South Eastern European Journal of Public Health (SEEJPH - Universität Bielefeld)
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Neuropharmacological Activities of Evolvulus alsinoides Plant Extract in Swiss Albino Rats
Full text linkThe aim of the present study was to investigate the neuropharmacological (antidepressant) activities of Evolvulus alsinoides whole plant extract in swiss albino rats. Anti-depressant activities of the methanolic extract of Evolvulus alsinoides were assessed by behavioral tests like Forced Swimming Test (FST), Tail Suspension Test (TST), and Locomotor Activity Test in male Swiss albino rats. By measuring the levels of oxidative stress markers in the rat brain homogenates, including plasma nitrites, plasma corticosterone and catalase (CAT), reduced glutathione, malondialdehyde (MDA), and superoxide dismutase, we were also able to investigate the neuropharmacological activities. Methanolic extract of the Evolvulus alsinoides plant showed significant neuropharmacological activity in Swiss albino rats. In both TST and FST, they significantly reduced the immobility duration and demonstrated dose-dependent activity (p<0.001). It demonstrated much more activity than imipramine in FST at 400mg kg-1 (p<0.001). Compared to the control group, they demonstrated a statistically significant increase in swimming time (p < 0.001). According to our research, Evolvulus alsinoides exhibited significant antidepressant properties. It appears that the primary mechanism underlying this action is catecholamine reuptake inhibition
"The Role of Library Resources in Academic Success: A User-Centric Study in West Godavari District"
Full text linkThis study examines the role of library resources in fostering academic success among students and faculty in degree colleges across West Godavari District, Andhra Pradesh. Libraries are integral to the academic ecosystem, providing access to a wide range of resources and services that support teaching, learning, and research. This user-centric study explores the extent to which library resources, including physical collections, digital databases, and support services, meet the academic needs of students and faculty.Data was collected through structured surveys and interviews with library users, including students, faculty, and administrative staff from selected degree colleges. The study also evaluates the quality, accessibility, and utilization of library resources and their direct impact on academic performance and user satisfaction. Key parameters such as the adequacy of resources, the frequency of use, the relevance of materials, and the effectiveness of library staff were analyzed.The findings reveal that while libraries play a pivotal role in academic success, challenges such as inadequate funding, limited digital access, and insufficient user awareness impact their effectiveness. The study underscores the need for libraries to adapt to evolving educational demands by incorporating modern technologies and user-friendly services.This research highlights actionable recommendations for improving library resource management, enhancing user engagement, and aligning library services with academic goals. It emphasizes the critical role of stakeholder collaboration in transforming libraries into dynamic hubs of academic excellence
CHURCH AS AN INSTITUTION FOR MEDIATION IN INDIA.
Full text linkMediation is an alternative method for resolving disputes, where a neutral third party assists in guiding the discussions amongst the conflicting parties to support them in achieving an agreement. Unlike in a court of law, the mediator does not provide advice or make decisions; instead, they assist the parties in communicating and finding their own solutions. Mediation differs from the legal process in that it does not impose any decisions on the parties; rather, the parties themselves determine the terms of their settlement through mutual agreement. Unlike court rulings, which often result an outcome where one side wins and the other loses, Mediation seeks to achieve a mutually beneficial outcome for both parties. "Church mediation" is a specific form of mediation where churches play a role in resolving disputes among their members. In India, this form of mediation exists as "Reconciliation" at the parish level, though it is not widely recognized, even among parishioners of the particular diocese. The concept of church mediation or reconciliation is rooted in biblical teachings that emphasize the importance of love and harmony among people. This article will explore the potential the Church\u27s function as a mediator in resolving disputes among Christian believers in India, the reasons for its limited effectiveness thus far, the challenges of implementing church mediation in a secular country like India, and the different strategies the Church can adopt to enhance its effectiveness in this role
Understanding Trochlear Nerve Palsy: Etiological Perspectives fromthe Literature
Full text linkIntroduction: The trochlear nerve (cranial nerve IV) innervates the superior oblique muscle and is critical for eye movement control. As the thinnest and longest cranial nerve, it has unique anatomical and functional characteristics. Trochlear nerve palsy results in paralytic strabismus and diplopia, with treatment approaches varying based on etiology.Aim: To synthesize and analyze existing literature on the prevalence and etiology of trochlear nerve palsy (TNP).Methods: Literature review of major studies examining TNP, focusing on etiological distribution, clinical presentation, and demographic patterns across different patient populations.Results: Congenital TNP prevalence varied between 8-77.45% across studies, with most common presentation in the fourth decade of life. Traumatic causes represented 20-35% of cases, predominantly affecting males (60%) in their third decade. Microvascular causes accounted for 13-24% of cases, mainly presenting in the seventh decade and associated with hypertension and diabetes. Idiopathic cases ranged from 4-23%. Rare causes included tumors (9%) and other miscellaneous conditions (15%). Diplopia was more frequently reported in acquired versus congenital cases.Conclusions: TNP presents with diverse etiologies, varying significantly across studies. Standardized diagnostic criteria and longitudinal studies are needed for better categorization and understanding of disease progression. Early recognition of underlying causes is crucial for targeted treatment strategies, particularly in patients with trauma history or systemic vascular conditions
UNUSUAL PRESENTATION OF LOW-GRADE SYNOVIAL SARCOMA AS FLEXION CONTRACTURE OF THE KNEE
Full text linkSynovial sarcoma (SS) is an uncommon type of mesenchymal tumor that commonly involves the juxta-articular region, particularly around large joints like the knee. Although synovial sarcomas are usually high-grade tumors, this case highlights an instance of a low-grade variant with benign clinical features. A boy in late adolescence presented with persistent pain and progressive flexion contracture around the knee for four years. Imaging suggested a benign lesion; however, histopathology confirmed SS. Post-surgery, the patient received radiotherapy due to positive surgical margins. A year later, he exhibited a painless knee movement with a mild flexion deformity, showing no signs of recurrence. This report emphasizes the importance of molecular analysis and careful excision for low-grade SS, given the risk of recurrence despite benign appearances
Health Beliefs Behavior and Physical Exercise Behavior Among Chinese Adolescents An Analysis of Physical Exercise Behaviors Using the Health Belief Model
Full text linkPurpose:This study aims to examine the health beliefs influencing physical exercise behaviors among Chinese adolescents in Guangdong Province, applying the HBM to investigate the relationship between health beliefs and physical activity. Focusing on adolescents from eight cities within the province, this study assesses five HBM components in relation to their physical exercise behaviors.Methods: This study collects data from 3,000 Chinese adolescents aged 10–19 across eight cities in Guangdong Province, China. Using the Health Belief Model (HBM), five factors were analyzed: Perceived Risk, Perceived Severity, Perceived Benefit, Perceived Barriers, and Perceived Self-Efficacy, with Physical Exercise Behavior as the dependent variable.Results:Overall, health beliefs among adolescents were neutral (X̅ = 2.95, S.D. = 0.43). Perceived Barriers scored the highest (X̅ = 3.00, S.D. = 0.44), highlighting challenges like academic pressures. Perceived Self-Efficacy (X̅ = 2.99, S.D. = 0.44) and Perceived Severity (X̅ = 2.99, S.D. = 0.43) were also relatively high, while Perceived Benefit (X̅ = 2.89, S.D. = 0.42) and Perceived Risk (X̅ = 2.88, S.D. = 0.42) were moderate to low. Physical Exercise Behavior was neutral (X̅ = 2.91, S.D. = 0.42), with adolescents showing confidence in maintaining exercise routines but less in resisting peer pressure or performing exercises correctly.Chikan District, Zhanjiang City, showed a significant correlation between health beliefs and exercise behavior (r = 0.458, p < 0.001). Regression analysis revealed health beliefs explained 64.9% of exercise behavior variance (Adjusted R² = 0.644), with Perceived Risk being the strongest predictor (β = 0.799, p < 0.001). Conclusion:These findings highlight the need to enhance self-efficacy and address perceived barriers to promote physical activity among Chinese adolescents
A Cross Sectional Survey of Knowledge, Attitude and Practice of Antibiotic Use in Pregnancy Patients Among Undergraduate Students in Dental School
Full text linkObjective: Antibiotics were “invented” billions of years ago and susceptibility is largely the product of bacterial adaptation to aeons of antibiotic exposure. Because of antibiotics\u27 curative ability, their use in nature usually selects for pre-existing resistant bacteria populations. Antibiotics are the medications that are commonly prescribed for pregnant women. Antibiotics play a vital role in improving and enhancing the health of pregnant women. Materials and Methods: An online survey was conducted through google docs link. A questionnaire containing 18 questions was created and the questions were approved by Saveetha research board Chennai. Discussion: Dentist usually have a separate treatment plan for pregnant women as they too fear anesthesia, analgesics and some antibiotics which can lead to malformations. In a study conducted by tantradi et al, among interns, 35% of the participants had never treated a pregnant patient, 57 % had treated fewer than 5 pregnant patients, and 21% of the participants were not confident in treating such patients. Conclusion: Dental treatment for pregnant women needs special care and attention. From the results obtained it is known that the dental students have average knowledge about the use of antibiotics for pregnant women
EFFECT OF PRICE CONSCIOUSNESS OVER THE CROSS-SHOPPING BEHAVIOR AMONG MALL CLIENTELE IN CHENNAI
Full text linkThe phenomenon of cross-shopping behaviour comprises of the consumers getting actively engaged in a single channel at the time of searching for a product, however, getting switched to some other channel while actual purchase. The price comparisons are made during such a phenomenon and if the price of a specific product is less, the consumers make a switch to that product line. With this point in reference, the present study aims to explore the effect of price consciousness over the cross-shopping behaviour of the customers of malls. The respondents are selected through convenience sampling method of sampling and the sample size of the study is 205. The tool used for data collection is questionnaire and the instrument for analysis of data is Regression. Results of analysis show tha
Transdermal Nanogel formulation, development, and evaluation using a synergistic effect of anti-inflammatory drug with herbal extract
Full text linkThe study intended to design, develop, and assess a transdermal nanogel containing a synergistic combination of herbal extracts and anti-inflammatory and analgesic agents for effective pain and inflammation management. The nanogel was synthesised by a modified emulsion-ultrasonication method, with composition optimised via factorial design to attain the requisite physicochemical characteristics. The composition comprised 6-Gingerol resin and Capsaicin resin, with Nimesulide as the active ingredient and carbopol 940 serving as the gelling agent. Characterisation investigations indicated a mean particle size of 208.12 nm, a narrow particle size distribution of 0.231, and a zeta potential of -12.5 mV, thereby affirming the formulation\u27s stability. The nanogel demonstrated superior viscosity, spreadability, and pH compatibility, rendering it appropriate for transdermal application. Stability experiments performed in accordance with ICH criteria validated the formulation\u27s resilience under diverse situations. The results indicate that the formulated nanogel presents a promising, synergistic treatment strategy for alleviating pain and inflammation while improving patient adherence
DETERMINATION OF BIOACTIVE POTENTIAL OF EVOLVULUS ALSINOIDES AND TODDALIA ASIATICA ROOT EXTRACTS
Full text linkEvolvulusalsinoides, locally known as Vishnukranthi and Toddalia asiatica, commonly called as Kindu mullu which are well-known medicinal plants noted for itsmiraculousheathcare benefits. The present study focused on the determination of bioactive potential include anti-bacterial, anti-oxidant, anti-inflammatory and anti-diabetic activities of selected two plants. In the Disc diffusion method, the plant samples explored varying degrees of antibacterial activity against gram-positive bacteria(GPB) including Bacillus subtilis and Staphylococcus aureus, as well as gram-negative bacteria (GNB) including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas fluorescens. The higher DPPH, H2O2and NO scavenging activities were found in both the plant samples. From the results of anti-diabetic studies, we found that E.alsinoides and T.asiatica showed the excellent α-amylase and α-glucosidase inhibitory effect. This study conclude that E.alsinoides and T.asiaticaare the rich source of bioactive potential with anti-bacterial, anti-oxidant, anti-inflammatory and anti-diabetic properties