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Theoretical and methodological foundation of a self-perception scale on personal competencies and the cardinal virtues. An exploratory and pilot study.
Full text linkThe cardinal virtues (prudence, justice, fortitude, and temperance) have relevance within the areas of character education and integral or comprehensive formation. In recent years, there has been growing interest and a great deal of literature produced on character education and its measurement. In this paper, we propose a questionnaire (a Likert-type self-report scale of 22 items), the QCV, designed to measure competencies associated with the cardinal virtues. The theoretical foundation of the questionnaire lies in the Aristotelian-Thomistic tradition in dialogue with positive psychology. The paper also offers a review of the literature on the measurement of virtue and the principal instruments currently used to measure the cardinal virtues. The results of a preliminary application of the QCV with a sample of 325 university students indicate that the questionnaire, written in Spanish and conducted in Madrid, has good psychometric properties.811 K
[Reseña ] Si Aristóteles levantara la cabeza. Manual de escritura de series de Ruth Gutiérrez Delgado. Pamplona: Eunsa, 2023.
No full text3 p
La relación entre el ajuste diádico, la diferenciación del self y los celos en parejas españolas: un estudio empírico.
No full textEl aumento de las separaciones en los últimos años ha puesto de manifiesto la complejidad de las relaciones de pareja y el impacto de los diversos factores en su estabilidad. El presente estudio tiene como objetivo examinar la relación entre el ajuste diádico, la diferenciación del self y los celos, así como otras variables sociodemográficas. La muestra del estudio está compuesta por 106 personas que se encontraban en una relación de pareja. Se utilizó un diseño correlacional-predictivo y los participantes completaron un cuestionario sociodemográfico, la Escala de Ajuste Diádico (EAD-13), la Escala de Diferenciación del Self (EDS-R) y la Escala de Celos (CECLA). Los resultados mostraron que el ajuste diádico únicamente correlaciona positiva, moderada y significativamente con el grado de compromiso; con respecto a la diferenciación del self, se observó que existen diferencias entre sexo, siendo los hombres los que puntuaron más alto en la escala total y las mujeres en la dimensión de corte emocional. Paralelamente, el análisis de regresión múltiple mostró que solo la diferenciación del self tiene la capacidad de predecir el ajuste diádico, explicando el 18% de la varianza. Los resultados encontrados difieren de otros estudios previos, que han identificado una relación entre los celos y el ajuste diádico, lo que subraya la importancia de continuar investigando estos factores en la relación con la estabilidad de pareja53 p
Propuesta de intervención para reducir los síntomas del trastorno del espectro autista mediante realidad virtual en niños entre 8 y 10 años.
No full textEn los años recientes, ha aumentado el diagnóstico y los síntomas del Trastorno del Espectro Autista (TEA), especialmente en niños. Aunque el diagnóstico temprano es clave, el acceso a intervenciones adecuadas se ve limitado debido a la elevada demanda y la ausencia de personalización en los tratamientos. Esto subraya la necesidad de enfoques más específicos y adaptados a cada niño. El TEA afecta significativamente la calidad de vida, dificultando la interacción social, la ansiedad y la regulación emocional. Método: se propone un programa de intervención a través de realidad virtual, cuyo objetivo general es reducir los síntomas del autismo en niños entre 8 y 10 años. Los objetivos específicos serán mejorar las habilidades de comunicación social, modificar estrategias de regulación emocional, reducir los síntomas de ansiedad y evaluar la efectividad de la realidad virtual en comparación con las técnicas tradicionales. El programa consta de 10 sesiones y 18 actividades, organizadas en un total de 20 semanas. Resultados: se espera que la intervención con realidad virtual mejore las habilidades sociales y la gestión de la regulación emocional, reduzca la ansiedad en niños varones con TEA y resulte más efectiva que las terapias tradicionales. Discusión: la literatura científica respalda los hallazgos previstos en la mejora de síntomas del autismo mediante realidad virtual, especialmente en habilidades sociales, emocionales y reducción de ansiedad. No obstante, se observa una limitación en cuanto al tamaño de la muestra y la ausencia de un análisis a largo plazo.77 p
Inflation Persistence in the G7 : The Effects of the Covid-19 Pandemic and of the Russia-Ukraine War
Full text linkPublisher Copyright: © 2024 The Author(s). The Manchester School published by The University of Manchester and John Wiley & Sons Ltd.This note analyses how shocks caused by the Covid-19 and the Russia-Ukraine crisis impact on inflation persistence G7 countries. Using data ending at December-2019, high estimates of the persistence parameter d indicate a strong persistence of inflation. The unit root hypothesis could not be refuted for Germany, Japan, and the United States, while this hypothesis is rejected in favour of higher orders of integration in the remaining cases. Expanding the dataset to include the pandemic and the Russia-Ukraine crisis reveal that d-values remain significantly elevated across all countries, reinforcing the persistence of inflation. Interestingly, Canada, previously excluded from the group, now aligns with Germany, Japan, and the United States. This suggests a change in inflation dynamics for Canada during these extraordinary periods. Additionally, employing a recursive estimate reveals a slight increase in inflation persistence for most countries, except Japan, which exhibits an almost flat trend in the evolution of the differencing parameter.Peer reviewe
Extracellular Vesicles in Calcific Aortic Valve Disease : From Biomarkers to Drug Delivery Applications
No full textPublisher Copyright: © 2025 by the authors.Calcific aortic valve disease (CAVD) is a progressive disorder where molecular alterations occur long before visible calcification, making early biomarkers essential. Extracellular vesicles (EVs) have gained attention as stable biomarkers due to their lipid bilayer, which protects proteins, lipids, and RNAs, ensuring reliable detection even in archived samples. This review highlights the role of EVs as biomarkers and delivery tools in CAVD. EVs derived from valvular endothelial, interstitial, and immune cells carry disease-specific signatures, including osteogenic proteins (BMP-2, Annexins), inflammatory miRNAs (miR-30b, miR-122-5p), and lipid mediators. These reflect early pathogenic processes before macroscopic calcification develops. Their presence in minimally invasive samples such as blood, urine, or saliva facilitates diagnosis, while their stability supports long-term monitoring of disease progression and therapeutic response. Advances in purification and single-EV analysis increase specificity, though challenges remain in standardizing methods and distinguishing CAVD-derived EVs from those in atherosclerosis. Beyond diagnostics, engineered EVs show promise as therapeutic carriers. Delivery of anti-calcific miRNAs or combined RNA cargos has reduced calcification and inflammation in preclinical models. Overall, EVs act as molecular mirrors of CAVD, enabling early diagnosis, risk stratification, and novel therapeutic strategies. Yet, clinical translation requires technical refinement and validation of the disease-specific signatures.Peer reviewe
La educación para el Desarrollo Sostenible y el Diseño Universal para el Aprendizaje : una propuesta de Aprendizaje Servicio en la universidad.
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Treponema pallidum infection in asymptomatic persons : A puzzling scenario in the Canary Islands (Spain) (2001–2020)
Full text linkPublisher Copyright: © 2025 Pérez-Arellano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. publicly available at the following DOI: 10.5281/ zenodo.15168959.Background and objectives Syphilis is an infectious disease caused by T. pallidum subsp. Pallidum. In high-income countries the main mode of transmission is sexual. Approximately half of infected patients are asymptomatic, which does not exclude the possibility of transmission. The aim of this study was to evaluate syphilis seroprevalence among asymptomatic persons in Gran Canaria (Canary Islands, Spain). Patients and methods Three different groups were studied from 2001 to 2020: i) a “blood donor” sample of 948,869 voluntary blood donations as a proxy of health population.; ii) undocumented African immigrants, including 1,873 recent arrivals in Gran Canaria; and iii) people living with HIV (PLWH), a group of 1,690 patients followed by our team. The evaluation included both treponemal and reaginic tests. Results i) among blood donors, the mean seroprevalence of positive treponemal tests was 0.25% (95% CI: 0.19–0.31). Non-treponemal test positivity (RPR) ranged from 0.05 to 0.06% with titers ≤ 1:4 in all cases; ii) thirty-four of 641 undocumented African migrants (5.30%; 95% CI: 3.82–7.32%) had a confirmed positive treponemal test but only 4 had a positive RPR, with titers ranging from 1:1–1:4; iii) 46.51% (95% CI: 44.14–48.89) of PLWH patients had a confirmed positive treponemal test. For factors related to HIV-syphilis coinfection, multivariate analysis clearly showed the association with male sex and the MSM risk category. However, the results of this series call into question the overall role of immigration in the seroprevalence of syphilis among PLWH in our setting. Active syphilis (RPR > 1:8) was found in 20.10% of PLWH. Conclusions In summary, syphilis is a re-emerging infection, and asymptomatic persons constitute a group that facilitates its transmission and spread. In our setting, seroprevalence was lowest in blood donors, higher in recently arrived African migrants, and highest in PLWH, especially MSM. The presence of active syphilis however is mainly restricted to MSM. This information is of relevance for the design of syphilis control strategies.Peer reviewe
External validation and comparison of Fetal Medicine Foundation competing-risks model for small-for-gestational-age neonate in the first trimester : multicenter cohort study
Full text linkPublisher Copyright: © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.Objectives: To examine the predictive performance of the Fetal Medicine Foundation (FMF) competing-risks model for the first-trimester prediction of a small-for-gestational-age (SGA) neonate in a large, independent, unselected European cohort and to compare the competing-risks algorithm with previously published logistic-regression models. Methods: This was a retrospective, non-interventional, multicenter cohort study including 35 170 women with a singleton pregnancy who underwent a first-trimester ultrasound assessment between 11 + 0 and 13 + 6 weeks' gestation. We used the default FMF competing-risks model for the prediction of SGA combining maternal factors, uterine artery pulsatility index (UtA-PI), pregnancy-associated plasma protein-A (PAPP-A) and placental growth factor (PlGF) to obtain risks for different cut-offs of birth-weight percentile and gestational age at delivery. We examined the predictive performance in terms of discrimination and calibration and compared it with the published data on the model's development population and with published logistic-regression equations. Results: At a 10% false-positive rate, maternal factors and UtA-PI predicted 42.2% and 51.5% of SGA < 10th percentile delivered < 37 weeks and < 32 weeks, respectively. The respective values for SGA < 3rd percentile were 44.7% and 51.7%. Also at a 10% false-positive rate, maternal factors, UtA-PI and PAPP-A predicted 42.2% and 51.5% of SGA < 10th percentile delivered < 37 weeks and < 32 weeks, respectively. The respective values for SGA < 3rd percentile were 46.2% and 51.7%. At a 10% false-positive rate, maternal factors, UtA-PI, PAPP-A and PlGF predicted 47.6% and 66.7% of SGA < 10th percentile delivered < 37 weeks and < 32 weeks, respectively. The respective values for SGA < 3rd percentile were 50.0% and 69.0%. These data were similar to those reported in the original model's development study and substantially better than those calculated using pre-existing logistic-regression models (McNemar's test, P < 0.001). The FMF competing-risks model was well calibrated. Conclusions: The FMF competing-risks model for the first-trimester prediction of SGA is reproducible in an independent, unselected low-risk cohort and superior to logistic-regression approaches.Peer reviewe
Recommendations for the use of biomarkers for the management of adults with sepsis : a scoping review and critical appraisal
Full text linkPublisher Copyright: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.Objective A synthesis and appraisal of the recommendations for biomarkers in practice guidelines concerning sepsis is required to consolidate evidence-based practice. We generated an evidence gap map (EGM) on the use of biomarkers for managing adults with sepsis. Design Scoping review. Data sources MEDLINE, Guidelines International Network, Pan American Health Organization, Trip Database and UpToDate were searched from 2016 to March 2025. Eligibility criteria Guidance documents (GD) that searched at least one literature source and provided clinical recommendations for the use of biomarkers for the management (diagnosis and prognosis, including treatment response) of adults with sepsis. Data extraction and synthesis Two reviewers independently applied the eligibility criteria and extracted data. We used the AGREE-II (Appraisal of Guidelines for Research and Evaluation) tool to assess the GD quality. GDs that scored ≥50% on the AGREE-II 'Rigour of development' domain were considered robust. We also applied the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system to evaluate if the recommendations were strong or conditional. Results We found 10 GDs, with only half (4/8) having a robust methodology. There were 31 recommendations concerning biomarkers. Among these, 24 (77.4%) recommendations were about single biomarkers, with lactate (23; 74.2%) and procalcitonin (8; 25.8%) most frequently recommended. Biomarker testing focused on prognosis in 28 (90.3%) recommendations. Overall, 16 (51.6%) recommendations were graded strong and 13 (42.0%) were conditional, which we displayed in an EGM. Conclusions The methodology of GDs concerning adult sepsis was poor. Our review calls for more prudent use of biomarkers in specific prognostic scenarios and in combination with standard clinical assessments. Enhancing the methodological quality of future GDs is essential to generate more valid and robust recommendations for optimising patient care.Peer reviewe