Bioscientia Medicina - Journal of Biomedicine and Translational Research
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Histopathological Features of Primary Cutaneous Diffuse Large B-Cell Lymphoma Leg Type: A Case Report
Get PDFBackground: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), is a rare and aggressive lymphoma with poor prognostic. It is difficult to diagnose PCDLBCL-LT at an early stage due to its nonspecific manifestations that overlap with other lymphomas. A histopathological examination can be performed to establish the diagnosis.
Case Presentation: A 74-year-old female presented with itchy red, swollen patches accompanied by a burning sensation on both her legs. Clinical examination revealed a hard ping pong ball-sized lump palpable on her left inner thigh. Haematoxylin eosin staining demonstrated the proliferation of diffused neoplastic cells, homogenous cells with atypical nuclei, and mitoses. Immunohistochemical examination revealed positive for CD 45 as well as CD 20 and negative for CD3. These findings were consistent with a diagnosis of PCDLBCL-LT.
Conclusion: The presented case demonstrates that skin lesions in patients with diagnosed PCDLBCL-LT may have a variable clinical presentation. Histologically is characterized by a diffuse dermal infiltrate mostly consisting of activated B-cell (centroblast) and activated lymphocyte (immunoblast), with high mitotic activity and a minimal T-reactive component. Immunohistochemical analysis is necessary for establishing the diagnosis of PCDLBCL-LT which shows positive markers for CD 45, CD 20, CD79a, Bcl-2, MUM-1, FOX-P1, CD10, IgM, CD 138, Ki-67, CD 30 and MYC
Antidiabetic Effectiveness Test of Andaliman Fruit (Zanthoxylum acanthopodium) Extract on Histopathological Changes in Peripheral Nerves: An In Vivo Study
Get PDFBackground: Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood sugar levels, and the increase in sugar levels is triggered by low insulin production or the ineffective use of insulin by the body (relatively). Diabetic neuropathy is a complication that often attacks DM patients and is the highest complication of diabetes. This study aims to test the effectiveness of Andaliman fruit (Zanthoxylum acanthopodium) extract on the improved histopathology of Peripheral nerve in alloxan-induced Wistar rats (Rattus norvegicus).
Methods: This study is an experimental study using 24 Wistar rats, which were grouped into 6 groups (1: normal, 2: negative control, 3: positive control, 4-6: DM + andaliman extract 150mg/kgBW, 250 mg/kgBW, 350 mg /kgBB). Data analysis used SPSS to determine differences in the histological conditions of peripheral nerves.
Results: The administration of andaliman fruit extract at a dose of 350 mg/kgBW was most effective in inhibiting the proliferation of Schwann cells, which showed the potential of andaliman fruit extract in preventing the progression of diabetic neuropathy. The administration of andaliman fruit extract at a dose of 350 mg/kgBW also showed the most effective potential in inhibiting the inflammatory process in the peripheral nerves, which is believed to be responsible for peripheral nerve cell damage.
Conclusion: Andaliman fruit (Zanthoxylum acanthopodium) extract is effective against improving the histopathology of peripheral nerves in alloxane-induced Wistar rats (Rattus norvegicus)
The Effectiveness of Health Promotion Strategies for Pregnant Women on Fe Tablet Consumption in the Work Area of Bebesen Health Center, Central Aceh Regency
Get PDFBackground: The distribution coverage of Fe tablets in Bebesen Health Center is still very low, even the lowest compared to other health centers in Central Aceh District, namely 12.40% for Fe1 and 10.56% for Fe3. Failure to achieve the distribution target of Fe tablets in the district can increase the prevalence of anemia. However, there is no clear reporting of anemia in pregnant women, let alone data on adherence to consuming Fe tablets. One of the reasons is the weak monitoring, recording, and reporting system of health workers in consuming Fe tablets and the lack of routine Hb level checks. This study aims to evaluate the effectiveness of health promotion strategies for pregnant women on the consumption of Fe tablets in the Bebesen Health Center Work Area.
Methods: Experimental research with participatory action research design (PAR). A sample of 44 pregnant women who were in the Bebesen Health Center area with a gestational age of more than 20 weeks or less than 20 weeks but was the first visit and had made a health visit to a health service place in the working area of the Health Center. Data analysis was carried out with SPSS. Version 25, in the form of univariate and bivariate analysis.
Results: The promotional strategy applied was effective in changing the mother's behavior in consuming Fe tablets, Zcount = 5.781 (Zcount > 1.96), and p-value = 0.000 (p<0.05).
Conclusion: Provision of effective health promotion strategies on consumption behavior of Fe tablets
Comparison of Recurrence Rates in Patients with Locally Advanced Breast Cancer after Mastectomy and Received Aromatase Inhibitor Therapy with Steroids and Nonsteroids
Get PDFIntroduction. Breast cancer is a problem that is still faced throughout the world. The incidence of cancer in Indonesia is at number 8 in Southeast Asia. The incidence of breast cancer in women is 42.1 per 100,000 population. Aromatase inhibitors are hormonal therapy used in postmenopausal breast cancer with positive ER and/or positive PR. The third generation aromatase inhibitors are divided into 2 categories, namely non-steroidal agents that are reversible and steroid agents that are irreversible. Based on existing studies, there are no consistent research results regarding the incidence of recurrence after aromatase inhibitor therapy, both steroids and non-steroidal.
Methods. This study is an analytical observational study with a retrospective cross-sectional design using secondary data from medical records. The research was carried out at the Surgical Clinic of RSUD dr. Soetomo Surabaya on October 1, 2020 until the end with the subject of LABC patients at POSA Surgery RSUD Dr. Soetomo who has undergone mastectomy and radiotherapy and has received adjuvant hormonal aromatase inhibitor therapy for 2 years from January 2018 to January 2020.
Results. In the nonsteroidal aromatase inhibitor group, 18 subjects (60%) experienced recurrence and 16 subjects in the steroid aromatase inhibitor group (32%) with an OR of 0.314 (0.12-0.81; p=0.014. Based on the results of multivariate analysis, it was found that the increased risk of recurrence was significantly affected only by the administration of aromatase inhibitor p= 0.052
Conclusion. Women with locally advanced breast cancer after mastectomy who received aromatase inhibitor steroid therapy had a 0.314 times lower risk of recurrence than those who received non-steroidal aromatase inhibitor therapy
Comparison of Omega-3 Serum Level Between Hiv-Aids Patients Along with Their Clinical Profiles and Healthy Population in Mohammad Hoesin General Hospital Palembang
Get PDFIntroduction. Human Immunodeficiency Virus (HIV) infection has been a concerning health problem worldwide. It causes reduction in body immune system and inflammation that can affect its clinical profile. Undergoing ARV therapy patients causes intestine microbiota dysbiosis and translocation that lead to imperfect absorbtion of fatty acid. One way to control microbiota dysbiosis is by controlling the nutritional factor, especially with omega-3. However, different regions upstands different custom in fish consumption especially those of which are rich in omega-3. The purpose of this research is to compare omega-3 serum level between HIV-AIDS patients and healthy population, as well as analyzing the correlation of omega-3 serum level with of HIV-AIDS patient clinical profile.Methods. The research will be applying observational analytic study using comparative study approach which will be performed in Tropical Infection Internal Medicine polyclinic and Medical Check-Up Polyclinic in RSMH Palembang starting from April 2020 until January 2021. Sample consisted of 32 HIV-AIDS patients from 20-58 years of age and 16 healthy population from 27-35 years of age on whom will be performed physical examination as well as clinical profile and omega-3 serum level examination. All data processing and analysis will be performed using SPSS v.25 for windows.Results. Out of 32 HIV-AIDS patients, we obtained low omega-3 serum level with median value at 3 (2-4) Umol/L, while in healthy population was 4 (3-6) Umol/L. Multivariate analysis inferred that the lower omega-3 serum level correlated with HIV-AIDS stage, duration of ARV therapy, blood pressure, and sex.Conclusion. Omega-3 serum levels in HIV-AIDS patients were lower than the healthy population. There was a correlation between omega-3 serum levels and their clinical profile of HIV-AIDS patients in Mohammad Hoesin General Hospital Palembang
Improving the Quality of Life for the Elderly with Degenerative Diseases through to the Charitas Group Virtual Health Education Program during the Pandemic of the COVID-19
Get PDFBackground: In the era of the COVID-19 pandemic, various problems were experienced by the elderly, especially those with degenerative diseases, as the population most at risk of being exposed to COVID-19. The elderly are vulnerable to decreased physical, mental and social health; therefore, a new and effective strategy is needed to improve healthy living behavior in this population. This study aimed to analyze the effect of the Charitas Group virtual health education program on improving the quality of life of the elderly with degenerative diseases in the era of the COVID-19 pandemic.
Methods: The One Group Pretest-Posttest Pre-Experimental study was with a sample of 33 patients selected by purposive sampling in May - July 2021. The data collection was taken using the World Health Organization Quality of Life – Bref (WHOQOL-Bref) form, translated and validated into Bahasa Indonesia. The data was then compared before and after the intervention and analyzed using the Paired Samples T-Test.
Results: The T-Test showed a significant difference between the pre-test and post-test results (p-value 0.041 < 0.05). At the same time, the other T-Test results showed a significant influence on the quality of life of the elderly in the specific domains, namely: Psychological (p-value 0.025), Social Relationship (p-value 0.033) and Environmental (p-value 0.034).
Conclusions: The Charitas Group virtual health education program significantly influences the quality of life of elderly people with degenerative diseases in the COVID-19 pandemic era
COVID-19 Health Protocol and Religious Activities: Knowledge, Attitude, and Compliance among Generation Z
Get PDFBackground: COVID-19 (coronavirus disease 2019) is a contagious infection currently affecting people worldwide, including in Indonesia. The spread of this virus is extremely rapid, and the number of deaths continues to rise. Compliance with the health protocol is one method of preventing the spread of COVID-19. The purpose of this study is to determine the relationship between generation-Z (gen-Z) knowledge and attitudes toward the use of masks, keeping distance, and washing hands as a means of preventing COVID-19 in religious activities at houses of worship in Palembang.
Method: The observational analytic cross-sectional research design with the study's population consists of generation Z members who participate in religious activities in places of worship. The cluster random sampling method yielded 147 respondents. The data collected are primary data obtained directly from the research subjects via a questionnaire and secondary data obtained from the Palembang City Ministry of Religion. They were using the Pearson chi-square test to analyze descriptive data.
Results: According to the findings, 79 people (53.7%) out of 147 respondents have good knowledge, while 75 people have a good attitude (51% ). The results obtained a statistically significant p-value of 0.05, indicating a relationship between gene Z knowledge and attitude and adherence to the use of masks, keeping distance, and washing hands.
Conclusion: There is a significant relationship between knowledge and attitudes toward COVID-19 infection prevention in Generation Z who participate in religious activities in Palembang City
Staphylococcal Scalded Skin Syndrome in Healthy Infant
Get PDFStaphylococcal scalded skin syndrome (SSSS) describes a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus that originates from a focus of infection that may be a purulent conjunctivitis, otitis media, or occult nasopharyngeal infection. It usually begins with fever, irritability, and a generalized, paint, orange-red, macular erythema with cutaneous tenderness, and the rash progress from scarlatiniform to a blistering eruption in 24 to 48 hours. A diagnosis must distinguish SSSS from other skin diseases, such as toxic epidermal necrolysis, epidermolysis bullosa, bullous erythema multiforme, Streptococcal impetigo or listeriosis and thermal or chemical burns, all of which can manifest with similar symptoms. The prognosis of SSSS in children who are appropriately treated is good, with a mortality of less than 5%. A case was a three moths old boy hospitalized in Pediatric ward M. Djamil hospital with chief complain redness and peeling of the skin since 2 days before hospitalized. Culture of the skin, eyes and nose was Staphylococcus aureus, and patients was given ampicillin and gentamycin for seven days
Relation of Normal Childbirth Care Training to Midwives Knowledge and Attitudes at Bebesen Health Center Bebesen District of Central Aceh Regency in 2021
Get PDFBackground. Mortality and morbidity in pregnant and maternity women is a big problem in developing countries. In poor countries, about 25-50% of deaths of women of childbearing age are caused by pregnancy-related causes. It is estimated that every year 585,000 women die from pregnancy and childbirth. 99% of these deaths occur in developing countries. According to WHO, 60-80% of maternal deaths are caused by bleeding during childbirth, obstructed labor, sepsis, high blood pressure during pregnancy, and complications from unsafe abortion. The purpose of this study was to determine the relationship between normal delivery care (APN) training on the knowledge and attitudes of midwives at the Bebesen Health Center, Bebesen District, Central Aceh Regency in 2020.
Methods. The research method uses an analytical survey method with a cross sectional approach, which is a study to study the dynamics of the correlation between risk factors and effects, by approaching, observing or collecting data at once. The population in this study was all 63 midwives. The sampling method uses a total sampling technique that uses all members of the population as a sample. Data collection was carried out from November 14-16, 2020.
Results. The results showed that from the analysis obtained a value for the p-value of good knowledge as many as 20 respondents (31.7%) and a positive attitude that is as many as 32 respondents (50.8%).
Conclusion. There is a relationship between normal delivery care training (APN) with knowledge with a p value of 0.014 (p < 0.05) and normal delivery care (APN) with changes in the attitude of midwives with a p value of 0.00 (p < 0.05) in Bebesen Public Health Center, Bebesen District, Central Aceh Regency
The Relationship between Vitamin D and Autism Spectrum Disorder
Get PDFThe tendency for autism spectrum disorders or also known as Autism Spectrum Disorder (ASD) is increasing globally, even becoming 1 per 54 in 2016. Until now, the cause of autism is not known for certain, ASD is considered to be a combination of genetic and environmental factors. One of the environmental factors in this case is related to nutrition, one of which is vitamin D. Vitamin D deficiency is often found among children with ASD. Several studies have shown that vitamin D is involved in various brain bioprocesses including neuromodulation and nerve transmission and brain function while also influencing inflammatory processes, autoimmune disorders, oxidative stress and also neurotransmitters that are widely associated with the possibility of ASD. This review aims to describe vitamin D deficiency may contribute to ASD disorders. Based on this, in the future, it is necessary to consider when treating patients with ASD to consider the need to check the patient's vitamin D levels and if there is a deficiency it can be advised to sunbathe and or be given additional vitamin D intake