwayat kanker, tidak memiliki riwayat keluarga dengan kanker, tidak menggunakan kontrasepsi, dan tidak memiliki riwayat hipertensi.Overview of Endometrial Cancer Risk Factors at RSUP Dr. Hasan Sadikin in 2020 - 2022AbstractObjective: Indentifying the risk factor of endometrial cancer patients at RSUP Dr. Hasan Sadikin in 2020 - 2022.Method: This research used descriptive method by collecting secondary data. The inclusion criteria was patients with primary diagnosis of endometrial cancerResults: In this research, the majority of endometrial cancer patients were aged 50 - 59 years (34,8%), multiparous (40,9%), with body mass index ≥25 kg/m² (33,2%), menarche age of ≥12 years (68,8%), no history of infertility (49,0%), not menopausal yet (36,4%), no history of hormone therapy (74,1%), no patient history of cancer/Lynch syndrome (71,7%), no family history of lynch syndrome (75,7%), no history of contraceptive use (42,55), and no history of hypertension (72,9%).Conclusion: In 2020 - 2022, endometrial cancer patient in Dr. Hasan Sadikin Central General Hospital Bandung were mostly foung in the aged range 50 - 59 years, multiparous, obesity, not menopausal yet, menarche age of ≥12 years, no history of hormone therapy, no patient and family history of cancer, no history of contraceptive use and hypertension.Key words: Endometrial cancer, risk factor, descriptive stud
Efektifitas Penerapan Bundles IDO Sectio Caesarea: Scoping review
Get PDFTujuan: Tinjauan ini bertujuan untuk mengidentifikasi literatur tentang bundles IDO yang telah terbukti berhasil menurunkan angka kejadian IDO, dapat dijadikan panduan dalam penerapan bundles IDO pada pasien SC Metode: Pencarian dilakukan di beberapa database yaitu PubMed, Scopus dan CINAHL dengan kata kunci yang digunakan yaitu P=Pasien Post-operasi SC OR Cesarean Delivery, Concept=Surgical Site Infections OR SSI, Context=Bundles OR Procedure.Hasil: Delapan belas studi yang melibatkan total 24450. Tiga studi RCT, tujuh Cohort Studi retrospektif, lima Cross Sectional Studi, satu experiment dan dua Case Control studi. Kesimpulan: Bundles IDO terdiri dari Preoperasi: Mandi preoperasi,tidak dilakukan pencukuran rambut,bila mengganggu pakai clipper electrik, pertahankan kadar gula darah ≤200 mg/dl. Intraoperasi: Pemberian Antibiotik, skin dan vaginal preparasi, pertahankan normothermia, kebersihan tangan, penggantian sarung tangan dan set instrument, gunakan jahitan khusus untuk penutupan subkutan dan penutupan kulit. Post operasi: Pertahankan kadar gula darah ≤200 mg/dl, segera lepas kateter urine maksimal 24 jam kecuali ada indikasi, penggantian wound dressing Postoperative day 2, Edukasi Pasien tentang perawatan luka post operasi. Bundles ini dapat menurunkan angka kejadian infeksi IDO pada pasien yang dilakukan operasi SC.The Effectiveness of Implementing IDO Sectio Caesarea Bundles: Scoping reviewAbstractObjective: This review aims to identify the literature on SSI bundles which have been proven successful in reducing the incidence of SSI, which can be used as a guide in implementing SSI bundles in SC patients.Method: The search was carried out in several databases, namely PubMed, Scopus and CINAHL with the keywords used, namely P=Postoperative SC OR Cesarean Delivery Patient, Concept=Surgical Site Infections OR SSI, Context=Bundles OR Procedure.Results: Eighteen studies involving a total of 24450. Three RCT studies, seven Cohort Retrospective Studies, five Cross Sectional Studies, one experimental and two Case Control studies.Conclusion: SSI Bundles consist of Pre-surgery: Pre-surgery shower, no hair cutting, use an electric clipper if it bothers you, maintain blood sugar levels ≤200 mg/dl. Intraoperative: Administration of antibiotics, skin and vaginal preparation, maintain normothermia, hand hygiene, change of gloves and instrument sets, use special sutures for subcutaneous closure and skin closure. Post surgery: Maintain blood sugar level ≤200 mg/dl, immediately remove the urinary catheter for a maximum of 24 hours unless there is an indication, replace the wound dressing Postoperative day 2, educate patients about postoperative wound care. These bundles can reduce the incidence of SSI infections in patients undergoing SC surgery.Key words: Bundles, SSI, Post-Sesection Caesarean Patient
Effect Of Corona Virus Disease 2019 (Covid-19) on the Incidence of Preterm Birth And Asphyxia at Banjar Regional General Hospital
Get PDFObjective: This study aims to determine and analyze the effect of Corona Virus Disease (Covid-19) on the incidence of preterm birth and asphyxia at Banjar Regional General Hospital. Method: This was an analytical observational study with a retrospective cohort approach. The type of data involved in this study was secondary data derived from medical record with a total sample of 59 women in labor diagnosed with Covid-19 and 513 women in labor who were not diagnosed with Covid-19.Results : The result of the study showed that there was a significant difference in the incidence of preterm birth between women in labor diagnosed with Covid-19 and those who were not diagnosed with Covid-19 (ρ value=0.000 or ρ0.05. Women diagnosed with Covid-19 were at risk of giving birth to premature infants 5.308 times compared to women not diagnosed with Covid-19. The OR of the incidence of preterm birth was 5.308 with a 95% CI of 3.035-9.281. Furthermore, based on the statistical test result, it was revealed that Covid-19 had a low effect on the incidence of asphyxia with the OR value of 0.839 and a 95% CI of 0.489-1.439.Conclusion: Based on the results of the study, it can be concluded that there was an effect of Covid-19 just on the incidence of preterm birth.Pengaruh Corona Virus Disease 2019 (Covid-19) terhadap Kejadian Prematur dan Asfiksia di RSUD Kota BanjarAbstrak Tujuan: Penelitian ini mengukur dan menganalisis pengaruh Corona Virus Disease (Covid-19) terhadap kejadian prematur dan asfiksia di RSUD Kota Banjar. Metode: Penelitian berupa analitik observasi dengan pendekatan kohor retrospektif. Jenis data dalam penelitian ini adalah data sekunder dari rekam medis dengan jumlah sampel menggunakan total sampel yaitu 59 ibu bersalin dengan Covid-19 dan 513 ibu bersalin tidak dengan Covid-19.Hasil: Hasil penelitian menunjukkan terdapat perbedaan yang bermakna kejadian prematur pada Ibu Covid-19 dengan ibu yang tidak terdiagnosis Covid-19 (nilai ρ0.000) yang artinya p0.05. Ibu dengan Covid-19 berisiko melahirkan bayi prematur 5.308 kali dibandingkan pada ibu yang tidak terdiagnosis Covid-19, nilai OR kejadian prematur 5.308 dengan IK 95% 3.035-9.281. Dan dari hasil uji statistik diperoleh hasil yaitu Covid-19 berpengaruh rendah terhadap kejadian asfiksia dengan hasil uji statistik nilai OR 0.839 dengan IK 95% 0.489-1.439. Kesimpulan: Dari hasil penelitian dapat disimpulkan bahwa terdapat pengaruh Covid-19 terhadap kejadian prematur.Kata kunci: Asfiksia, Covid-19, Prematu
Optimal Maternal-Fetal Interface Environment Affects Neonatal Viability in Preterm Preeclampsia and IUGR Pregnancy
Get PDFObjective: to report rare case of fetal viability on preterm pregnancy with preeclampsia and IUGRMethods: case reportCase: A 29-year-old woman (G1P0A0) at 29 weeks of gestation, came to the Obstetrics and Gynecology Outpatient Clinic of Bhayangkara Tk. I R. Said Sukanto Police Hospital Jakarta with complaints of left-sided headache since 25 weeks of gestation. After examination, the patient was diagnosed with preeclampsia with IUGR. The caesaria section was performed at 28 weeks and a baby was born with BW: 850 grams, BL: 31 cm, and an APGAR score of 5/6. No inflammatory cells were found in chorionic villi. The baby continues to live after being treated in the NICU for 30 days.Conclusion: Optimal maternal fetal interface environment secures neonatal viability.Lingkungan Antarmuka Maternal-Fetal yang Optimal Mempengaruhi Kelangsungan Hidup Neonatal pada Kehamilan Prematur dengan Preeklamsia dan IUGRAbstrak Tujuan: untuk melaporkan kasus jarang viabilitas fetus pada kehamilan preterm dengan preeklampsia dan IUGRMetode: laporan kasusKasus: Seorang perempuan berusia 29 tahun (G1P0A0) dengan usia kehamilan 29 minggu, datang ke Poliklinik Obstetri dan Ginekologi Rumah Sakit Bhayangkara Tk. I R. Said Sukanto Jakarta mengalami pusing pada kepala sebelah kiri sejak usia kehamilan 25 minggu. Setelah pemeriksaan, pasien didiagnosa mengalami preeklamsia dengan perburukan IUGR. Operasi Seksio sesarea dilakukan pada usia kehamilan 28 minggu dan lahir seorang bayi dengan BB: 850 gram, PB: 31 cm, dan skor APGAR 5/6. Tidak ditemukan sel yang mengalami inflamasi pada vili chorionic. Bayi tetap hidup setelah dirawat di NICU selama 30 hari.Kesimpulan: Interaksi maternal fetal yang optimal menjamin viabilitas fetus.Kata kunci: Inflamasi, IUGR, Preeklamsia, Viabilitas Fetus, Preeklamsia
Correlation of Leucine-Rich-α-2-Glycoprotein- 1 (LRG-1) Level in Urine with Cervical Cancer Stage, Histology Type and Histology Grading
Get PDFObjective: To determine if the level of LRG-1 in urine correlates with cervical cancer stage, histology type and histology gradingMethod: This cross-sectional study using ELISA to test urinary LRG-1 of 59 cervical cancer patients. Data were analyzed using Kruskal-Wallis test.Results: From the total of 59 samples, LRG-1 in urine ranged from 0.48 ng/mL to 170.43 ng/mL, with median value 58.42 ng/mL. A median value of 21.42±52.29 ng/mL was found in the urine at early stage and 115.32±59.36 ng/mL at advanced stage. Most patients had cervical cancer at advanced stage (69.4%), squamous cell carcinoma (66.1%), and grade cannot be assessed (45.8%). Median LRG-1 levels were highest in squamous cell carcinoma (66.42±60.89 ng/mL) and poorly differentiated (127.74 ±54.13 ng/mL). LRG-1 levels were significantly correlated with cervical cancer stage (p-value=0.045) but not histological type (p-value=0.940) or histopathological grade (p-value=0.488).Conclusion: The more advanced the cervical cancer stage, the more elevated urinary LRG-1 levels. LRG-1 contributes to angiogenesis and antiapoptotic processes in cancer. Further studies are required to identify and evaluate LRG-1 in urine as an important biomarker for making clinical decisions and developing potential treatments.Hubungan Kadar Protein Leucine-Rich-α-2-Glycoprotein-1 (LRG-1) Urine dengan Stadium, Tipe Histologis, dan Derajat Diferensiasi Kanker ServiksAbstrakTujuan: Untuk mengetahui hubungan kadar LRG-1 dalam urine dengan stadium, tipe histologis, dan derajat diferensiasi kanker serviks.Metode: Studi ini menggunakan desain penelitian cross-sectional pada 59 perempuan yang telah didiagnosis kanker serviks, kemudian diperiksa kadar protein LRG-1 dalam urine dengan metode ELISA. Uji statistik menggunakan Kruskal Wallis. Hasil: Dari total 59 sampel didapatkan kadar LRG-1 dalam urine terendah 0,48 ng/mL dan tertinggi 170,43 ng/mL, nilai median 58,42 ng/mL. Nilai median pada stadium awal 21,42±52,29 ng/mL dan stadium lanjut 115,32±59,36 ng/mL. Lebih banyak penderita mengalami kanker serviks pada stadium lanjut (69,4%), tipe histopatologis Squamous Cell Carcinoma (66,1%), derajat diferensiasi tidak dapat ditentukan (45,8%). Median tertinggi kadar LRG-1 pada tipe Squamous Cell Carcinoma (66,42±60,89 ng/mL), dan derajat diferensiasi yang buruk (127,74±54,13 ng/mL). Terdapat hubungan yang signifikan antara kadar LRG-1 dan stadium kanker serviks (nilai p = 0,045), tetapi tidak dengan tipe histologis (nilai p=0,940) dan derajat diferensiasi (nilai p=0,488).Kesimpulan: Semakin tinggi stadium maka semakin tinggi kadar protein LRG-1 dalam urine. LRG-1 berperan dalam proses angiogenesis dan antiapoptosis pada kanker. Diperlukan penelitian lebih lanjut agar identifikasi dan evaluasi biomarker LRG-1 urine dapat menjadi penanda penting yang membantu dalam pengambilan keputusan klinis, serta pengembangan terapi.Kata Kunci: Derajat diferensiasi, Kanker serviks, LRG-1, Stadium, Tipe histologi