5585 research outputs found
Sort by
Industry study sponsorship and conflicts of interest on the effect of unprocessed red meat on cardiovascular disease risk: a systematic review of clinical trials.
No full textBackground
Experimental research on the link between unprocessed red meat and cardiovascular disease risk is inconsistent and may differ according to the financial interests of red meat industry sponsors.
Objectives
This study aims to assess whether studies sponsorship or conflicts of interest with the red meat industry are associated with reported outcomes of unprocessed red meat consumption effect on risk factors for cardiovascular disease.
Methods
PubMed, Cochrane Library, and Scopus were searched from the inception of the databases to 3 March 2024. Studies were classified as “Red meat industry-related” if any of the authors declared affiliation or financial disclosure indicating a link to the red meat industry; or “Red Meat industry-independent.” Reported outcomes were independently graded as favorable, neutral, or unfavorable. Studies were also categorized by type of control group. The quality of evidence for each outcome was evaluated using the Grading of Recommendations Assessment, Development and Evaluation approach.
Results
A total of 44 studies were included, of which 66% had a link to the red meat industry. All independent studies reported either unfavorable (73.3%) or neutral (26.7%) cardiovascular outcomes when consuming unprocessed red meat. Conversely, all studies related to the red meat industry reported either favorable (20.7%) or neutral (79.3%) cardiovascular outcomes for red meat intake. A total of 69.6% of trials (16 of 23) showed a neutral effect of unprocessed red meat compared with other animal proteins, whereas 70% (7 of 10) reported an unfavorable effect compared with plant proteins. Studies with conflicts of interest were nearly 4 times more likely to report “Favorable/Neutral” outcomes compared with independent studies (odds ratio 3.75, 95% confidence interval: 1.62, 8.67).
Conclusions
Our findings highlight that using animal protein as a comparator in industry-funded studies, with quality of evidence rated as very low to low, may underestimate the cardiovascular benefits of reducing red meat intake. Most studies without conflicts of interest with the red meat industry suggested an unfavorable effect of unprocessed red meat consumption on risk factors for cardiovascular disease.41 p
Los ciclos cortos de Educación Superior : un eslabón entre el EEES y el EEE
Full text linkPeer reviewe
Transcystic management of choledocholithiasis : Outcomes, factors associated with bile duct injury and implications for surgical practice
Full text linkPublisher Copyright: © The Korean Association of Hepato-Biliary-Pancreatic Surgery.Peer reviewe
Early Access to Tafamidis for Patients With Transthyretin Amyloid Cardiomyopathy
No full textPublisher Copyright: © 2025 The AuthorsBackground: Tafamidis is a standard of care treatment for patients with transthyretin amyloid cardiomyopathy (ATTR-CM). While evidence was being assessed by regulatory authorities, a new, independent, and inclusive cohort of the phase 3 long-term extension study offered early access to tafamidis. Objectives: The purpose of this study was to present safety, mortality, and hospitalization findings for patients who received early access tafamidis. Methods: Patients with ATTR-CM and who had not taken part in the phase 3 study were able to receive tafamidis free acid 61 mg (the dose later approved) for up to 60 months or until commercial availability in their region. Enrollment criteria were minimal. Results: Among the 1,476 patients initiating tafamidis in the study between 2018 and 2023, mean (SD) age at enrollment was 76.5 (7.8) years, 88.8% were male, 85.6% had wild-type ATTR-CM, and 52.9% had NYHA class II symptoms (I: 14.9%, III: 30.8%, IV: 1.3%). Median exposure and follow-up were 12 (range: 0-55) and 19 (95% CI: 18.4-20.7) months, respectively. Overall, 7.6% of patients reported treatment-related adverse events, with 0.6% considered serious and 0.6% leading to study discontinuation. No new safety signals were identified. In Kaplan-Meier analyses, all-cause and cardiovascular (CV)-related mortality occurred in 23.4% and 13.8% of patients over the study period. Furthermore, 43.3% and 26.5% of patients had all-cause and CV-related hospitalizations. The total annual CV-related hospitalization rate was 0.26. Conclusions: In an inclusive patient cohort receiving early access to tafamidis, safety findings were consistent with those reported from other trials and real-world studies.Peer reviewe
Bimekizumab as-needed dosing in patients with psoriasis : a case series
Full text linkPublisher Copyright: © 2025 The Author(s). Published with license by Taylor & Francis Group, LLC.Introduction: Despite significant advances in psoriasis treatment, off-label dosing studies of psoriasis biologic therapies are limited. Materials and methods: In this retrospective case series, medical records from 28 patients with moderate-to-severe psoriasis treated with bimekizumab during 64-week period from May 2023 to October 2024 at the Psoriasis Unit of the Grupo Jaen (Madrid, Spain), were evaluated. Patients were managed with an off-label, as-needed, dosing strategy, with all patients initially receiving two 320 mg doses of bimekizumab at Weeks 0 and 4; subsequent doses were administered only if a given patient dropped below a PASI90 response. Primary outcome was the percentage of patients that achieved and maintained optimal skin control over time, defined as achieving a PASI90 response. Results: Twenty-seven out of the 28 patients achieved a PASI90 response after the first two bimekizumab doses, and all maintained PASI90 responses with as-needed dosing over time. One patient achieved PASI90 after a single dose of bimekizumab, and voluntarily decided not to receive a second dose. No adverse events were observed. Conclusions: Larger prospective studies comparing efficacy and safety of this off-label, as needed, bimekizumab dosing regimen with standard on-label dosing are necessary to corroborate these findings.Peer reviewe
A perfect storm : the deadly intersection of sickle cell disease and COVID-19
Full text linkPublisher Copyright: Copyright © 2025 Martí-Carvajal and De Sanctis.This review critically examines the latest research on the intersection of sickle cell disease (SCD) and COVID-19, highlighting meaningful immunopathological interactions. It reveals significant knowledge gaps, particularly in the analysis of inflammatory markers in clinical studies and the oversight of SCD in malaria-COVID-19 research conducted in African contexts. The investigation explores shared pathophysiological mechanisms, including the cytokine storm phenomenon, vascular complications, and autoimmune responses, which exemplify the perilous interplay between SCD’s chronic inflammatory state and the acute inflammatory response triggered by COVID-19. Furthermore, it provides a comprehensive analysis of hyperhaemolysis syndrome (HHS), related autoimmune conditions, and avascular necrosis (AVN) as critical complications affecting SCD patients during the COVID-19 pandemic. The aim is to establish a comprehensive framework for understanding this crucial intersection while proposing vital directions for future research and therapeutic interventions.Peer reviewe
Health-related quality of life in people with HIV from the multicentre CoRIS cohort in Spain : Associated factors and short-term changes over time
No full textPublisher Copyright: © 2025 The Author(s). HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.Objectives: We aimed to describe health-related quality of life (HRQoL), overall and across its dimensions, identify associated factors, and assess changes over time among people with HIV (PWH) from the Spanish multicentre CoRIS cohort. Methods: We developed a mobile app to collect HRQoL data every 3 months using the WHOQOL-HIV-BREF questionnaire (31 items across six domains), among PWH followed in CoRIS in 2021–2023. Factors associated with good/very good global HRQoL and with domain-specific mean scores were identified using multivariable logistic and linear regression, respectively. Results: Of 414 PWH (94.2% on antiretroviral treatment, 91.1% virally suppressed), 51.2% reported good/very good HRQoL. Latin American migrants (adjusted OR: 0.60 [95% CI: 0.36; 1.00]), and participants with lower educational level (0.36 [0.21; 0.64]), a previous AIDS diagnosis (0.56 [0.29; 1.11]) and a history of non-AIDS-related cancers (0.40 [0.14; 1.14]) were less likely to report good/very good global HRQoL. The most affected items included sexual satisfaction, forgiveness and blame, sleep and rest, and concerns about the future, with spirituality, religion and personal beliefs as the most affected domain. Latin American origin, lower educational level and shorter (15 years) time since HIV diagnosis were associated with poorer HRQoL in specific domains. No significant changes in HRQoL were observed after 12 months except slightly higher scores in physical health. Conclusions: Only half of PWH reported good/very good global HRQoL. This highlights the need to develop targeted strategies to improve HRQoL among PWH, focusing on addressing the most affected dimensions and supporting the most vulnerable groups.Peer reviewe
Self-Concept and Academic Performance in Students with and Without Learning Difficulties : A Longitudinal Study in an Inclusive School Setting
No full textPublisher Copyright: © The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).In this research, we investigated the relationship between self-concept and academic performance, particularly focusing on students with learning difficulties and special educational needs. Conducted in an inclusive educational setting without the implementation of specific or external intervention programs, this this non-experimental longitudinal study involved 112 students from grades equivalent to third to fifth grade of primary school and first grade of Secondary Education. Academic performance was evaluated using a customized rubric, while self-concept was assessed with the AF-5 test. The results, analyzed through Student’s t-test, ANOVA, and Pearson correlation, revealed improvements in both academic performance and self-concept, especially among students with learning difficulties. Moreover, a significant correlation between different performance dimensions and academic self-concept was found. These findings highlight the potential of inclusive pedagogical environments and integrated classroom-based support in promoting academic achievement and socioemotional development, particularly in students with diverse educational needs.Peer reviewe