Higher Institute on Territorial Systems for Innovation
PORTO@iris (Publications Open Repository TOrino - Politecnico di Torino)Not a member yet
146173 research outputs found
Sort by
FedAGF: Adaptive Concurrency via Gradient Feedback for Mitigating Extreme Label Skew in Budget-Constrained Federated Learning
No full textDynamics of a charged Ziegler’s double pendulum with a nonholonomic constraint under the joint action of a dead force and a Lorentz force
No full textBack-to-Back Testing Platform for Inverter Efficiency Mapping using Standard CAN Communication
No full textWO3-based bifunctional devices for light harvesting-energy storage
No full textL'abstract è presente nell'allegato / the abstract is in the attachmen
Action Potential Dynamics on Heterogeneous Neural Networks: From Kinetic to Macroscopic Equations
No full textIn the context of multi-agent systems of binary interacting particles, a kinetic model for action potential dynamics on a neural network is proposed, accounting for heterogeneity in the neuron-to-neuron connections, as well as in the brain structure. Two levels of description are coupled: in a single area, pairwise neuron interactions for the exchange of membrane potential are statistically described; among different areas, a graph description of the brain network topology is included. Equilibria of the kinetic and macroscopic settings are determined and numerical simulations of the system dynamics are performed with the aim of studying the influence of the network heterogeneities on the membrane potential propagation and synchronization
Bioinspired scaffold design using a custom Voronoi path generator for extrusion-based 3D printing
Full text linkNatural systems are often arranged into specialized patterns, conferring unique biological features and functions to tissues and organs. Engineered microenvironments, aiming to support cell cultures and tissue-specific functions, have to accurately recreate biological arrangements for the development of relevant biological models. To this aim, we designed a custom Python-based software tool to produce the biomimetic and irregular structure known as the Voronoi pattern by extrusion-based additive manufacturing techniques—melt electrowriting (MEW) and fused deposition modelling (FDM). The printed Voronoi backbone was integrated with an electrospun nanofibrous membrane, providing a multiscale construct that combines the morphological fidelity of additive manufacturing with the ECM-like features of electrospinning. As the Voronoi arrangement is observed in lung tissue organization, we cultured alveolar epithelial and endothelial cells on the upper and lower sides of the construct, respectively, to reassemble the alveolar-capillary barrier in vitro. The culture was maintained under air–liquid-interface (ALI) conditions for 10 days, reaching complete coverage of the two sides of the construct and a physiological-like organization of the cells within the biomimetic architecture. Overall, this study introduces a flexible approach that merges digital design and hybrid fabrication to manufacture in vitro tissue models that more closely mimic physiological environments
Interface Conditions in Phenotype-Structured Models with Basement Membranes and Cell Layers
No full textThe purpose of this article is to identify the appropriate interface conditions to be coupled with phenotype-structured models, in which the motility terms depend on both cell density and phenotypic expression and where the cell population lives in a domain characterized by the presence of thin physical structures, such as basement membranes, vessel walls, and cell layers. A set of biophysically consistent transmission conditions is derived through an asymptotic method. The way in which they depend on the phenotype is found, determining the ability or inability of the cells to cross the membrane-like structure. In this way, the interface can act as a selector of more invasive phenotypes with respect to more residential ones. Numerical simulations confirm the analytical findings and provide additional insights into the influence of each model component. Overall, our results highlight how the interplay between phenotypic traits and migratory behaviour governs the spatial distribution of heterogeneous cell populations in the presence of physical interfaces, laying the groundwork for future theoretical and computational studies
Analysis of Electric Fault in a MV DC MgB 2 Transmission Line Cooled by Liquid Hydrogen
No full textA submarine superconducting cable for the hybrid transmission of electricity and liquid hydrogen from a wind and solar offshore plant is under investigation in the frame of a project funded by the Italian Ministry of University and Research. The DC MgB2 line is designed to connect the 300 MW offshore plant to the Ravenna port (Italy), approximately 22 km away, at an operating voltage of 30 kV. In this work, an electric model based on a lumped-parameter circuit of a DC medium voltage (MV) line including a MgB2 conductor is coupled with a fluid-dynamic model suited to simulate fast thermodynamic transients in liquid hydrogen
Polyphenols promote stem cell surface adaptation onto low-adhesion chitosan-titanium through protein synthesis and cytoskeletal remodeling
Full text linkImplant surface modification aims to facilitate integration by enhancing cell-material interactions at the interface. Accordingly, a Ti6Al4V alloy was chemically treated to obtain a microtextured topography with a high density of reactive -OH groups, then coated with chitosan and finally functionalized with a polyphenol extract from white grape seeds. Chitosan was crosslinked with sodium tripolyphosphate to reduce swelling. The extract and the functionalization solution were analyzed through HPLC, DLS, zeta potential, Folin-Ciocalteu assay, and UV–Vis spectroscopy. The functionalized Ti alloys were characterized through fluorescence and XPS analysis. The biological characterization using human bone marrow-derived stem cells (hBM-MSCs) showed low adhesion on chitosan, while polyphenols significantly improved surface colonization. Immunocompatibility studies using peripheral blood mononuclear cells excluded alterations in the balance of immune cell subsets due to the interaction with the polyphenol-functionalized titanium. Proteomic studies were performed on proteins expressed by hBM-MSCs and on proteins adsorbed from a rich protein source such as fetal bovine serum (FBS). Results demonstrated that polyphenols enhanced protein synthesis and extracellular matrix organization for hBM-MSCs, while they significantly promoted the adsorption of proteins from FBS
Robotics and related Digitalization for high human intensive A/C assembly activities
Full text linkL'abstract è presente nell'allegatoThe abstract is in the attachmen