Indonesian Journal of Obstetrics and Gynecology (INAJOG)
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Sexual Function in Female of Reproductive Age Post Total Hysterectomy
Get PDFBackground: Sexual intercourse and having offspring are essential in a household to live because they are determinant of marital happiness. Many women reported increasing sexual function after hysterectomy; meanwhile, others complained about sexual dysfunction after the hysterectomy procedure.
Objective: To determine the effect of sexual function on women of reproductive age after a total hysterectomy
Method: This study is a descriptive retrospective study with a cross-sectional study design.
Results: This study is based on the data of 23 samples that met the inclusion criteria. With 11 samples increasing FSFI score, 11 samples with a decreasing of FSFI score and 1 sample had an unchanged sexual function before and after surgery. Then from those 23 samples, 16 samples with Female Sexual Dysfunction (FSD) have FSFI score of less than or equal to 26.55 before surgery, and 17 samples with FSD after surgery. Based on the T-Test, there were significant differences between the Female Sexual Function Index (FSFI) before and after the surgery. Most of the respondents experienced decreasing sexual satisfaction (14 samples), while only five samples experienced increased sexual satisfaction and the other four samples had unchanged sexual satisfaction. In our study, most of the respondents (17 samples) claimed that there were better or decreased pain after the hysterectomy procedure. While there were only three samples that claimed an increase of pain, and only three samples claimed that there was unchanged pain scale.
Conclusion: There were changes in sexual function before and after hysterectomy as measured by Female Sexual Function Index (FSFI)
Key Words : Sexual function, FSFI, before hysterectomy, after hysterectom
Successful pregnancy after hCG/hMG treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadism
Get PDFIdiopathic hypogonadotropic hypogonadism (IHH) is one of the correctable causes of male infertility. Although there have been several previous reports about fertility treatment for IHH, there are no established guidelines of therapeutic method yet. We present an azoospermic male of IHH who succeeded in pregnancy and full term live birth after 18 months of treatment with human chorionic gonadotropin (hCG)/human menopausal gonadotropin (hMG), and then changed his treatment into testosterone replacement therapy to maintain an appropriate male hormone level. This case report shows that a thorough and careful examination of whether it is a reversible cause is necessary and important in the approach to male infertility. In addition, it further proves that, in the case of IHH, a continuous long-term gonadotrophic stimulation therapy contributes to successful pregnancy and may need a testosterone replacement therapy after birth
Efficacy of Channa Striata Extract Capsule (Vipalbumin®) for Serum Albumin Level and Wound Healing Postradical Hysterectomy in Cervical Cancer Patients: Efektivitas Konsumsi Kapsul Ekstrak Ikan Gabus terhadap Kadar Albumin Serum dan Penyembuhan Luka Pascahisterektomi Radikal Pasien Kanker Serviks
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Objective: To determine the efficacy of Channa striata extract on serum albumin level and wound healing after radical hysterectomy in cervical cancer patients in Mohammad Hoesin Hospital Palembang.Methods: A clinical trial was conducted in Mohammad Hoesin Hospital Palembang during period of January – September 2019. Samples were cervical cancer patients undergoing radical hysterectomy. Serum albumin level was measured before surgery, after surgery, and after the administration of Channa striata extract capsule. Efficacy of the supplement was analyzed with SPSS version 20 using paired t-test.Result: Twenty-eight cervical cancer patients undergoing radical hysterectomy who fulfilled inclusion criteria were obtained. Majority of patients were aged between 40-49 years old (89.3%), normoweight (39.3%), and lived in rural area. Mean duration of surgery was 154.46 ± 40.47 minutes. Serum albumin level before surgery, after surgery and after the administration of Channa striatus extract were 3.4 ± 0.61 g/dL, 2.91 ± 0.42 g/dL, and 3.11 ± 0.49 g/dL, respectively. There was a statistically significant difference between serum albumin level before and after the surgery (p=0.000). However, no statistically significant difference was found between serum albumin level after surgery and after administration of Channa striata extract capsule (p=0.750).Conclusions: There was no significant difference between serum albumin level after surgery and after administration of Channa striata extract capsule.Keywords: cervical cancer , channa striatus extract , radical hysterectomy, serum albumin level.
Abstrak
Tujuan: Untuk mengetahui efikasi ekstrak Channa striata terhadap kadar albumin serum dan penyembuhan luka pasca histerektomi radikal pada pasien kanker serviks di RS Mohammad Hoesin Palembang.Metode: Uji klinis dilakukan di RS Mohammad Hoesin Palembang selama periode Januari – September 2019. Sampel adalah pasien kanker serviks yang menjalani histerektomi radikal. Kadar albumin serum diukur sebelum operasi, setelah operasi, dan setelah pemberian kapsul ekstrak Channa striata. Khasiat suplemen dianalisis dengan SPSS versi 20 menggunakan uji-t berpasangan.Hasil: Didapatkan 28 pasien kanker serviks yang menjalani histerektomi radikal yang memenuhi kriteria inklusi. Mayoritas pasien berusia antara 40-49 tahun (89,3%), normoweight (39,3%), dan tinggal di daerah pedesaan. Durasi rata-rata operasi adalah 154,46 ± 40,47 menit. Kadar albumin serum sebelum operasi, setelah operasi dan setelah pemberian ekstrak Channa striatus berturut-turut adalah 3,4 ± 0,61 g/dL, 2,91 ± 0,42 g/dL, dan 3,11 ± 0,49 g/dL. Ada perbedaan yang signifikan secara statistik antara kadar albumin serum sebelum dan sesudah operasi (p=0,000). Namun, tidak ditemukan perbedaan yang signifikan secara statistik antara kadar albumin serum setelah operasi dan setelah pemberian kapsul ekstrak Channa striata (p=0,750).Kesimpulan: Tidak terdapat perbedaan yang bermakna antara kadar albumin serum setelah pembedahan dan setelah pemberian kapsul ekstrak Channa striata.Kata kunci: ekstrak Channa striatus, histerektomi radikal, kadar albumin serum, kanker serviks
Adiponection Serum Levels in Severe Preeclampsia: Kadar Adiponektin pada Pasien Preeklamsia Berat
Get PDFObjective : To determine the difference adiponectin serum levels in pregnant patient with severe preeclampsia and normotency in Manado.
Methods : This study is a cross sectional study which the number of samples obtained was 52 samples in which the sample was divided into 26 pregnant samples with severe preeclampsia and 26 control samples. Samples were taken from Prof. dr. R. D. Kandou Manado Hospital and network hospitals around Manado within the inclusion and exclusion criteria. All patients were explained about the research procedure and singning the informed consent and take a blood sample by using the ELIZA method. After the data is collected, it is entered into the SPSS version 23.0 program for data analysis.
Results : There was a significant relationship between adiponection serum levels with the incidency of severe preeclampsia and normotency. But for body mass index variables there were no significant differences by using T test (independent sample) in each severe preeclampsia and normotency pregnancy group where p=0.903. Body mass index, height, weight, and weight gain during pregnancy showed that there is no difference between cases and controls (p>0.05) which means that body mass index is not related to the stete of the severe preeclampsia and normotency.
Conclusions : There was no relationship between BMI, age, parity, smoking, baby outcomes, delivery method and gestational age with the incidence of severe preeclampsia and normotency against adiponectin in this study.
Keywords: adiponectin, obstetrics, preeclampsia.
Abstrak
Tujuan : Untuk mengetahui perbedaan kadar adiponektin serum pada pasien hamil preeklamsia berat dengan hamil normal di Kota Manado.
Metode : Studi ini merupakan studi potong lintang. Jumlah Sampel yang didapatkan sebesar 52 sampel dimana sampel dibagi menjadi 26 sampel hamil dengan preeklamsia berat dan 26 sampel kontrol. Sampel diambil dari RSUP Prof. dr. R. D. Kandou Manado dan rumah sakit jejaring sekitar manado yang memenuhi kriteria inklusi dan eksklusi. Semua pasien dijelaskan mengenai prosedur penelitian dan penandatanganan inform consent baru dilakukan pengambilan sampel darah untuk dilakukan pemeriksaan laboratorium dengan menggunakan metode ELISA. Setelah data dikumpulkan, maka dimasukkan ke dalam program SPSS versi 23.0 untuk data analisis.
Hasil : Perhitungan dengan menggunakan uji statistik Mann - Whitney menunjukkan bahwa terdapat perbedaan bermakna nilai rata-rata kadar adiponektin pada pasien hamil normal dengan pasien PEB (p = 0,000). Adanya hubungan bermakna kadar adiponektin dengan kejadian preeklamsia berat. Namun untuk variabel IMT yang dilakukan secara uji t (sampel independen) didapatkan kesimpulan tidak terdapat perbedaan bermakna pada masing-masing kelompok normotensi dan kelompok preeklamsia berat di mana p= 0,903, indeks massa tubuh, tinggi badan, berat badan, serta pertambahan berat badan selama kehamilan tidak berbeda antara kasus dan kontrol (p>0,5). Ini berarti bahwa IMT tidak berhubungan dengan keadaan terjadinya preeklamsia berat.
Kesimpulan: Tidak didapatkan hubungan antara IMT, usia, paritas, merokok, luaran bayi, cara persalinan dan usia kehamilan dengan kejadian preeklamsia berat dan normotensi terhadap adiponektin pada penelitian ini.
Kata kunci : adiponektin, obstetri, preeklamsia
Neutrophil to Lymphocyte Ratio in Preeclampsia: Rasio Neutrofil terhadap Limfosit pada Preeklamsia
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Objective: To determine the correlation between neutrophil to lymphocyte ratio and preeclampsia. To determine whether neutrophil to lymphocyte ratio can be used as a screening tool for preeclampsia.Methods: This study was conducted with a systematic review method. Articles that had been gathered and filtered were reviewed by QUADAS-2 tool. Guidelines from the American Congress of Obstetricians and Gynecologists (ACOG) and Pedoman Nasional Pelayanan Kedokteran were used as a diagnostic criteria for determining preeclampsiaResults: Studies conducted by Kirbas et al, Cakmak et al, Wang et al and Panwar et al stated that there is a correlation between neutrophil to lymphocyte ratio to preeclampsia (p-value < 0.05). Cut-off values are diverse between 3.5 - 5.6 with different sensitivity and specificity.Conclusion: This systematic review shows that there is a relationship between neutrophil to lymphocyte ratio and preeclampsia. Neutrophil to lymphocyte ratio can be used as screening tools for preeclampsia in the first trimester.Keywords: neutrophil to lymphocyte ratio, NLR, preeclampsia.
Abstrak
Tujuan: Mengetahui apakah terdapat hubungan antara rasio neutrofil terhadap limfosit dengan preeklampsia. Mengetahui apakah rasio neutrofil terhadap limfosit dapat dijadikan sebagai alat bantu skrining preeklampsia.Metode: Penelitian ini dilakukan dengan metode systematic review. Artikel yang disaring akan ditentukan kualitasnya menggunakan QUADAS-2. Kriteria diagnostik preeklampsia yang digunakan adalah American College of Obstetricians and Gynecologists (ACOG) untuk penelitian luar negeri dan Pedoman Nasional Pelayanan Kedokteran untuk penelitian dalam negeri.Hasil : Penelitian yang dilakukan oleh Kirbas et al, Cakmak et al, Wang et al, dan Panwar et al menyatakan bahwa terdapat hubungan antara rasio neutrofil terhadap limfosit dengan preeklampsia ( p-value < 0.05). Nilai cutoff dari rasio neutrofil terhadap preeklampsia beragam mulai dari 3.5 - 5.6 dengan sensitivitas dan spesifisitas yang berbeda-beda.Kesimpulan : Penelitian systematic review ini menunjukan bahwa rasio neutrofil terhadap limfosit memiliki hubungan dengan penyakit preeklampsia. Rasio neutrofil terhadap limfosit dapat dijadikan sebagai alat bantu skrining untuk preeklampsia pada trimester pertama.Kata kunci: rasio neutrofil terhadap Limfosit, NLR, preeklamsia
Maternal Mortality Rate before and after BPJS Health services Era : Angka Kematian Ibu sebelum dan sesudah Era BPJS
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Objective: To compare maternal death in RSUD dr. Aloei Saboe Gorontalo before BPJS (in 2011-2013) and after BPJS (2014-2016)Methods: Descriptive Retrospective. Data in this study obtained from the secondary data. This data obtained by the researcher from medical records in RSUD Prof. Dr. Aloei Saboe Gorontalo.Results: In this study, the number of delivery in hospitals Prof. Dr. Aloei Saboe before BPJS (2011-2013) of 7906 deliveries of live births after 7735 and health services BPJS (years 2014-2016) of 6493 deliveries of live births BPJS 6333. Maternal mortality before and after as many as 34 cases BPJS many as 42 cases, so we get the MMR before BPJS 4.39 ‰ and 6.63 ‰ after BPJS.Conclusion: There is a significant increase in maternal mortality rate in Prof. Dr. Aloei Saboe Gorontalo (p = 0.036), after BPJS maternal mortality (years 2014-2016) was 42 cases, compared with a prior health services BPJS (2011-2013) was 34 cases. This increase occurred because of a referral system BPJS make the decreasing number of births was in the hospital decreased, and hospitals Prof. Dr. Aloei Saboe a referral centre in Gorontalo province and surrounding areas.Keywords: death, BPJS, maternal, mortality.
Abstrak
Tujuan: Untuk membandingkan kematian maternal di RSUD Prof. Dr. Aloei Saboe sebelum BPJS (2011-2013) dan sesudah layanan kesehatan BPJS (2014-2016).Metode: Deskriptif Retrospektif. Jenis data yang digunakan dalam penelitian ini adalah data sekunder yang diperoleh dari rekam medik di RSUD Prof. Dr. Aloei Saboe Gorontalo.Hasil: Pada penelitian ini didapatkan jumlah persalinan di RSUD Prof. Dr. Aloei Saboe sebelum BPJS (2011-2013) sebanyak 7906 persalinan dengan kelahiran hidup 7735 dan sesudah layanan kesehatan BPJS (2014-2016) sebanyak 6493 persalinan dengan kelahiran hidup 6333. Kematian maternal sebelum BPJS sebanyak 34 kasus dan sesudah BPJS sebanyak 42 kasus, sehingga didapatkan AKI sebelum BPJS 4.39 ‰ dan sesudah BPJS 6.63 ‰.Kesimpulan: Ternyata terdapat peningkatan yang bermakna (p=0,036) kematian maternal sesudah BPJS (2014-2016) sebanyak 42 kasus, bila dibandingkan dengan sebelum layanan kesehatan BPJS (2011-2013) sebanyak 34 kasus. Peningkatan ini terjadi karena sistem rujukan BPJS membuat menurunnya jumlah persalinan yang ada dirumah sakit menurun, dan RSUD Prof. Dr. Aloei Saboe merupakan pusat rujukan di propinsi Gorontalo dan sekitarnya.Kata Kunci: BPJS, kematian, maternal,mortalita
Serum Nephrin Levels in Severe Preeclampsia: A Cross-Sectional Study : Kadar Nephrin Serum pada Preeklamsia Berat: Sebuah Studi Potong Lintang
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Objective: To determine differences in serum nephrin levels in severe preeclampsia compared to normal pregnancy and also its correlation with systolic and diastolic blood pressure and proteinuria.Methods: This study is an analytical observational with cross sectional study. The observation group consisted of severe preeclampsia (n= 30) and normal pregnancy group as a control (n= 30). Both groups measured systolic and diastolic blood pressure, proteinuria and serum nephrin using the Human NPHN (Nephrin) ELISA Kit. Statistical test were performed with Mann-Whitney test and the Spearman’s rank test. A value of p<0.05 was considered significant. The study was conducted in the Obstetric Clinic Inward and Laboratorium Department of Clinical Pathology Dr. Hasan Sadikin General Hospital/Faculty of Medicine Universitas Padjadjaran on March–May 2019.Results: Levels of serum nephrin in the severe preeclampsia group were significantly higher than in normal pregnancies (6.4 ng/mL vs 4.2 ng/mL; p= 0.014). There is a positive weak correlation but statistically significant between serum nephrin with systolic blood pressure (r= 0.36; p= 0.02) but not significant to diastolic blood pressure (r= 0.3; p= 0.05). There is no significant correlation was found between serum nephrin levels and proteinuria (r= 0.18; p= 0.54).Conlusions: Levels of serum nephrin in the severe preeclampsia group were significantly higher than in normal pregnancies and there is a correlation between serum nephrin with systolic blood pressure.
Keywords: blood pressure, proteinuria, serum nephrin, podocyte, severe preeclampsia.
Abstrak
Tujuan: Untuk mengetahui perbedaan kadar nephrin serum pada preeklamsia berat dibandingkan dengan kehamilan normal dan juga hubungannya dengan tekanan darah sistolik dan diastolik serta proteinuria.Metode: Penelitian ini bersifat analitik observasional dengan pendekatan potong silang. Kelompok pengamatan terdiri dari kelompok preeklamsia berat (n= 30) dan kelompok kehamilan normal sebagai kontrol (n= 30). Pada kedua kelompok dilakukan pengukuran tekanan darah sistolik dan diastolik, proteinuria serta pengukuran kadar nephrin serum menggunakan Human NPHN (Nephrin) ELISA Kit. Uji statistik dilakukan dengan uji Mann-Whitney dan uji rank Spearman. Nilai p<0,05 dianggap bermakna. Penelitian dilakukan di ruang perawatan obstetri FKUP/RSHS dan Laboratorium Patologi Klinik FKUP/RSHS pada bulan Maret-Mei 2019.Hasil: Rerata kadar nephrin serum pada kelompok preeklamsia berat lebih tinggi secara bermakna dibandingkan kehamilan normal (6,4 ng/mL vs 4,2 ng/mL; p= 0,014). Terdapat korelasi positif dengan derajat lemah namun bermakna secara statistik antara nephrin serum dengan tekanan darah sistolik (r= 0,36; p= 0,02) namun tidak signifikan terhadap tekanan darah diastolik (r= 0,3; p= 0,05). Tidak ditemukan korelasi yang bermakna antara kadar nephrin serum dengan proteinuria (r= 0,18; p= 0,54). Kesimpulan: Kadar nephrin serum pada kelompok preeklamsia berat lebih tinggi dibandingkan kehamilan normal dan terdapat korelasi antara nephrin serum dengan tekanan darah sistolik.
Kata kunci: nephrin serum, podosit, preeklamsia berat, proteinuria, tekanan dara
Role of C-Reactive Protein, Erythrocyte Sedimentation Rate, Progesterone and Estradiol Hormone Levels in First Trimester Threatened Abortion: Peran C-Reactive Protein, Laju Endap Darah, Progesteron dan Estradiol pada Abortus Imminens Trimester Pertama
Get PDFObjective: To assess correlation of High sensitivity C-Reactive Protein (Hs-CRP), erythrocyte sedimentation rate (ESR), progesterone and estradiol levels in the first trimester threatened abortion incidence in Dr. Zainoel Abidin Hospital, Banda Aceh.Methods: Case control design used in this study divided threatened abortion into a case group and normal pregnancy into a control group with a total of 20 subjects for each group. This research was conducted in the Emergency Room and Obstetric Ward of Dr. Zainoel Abidin hospital Banda Aceh in 2019. Eta correlation test was conducted to find out the link between variables towards threatened abortion with 95% confidence level followed by the Receiver Operating Curve (ROC) analysis to find out the cut off points.Results: Progesterone levels (14.76 ng/mL), estradiol (427.61 pg/mL), Hs-CRP (2.57 mg/L) and ESR (28.75 mm/hour) case group were lower compared to the control group. Incidence of threatened abortion correlates to progesterone and estradiol with the correlation strength respectively -0.838 and -0.416.Conclusion: Progesterone and estradiol correlate negatively with first-trimester abortion incidence. Evaluation of these two hormones levels is useful for diagnostic purposes and screening of threatened abortion with a cut point of progesterone 23.03 ng/mL and estradiol 468.8 pg/mL.Keywords: C-Reactive Protein, erythrocyte sedimentation rate, estradiol, progesterone, threatened abortion
Abstrak
Tujuan: Penelitian ini bertujuan untuk menilai korelasi antara kadar High sensitivity C-Reactive Protein (Hs-CRP), Laju Endap Darah (LED), progesteron dan estradiol terhadap kejadian abortus imminens pada trimester pertama di RSUD Dr. Zainoel Abidin Banda Aceh. Metode: Desain kasus kontrol digunakan dalam penelitian ini dimana kejadian abortus imminens menjadi kelompok kasus dan kehamilan normal menjadi kelompok kontrol dengan jumlah masing-masing kelompok sebanyak 20 sampel. Penelitian ini dilakukan di Instalasi Gawat Darurat dan ruang rawat Obstetri Rumah Sakit Umum Dr. Zainoel Abidin (RSUDZA) Banda Aceh pada tahun 2019. Uji korelasi Eta digunakan untuk mengetahui korelasi antar variabel terhadap abortus imminens dengan tingkat kepercayaan 95% dilanjutkan dengan analisis Receive Operating Curve (ROC) untuk menentukan titik potong. Hasil: Kadar progesteron (14,76 ng/mL), estradiol (427,61 pg/mL), Hs-CRP (2,57 mg/L) dan LED (28,75 mm/jam) kelompok kasus lebih rendah dibandingkan kelompok kontrol. Kejadian abortus imminens berkorelasi terhadap progesteron dan estradiol dengan kekuatan korelasi (R) secara berurutan -0,838 dan -0,416. Kesimpulan: Progesteron dan estradiol berkorelasi negatif terhadap kejadian abortus imminens pada trimester pertama kehamilan. Evaluasi kadar kedua hormon tersebut bermanfaat untuk kepentingan diagnostik dan penapisan abortus imminens dengan titik potong progesteron 23,03 ng/mL dan estradiol 468,8 pg/mL. Kata kunci: abortus imminent, C-Reactive Protein, estradiol, laju endap darah, progestero
Increased Levels of Umbilical Cord Blood Interleukin-6 (IL-6) and Serum C-Reactive Protein (CRP) in Premature Infants of Vitamin D Deficient Mothers: Peningkatan Kadar Interleukin-6 (IL-6) Darah Tali Pusat dan Serum C-Reactive Protein (CRP) pada Bayi Prematur dari Ibu dengan Defisiensi Vitamin D
Get PDFObjective: Increased levels of inflammatory factors in newborns are often associated with lower maternal vitamin D levels. This study aimed to find out the relationship between maternal and umbilical cord vitamin D serum levels on umbilical cord Interleukin-6 (IL-6) and serum C-Reactive Protein (CRP) levels in premature infants.Methods: The study was an observational analytic, cross-sectional design in mothers who underwent preterm birth at 28-34 weeks' gestation due to premature rupture of membranes (PROM) and their infants at Dr. Cipto Mangunkusumo General Hospital (RSCM), Jakarta and Persahabatan General Hospital, Jakarta, from January 2017 to August 2018. Levels of serum vitamin D of the maternal and umbilical cord, umbilical cord IL-6 and serum CRP in premature infants were recorded. Vitamin D level was divided into deficiency (<10 ng/mL), insufficiency (10–29 ng/mL), and normal (>30 ng/mL) groups. The relationship of vitamin D levels with IL-6 and CRP was carried out using Kruskal Wallis test.Results: A total of 70 subjects met the research criteria. Umbilical cord IL-6 and serum CRP levels in premature infants of vitamin D deficient mothers were higher (20.31 pg/mL and 0.50 mg/L) compared to insufficient (3.34 pg/mL and 0.45 mg/L) and normal mothers (3.29 pg/mL and 0.30 mg/L), although not statistically significant (IL-6 p = 0.665, CRP p = 0.89). Referring to the umbilical cord blood vitamin D levels, the results were different and not as expected, in which the umbilical cord IL-6 and serum CRP levels of preterm infants in the deficiency (3.76 pg/mL and 0.35 mg/L) and insufficiency (3.37 pg/mL and 0.40 mg/L) groups were lower (IL-6) and not different (CRP) than the normal group (9.41 pg/mL and 0.40 mg/L).Conclusion: There were an increasing tendency for umbilical cord IL-6 and serum CRP levels in premature infants of vitamin D deficient mothers although these were not statistically significant. Based on the levels of vitamin D umbilical cord blood, the CRP levels in the serum of premature infants were not different, while the IL-6 levels in the deficiency and insufficiency group were lower than in the normal group.Keywords: CRP, IL-6, maternal vitamin D, umbilical cord vitamin D.
Abstrak
Tujuan: Peningkatan kadar faktor inflamasi pada bayi baru lahir sering dikaitkan dengan rendahnya kadar vitamin D ibu. Penelitian ini bertujuan untuk mengetahui hubungan kadar serum vitamin D ibu dan tali pusat, dengan kadar IL-6 tali pusat dan serum C-Reactive Protein (CRP) bayi prematur.Metode: Studi observasional analitik dengan desain potong lintang pada subjek ibu yang mengalami kelahiran prematur di usia 28–34 minggu kehamilan disebabkan ketuban pecah dan bayi yang dilahirkannya, di Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo (RSCM) dan Rumah Sakit Umum Pusat Persahabatan, Jakarta, pada bulan Januari 2017 sampai Agustus 2018. Variabel data adalah kadar serum vitamin D ibu dan tali pusat, kadar serum IL-6 tali pusat dan kadar CRP darah bayi. Kadar vitamin D (25(OH)D) dibagi menjadi defisiensi (<10 ng/mL), insufisiensi (10–29 ng/mL) dan normal (>30 ng/mL) dan dicari hubungannya dengan kadar IL-6 tali pusat dan serum CRP bayi prematur, menggunakan uji Kruskal Wallis. Hasil: Sebanyak 70 subjek telah memenuhi kriteria penelitian. Kadar IL-6 tali pusat dan serum CRP bayi prematur dari kelompok ibu defisiensi vitamin D (20,31 pg/ml dan 0,50 mg/L) lebih tinggi dibandingkan kelompok ibu insufisiensi vitamin D (3,34 pg/mL dan 0,45 mg/L) maupun kelompok ibu normal vitamin D (3,29 pg/mL dan 0,30 mg/L) tetapi perbedaan tersebut tidak bermakna (IL-6 p=0,665 dan CRP p = 0,899). Mengacu pada kadar vitamin D darah tali pusat didapatkan hasil yang berbeda dan tidak sesuai harapan, dimana tali pusat IL-6 dan serum CRP bayi prematur mengalami defisiensi (3,76 pg / mL dan 0,35 mg / L) dan insufisiensi. (3,37 pg / mL dan 0,40 mg / L) kelompok lebih rendah (IL-6) dan tidak berbeda (CRP) dibandingkan kelompok normal (9,41 pg / mL dan 0,40 mg / L).Kesimpulan: Didapat kecenderungan peningkatan kadar IL-6 darah tali pusat dan serum CRP bayi prematur dari ibu dengan defisiensi kadar vitamin D walaupun secara statistik tidak signifikan. Berdasarkan kelompok vitamin D darah tali pusat, kadar CRP serum bayi prematur tidak berbeda, sedangkan kadar IL-6 pada kelompok defisiensi dan insufisiensi lebih rendah dibandingkan pada kelompok normal.Kata kunci: CRP, IL-6, vitamin D ibu, vitamin D tali pusat.