University of Extremadura
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Gutierre González en el contexto de la Roma del Renacimiento
No full textLa Roma de inicios del Renacimiento representa un espacio vital para comprender no sólo la trayectoria de Gutierre González, sino
las influencias que recibió y que se plasmaron en gran medida en el proyecto planteado para la fundación de una cofradía en Jaén, que incluía la enseñanza de la doctrina cristiana a niños y la atención a jóvenes doncellas.Rome at the dawn of the Renaissance represents a crucial setting to understand not only the trajectory of Gutierre González but also the influences he received. These influences were significantly reflected in the proposed project for the founding of a brotherhood in Jaén, which included teaching Christian doctrine to children and caring for young maidens.Este trabajo se inserta dentro de los resultados de nuestras investigaciones en el grupo de investigación GESHOMP, dirigido desde el Área de Historia Moderna de la Universidad de Extremadura y financiado por la Junta de Extremadura.peerReviewe
The role emotions play in loyalty and WOM intention in a Smart Tourism Destination Management
No full textThis study applies an extension of the theory of planned behaviour (TPB) by including moral regulation and
negative and positive emotions to determine the attitudinal and emotional factors that influence tourist loyalty
and word-of-mouth. Structural equation modeling was applied to a sample of 303 face-to-face interviews with
tourists visiting the smart tourism destination of C´aceres, a city that has also been declared a World Heritage site.
The results indicate that the original components of the TPB, moral norms and positive and negative emotions
significantly impact loyalty and intention to recommend the smart destination. Additionally, the proportion of
variance explained shows that including moral norms and positive and negative emotions significantly improve
the explanatory power of the original model. The joint communication of information in local campaigns and
through social networks offering memorable experiences is the main strategy destination managers should follow
in order to promote socially and environmentally responsible attitudes, positive emotions, and a greater intention
to recommend the destination and build loyalty to it.Este estudio aplica una extensión de la teoría del comportamiento planificado (TPB) al incluir la regulación moral y emociones negativas y positivas para determinar los factores actitudinales y emocionales que influyen en la lealtad del turista y el boca a boca. Se aplicó un modelo de ecuaciones estructurales a una muestra de 303 entrevistas cara a cara con turistas que visitan el destino turístico inteligente de C´aceres, ciudad que también ha sido declarada Patrimonio de la Humanidad.
Los resultados indican que los componentes originales del TPB, las normas morales y las emociones positivas y negativas impacta significativamente en la lealtad y la intención de recomendar el destino inteligente. Además, la proporción de la variación explicada muestra que incluir normas morales y emociones positivas y negativas mejora significativamente el poder explicativo del modelo original. La comunicación conjunta de información en campañas locales y a través de las redes sociales ofrecer experiencias memorables es la principal estrategia que deben seguir los gestores de destinos con el fin de promover actitudes social y ambientalmente responsables, emociones positivas y una mayor intensidad recomendar el destino y fidelizarlo.This publication has been made possible thanks to funding granted by the Consejería de Economía, Ciencia and Agenda Digital de la Junta de Extremadura and by the European Regional Development Fund of the European Union through the reference grant GR21161 and the University of Extremadura through the Initiation Plan for Research, Technological Development and Innovation 2022.peerReviewe
El cuerpo inminente
No full textObra premiada en el VI Certamen Literario de Cartas de (Des) amor "Mercedes Gallego".Work awarded in the VI Literary Contest Cartas de (Des) amor "Mercedes Gallego".peerReviewe
Anti-biofilm perspectives of propolis against staphylococcus epidermidis infections
No full textStaphylococcus epidermidis ha surgido como el principal agente causante de infecciones relacionadas con dispositivos médicos. Su principal factor de patogenicidad radica en su capacidad para adherirse a superficies y proliferar en biofilms, lo que aumenta su resistencia a los antibióticos. El objetivo principal de este estudio fue evaluar el uso y el mecanismo de acción de un extracto etanólico de propóleos español (EESP) como una alternativa potencial para prevenir infecciones relacionadas con biofilms causadas por S. epidermidis. Se informa sobre la composición química del propóleos y se evalúa su actividad antibacteriana frente a varias cepas de S. epidermidis con diferentes capacidades de formación de biofilms. Se estudiaron la influencia de concentraciones subinhibitorias (sub-MICs) de EESP en su crecimiento, propiedades fisicoquímicas de la superficie, adherencia y formación de biofilms. El EESP interfiere con las células planktonicas, homogeneizando sus propiedades fisicoquímicas de la superficie e introduciendo un retraso significativo en su crecimiento. La adherencia y los biofilms en las concentraciones de EESP investigadas se redujeron hasta un 90,5 % entre las cepas. El análisis microscópico indicó que las células planktonicas que sobrevivieron al tratamiento fueron las que se adhirieron y proliferaron en las superficies. Los resultados obtenidos sugieren que el EESP tiene un alto potencial para ser utilizado como un inhibidor tanto de la adhesión como de la formación de biofilms de S. epidermidis.Staphylococcus epidermis has emerged as the main causative agent of medical device-related infections. Their major pathogenicity factor lies in its ability to adhere to surfaces and proliferate into biofilms, which increase their resistance to antibiotics. The main objective of this study was to evaluate the use and the mechanism of action of an ethanolic extract of Spanish propolis (EESP) as a potential alternative for preventing biofilm-related infections caused by S. epidermidis. The chemical composition of propolis is reported and its antibacterial activity against several strains of S. epidermidis with different biofilm-forming capacities evaluated. The influence of sub-inhibitory concentrations (sub-MICs) of EESP on their growth, physicochemical surface properties, adherence, and biofilm formation were studied. EESP interferes with planktonic cells, homogenizing their physicochemical surface properties and introducing a significant delay in their growth. The adherence and biofilms at the EESP concentrations investigated decreased up to 90.5% among the strains. Microscopic analysis indicated that the planktonic cells that survived the treatment were the ones that adhere and proliferate on the surfaces. The results obtained suggest that the EESP has a high potential to be used as an inhibitor of both the adhesion and biofilm formation of S. epidermidis.The publication is part of Project PID2022-140422OB-I00, funded by MCIN/AEI/10.13039/ 501100011033/FEDER, EU.peerReviewe
Efeitos combinados do tempo despendido em atividade física, comportamentos sedentários e sono nos indicadores de saúde psicossocial em adolescentes em idade escolar
No full textEl presente estudio tiene como objetivo examinar en qué medida la combinación de los comportamientos saludables de las 24 h presentan mayor incidencia en la salud psicosocial. Participaron 452 estudiantes adolescentes de 12 a 17 años, tanto varones 258 (13,87 ± 0,77) como mujeres 194 (13,90 ± 0,81). Todas las variables del estudio se midieron a través de cuestionarios de manera autoreportada: actividad física y tiempo sedentario (I-paq), felicidad subjetiva (SHS) y calidad de vida (Kidscreen-10). Los resultados del estudio se obtuvieron a través de análisis de correlación, regresiones líneas y modelos lineales univariados. Se observó que los comportamientos que más predecían la felicidad subjetiva y calidad de vida fueron el tiempo sedentario y el tiempo de sueño. Asimismo, los análisis de los modelos univariados revelaron que los participantes que cumplían con las recomendaciones de los comportamientos saludables de las 24 horas presentaban mayores puntuaciones media en felicidad subjetiva y calidad de vida que aquellos que no cumplieron estas recomendaciones. Se concluye que los jóvenes que cumplieron conjuntamente las recomendaciones de actividad física, tiempo sedentario y sueño tienen una mayor salud psicosocial en comparación aquellos que no las cumplen.The aim of the present study was to examine the degree to which the combination of healthy behaviors in the 24 h had a greater incidence on subjective happiness and quality of life. A total of 452 adolescent students aged 12 to 17 years participated, both males 258 (13.87 ± 0.77) and females 194 (13.90 ± 0.81). All study variables were measured by self-reported questionnaires: physical activity and sedentary time (I-paq), subjective happiness (SHS) and quality of life (Kidscreen-10). The results of the study were obtained through correlation analysis, linear regression and univariate linear models. It was observed that the behaviors that most predicted subjective happiness and quality of life were sedentary time and sleep time. Also, univariate model analyses revealed that participants who complied with the recommendations of the 24-hour healthy behaviors had higher mean scores in subjective happiness and quality of life than those who did not comply with these recommendations. It is concluded that youth who jointly met the physical activity, sedentary time, and sleep recommendations have greater psychosocial health compared to those who do not.O presente estudo tem por objetivo analisar em que medida a combinação de comportamentos saudáveis durante 24 horas tem o maior impacto na felicidade subjectiva e na qualidade de vida. Participaram no estudo 452 estudantes adolescentes com idades compreendidas entre os 12 e os 17 anos, tanto do sexo masculino (13,87 ± 0,77) como do sexo feminino (13,90 ± 0,81). Todas as variáveis do estudo foram medidas de forma auto-relatada. Os resultados do estudo foram obtidos através de análises de correlação, regressões lineares e modelos lineares univariados. Observou-se que os comportamentos que mais predizem a felicidade subjectiva e a qualidade de vida são o tempo de sedentarismo e o tempo de sono. Além disso, as análises dos modelos univariados revelaram que os participantes que cumpriram as recomendações de comportamentos saudáveis durante 24 horas tiveram pontuações médias mais elevadas na felicidade subjectiva e na qualidade de vida do que aqueles que não cumpriram esas recomendações. Conclui-se que os jovens que cumprem conjuntamente as recomendações de atividade física, tempo de sedentarismo e sono têm melhor saúde psicossocial do que os que não cumprem.peerReviewe
STIM1 nuclear function: a role in DNA damage response
No full textPrograma de Doctorado en Biomarcadores de Salud y Estados PatológicosEsta Tesis Doctoral se ha centrado en el estudio de una función adicional y no canónica para el sensor de Ca2+ STIM1, en concreto, el estudio de su función nuclear. Para establecer este objetivo, nos basamos en los resultados del interactoma de STIM1, en el que se observa interacción con numerosas proteínas de transporte núcleo-citoplasmático, así como proteínas de la ruta FA/BRCA, implicadas en la reparación del daño en el ADN. En este trabajo hemos comprobado que STIM1 presenta una secuencia de localización nuclear que le permite ser transportado al núcleo y que esta translocación se ve incrementada tras la exposición a la mitomicina-C (MMC), un inductor de entrecruzamientos intercatenarios en el ADN. Además, se ha comprobado que las células deficientes en STIM1 presentan daño en el ADN, mayor sensibilidad a MMC y bloqueo del ciclo celular en la fase G2/M. Así mismo, se muestra que la ausencia de STIM1 conlleva un estrés replicativo, que es responsable del daño endógeno en el ADN. Adicionalmente, en este estudio hemos demostrado que STIM1 interacciona con la cromatina nuclear y que tanto el transporte de STIM1 al núcleo como su interacción con la cromatina son necesarios para prevenir el daño en el ADN. Finalmente, este trabajo muestra que STIM1 normaliza los niveles de la proteína FANCD2 en el núcleo, de modo que la ausencia de STIM1 lleva asociada niveles más bajos de FANCD2 nuclear, lo que explicaría la mayor sensibilidad que muestran las células STIM1-KO a la MMC.This Doctoral Thesis has focused on the study of an additional and non-canonical function for the Ca2+ sensor STIM1, specifically, the study of its nuclear function. To establish this objective, we rely on the results of the STIM1 interactome, in which we observed interaction with numerous nucleo-cytoplasmic transport proteins, as well as proteins of the FA/BRCA pathway, involved in DNA damage repair. In this work we have shown that STIM1 presents a nuclear localization sequence that allows it to be transported to the nucleus and that this translocation is increased after exposure to mitomycin-C (MMC), a DNA interstrand crosslinking agent. In addition, it has been shown that STIM1-deficient cells show DNA damage, increased sensitivity to MMC and cell cycle arrest in the G2/M phase. Likewise, it is shown that the absence of STIM1 leads to replicative stress, which is responsible for endogenous DNA damage. Additionally, in this study we have shown that STIM1 interacts with the nuclear chromatin and that both the transport of STIM1 to the nucleus and its interaction with chromatin are necessary to prevent DNA damage. Finally, this work shows that STIM1 normalizes nuclear FANCD2 protein levels, so that the absence of STIM1 is associated with lower levels of nuclear FANCD2, which would explain the higher sensitivity of STIM1-KO cells to MMC.My incorporation to the research group "Cell Signaling in Clinical Pathologies" ("Sefializaci6n Celular en Patologfas Clfnicas") (Code: BBB010) and the research conducted in the Doctoral Thesis have been supported by:
1. Funding from the "Consejerfa de Economfa e lnfraestructuras" of the "Junta de Extremadura" and the "Fondo Europeo de Desarrollo Regional (FEDER)" for research projects of public Centers of l+D+l of Extremadura. Code: lB16088.
2. Project BFU2017-82716-P, funded by the "Ministerio de Ciencia, lnnovaci6n y Universidades".
3. Grant of the "Plan de lniciaci6n a la lnvestigaci6n, Desarrollo Tecnol6gico e lnnovaci6n" from the Universidad de Extremadura (15/03/2020-14/03/2021).
4. Project PlD2020-112997GB-l00 funded by the "Ministerio de Ciencia e lnnovaci6n" and "Agencia Estatal de lnvestigaci6n".
5. Contracts of the "Plan de lniciaci6n a la lnvestigaci6n, Desarrollo Tecnol6gico e lnnovaci6n" from the Universidad de Extremadura (Code: EPL03851). (01/03/2022-28/02/2023) and (01/03/2023-28/02/2024).
6. Funding from the "Consejerfa de Economfa, Ciencia y Agenda Digital" of the "Junta de Extremadura". Code: GR21101
7. A general travel grant of the Biochemical Society for a short stay in a foreign country
The audiovisual documentalist-journalist as a professional profile for television information services
No full textSe analizan las labores profesionales de un perfil híbrido con conocimientos de documentación audiovisual y de periodismo en los servicios de información de las cadenas televisivas. Este perfil, procedente de la unión de dos ámbitos profesionales distintos pero relacionados, genera nuevos flujos de trabajo en el proceso informativo y, muy especialmente, en la generación de nuevos productos y nuevas tareas procedentes de la fusión de disciplinas pivotando la labor del periodista-documentalista en Media Asset Management de la cadena, aportando así un claro valor a la formación universitaria con dobles titulaciones. Se ha llevado a cabo un análisis de la literatura científica, así como de los servicios documentales de cadenas españolas, tanto públicas como privadas. De igual manera, se han analizado las potencialidades de los planes conjuntos de los grados de Información y Documentación junto a los de Periodismo. Se detecta la necesaria hibridación de perfiles atendiendo a requerimiento de las nuevas formas de hacer en los medios de comunicación, así como la potencialidad que genera el contar con trabajadores con habilidades procedentes del periodismo y de la documentación.The professional tasks of a hybrid profile with knowledge of audiovisual documentation and journalism in the information services of television networks are analyzed and developed. This profile, coming from the union of two different but related professional fields, generates new workflows in the information process and, especially, in the generation of new products and new tasks from the fusion of disciplines, pivoting its work in Media Asset Management of the sector. chain, thus providing clear value to university training with double degrees. An analysis of the scientific literature has been carried out, as well as the documentary services of Spanish channels, both public and private. Likewise, the potential of the joint plans of the Information and Documentation degrees together with those of Journalism has been taken into account. The necessary hybridization of profiles is detected in response to the requirements of new ways of doing things in the media, as well as the potential generated by having workers with skills from journalism and documentation.This research was supported by the Junta de Extremadura and FEDER Funds “A way to make Europe” [QUINARI Research Group SEJ013 GR18130].peerReviewe
Análisis de la responsabilidad socioambiental en el ámbito interno de la empresa: percepciones del empleado y repercusión sobre su identificación, confianza y compromiso
No full textPrograma de Doctorado en Economía y EmpresaLa Responsabilidad Socioambiental (RSA) es una importante herramienta de gestión, que viene ganando protagonismo al permitir mayores logros y beneficios. Este estudio se planteó como objetivo general analizar la RSA en el ámbito interno de la empresa bajo la percepción del empleado, porque la visión de los empleados hacia la RSA sigue siendo en gran parte desconocida.
El planteamiento de las hipótesis a investigar proponía contrastar la relación que la RSA puede alcanzar frente a elementos como la imagen y la reputación percibida y su relación con la identificación, confianza y compromiso del empleado hacia la empresa donde trabaja. El estudio empírico se ha realizado a una muestra de cinco industrias textiles del estado de Santa Catarina, Brasil, a través de encuestas y se ha recogido información de 997 empleados. La metodología utilizada para validar el modelo se ha basado en la técnica de Partial Least Squares (PLS).
Los resultados obtenidos han puesto de manifiesto que, la imagen y la reputación corporativa son factores muy influyentes en la identificación del empleado que quiere sentirse parte de una empresa prestigiosa que se preocupa por los temas medioambientales, y que, tanto la identificación del empleado con su empresa como la confianza que deposita en la misma tienen un impacto positivo en el compromiso que éste establece con la entidad. Se evidencia que, entre los tres elementos fundamentales en la construcción de relaciones (identificación, confianza y compromiso), es este último el que actúa directamente en los procesos y objetivos de la empresa.The Environmental Corporate Social Responsibility (ECSR) is an important management tool that has been gaining prominence by allowing greater achievements and benefits. The general objective of this study was to analyze ECSR in the internal sphere of the company from the employee's perception, because the employees' vision towards ECSR remains largely unknown.
The formulation of the hypotheses of our research, proposed to contrast the relationship that the ECSR can achieve with elements, such as image and perceived reputation and its relationship with the identification, trust and commitment of the employee towards the company where they work. The empirical study was carried out with a sample of five textile industries in the state of Santa Catarina, Brazil, through surveys and information has been collected from 997 employees. The method used to validate the model was based on the technique of Partial Least Squares (PLS).
The results achieved can demonstrate that the image and corporate reputation are very influential factors in the identification of the employees, who want to feel like they belong to a prestigious company that is concerned about environmental issues. This way, both the identification of the employee with their companies as the trust it places in it has a positive impact on the commitment it establishes with the entity. It is evident that, among the three fundamental elements in building relationships (identification, trust and commitment), it is the latter that acts directly in the company's processes and objectives
A multi-criteria decision support system to evaluate the effectiveness of training courses on citizens’ employability
No full textThis study examines the impact of lifelong learning on the professional lives of employed and unemployed individuals. Lifelong learning is a crucial factor in securing employment or enhancing one’s existing career prospects. To achieve this objective, this study proposes the implementation of a multi-criteria decision support system for the evaluation of training courses in accordance with their capacity to enhance the employability of the students. The methodology is delineated in four stages. Firstly, a ‘working life curve’ was defined to provide a quantitative description of an individual’s working life. Secondly, an analysis based on K-medoids clustering defined a control group for each individual for comparison. Thirdly, the performance of a course according to each of the four predefined criteria was calculated using a t-test to determine the mean performance value of those who took the course. Ultimately, the unweighted TOPSIS method was used to evaluate the efficacy of the various training courses in relation to the four criteria. This approach effectively addresses the challenge of using extensive datasets within a system while facilitating the application of a multi-criteria unweighted TOPSIS method. The results of the multi-criteria TOPSIS method indicated that training courses related to the professional fields of administration and management, hostel and tourism and community and sociocultural services have positive impact on employability and improving the working conditions of citizens. However, courses that demonstrate the greatest effectiveness in ranking are the least demanded by citizens. The results will help policymakers evaluate the effectiveness of each training course offered by the regional government.This work was developed with the support of Grant PID2021-127412OB-I00, and Grant CPP2021-008491, funded by MCIN/AEI/10.13039/501100011033 and “European Union NextGenerationEU/PRTR”.peerReviewe
Respectful children’s shoes: a systematic review
No full textBackground: Child footwear, both in pathologies and in normal situations, can affect the foot in various ways depending on its characteristics. Below, some features of child footwear are described, and how they can influence the foot, including suitable size, shape and design, flexibility, and transpirable material; inadequate footwear includes situations with flat foot, equine foot, and hammer toes. It is important to highlight that each child is unique and may have different footwear needs. In case of specific pathologies or concerns, it is recommended to consult a specialist in podology or foot medicine for personalized assessment and recommendations. Methods: The present systematic review was conducted in accordance with the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Children’s footwear must adapt to all stages of children’s growth, starting from when they begin to walk, to promote the correct evolution of their musculoskeletal system. For up to six months, they do not need to wear shoes; socks and similar clothing are enough to warm your feet like a second skin. The flexibility of respectful footwear is essential between six months and three or four years. From that age onwards, the soles can be somewhat thicker, and the buttress can have a certain firmness, but the shoes should remain flexible. Conclusions: Eco-friendly footwear, which typically comes from small businesses and factories, is sometimes described as “ergonomic footwear”. However, there is some reluctance towards this term. When choosing this type of footwear for children, it is important to not just look at the label; rather, one should verify that it meets all the necessary characteristics to be considered respectful.peerReviewe