5585 research outputs found
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Biparietal diameter for first-trimester pregnancy dating : multicenter cohort study
Full text linkPublisher Copyright: © 2025 International Society of Ultrasound in Obstetrics and Gynecology.Objective: To evaluate the accuracy of fetal biparietal diameter (BPD) measurement in comparison with crown–rump length (CRL) measurement for pregnancy dating at 11–13 weeks' gestation. Methods: This was a retrospective multicenter cohort study performed in five maternity units in Spain, the UK, Belgium and Bulgaria between January 2011 and December 2019. We included all women who attended a routine ultrasound examination at 11 + 0 to 13 + 6 weeks who had a singleton pregnancy with a viable non-malformed fetus/neonate and ultrasound-derived measurements for both CRL and BPD, along with a comprehensive record of pregnancy outcomes. We developed a formula for pregnancy dating based on BPD using data from pregnancies conceived via in-vitro fertilization (IVF) by applying a simple linear regression. We validated this formula both internally and externally and compared it with the most commonly used formulae (Robinson's CRL-based and Kustermann's BPD-based formulae) through utilization of the Euclidean distance, relative absolute error and mean squared error. We also examined the rate of induction of labor for post-term pregnancy based on dating using each of the formulae. Results: A total of 49 492 women were included in the study, comprising 47 223 (95.4%) who conceived spontaneously and 2269 (4.6%) who conceived via IVF. In the internal validation performed using data from IVF pregnancies, our newly developed formula showed no significant difference when compared with the true gestational age calculated using conception date, with a mean difference of 0.0006 (95% CI, –0.09 to 0.09) days. In contrast, the mean difference of Kustermann's BPD-based formula was −0.31 (95% CI, −0.46 to −0.17) days and the mean difference of Robinson's CRL-based formula was –1.78 (95% CI, –1.88 to –1.68) days. In the external validation using data from spontaneously conceived pregnancies, with dating using Robinson's formula as the reference for ‘true’ gestational age, both our formula and Kustermann's formula resulted in underestimation of gestational age, with significant mean differences of –1.25 (95% CI, –1.28 to –1.22) days and –0.96 (95% CI, –0.98 to –0.93) days, respectively. The largest differences compared with Robinson's formula-based dating results were observed between 11 + 0 and 12 + 0 weeks. Dating the pregnancy using Robinson's formula led to 8.1% of pregnancies identified as requiring induction after 41 + 3 weeks, compared with 6.8% (P < 0.001) and 7.0% (P < 0.001) when applying our formula and Kustermann's formula, respectively. Conclusion: Pregnancy dating based on ultrasound measurement of fetal BPD between 11 + 0 and 13 + 6 weeks' gestation is a reliable alternative to dating based on fetal CRL.Peer reviewe
A Comprehensive Review of the Mechanisms of Human Q Fever : Pathogenesis and Pathophysiology
Full text linkPublisher Copyright: © 2025 by the authors.Coxiella burnetii infection has a worldwide distribution, although the incidence and clinical manifestations vary between and within countries. There are the following four basic forms: asymptomatic infection, acute Q fever, chronic Q fever, and post-Q fever fatigue syndrome. The aim of this review is to provide a comprehensive overview of the important aspects of its pathogenesis and pathophysiology. First, we provide a brief update of the taxonomic aspects, basic structures, and genotypes of C. burnetii necessary for the proper interpretation of the following sections. Routes of infection, different stages of pathogenesis (respiratory entry of C. burnetii; penetration into alveolar macrophages, life cycle, and effects; systemic dissemination), and innate, acquired humoral and cell-mediated immune responses in different forms of infection are described in detail. The pathophysiology and clinical manifestations of Q fever, such as the main mechanisms of injury, in isolation and in combination, are reviewed. The clinical and biological manifestations of the two main forms of Q fever (acute and chronic) are outlined, with a brief definition and mention of the mechanisms of post-Q fever fatigue syndrome.Peer reviewe
Effects of Isometric Training on Ankle Mobility and Change-of-Direction Performance in Professional Basketball Players
No full textPublisher Copyright: © 2025 by the authors.Basketball requires high-intensity, multidirectional movements that place significant stress on the ankle joint. Limited dorsiflexion and reduced change-of-direction (COD) ability are associated with impaired movement efficiency and may contribute to injury mechanisms. Isometric training may help address these limitations in professional players. To assess the effects of a season-long isometric intervention program on ankle dorsiflexion and COD performance in professional basketball players. Fourteen professional players (mean age 25.6 ± 3.9 years) completed a season-long isometric intervention program (5 days/week), which included three force-steady sustained running postures and two gym-based exercises performed at 80% maximal voluntary contraction for 15–20 s per repetition (12 reps/set, 3 sets/session). Significant improvements were observed in both ankle dorsiflexion and COD performance. Dorsiflexion increased by 34.0% in the left leg and 19.4% in the right leg (Lunge Test). COD performance in the L-Test improved by 10.0% for the leftwards side and 11.6% for the rightward side from pre- to post-intervention. Isometric training improved ankle dorsiflexion and COD performance in professional basketball players, suggesting potential performance benefits and enhanced movement efficiency in multidirectional tasks.Peer reviewe
Survival in a Real-World Cohort of Patients With Transthyretin Amyloid Cardiomyopathy Treated With Tafamidis : An Analysis From the Transthyretin Amyloidosis Outcomes Survey (THAOS)
No full textPublisher Copyright: © 2024 The AuthorsPeer reviewe
Do audience response systems truly enhance learning and motivation in higher education? A systematic review
No full textPublisher Copyright: © The Author(s) 2025.Esta revisión sistemática, que siguió el marco PRISMA, examinó si los sistemas de respuesta inmediata (SRI) mejoran de manera efectiva el aprendizaje y la motivación en la educación superior. Se plantearon tres preguntas de investigación: (1) sobre la calidad metodológica de los estudios que analizan los SRI, (2) sobre las variables psicoeducativas estudiadas al utilizar estos sistemas y (3) sobre su impacto en el aprendizaje. La búsqueda bibliográfica se realizó en Web of Science (WoS), Scopus y ERIC, obteniéndose un total de 653 registros. Tras el proceso de cribado, el número se redujo a 135, de los cuales 79 fueron descartados según los criterios de exclusión. Finalmente, se seleccionaron 11 estudios para la revisión (653 → 135 → 11). Los resultados indican que la metodología y el análisis de datos de los estudios revisados no son muy sólidos, mostrando limitaciones en el control de variables y un uso limitado de instrumentos validados para la recogida de datos. Las principales variables psicoeducativas investigadas incluyen el rendimiento, la motivación, la implicación del estudiante y la satisfacción. En cuanto al efecto sobre el aprendizaje, se evidencia que no existe consenso en la literatura sobre cómo contribuyen los SRI al rendimiento académico. En la actualidad, existe un debate sobre el impacto real de estas aplicaciones en la educación superior, a pesar de su popularidad. Kahoot! es, con diferencia, el sistema de respuesta inmediata más utilizado en las aulas, superando a Mentimeter, Socrative o Wooclap. Esta revisión concluye, en línea con trabajos similares, que es necesario mejorar la calidad metodológica de la investigación sobre SRI para obtener evidencia más robusta y confirmar sus efectos sobre el aprendizaje y la motivación en la educación superior.This systematic review, that followed the PRISMA framework, examined whether Audience Response Systems (ARS) effectively enhance learning and motivation in higher education. Three research questions were posed: (1) concerning the methodological quality of studies on ARS, (2) regarding the psychoeducational variables studied when using ARS, and (3) about the impact of ARS on learning. The literature search was conducted in Web of Science (WoS), Scopus, and ERIC, yielding a total of 653 records. After the screening process, the number was reduced to 135, of which 79 were rejected based on exclusion criteria. Finally, 11 studies were selected for the review (653 → 135 → 11). The results indicate that the methodology and data analysis of the reviewed studies are not very robust, showing limitations in variable control and a limited use of validated instruments for data collection. The main psychoeducational variables investigated include performance, motivation, student engagement and satisfaction. As for the effect on learning, it is demonstrated that there is no consensus in the literature regarding how ARS contribute to academic performance. Currently, there is a debate about the real impact of these applications in higher education despite their popularity. Kahoot! is, by far, the most widely used audience response system in classrooms, surpassing Mentimeter, Socrative, or Wooclap. This review concludes, in line with similar works, that it is necessary to improve the methodological quality of research on ARS to obtain more robust evidence and to confirm their effects on learning and motivation in higher education.Peer reviewe
Comprehensive retrospective analysis of the European hernia Society quality of life in patients undergoing abdominal wall reconstruction.
No full textIntroduction
This study aimed to analyze the European Hernia Society Quality of Life (EHS-QoL) in abdominal wall reconstruction by comparing preoperative scores with those at 1 and 2 postoperative years.
Methods
Data from 105 patients with complex incisional hernias were collected preoperatively and at 1 and 2 years postoperatively. Statistical analyses included three ART ANOVA models to compare scores among the three time points and within each time point's items.
Results
The EHS score significantly decreased from preoperative (Mdn = 57) to 1 year (Mdn = 10.5) and 2 years postoperative (Mdn = 8). The most significant changes occurred between preoperative and 1-year measurements, particularly in pain levels during activities and limitations in heavy labor and activities outside the home.
Conclusion
Patients' quality of life notably improved at 1 year post-surgery, with some reaching near-maximum levels, and this improvement was generally sustained or increased at 2 years post-surgery.10 p
Effects of dietary interventions in patients with migraine: a systematic review.
No full textContext
Migraine is a disabling neurological disorder. Diet may be a factor to consider because measures of diet quality have been linked to both frequency and severity of attacks.
Objectives
To investigate the effects of dietary interventions on the clinical symptoms of migraine, quality of life, and body composition of patients with migraine.
Data Sources
The MEDLINE, Embase, and Web of Sciences databases were searched since database inception to February 13, 2024. We included articles on randomized clinical trials that assessed the effect dietary interventions on clinical symptoms of migraines and the quality of life and body composition of individuals with migraine.
Data Extraction
Data from the included articles were independently extracted by 2 researchers; another independent reviewer further verified the extractions. The Cochrane risk-of-bias tool was used to evaluate the risk of bias of selected studies, and the Physiotherapy Evidence Database scale was used to assess the methodological quality.
Results
Eight articles were included in this review. Of these, 3 reported on studies that assessed the ketogenic diet (KD), 2 reported on the Dietary Approaches to Stop Hypertension (DASH), and 3 reported on studies of other dietary strategies. Strong evidence exists regarding the effectiveness of the KD and DASH in reducing the frequency of migraine attacks, whereas their efficacy in improving patients’ quality of life was supported only by limited evidence. There also is strong evidence regarding the effectiveness of DASH in reducing migraine’s severity and patients’ body weight. Insufficient evidence was found regarding the effectiveness of the other dietary interventions on all variables.
Conclusions
The DASH and KD may help reduce migraine frequency and severity. However, more high-quality studies are needed to confirm their effectiveness.33 p
Modo avión. Jornadas de desconexión digital.
No full textModo Avión es una idea de negocio que nace como respuesta a la creciente necesidad de desconectar del entorno digital actual. El proyecto se centra en la organización de jornadas de desconexión digital para adultos, tanto para particulares como para empresas, desarrolladas en un entorno natural, una finca en Navacerrada, con una duración de dos días y medio. Su misión es ofrecer una experiencia transformadora que combina ocio, bienestar, formación y conexión humana, promoviendo hábitos saludables y un estilo de vida más equilibrado digitalmente.
Desde el punto de vista empresarial, se ha definido un modelo que busca diferenciarse por su enfoque personalizado, la variedad de actividades y una propuesta de valor centrado en la recurrencia del cliente. Se detalla la estructura organizativa, la subcontratación de servicios clave y un sistema digital eficiente para la gestión de reservas y atención al cliente.107 p
Caracterización de nuevas funciones de HIF2α en fisiopatología cardiovascular en respuesta a hipoxia crónica.
No full textNota: fecha de lectura 26/05/2025La hipoxia (Hx) está asociada a la aparición de enfermedades cardiovasculares (ECV) como la hipertrofia cardiaca y la hipertensión pulmonar (HP). El cuerpo carotídeo es el órgano encargado de detectar las fluctuaciones en la presión arterial de oxígeno (PO2) en sangre y desencadenar las respuestas fisiológicas por parte del sistema nervioso simpático para que pueda llevarse a cabo la adaptación a un menor aporte de O2. Dentro de las primeras respuestas a Hx se produce la elevación de los niveles de eritropoyetina (EPO) y del factor vascular de crecimiento endotelial (VEGF), favoreciéndose un aumento en la cantidad de glóbulos rojos en circulación y un mayor número de vasos para incrementar el flujo de O2 a los tejidos. Además, el bazo, que es un reservorio de sangre, ante una situación de estrés por Hx se contrae, liberando al torrente sanguíneo el 40% del volumen total de eritrocitos. Tanto el aumento de EPO como VEGF están inducidos por HIF2α. La señalización endotelial de HIF2 interviene en el remodelado de arterias pulmonares y el consiguiente aumento de la presión sistólica del ventrículo derecho (PSVD) durante la progresión de HP en respuesta a Hx crónica, lo que ha planteado explorar nuevas oportunidades terapéuticas para esta patología basadas en inhibidores específicos de HIF2. Sin embargo, la relevancia de este factor de transcripción en el desarrollo y progresión de HP más allá de su papel en el endotelio pulmonar, así como su importancia en la adaptación cardiaca a Hx no se han explorado en profundidad.214 p