5585 research outputs found
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Is there a domestication syndrome in Vitis (Vitaceae) seed morphology?
Full text linkPublisher Copyright: © The Author(s) 2024.Peer reviewe
Tratamiento con agonistas dopaminérgicos en la enfermedad de ParkinsonConsenso de expertos españoles sobre su uso en diferentes situaciones clínicas
No full textPublisher Copyright: © 2023 Sociedad Española de NeurologíaBackground: Different types of therapies were proven effective for the medical management of motor and non-motor symptoms in Parkinson's disease (PD). We aimed to gain consensus on the dopamine agonist (DA) therapy use in different clinical scenarios of Parkinson's disease (PD) patients. Methods: This consensus study was based on the nominal group technique. Initially, a consensus group comprising 12 expert neurologists in the PD field identified the topics to be addressed and elaborated different evidence-based preliminary statements. Next, a panel of 48 Spanish neurologists expressed their opinion on an internet-based systematic voting program. Finally, initial ideas were reviewed and rewritten according to panel contribution and were ranked by the consensus group using a Likert-type scale. The analysis of data was carried out by using a combination of both qualitative and quantitative methods. The consensus was achieved if the statement reached ≥ 3.5 points in the voting process. Results: The consensus group produced 76 real-world recommendations. The topics addressed included 12 statements related to DA therapy in early PD, 20 statements concerning DA treatment strategy in patients with motor complications, 11 statements associated with DA drugs and their side effects, and 33 statements regarding DA therapy in specific clinical scenarios. The consensus group did not reach a consensus on 15 statements. Conclusion: The findings from this consensus method represent an exploratory step to help clinicians and patients in the appropriate use of DA in different stages and clinical situations of PD.Peer reviewe
A scoping review of nature education programs and their effects on schoolchildren
Full text linkPublisher Copyright: © 2025, Universidad del Norte. All rights reserved.Objectives: The objective was to synthesize the main characteristics of educational programs based on contact with nature and their impacts on students, given that although the benefits of this education have been studied, little is known about the specific characteristics of programs implemented in school contexts. Materials and methods: The review was conducted following the guidelines of the PRISMA statement. ERIC, Google Scholar, Scielo, and Redalyc databases were used, covering studies from 2016 to March 2024. A total of 11 studies analyzing school programs involving 605 students were included. Results: Most of the programs reviewed were 60 minutes in duration per session, with a daily or weekly frequency, and ranged from one to three weeks. The programs took place primarily in natural settings such as backyards, forests, and parks. The main activities included natural environment exploration, flora and fauna identification, and greenhouse activities. These interventions were mainly implemented by teachers in the school context. Results indicated positive effects on both connections to nature and students’ academic performance. Conclusions: The findings highlight the importance of integrating nature contact programs into school education to foster greater student connection with their natural environment. Although more research is needed in this area, the results suggest that these interventions can contribute significantly to students’ personal and academic development.Peer reviewe
Prediction of Small for Gestational Age and Growth-Restricted Neonates at 35 to 36 Weeks of Gestation : A Multicenter Cohort Study
No full textPublisher Copyright: © 2025 by the authors.Background and Objectives: Third-trimester screening is widely used to identify small for gestational age (SGA) and fetal growth restriction (FGR), but optimal models and timing remain under investigation. This study aimed to assess the performance of combined maternal factors and biomarkers, including ultrasound estimated fetal weight (EFW), Doppler indices, mean arterial pressure (MAP), and angiogenic biomarkers, for predicting SGA neonates after a routine 35–36 weeks’ scan in an unselected population. Materials and Methods: We conducted a retrospective cohort study in three Spanish centers offering universal third-trimester ultrasound. Logistic regression analyses were carried out to predict birthweight 80%, an SPR of approximately 40% was required. Performance improved when focusing on neonates born before 38 weeks, with a DR of 77.5 (95% CI: 68.6 to 84.9) at 10% FPR for SGA < 10th percentile. However, less than 40% of screen-positive women remained undelivered by 40 weeks, limiting the number requiring further surveillance. Conclusions: A third-trimester screening at 35–36 weeks using maternal characteristics and EFW identifies most SGA neonates, particularly those delivering before 38 weeks. Even including other biomarkers, an SPR of about 40% should be necessary to achieve a high DR. However, less than 40% of the women would remain undelivered before a subsequent follow-up is required.Peer reviewe
Problematic Internet use among adultsA longitudinal European study
No full textPublisher Copyright: © 2025, Edita Socidrogalcohol. All rights reserved.There are few cross-cultural studies utilizing longitudinal analysis to explore problematic internet use (PIU), and almost none among adults. The present follow-up study compared three waves across 12-month period every six months and observed the natural course and trajectory of PIU in a European multi-country sample of adults from 11 countries (Finland, Germany, Italy, Spain, France, Switzerland, Hungary, Poland, UK, Norway, Belgium). A total of 139 participants (45.5% females) provided data across all three waves with an average age of 26.14 years (SD = 5.92). There were longitudinal effects in PIU, with statistical differences between at-risk users compared to healthy users in Waves 1 and 2, and Waves 1 and 3. The analyses of variance showed a longitudinal effect of waves on the PIU symptoms. PIU was significantly affected by time and type of user, with those classed as at-risk having higher scores than healthy users, although PIU decreased over time. In addition, the type of PIU detected in adults contained mild addictive symptoms. In conclusion, this study demonstrated that PIU was generally low among European adult population and tended to decrease over the one-year period, what contrasts with adolescent population findings.Peer reviewe
Long-Run Trends and Cycles in US House Prices
Full text linkPublisher Copyright: © The Author(s) 2025.This paper analyses US nominal house prices at an annual frequency over the period from 1927 to 2022 by means of a very general time series model. This includes both a (linear and non-linear) deterministic and a stochastic component, with the latter allowing for fractional orders of integration at both the long-run and the cyclical frequencies. The results are heterogeneous depending on the model specification and on whether or not the series have been logged. Specifically, a linear model appears to be more appropriate for the logged data whilst a non-linear one appears to be a better fit for the original ones. Further, the order of integration at the zero or long-run frequency is much higher than at the cyclical one. The former is in fact around 1 in all specified models, which implies a high degree of persistence of this component. Finally, the order of integration of the cyclical structure implies that cycles have a periodicity of about 8 years, but it is almost insignificant in all cases.Peer reviewe
Vaginal Administration of Progesterone in Twin Gestation : Influence on Bone Turnover and Oxidative Stress
Full text linkPublisher Copyright: © 2025 by the authors.Twin pregnancies, with higher incidences of preterm birth, are becoming more prevalent. Progesterone has shown effectiveness in the prevention of preterm labour, though other factors related to pregnancy and neonatal health may be affected by this hormone and have not been previously addressed. This study aims to evaluate the impact of progesterone administration on oxidative stress and bone turnover during twin gestation and investigate associations with some maternal/neonatal variables of interest. Women pregnant with twins were recruited in the “Virgen de la Arrixaca” University Hospital and randomly assigned to two groups: control (n = 49) and progesterone (n = 50). A total of 600 mg/day of progesterone was vaginally administered from 11 to 14 to 34 weeks of gestation. Blood samples were taken in the first (T1) and third trimester (T3), analyzing biomarkers related to oxidative stress and bone turnover. Most bone turnover and oxidative markers experiment with significant changes during gestation. Progesterone administration significantly increased (p < 0.05) the levels of osteocalcin in T3 and decreased (p < 0.05) the levels of sclerostin. Regarding oxidative stress, the progesterone group, unlike the control group, showed no significant increase in oxidative stress between T1 and T3. In conclusion, results show that progesterone administration could increase maternal bone formation and modulate oxidative stress.Peer reviewe
Validation of artificial intelligence algorithm LuxIA for screening of diabetic retinopathy from a single 45° retinal colour fundus images : The CARDS study
Full text linkPublisher Copyright: © Author(s) (or their employer(s)) 2025.Objective This study validated the artificial intelligence (AI)-based algorithm LuxIA for screening more-than-mild diabetic retinopathy (mtmDR) from a single 45° colour fundus image of patients with diabetes mellitus (DM, type 1 or type 2) in Spain. Secondary objectives included validating LuxIA according to the International Clinical Diabetic Retinopathy (ICDR) classification and comparing its performance between different devices. Methods In this multicentre, cross-sectional study, retinal colour fundus images of adults (≥18 years) with DM were collected from five hospitals in Spain (December 2021-December 2022). 45° colour fundus photographs were captured using non-mydriatic Topcon and ZEISS cameras. The Discovery platform (RetinAI) was used to collect images. LuxIA output was an ordinal score (1-5), indicating a classification as mtmDR based on an ICDR severity score. Results 945 patients with DM were included; the mean (SD) age was 64.6 (13.5) years. The LuxIA algorithm detected mtmDR with a sensitivity and specificity of 97.1% and 94.8%, respectively. The area under the receiver-operating characteristic curve was 0.96, indicating a high test accuracy. The 95% CI data for overall accuracy (94.8% to 95.6%), sensitivity (96.8% to 98.2%) and specificity (94.3% to 95.1%) indicated robust estimations by LuxIA, which maintained a concordance of classification (N=829, kappa=0.837, p=0.001) when used to classify Topcon images. LuxIA validation on ZEISS-obtained images demonstrated high accuracy (90.6%), specificity (92.3%) and lower sensitivity (83.3%) as compared with Topcon-obtained images. Conclusions AI algorithms such as LuxIA are increasing testing feasibility for healthcare professionals in DR screening. This study validates the real-world utility of LuxIA for mtmDR screening.Peer reviewe
Pecos Bakery & Coffee. Rebranding completo de la cafetería Pecos Bakery & Coffee.
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A path to better mental health among emerging adults : forgiveness as a solution to interpersonal conflicts
No full textPublisher Copyright: Copyright © 2025 Bonete, Molinero, Sendra and González De Abreu.The present study offers insight into the importance of forgiveness in the holistic development of university students, through an empirical analysis of forgiveness associated with variables related to well-being such as self-esteem, hope, depression, anxiety, stress and anger among Spanish students (n = 463). The aim was to identify the needs of the group and to explore the relationship between forgiveness and these variables. A quantitative analysis was conducted using a battery of questionnaires. Pearson correlations and one-way ANOVA tests were performed. Results showed significant positive relationships between forgiveness, self‑esteem, and hope, and negative relationships with depression, anxiety, stress, and anger. Students with higher forgiveness levels showed significantly greater self-esteem and hope and lower depression and anger than those with lower forgiveness levels. This research tentatively highlights the need to implement forgiveness programs to improve university students’ skills, promote psychological well‑being, and facilitate positive adaptation to the workplace.Peer reviewe