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Severity of placental abruption in restrained pregnant vehicle drivers: Correct seat belt use confirmed by finite element model analysis
滋賀医科大学博士(医学)International journal of environmental research and public health. 2022 Oct 26;19(21):13905.令和5年度thesi
Optimal sampling strategy and threshold of serum vancomycin concentration in elderly Japanese patients undergoing high-flux hemodialysis
滋賀医科大学博士(医学)application/pdfThesis or DissertationTherapeutic drug monitoring. 2022 Jun 1;44(3):396-403.令和4年度thesi
Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects
滋賀医科大学博士(医学)application/pdfThesis or DissertationScientific Reports. 2022 Nov 29;12(1):20589.令和4年度thesi
Larger Volume and Higher Fat Content of the Pancreatic Head Are Predictive Factors for Postendoscopic Retrograde Cholangiopancreatography Pancreatitis
滋賀医科大学博士(医学)application/pdfThesis or DissertationPancreas. 2022 Jan 1;51(1):28-34.令和4年度thesi
Insufficient antenatal identification of fetal growth restriction leading to intrauterine fetal death: a regional population-based study in Japan.
application/pdfObjective:
Fetal growth restriction (FGR) is associated with perinatal adverse outcomes including intrauterine fetal death. Antenatally unidentified FGR has a higher risk of intrauterine fetal death than that identified antenatally. We, therefore, investigated the antenatal identification of FGR among intrauterine fetal deaths, and assessed the perinatal factors associated with the identification of FGR.Methods:
This retrospective and population-based study reviewed all stillbirths in Shiga Prefecture, Japan, from 2007 to 2016 with exclusion criteria of multiple births, births at unidentified gestational weeks or < 22 gestational weeks, and lethal disorders. We analyzed cases of FGR, using the Japanese clinical definition: Z-score of estimated fetal weight for gestational age <-1.5 standard deviations (SD).Results:
We identified 94 stillbirths with FGR among 429 stillbirths. Thirty-seven cases were antenatally identified during pregnancy management (39%). Dividing cases by a Z-score of -2.5 SD, 51 cases were classified as ≤-2.5 SD. Twenty-eight of the 51 cases (55%) with a Z-score <-2.5 SD were antenatally identified as having FGR, whereas 9 of the 43 cases (21%) with a Z-score ≥-2.5 SD were antenatally identified as having FGR (p = .002). Among cases with a Z-Score <-2.5 SD, 16 of 21 (76%) beyond 28 weeks' gestation and 12 of 30 (40%) before 28weeks' gestation were antenatally identified as having FGR (p = .023).Conclusion:
Fetal growth restriction leading to intrauterine fetal death in Japan was antenatally identified in less than half of cases. Antenatal identification of FGR was associated with the severity of growth restriction.Journal Articlejournal articl
Traumatic asphyxia death in a bicyclist: an autopsy case
We report an autopsy case of fatal traumatic asphyxia in a bicyclist. A 15-year-old female bicyclist fell from her bike after collision with the rear end of a truck that was backing up. Her body was pinned between the ground and a spare tire attached to the bottom of the truck. Autopsy revealed congestion of the head, face, neck, upper anterior aspect of the chest, and bilateral arms, and many petechial hemorrhages in the oral mucosa and bilateral palpebral conjunctivae. Internal examination revealed hemorrhage of the intercostal muscles with a rib fracture, mild liver laceration, and pelvic fracture resulting from compression of the thoracoabdominal region, and the findings of acute death. The cause of death was diagnosed as traumatic asphyxia. Known mechanisms of traumatic asphyxia in motor vehicle collisions include crushing of pedestrians or ejected occupants by the vehicle and crushing of occupants by intrusion into the passenger compartment; traumatic asphyxia resulting from vehicle collision involving in a bicyclist has not been reported. The present case indicates that forensic pathologists should consider the possibility of traumatic asphyxia when investigating vehicle collision deaths, especially in bicyclists.外傷性窒息により死亡した自転車乗員の剖検事例を報告する.症例は15歳の女子,自転車に乗車し空き地を走行中,空き地に駐車するため後進する大型トラックの後部と衝突した.死者は自転車から転落し,地面と大型トラックの底面に取り付けられたスペアタイヤの間に挟まれ死亡した.翌日司法解剖が施行された.外表所見では,頭部,顔面,頚部,胸部上前面,両上肢にうっ血と,左右眼瞼結膜下及び口腔粘膜下に多数の溢血点を認めた.内景所見では,急死の所見,左第2から第5肋骨及び右第5から第7肋骨の骨折,軽度の肝挫傷,胸腹部圧迫による骨盤骨折を認め,死因は外傷性窒息と診断した.自動車衝突事故における外傷性窒息では,歩行者や車外放出された乗員の車両底面による圧迫,車両の陥凹に伴う乗員の圧迫などが知られているが,自転車乗員の車両衝突事故による外傷性窒息は報告されていない.本事例は,自転車乗員の衝突事故死例を経験した際に,外傷性窒息の可能性を検討すべきことを示唆している.departmental bulletin pape
Inhibition of mitochondrial fission protects podocytes from albumin-induced cell damage in diabetic kidney disease
滋賀医科大学博士(医学)application/pdfThesis or DissertationBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2022 May 1;1868(5):166368.令和4年度thesi
In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD
滋賀医科大学博士(医学)Neuroscience research. 2023 Aug:193:41-51.令和5年度thesi
Factors influencing fatalities or severe injuries to pedestrians lying on the road in Japan:Nationwide police database study.
滋賀医科大学博士(医学)Healthcare (Basel). 2021 Oct 24;9(11):1433.令和5年度thesi