Jurnal Fakultas Farmasi Umi (Universitas Muslim Indonesia)
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PENELUSURAN ZAT TOKSIK SARANG SEMUT ACEH (Mymercodia sp) DENGAN METODE BST TERHADAP LARVA UDANG Artemia salina
Get PDFThe Myrmecodia species as medicinal plants find Papua Island and Sumatera Island like Aceh forest.It is a member of Rubiaceae family and lives as ephyphyte on other plants. Local peoples in Aceh province boiled the tubers parts of myrmecodia species to treat inflammation, rheumatic,cancer and other diseases. Meanwhile, there is still limited scientific evidence to proof the efficacy of myrmecodia species. The dried simplicia was extracted using maceration technique, then partitioned usingn-hexane, chloroform and n-buthanol solvent. Toxicity test was done by the Brine Shrimp Lethality Test (BST) methodat four concentration levels, i.e: 1000, 500, 250, 125 and 6.5 ppm. The result of the research showed that n-buthanol, chloroform and n-hexan of Myrmecodia sphad acute toxicity by LC50 value 97.72 ppm, 262.02 ppm and 223.87 ppm respectively. Analysis Infrared spectrum of buthanol extract showed some functional groups. like hydroxy, aether and aromatic ring
DAYA TOLAK INFUSA DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) TERHADAP PELETAKAN TELUR NYAMUK Aedes spp
Get PDFAedes spp larval resistance against chemical insecticide has been reported in many country. The new methods that can be used to control the mosquito populations as a dengue fever vector and alternative compound which is safe for environtment and can’t cause the resistance need to be found. Pandan leaves have aromatic fragrant that can be expected as a oviposition deterrent effect against Aeses spp mosquito. To know oviposition deterrent effects and optimum consentration of pandan leaves (Pandanus amaryllifolius Roxb.) infusa against Aedes spp. This research was an experimental research using six groups of concentration. There was 0 mL/L (control), 3 mL/L, 3,5 mL/L, 4 mL/L, 4,5 mL/L and 5 mL/L. Every groups would be repeated by fourth. Ovitraps with different concentration of pandan leaves infusa placed at research location. The mosquito eggs that caught at the ovitrap would be counting and identifying in the laboratorium. Data was analyzed using One Way Anova test via computer program SPSS 19.0 and then continued by LSD test with 95% confidence level. The repellency percentage at 3 mL/L concentration is 30.35%; 3,5 mL/L is 55.35%; 4 mL/L is 65.17%; 4,5 mL/L is 82.14% and 5 mL/L is 100% with significancy value is 0,000 (p<0,05)
ANALISIS KADAR FLAVONOID DAN FENOLIK TOTAL FRAKSI ETIL ASETAT DAUN KETEPENG CINA (Senna alata (L.) Roxb) DENGAN METODE SPEKTROFOTOMETRI UV-VISIBLE
Get PDFAnalysis of flavonoid and phenolic content of ethyl acetate fraction have done in chinese ketepeng leaves (Senna alata (L.) Roxb) using UV-Visible spectrophotometric method. This research aimed to analyzed of flavonoids and phenolic content of ethyl acetate fraction of chinese ketepeng leaves. Chinese ketepeng leaves were extracted using ethanol 96%, and then were partitioned using a liquid-liquid partition method of ethyl acetate to obtain ethyl acetate fraction. Flavonoid and phenolic content determined using UV-VIS spectrophotometric at 415 nm wavelength for flavonoid and 730 nm for phenolic. This research results showed that the flavonoid content of ethyl acetate fraction of chinese ketepeng leaves is 2,665 mgRE/g and phenolic content of ethyl acetate fraction of chinese ketepeng leaves is 3,729 mgRE/g
ANALISIS PENGARUH BERWUDHU TERHADAP PERUBAHAN TEKANAN DARAH SESAAT
Get PDFThe ablution is a very important Islamic teachings as a condition of validity of prayers, besides ablution provide a very important benefit to human health. Objective: To determine the effect of berwudhu to changes in blood pressure on high school students shortly Global Mandiri Al - Ashri Makassar. Methods: This study used a survey method that uses the analytic approach of Cross Sectional. The samples used were mostly high school students Global Mandiri Al - Ashri Makassar as many as 50 people. Results : The results showed a mean systolic blood pressure was 123.56 mmHg before her ablutions, then after berwudhu 122.28 mmHg. Mean diastolic blood pressure before berwudhu was 64.08 mmHg , and 62.32 mmHg after her ablutions, with kemanaknaan p > 0.005 ( p = 0.270 ). Conclusion : There is a change in blood pressure just before and after her ablutions, although it is not significant
UJI EFEKTIVITAS KOMBINASI SARI BUAH MERAH (Pandanus conoideus Lam.) DAN PERASAN DAUN KUMIS KUCING (Orthosiphon aristatus Mig.) SEBAGAI ANTIINFLAMASI PADA MENCIT (Mus musculus) SECARA TOPIKAL
Get PDFInflammation is a protective response on the body from injury of cell. Edema is one of inflammation sign. It was reported that Pandanus conoideus Lam. and Orthosiphon aristatus Mig. empirically used as an antiinflammation. The aim of this research was determining the combination effect of Pandanus conoideus Lam. and Orthosiphon aristatus Mig. based on formation edema volume on sole of foot male mice againts carrageenan, inflammation that occurs is measured using the pletysmometer. In the research, we used sodium CMC as a negative control and sodium diclofenac as a positive control administered topically. While combination of Pandanus conoideus Lam. and Orthosiphon aristatus Mig. with a ratio of 2:1. The result showed decrease edema with percent of inhibition 76,92% Respectively, as a conclussion the result indicate Natrium diklofenak didn't showed significant effect compare with the testing data
UJI DAYA HAMBAT EKSTRAK ETIL ASETAT DAUN BINAHONG (Anredera coliforlia (Ten.) Steenis) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus DAN Escherichia coli.
Get PDFBinahong (Anredera coliforlia (Ten.) Steenis) is a potential medicinal plants that can superintend with different kinds of diseases. Research on antibacterial activity of binahong leaves and the secondary metabolites content ever done that in binahong leaves contained alkaloids, saponins, polyphenols. This research is a laboratory experiments that aim to find out the inhibition of leaves binahong ethyl acetate extract (Anredera coliforlia (Ten.) Steenis) against bacteria test. Binahong leaf extract work done by maceration method. Bacteria test i.e. Staphylococcus aureus and Escherichia coli. The zone of inhibition are determined for concentration ranging between 5%, 10%, 15%, and 20%. Test of antibacterial activity is done using paper discs and disc diffusion method. The results of research can be drawn the conclusion that the ethyl acetate extract, binahong leaves at concentrations of 5% inhibition zone not seen against the bacteria Staphylococcus aureus, Escherchia coli and bacteria while at concentrations of 10%, 15% and 20% visible inhibition zone against both the bacteria i.e. 1.7 mm, 2.0 mm and 2.6 mm for the bacteria Staphylococcus aureus and 1.8 mm and 2.3 mm 2.8 mm for the bacterium Escherichia coli. It can be said that the extract of binahong leaves influential ethyl acetate can potentially inhibit the growth of Staphylococcus aureus and Escherichia coli, and based on the diameter of the inhibition zone caused by any concentration of the extract can also be inferred that the higher the concentration of a sample is then the higher the diameter of the inhibition zone is generated
UJI TOKSISITAS EKSTRAK ETANOL UMBI TALAS (Colocasia esculenta L. Schoot ) DENGAN METODE BRINE SHRIMP LETHALITY TEST TERHADAP Artemia Salina Leach
Get PDFThe research of toxicity assay of Ethanol Extracts of Taro tubers (Colocasia esculenta L. Schott) have been conducted with the aim of determining the effects of toxicity and anticancer potential of ethanol extract of tubers of taro (Colocasia esculenta L. Schott) by Brine Shrimp Lethality Test method against Artemia salina Leach. Ethanol extract, made with concentrations of 0.1, 1, 10, 100, 1000, and 10000 µg/ml and for comparison with the drugs vincristine concentrations of 0.01, 0.1, 1, and 10 µg/ml. Negative control using sea water made with the same concentrations. Furthermore, each concentration 10 ml of sea water and then put 10 shrimp larvae. The treatment is done by 10 replication at each concentration. Observations were made after 24 hours of treatment by counting the number of dead larva. The observations calculated using probit analysis program, showed LC50 values with 95% confidence level is 33,997 µg/ml (7,970 µg/ml-151,231 µg/ml). And the results of a comparison of data from drug vincristine showed LC50 value is 0,398 µg/ml (0,259 µg/ml-0,624 µg/ml)
UJI EFEK ANTIINFLAMASI FRAKSI KLOROFORM DAUN JOHAR (Cassia siamea Lamk.) DENGAN METODE RAT HIND PAW EDEMA
Get PDFJohar (Cassia siamea Lamk.) leaves widely used as a traditional medicine. Johar leaves contain chemical compounds such us alkaloids, tannins, saponins, flavonoids, sitosterol and barakol which have effect of treatment for several diseases including inflammatory. This study aims to determine anti-inflammatory effect of chloroform fraction C.siamea leaves. This study was conducted using 15 Wistar rats were divided into 5 groups: control group who were given suspension of Na.CMC 1% w / v, the comparison group were given diclofenac sodium suspension 0.35 mg / kg, the test group dose of 75 mg / kg, the test group dose of 150 mg / kg and a test group of 300 mg / kg. Evaluation of anti-inflammatory activity was done by measured initial volume of the foot all test animal then given the drug orally according to dosage of its group. After 30 minutes, each group made inflammatory by induced karagen 1% 0.1 mL by intraplatar. Furthermore, inflammation’s degrees was measured every hour for 8 hours. The results obtained show that after 2 hours, inflammatory of the control group Na.CMC had increased much higher compared to the other groups. This is shows that Na.CMC doesn’t have effects anti-inflammation. The comparison group diclofenac sodium gave the best inhibitory effect that have been shown from an increase volume of feet smaller than the test group chloroform fraction of Johar leaves. While in chloroform fraction of Johar leaves test group, group with dosage 75 mg/kg gave an inhibitory effect better than the other test group dosage
OPTIMASI BAHAN POLIMER PEMBENTUK MATRIKS TABLET SUSTAINED RELEASE Na. DIKLOFENAK
Get PDFSustained release tablet is one of drug delivery system with an extended release drugs which use polymer to control the release of drug from its dosage form. The advantages of this dosage form is can produce fixed blood levels are without repeat the administration of the unit dose. The aim of this study is to obtain the most optimum polymer as a matrix in sustained release tablets of Diclofenac Sodium. Sustained release tablets made by direct compression method from a mixture of three types of polymer combinations. F1 consists of a combination of HPMC polymer: Etilsellulosa, F2 is the combination of HPMC: Xanthan Gum and F3 consists of a combination of HPMC polymer: Na. Alginate. Each combination of polymer use the same ratio is 1: 2. Tablet evaluations include the weight uniformity of tablet, size,drug content and dissolution test. Result showed that the most optimum combination of polymer as a sustained release tablet matrix is F1 even F2 have an optimum dissolution
AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN FRAKSI DAUN Colocacia esculenta L. DENGAN METODE KLT-BIOAUTOGRAFI DAN DIFENILPIKRIL HIDRAZIL
Get PDFThe aim of the research to determine the antibacterial and antioxidant activity of Colocacia esculenta fraction leaves derive from Pare-Pare South Sulawesi in using TLC- Bioautography and diphenilpycril Hydroxil. Screening antibacterial activity test of the Colocacia esculenta fraction leaves exhibited in concentration 1% active on pathogenic bacteria Salmonella thypi. Based on either antibacterial and antioxidant activities by TLC-Bioautography showed that fraction at Rf 0.70 value active on bacteria Salmonella thypi and antioxidant active as well. Identification of active chemical compound showed flavonoid compound using Iodium-KI and antimo (III) clorida as reagent