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Can Clinical, Psychological, and Cognitive Patient-Reported Outcome Measures (PROMs) Help to Discriminate Women with Fibromyalgia from Those with Other Localized/Regional Pain Conditions? A Diagnostic Accuracy Study
No full textPublisher Copyright: © 2025 by the authors.Background and Objectives: The heterogeneous clinical manifestations of fibromyalgia syndrome have led to the revision of diagnostic criteria in the last decade. The aim of this study was to determine the capability of clinical, psychological, and cognitive patient-related outcome measures (PROMs) to differentiate women with fibromyalgia syndrome (FMS) from women with localized or regional pain conditions. Materials and Methods: A diagnostic accuracy study was conducted. Clinical (pain intensity—NPRS; related disability—FIQ), psychological (anxiety/depressive levels—HADS-A/HADS-D), and cognitive (sleep quality—PSQI; pain hypervigilance—PVAQ-9) PROMs were collected in 129 women with FMS and 65 women with localized/regional chronic pain conditions. The area under the receiver operating characteristic (ROC) curve, cut-off point, sensitivity/specificity values, and positive and negative likelihood (LR) ratios of each variable were calculated. Results: Women with FMS showed higher levels of pain, related disability, and anxiety/depressive levels, worse sleep quality, and higher levels of hypervigilance (all, p < 0.001) than women without FMS. All PROMs showed excellent discriminatory power and good sensitivity (pain intensity: ROC 0.987, sensitivity 91.5%; related disability: ROC 0.980, sensitivity 93.8%; HADS-A: ROC 0.901, sensitivity 81.4%; HADS-D: ROC 0.906, sensitivity 85.3%; PSQI: ROC 0.909, sensitivity 79.1%; PVAQ-9: ROC 0.798, sensitivity 80.6%). Specificity was extremely small for all variables (<18%) except for pain hypervigilance (specificity: 34%). Conclusions: Women with FMS exhibited worse clinical, psychological, and cognitive variables than women with localized/regional chronic pain. Although all PROMs had good discriminatory power, related disability and pain hypervigilance were those showing the best models. These PROMs could be combined with the American College of Rheumatology (ACR) diagnostic criteria to better discriminate between women with and without FMS. Studies investigating the relevance of combining these PROMs with the ACR diagnostic criteria in clinical settings are needed.Peer reviewe
¿INFLUYE EL CICLO MENSTRUAL EN EL RENDIMIENTO DEPORTIVO DE LAS JUGADORAS DE VOLEIBOL? UN ESTUDIO PILOTO
No full textPublisher Copyright: © 2025, Universidad Catolica San Antonio Murcia. All rights reserved.The menstrual cycle (MC) is a physiological concept that has had an exponential increase in the field of sports and research in recent years. In addition, it is a biological process corresponding to women and regulated by certain hormones that allow the possibility of fertility and may also affect other functional capacities of the female organism. Nevertheless, the related scientific literature is scarce. For this reason, the aim of the study was to perform research on female volleyball players, applying an educational methodology consisting of a talk and a workshop/focus group to discover the possible improvements in the analyzed variables. The sample consisted of eight female players (age = 20.5 ± 1.41 years; weight = 59.25 ± 7.59 kg; height = 168.75 ± 6.23 cm). A descriptive and association study was carried out between the study variables considering the time of data collection. The results highlight the importance of developing educational plans related to the MC in teams of female athletes because significant associations were found in the knowledge (question three and question six) and communication (question 14) sections. Finally, the results suggest the need to motivate and encourage the use of tools and education regarding to the MC both in sports and in the social sphere, to promote and improve knowledge, communication, and the perception of the influence of the MC. For this reason, it is recommended that sporting institutions to consider planning and developing informative talks before, during and after sports seasons.Peer reviewe
Teaching how to lead and manage talent
Full text linkPublisher Copyright: © 2025, HISIN (History of Information Systems). All rights reserved.La empresa que pretenda contribuir al progreso sostenible debe ser entendida y gestionada como una comunidad que produce bienes y servicios, para satisfacer necesidades reales de las personas y para procurar el bien común y el desarrollo sostenible de la sociedad. Esto implica considerar a las personas como fines, y no como medios o recursos humanos que se gestionan para lograr solo prestigio, poder o beneficio económico. Metodología Se ha diseñado un itinerario formativo, mediante la colaboración y discusión de empresarios y académicos, que pretende promover el liderazgo, la responsabilidad y el compromiso necesarios para generar confianza en los colaboradores y otros grupos de interés. Resultados y discusión: La formación facilita la identificación de la misión y la cultura de la empresa y el alineamiento de los propósitos personales, profesionales y organizacionales para garantizar la sostenibilidad. Conclusiones. Esta formación permite desarrollar líneas de investigación sobre la humanización de la empresa, el comportamiento organizacional, el sentido del trabajo y la gestión del talento en estructuras complejas. Palabras clave: itinerario formativo; liderazgo; responsabilidad; bien común; sostenibilidad; empresa; talento; propósito.Introduction: A company that aims to contribute to sustainable progress must be understood and managed as a community that produces goods and services, to satisfy real needs of people and to promote the common good and sustainable development of society. This implies considering people as ends in themselves, and not as means or human resources that are managed to achieve prestige, power or economic benefit. Methodology A training itinerary has been designed, through the collaboration and discussion of business people and academics, which aims to promote the leadership, responsibility and commitment necessary to generate trust among employees and other stakeholders. Results and discussion: This training facilitates the identification of the company's mission and culture, aligning personal, professional, and organizational purposes to ensure sustainability. Conclusions. This training allows for the development of research lines on humanizing the company, organizational behavior, the meaning of work, and talent management in complex structures.Peer reviewe
Long-term prognostic implications of type 2 diabetes mellitus in colorectal cancer patients
Full text linkPublisher Copyright: © 2025 The Author(s). Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland.Aim: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Epidemiological evidence has identified Type 2 Diabetes Mellitus (T2DM) as a risk factor for CRC. This study aimed to evaluate the impact of T2DM, along with clinicopathological and socio-demographic factors, on long-term overall survival in a large, nationally representative cohort of CRC patients with T2DM. Method: A prospective cohort of 1186 CRC patients was analysed, approximately 20% of whom had a diagnosis of T2DM. Kaplan–Meier estimates and multivariable Cox proportional hazards models were used to assess overall survival. Results: CRC patients with T2DM were more often older, had lower educational attainment, were former smokers, and presented higher comorbidity, right-sided tumours, prior symptoms, depressive symptoms, elevated Body Mass Index (BMI) and lower baseline quality of life (EORTC QLQ-C30 < 75). In multivariable analysis, the co-occurrence of T2DM and depression (p = 0.007; HR 1.77; 95% CI: 1.17–2.68) and low quality of life (p = 0.04; HR 1.42; 95% CI: 1.02–1.97) emerged as independent predictors of poorer long-term survival. Conclusion: Our findings highlight the compounded negative impact of T2DM and depression on overall survival in CRC patients. Their combined presence significantly worsens prognosis, underscoring the need for integrated care approaches that address both physical and mental health. Future research should explore targeted interventions for these comorbidities to improve long-term outcomes and quality of life in this high-risk population.Peer reviewe
Oxidative Stress and Postoperative Outcomes : An Umbrella Review of Systematic Reviews and Meta-Analyses
Full text linkPublisher Copyright: © 2025 by the authors.Background: Oxidative stress (OS) is a key biological mechanism influencing surgical recovery, contributing to impaired healing, infectious complications, cardiovascular events, and mortality. This umbrella review aimed to synthesize evidence from systematic reviews and meta-analyses exclusively focused on the relationship between validated oxidative stress biomarkers and postoperative outcomes. Narrative and non-systematic reviews were excluded. Methods: A comprehensive search of PubMed, Scopus, and Web of Science was conducted on 15 March 2024 and updated on 12 December 2024 to identify systematic reviews and meta-analyses including adult surgical patients, validated oxidative stress biomarkers, and clinical outcomes. Methodological quality was evaluated with AMSTAR 2 and ROBIS. The SANRA checklist was used only to verify that narrative or bibliometric reviews did not meet the inclusion criteria. These non-systematic reviews were excluded from the synthesis and cited solely as contextual references. Findings: From 527 records, ten systematic reviews of moderate to high methodological quality were included, encompassing approximately 230 primary studies. The most frequently reported biomarkers were total antioxidant capacity (TAC), glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and 8-hydroxy-2′-deoxyguanosine (8-OHdG). Lower TAC, GSH, and SOD levels were consistently associated with poor recovery and multiorgan dysfunction, whereas elevated MDA and 8-OHdG levels correlated with infectious complications, delayed healing, cardiovascular events, persistent pain, and mortality. Antioxidant-based interventions such as vitamin C, N-acetylcysteine, and propofol showed heterogeneous but promising effects, particularly in high-risk surgical populations. The main limitations were the heterogeneity of biomarkers, variability in perioperative protocols, and partial overlap of primary evidence across reviews. Interpretation: The findings were organized into three main clinical domains: (1) infectious complications and impaired healing; (2) cardiovascular and systemic complications; and (3) predictive and prognostic value of OS biomarkers for perioperative risk assessment. This thematic synthesis integrates evidence across different surgical specialties, highlighting consistent mechanistic patterns and key research gaps to inform future investigations and clinical decision-making.Peer reviewe
Analysis of persistence in obesity and severe obesity rates : short-term versus long-term interventions in 38 OECD countries
Full text linkPublisher Copyright: © The Author(s) 2025.This paper investigates time series persistence in obesity and severe obesity rates in a group of 38 OECD countries by using techniques based on fractional integration. The idea is to determine if there are trends in the time series and if the impact of health policy exposure might have permanent or transitory effects. The results based on aggregated and disaggregated data by sex indicate high levels of persistence in all cases, with orders of integration of magnitude higher than three. Trends in these rates are also of high magnitudes, particularly in Australia, New Zealand and United Kingdom. An implication of the findings is that long-term measures are required to tame obesity rates and severe obesity rates in OECD countries. The paper finally highlights the long-term measures needed to reduce the alarmingly high obesity rates in the developed countries.Peer reviewe
Fermentable dietary fibers reduce voluntary alcohol intake and modulate gut microbiota composition in rats
No full textPublisher Copyright: Copyright © 2025. Published by Elsevier Ltd.Fermentable dietary fibers can reshape the gut microbiota and boost short-chain fatty acid (SCFA) production, processes impaired by chronic alcohol use. We compared five fibers—cellulose, pectin, resistant starch, guar gum, and inulin—in male Wistar rats. After 10 days on the test diets, voluntary alcohol intake was measured with a multiple-scheduled-access paradigm, followed by a 10-day alcohol-intoxication phase. 16S rRNA profiling showed that fermentable fibers (inulin, pectin, guar gum) lowered ethanol consumption by 40–60 % and enriched SCFA-producing Bacteroidia and Muribaculaceae while reducing Proteobacteria. These microbiota shifts persisted after repeated intoxication, indicating ecological resilience. Locomotor testing confirmed that decreased drinking was not attributable to altered activity. Low-/non-fermentable fibers (cellulose, resistant starch) had no effect on intake or community structure. Our results identify fiber fermentability as a critical functional trait and support the incorporation of fermentable fibers into functional foods aimed at microbiota-based modulation of alcohol-related behaviors.Peer reviewe
Transition to online teaching in communication degrees during COVID-19tools and strategies in University Education
Full text linkPublisher Copyright: © 2025, HISIN (History of Information Systems). All rights reserved.Introduction: The COVID-19 pandemic prompted a rapid transition from face-to-face to online teaching, creating significant challenges for faculty and institutions. This study analyzes how Communication degree programs in Spanish universities adapted to this transformation. Methodology: A quantitative and exploratory approach was employed. The research was based on a literature review and the administration of a structured questionnaire to 201 professors from both public and private universities in Spain. Variables evaluated included the use of digital platforms, teaching strategies, perceived barriers, and faculty satisfaction. Results: Faculty members showed a preference for synchronous teaching through videoconferencing. PowerPoint and Google Drive were the most commonly used tools, while the use of interactive platforms and advanced audiovisual resources was limited. A generational gap and disparities in access to resources between public and private universities were also observed. Discussion: Although teaching continued, a traditional lecture-based approach prevailed, failing to fully leverage the digital environment. Limited digital skills training among faculty hindered methodological innovation. Conclusions: There is a need to improve teacher training in digital competencies, promote hybrid teaching models, and encourage the use of advanced technologies to achieve a more flexible, interactive, and adapted higher education system in the post-pandemic context.Peer reviewe
The significance of isolated de novo red patches in the bladder in patients referred with suspected urinary tract cancer : Results from the IDENTIFY study
No full textPublisher Copyright: © 2024 The Author(s). BJUI Compass published by John Wiley & Sons Ltd on behalf of BJU International Company.Objectives: To assess the contemporary malignancy rate in isolated de novo red patches in the bladder and associated risk factors for better selection of red patch biopsy. Patients: Patients from the IDENTIFY dataset; Patients referred to secondary care with suspected urinary tract cancer and found to have isolated de novo red patches on cystoscopy. Methods: We reported the unadjusted cancer prevalence in isolated de novo red patches that were biopsied; multivariable logistic regression was used to explore cancer-associated risk factors including age, sex, smoking, type of haematuria, LUTS, UTIs and a suspicious-looking red patch (as reported by the cystoscopist). Sub-analysis of these by clinical role and experience was performed. Results: A total of 1110 patients with isolated de novo red patches were included. 41.5% (n = 461) were biopsied, with a malignancy rate of 12.8% (59/461), which was significantly higher in suspicious versus non-suspicious red patches (19.1% vs. 2.81%, p < 0.01). There was a significant association between bladder cancer and age (OR 1.04, 95% CI 1.01–1.07, p = 0.01), smoking history (OR 2.62, 95% CI 1.09–6.27, p = 0.03) and suspicious-looking patch (OR 6.50, 95% CI 2.47–17.1, p < 0.01). The majority of malignancies were in over 60-year-olds. Malignancy rates in suspicious versus non-suspicious red patches did not differ significantly between clinical roles or experiences. Limitations included subjectivity in classifying a suspicious patch and selection bias as not all patches were biopsied. Conclusions: Many patients still undergo unnecessary biopsies under general anaesthetic for isolated de novo red patches. Clinicians should consider the patient's age, smoking status and how suspicious-looking the patch is, before deciding on surveillance versus biopsy to improve cancer diagnostic yield.Peer reviewe
Orthorexia Nervosa : Prevalence Among Spanish University Students and Its Effects on Cardiometabolic Health
No full textPublisher Copyright: © 2025 by the authors.Purpose: This study aims to determine the prevalence of orthorexia nervosa (ON) among university students and to evaluate the relationship between stress and ON, as well as the effects that ON may have on the health of these individuals. Methods: In this cross-sectional study, a total of 205 participants (66.7% women) were recruited through informational posters on the university campus during the 2022–2023 academic year. They answered different questionnaires to yield socio-demographic data and completed specific tests for the evaluation of ON (Düsseldorf Orthorexia Scale (DOS-ES), Eating Habits Questionnaire (EHQ-ES)) and stress (Perceived Stress Scale (PSS-ES)). The analytical determination of blood biomarkers was also carried out. Results: The prevalence of ON obtained from the DOS-ES questionnaire was 1.5%, while 7.5% of the individuals showed a risk of ON. In addition, a positive correlation was observed between DOS-ES and EHQ-ES scores (rs = 0.674). A weak correlation (rs = 0.138) was reported between stress and ON. Individuals with underweight BMI (OR: 1.11, 95% CI: 1.01–1.22) and elevated monocyte levels (OR: 1.15, 95% CI: 1.05–1.26) were more likely to have higher DOS-ES scores compared to those with normal weight and normal monocyte levels. Conclusions: Our study demonstrated a lower rate (1.5%) than previous studies, and differences by sex or age were not observed in ON diagnosis, nor was a link between underweight BMI and an increased risk of ON. Additionally, a higher monocyte count was associated with ON, suggesting potential immune and cardiometabolic implications, but further research with larger populations is needed to confirm these findings.Peer reviewe