Indonesian Journal of Obstetrics and Gynecology (INAJOG)
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Changes in Quality of Life Score of Patients with Pelvic Organ Prolapse after Vaginal Surgery Measured by Pelvic Floor Distress Inventory (PFDI20) and Pelvic Floor Impact Questionnaire (PFIQ7) Questionnaires: Perubahan Skor Kualitas Hidup Pasien Prolaps Organ Panggul setelah Operasi Vagina yang Diukur dengan Kuesioner Pelvic Floor Distress Inventory (PFDIÂ20) dan Pelvic Floor Impact Questionnaire (PFIQÂ7)
Get PDFObjective: To determine changes in the quality of life in patients with pelvic organ prolapse who had undergone vaginal surgery.
Methods: Prospective cohort study, carried out in Dr. Cipto Mangunkusumo and Fatmawati during the period of July 2015 to October 2016. The quality of life of the subjects was followed up three months after undergoing vaginal surgery. We used the Indonesian version of Pelvic Floor Distress Inventory (PFDI-20) and Pelvic Floor Impact Questionnaire (PFIQ-7).
Results: In this study, 25 subjects were involved. The results showed significant score reduction in the quality of life in patients
treated with vaginal surgery with p < 0.05 in almost all scales except CRAIQ-7.
Conclusion: There is a reduction in quality of life scores in patients treated with vaginal surgery at all scales except CRAIQ-7
with a value of p <0.05.
[Indones J Obstet Gynecol 2017; 5-3: 164-167]
Keywords: PFDI-20, PFIQ-7, POP, vaginal surger
The Role of Tumor Necrosis Factor ï¡ (TNF ï¡) and Matrix Metalloproteinase9 (MMP9) Serum in Preterm Premature Rupture of Membranes: Peran Tumor Necrosis FactorÂï¡ (TNFÂï¡) dan MMPÂ9 Serum pada Ketuban Pecah Dini Kehamilan Preterm dan Kehamilan Preterm tanpa Ketuban Pecah Dini
Get PDFObjective: To investigate the role of TNF-ï¡ and MMP-9 serum in preterm premature rupture of membranes (PPROM).
Methods: We used cross-sectional study design. Subjects were all pregnant women with and without PPROM who underwent checkup at Obstetrics and Gynecology Functional Medical Staff General Hospital Dr. M. Djamil and networking hospital.
Results: A total of 48 subjects were enrolled in this study. The mean serum levels of TNF-ï¡ in patients with PPROM 17.43 ng/ml  12.4 ng/ml and without PPROM 8.45 ng/ml  6.86 ng/ml. The mean serum levels of MMP-9 in patients with PPROM 8.77 ng/ml  4.41 ng/ml, and without PPROM 4.46 ng/ml  3.04 ng/ml. Statistical test result p value <0.05, it can be conclude there are differences in the levels of TNF-ï¡ and MMP-9 serum in premature rupture of membranes and without premature rupture of membranes pregnancy of preterm.
Conclusion: There are differences in the levels of TNF-ï¡ and MMP-9 serum in PPROM and without PPROM.Keywords: MMP-9, premature rupture of membranes, TNF-ï
The Role of Matrix Metalloproteinase9 (MMP9) in Endometriosis: Peran Matriks MetalloproteinaseÂ9 (MMPÂ9) pada Endometriosi
Get PDFObjective: To investigate the role of MMP-9 expression in endometriosis.
Methods: The study was conducted from October 2015 to March 2016, an observational study with cross-sectional design. Samples are all endometriosis patients who underwent laparoscopic surgery in Dr. Wahidin Sudirohusodo Hospital and several other hospitals in Makassar. Samples were stored and fixed in the Grand Medika Histopathology Laboratory Makassar for examination the expression of MMP-9 using immunohistochemical methods. Conducted an analysis of 50 samples, of which 11 samples of stage II, 21 stage III samples, and 18 samples of stage IV. The data obtained and analyzed statistically using Mann Whitney and Chi Square test with a significance level of p <0.05.
Results: The results reported rankings mean the expression of MMP-9 in stage I-II = 16.68, stage III-IV 27.99 (p = 0.013). There were differences in the expression of MMP-9 based on the stage. Stage I-II endometriosis had a more positive 2 expression of MMP-9 (45.5%), stage III-IV endometriosis have more positive 3 expression of MMP-9 (59.0%). The results of chi square test (p = 0.043).
Conclusion: Higher expression of MMP-9 is significantly associated with higher degree of endometriosis.
Keywords: matrix metalloproteinase-9, stages of endometriosi
Radiotherapy Response of Cervical Cancer Patients at a Tertiary Referral Hospital in Indonesia: Respon Terapi Radiasi Pasien Kanker Serviks pada suatu Rumah Sakit Rujukan Tersier
Get PDFObjective: To investigate the response of radiotherapy and related clinicopathologic characterictics on cervical cancer patients.
Methods: This was a retrospective study. Subjects were patients diagnosed with cervical cancer stage IIA-IIIB who had undergone radiation therapy based on standard protocol in our hospital, during the period of January 2014 to December 2015. The clinical factors ofthose patients, such as age, Body Mass Index, blood pressure, hemoglobin level, blood leucocyte count, serum albumin, largest tumor diameter, the International Federation of Gynecology and Obstetrics (FIGO) staging, as well as pathologic characteristic, i.e histopathology and grading were recorded. During radiation protocol until 3months post radiation, we also noted any side effects of gastrointestinal tract, genitourinary tract, and hematologic. Evaluation of radiotherapy response was based on Response Evaluation Criteria in Solid Tumors (RECIST).
Results: A total of 123 subjects were enrolled in this study. 84 cases or 68.29% was complete response, 30 cases or 24.39% was partial response, 6 cases or 4.88% was stabile response, and 3 cases or 2.44% was progressive. Based on gastrointestinal side effect, there was no side effect or grade 0 on 99 cases (80.49%), grade 1 on 20 cases (16.26%), grade 2 on 4 cases (3.25%), grade 3 on 0 case (0%). Based on side effect of genitourinary, there was no side effect or grade 0 on 105 cases (85.37%), grade 1 on 17 cases (13.82%), grade 2 on 1 case (0.81%), grade 3 on 0 case (0%). Based on hematologic side effects, there was no side effecton 108 cases (87.80%), grade 1 on 15 cases (12.20%), grade 2 on 0 case (0%), grade 3 on 0 case (0%). Largest tumor diameter was statistically significant, with p=0.036 (RR 2.64 (1.07-6.56)).
Conclusion: The majority of definitive-curative radiotherapy response on cervical cancer stage IIA-IIIB was complete (68.29%). Acute side effects involving the gastrointestinal, genitourinary, and hematologic system were commonly can be tolerable during and 3 months post radiation therapy. Clinicopathologic characteristics significantly associated with the complete response of radiotherapy was the largest tumor diameter.
Keywords: largest tumor diameter, radiation response, radiationside effec
Vaksin Human Papillomavirus: Suatu Alternatif dalam Pengendalian Kanker Serviks di Masa Depan
Get PDFKanker serviks merupakan kanker yang terbanyak ditemukan di Indonesia. Human Papiloma Virus merupakan penyebab kanker ini. Di Indonesia program deteksi dini dengan tes Pap sulit dilaksanakan karena keterbatasan dana, tenaga dan fasilitas. Imunisasi dengan vaksin Human Papiloma Virus diharapkan dapat merupakan Prevalens atau Insidens kanker serviks secara drastis. Meskipun masih dalam percobaan namun hasilnya cukup menggembirakan baik sebagai pencegahan infeksi HPV maupun pengobatan terutama
pada lesi prakanker
Gambaran Kadar Interleukin-6 Serum dan Sekret Serviks pada Wanita Infertilitas yang Dicurigai Menderita Penyakit Radang Panggul Subklinik
Get PDFTujuan: Mendapatkan gambaran kadar IL-6 serum dan sekret
serviks pada kasus infertilitas yang terbukti mengalami Penyakit Radang Panggul dan bukan Penyakit Radang Panggul.
Rancangan penelitian: Penelitian ini bersifat deskriptif dan dilakukan
secara potong lintang. Sebanyak 20 wanita infertilitas tersangka
PRP subklinik dilakukan pengambilan darah dan sekret servikal untuk
diperiksa kadar IL-6 serum maupun sekret serviks serta dilakukan biopsiendometrium untuk menegakkan ada tidaknya PRP sesuai dengan kriteria Kiviat.
Hasil: Rerata kadar IL-6 serum pada wanita yang terbukti PRP tidak
menunjukkan perbedaan dengan yang tidak terbukti PRP (Rerata 2,56 vs 2,47 pg/ml; median 1,90 vs 1,95 pg/ml; minimum 0,80 vs 0,73 pg/ml;maksimum 10,65 vs 4,87 pg/ml dengan p=0,74)
Sedangkan rerata kadar IL-6 sekret serviks pada wanita yagn terbukti
PRP lebih tinggi dibandingkan dengan yang tidak terbukti PRP
(Rerata (SD) 1275,8 (1073,9) vs 330,7 (178,2) pg/ml; kisaran 85,86 -
3928,86 vs 120,28 - 520,82 pg/ml dengan p= 0,016).
Kesimpulan: Rerata kadar IL-6 sekret serviks pada wanita dengan
PRP lebih tinggi dibandingkan pada wanita tanpa PRP. Sedangkan
rerata kadar IL-6 serum pada wanita dengan PRP dan tanpa PRP tidak
menunjukkan perbedaan. [Maj Obstet Ginekol Indones 2006; 30-1: 30-5]
Kata kunci: IL-6, Penyakit Radang Panggul Subklinik, endometritis,
sekret serviks.
Objective: To obtain profile of IL-6 serum level and cervical secretes
in infertility proved to have experienced pelvic inflammatory disease
and not pelvic inflammatory disease.
Design: This study was a descriptive, cross-sectional trial. As many
as 20 infertile women suspected of subclinical PID (pelvic inflammatory disease) were submitted to blood taking and cervical secretes for the examination of IL-6 serum level and cervical secretes, and endometrial biopsy to confirm the presence or absence of PID in accordance with Kiviat criteria.
Results: Mean IL-6 serum level in women with confirmed PID did
not show any difference from that in women without confirmed PID
(mean 2.56 vs 2.47 pg/ml; median 1.90 vs 1.95 pg/ml; minimum 0.80 vs 0.73 pg/ml; maximum 10.65 vs 4.87 pg/ml with p = 0.74. On the other hand, mean IL-6 level of cervical secretes in women with confirmed PID was higher than that in women without confirmed PID (mean (SD) 1275.8 (1073.9) vs 330.7 (178.2) pg/ml; range 85.86 - 3928.86 vs 120.28 - 520.82 pg/ml, with p = 0.016).
Conclusion: Mean IL-6 level of cervical secretes in women with
PID was higher than that in women without PID. On the other hand,
means IL-6 serum level in women with PID and without PID did not
show any difference. [Indones J Obstet Gynecol 2006; 30-1: 30-5]
Keywords: IL-6, subclinical pelvic inflammatory disease, endometriosis, cervical secretes
Tantangan, Harapan dan Pengobatan Alternatif dalam Meningkatkan Produktivitas dan Kualitas Hidup Wanita Menopause*
Get PDFFitoestrogen yang berasal dari tumbuh-tumbuhan dan memiliki struktur kimia serta fungsi biologi menyerupai estradiol diharapkan dapat dimanfaatkan untuk mengatasi permasalahan kesehatan wanita menopause yang terkait dengan rendahnya kadar estrogen
Pola Hidup untuk Meningkatkan Kualitas Wanita Menopause*
Get PDFPola hidup wanita menopause merupakan faktor utama untuk tercapainya kehidupan yang berkualitas. Tujuan pemberian Terapi Sulih Hormon (TSH) adalah semata-mata untuk meningkatkan kualitas hidup wanita menopause
Assistance Influence on Labor Pain Level
Get PDFObjective: To assess assistance influence on labor pain level.
Method: This study was a randomized-clinical, unmasked trial with
concealment by measuring labor pain level in two patients group:
with and without assistance during labor; each group consisted of 36
subjects. Pain intensity were measured using Faces Pain Rating
Scale. Mann-Whitney analysis was done to assess significance of
pain level between two groups.
Result: Majority of patient who were in non-assisted group had very
painful score 50% with mean of VAS 7.38±2.12, meanwhile most of
assisted group complained painful score 44.44%, with mean of VAS
6.11±1.90.
Conclusion: There was significance level of painful score between
non-assisted and assisted subjects x(
Fetal Fibronectin (fFN) on the Imminent Premature Parturition in Correlation with Incidence of Preterm Labor
Get PDFObjective: To determine the relationship of fFn levels in cervicovaginal
discharge of pregnant women who experience imminent
premature parturition with the incidence of preterm labor.
Method: The study was carried out with Analytic Observational Prospective
Cohort using cervicovaginal discharge of pregnant women
that experienced imminent premature parturition taken from the
delivery room of Obstetrics and Gynecology department dr. Saiful
Anwar Hospital, Malang as well as Bangil Hospital and Ngudi
Waluyo Wlingi Hospital. Statistical analysis was performed using the
Shapiro-Wilk test and comparison test used independent samples t
test for normal data, Mann-Whitney test if not. All analysis used SPSS
for Windows 19.0 software.
Result: Thirty two patient samples was examined, 14 patients
(43.75%) were primigravida and 18 patients (52.56%) is multigravida.
17 of these patients (53.13%) experienced aterm labor and
15 patients (46.87%) experienced preterm labor. Mann-Whitney
test of the mean fFN levels between the aterm group (13.01 ± 7.57
ng/ml) and the preterm group (56.29 ± 27.77 ng/ml) showed a significant
difference (p-value = 0.000 > 0.05). Moreover, Spearman’s
Rho correlation test also showed a strong correlation between fFN
level and incidence of preterm labor (R = 0.797, p < 0.05).
Conclusion: fFN levels is significantly increase in cervicovaginal discharge
from pregnant women with imminent premature parturition
who experience preterm labor than pregnant women who experience
aterm labor. Therefore, this result suggests that fFN has potential
ability to become useful modality in preterm labor diagnosis.
[Indones J Obstet Gynecol 2016; 1: 8-14]
Keywords: cervicovaginal discharge, fFN, imminent premature parturition,
preterm labo